Matrix metalloproteinase-sensitive hydrogel microparticles for pulmonary drug delivery of small molecule drugs or proteins

2015 ◽  
Vol 3 (27) ◽  
pp. 5629-5634 ◽  
Author(s):  
Emilie Secret ◽  
Kelsey E. Crannell ◽  
Stefan J. Kelly ◽  
Maria Villancio-Wolter ◽  
Jennifer S. Andrew
Keyword(s):  
Drug Delivery ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Small Molecule ◽  
Pulmonary Drug Delivery ◽  
Hydrogel Microparticles ◽  
Small Molecule Drugs

Hydrogel microparticles sensitive to matrix metalloproteinases are studied for release of drugs and proteins into the lungs.

Enzyme-Responsive Hydrogel Microparticles for Pulmonary Drug Delivery

2014 ◽  
Vol 6 (13) ◽  
pp. 10313-10321 ◽  
Author(s):  
Emilie Secret ◽  
Stefan J. Kelly ◽  
Kelsey E. Crannell ◽  
Jennifer S. Andrew
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Hydrogel Microparticles

Self-assembling peptide-based nanodrug delivery systems

2019 ◽  
Vol 7 (12) ◽  
pp. 4888-4911 ◽  
Author(s):  
Qian Wang ◽  
Nan Jiang ◽  
Bo Fu ◽  
Fan Huang ◽  
Jianfeng Liu
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Delivery Systems ◽  
Present Review ◽  
Peptide Conjugates ◽  
Nanodrug Delivery ◽  
Self Assembling ◽  
Small Molecule Drugs ◽  
Delivery Strategies

The present review outlines the methods designing self-assembling peptide-based NDDs for small molecule drugs, with an emphasis on the different drug delivery strategies and their applications in using peptides and peptide conjugates.

scholarly journals Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Na Yu ◽  
Yang Xu ◽  
Tao Liu ◽  
Haiping Zhong ◽  
Zunkai Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Functional Group ◽  
Building Blocks ◽  
Hydroxyl Group ◽  
Reaction Conditions ◽  
Small Molecule Drugs ◽  
Wide Range ◽  
Scalable Synthesis ◽  
Traditional Approaches

AbstractIsopropenyl ethers are critical intermediates for accessing medicinally valuable ketal-based prodrugs and biomaterials, but traditional approaches for the synthesis of isopropenyl ethers suffer from poor functional group compatibility and harsh reaction conditions. Here, we develop an organocatalytic transisopropenylation approach to solve these challenges, enabling the synthesis of isopropenyl ethers from various hydroxyl-group-containing small-molecule drugs, polymers, and functional building blocks. The method provides a straightforward and versatile synthesis of isopropenyl ethers, features excellent tolerance of diverse functional groups, applies to a wide range of substrates, and allows scalable synthesis. The development of this organocatalytic transisopropenylation approach enables access to modular preparation of various acid-sensitive ketal-linked prodrugs and functionalized ketalated biomaterials. We expect our syntheses and transformations of isopropenyl ethers will find utility in several diverse fields, including medicinal chemistry, drug delivery, and biomaterials.

Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase- 7

2020 ◽  
Vol 20 (27) ◽  
pp. 2459-2471
Author(s):  
Ling-Li Wang ◽  
Bing Zhang ◽  
Ming-Hua Zheng ◽  
Yu-Zhong Xie ◽  
Chang-Jiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Matrix Metalloproteinases ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Selective Inhibitor ◽  
Migration And Invasion ◽  
Side Chains ◽  
Mesenchymal Transition ◽  
Targeted Drug

Background: Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that play a key role in both physiological and pathological tissue degradation. MMPs have reportedly shown great potentials in the degradation of the Extracellular Matrix (ECM), have shown great potentials in targeting bioactive and imaging agents in cancer treatment. MMPs could provoke Epithelial to Mesenchymal Transition (EMT) of cancer cells and manipulate their signaling, adhesion, migration and invasion to promote cancer cell aggressiveness. Therefore, targeting and particularly inhibiting MMPs within the tumor microenvironment is an effective strategy for cancer treatment. Based on this idea, different MMP inhibitors (MMPIs) have been developed to manipulate the tumor microenvironment towards conditions appropriate for the actions of antitumor agents. Studies are ongoing to improve the selectivity and specificity of MMPIs. Structural optimization has facilitated the discovery of selective inhibitors of the MMPs. However, so far no selective inhibitor for MMP-7 has been proposed. Aims: This study aims to comprehensively review the potentials and advances in applications of MMPs particularly MMP-7 in targeted cancer treatment approaches with the main focus on targeted drug delivery. Different targeting strategies for manipulating and inhibiting MMPs for the treatment of cancer are discussed. MMPs are upregulated at all stages of expression in cancers. Different MMP subtypes have shown significant targeting applicability at the genetic, protein, and activity levels in both physiological and pathophysiological conditions in a variety of cancers. The expression of MMPs significantly increases at advanced cancer stages, which can be used for controlled release in cancers in advance stages. Methods: Moreover, this study presents the synthesis and characteristics of a new and highly selective inhibitor against MMP-7 and discusses its applications in targeted drug delivery systems for therapeutics and diagnostics modalities. Results: Our findings showed that the structure of the inhibitor P3’ side chains play the crucial role in developing an optimized MMP-7 inhibitor with high selectivity and significant degradation activities against ECM. Conclusion: Optimized NDC can serve as a highly potent and selective inhibitor against MMP-7 following screening and optimization of the P3’ side chains, with a Ki of 38.6 nM and an inhibitory selectivity of 575 of MMP-7 over MMP-1.

Application of Chitosan and its Derivatives in Nanocarrier Based Pulmonary Drug Delivery Systems

2018 ◽  
Vol 5 (4) ◽  
Author(s):  
Kamal Dua ◽  
Mary Bebawy ◽  
Rajendra Awasthi ◽  
Rakesh K. Tekade ◽  
Muktika Tekade ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery
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