Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides

2016 ◽  
Vol 52 (27) ◽  
pp. 4894-4897 ◽  
Author(s):  
Nico Ueberschaar ◽  
Florian Meyer ◽  
Hans-Martin Dahse ◽  
Christian Hertweck
Keyword(s):  
Soluble Sugar ◽  
Water Soluble ◽  
Antiproliferative Activities

1,4′-Bipiperidine-1′-carbamate residues were evaluated as sugar surrogates in daunorubicin and chartreusin, yielding water-soluble derivatives and prodrugs with dramatically improved antiproliferative activities.

scholarly journals Characterization and Prebiotic Potential of Longan Juice Obtained by Enzymatic Conversion of Constituent Sucrose into Fructo-Oligosaccharides

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2596 ◽  
Author(s):  
Yongxia Cheng ◽  
Haibo Lan ◽  
Lei Zhao ◽  
Kai Wang ◽  
Zhuoyan Hu
Keyword(s):  
Soluble Sugar ◽  
Monosaccharide Composition ◽  
Water Soluble ◽  
Lactobacillus Delbrueckii ◽  
Soluble Solids ◽  
Enzyme Treatment ◽  
Bacteria Growth ◽  
Before And After ◽  
Soluble Polysaccharide

The prebiotic potential of longan juice obtained by a commercial Viscozyme L for conversion of constituent sucrose to fructo-oligosaccharide was investigated. The physicochemical properties and carbohydrate composition of the longan juice was evaluated before and after enzymatic treatment. The stimulation effects of the treated longan juice on probiotic bacteria growth were also studied in vitro. The results showed that total soluble solids, yield and clarity of longan juice were all significantly improved after enzyme treatment. The water-soluble polysaccharide content, including pectin, was significantly increased. Compared with the natural longan pulp, the enzyme treated juice showed a significant decrease in sucrose content. Substantial fructo-oligosaccharides including 1-kestose and nystose were synthesized after enzyme treatment. The molecular weight distribution and the monosaccharide composition of the water-soluble polysaccharide were significantly changed by enzyme treatment. The treated longan juice and its ethanol-soluble sugar fraction promoted the growth of Streptococus thermophiles, Lactobacillus acidophilus and Lactobacillus delbrueckii, showing a good potential of the treated longan juice for producing functional foods and nutraceuticals.

scholarly journals The Response of Critical Microbial Taxa to Litter Micro-Nutrients and Macro-Chemistry Determined the Agricultural Soil Priming Intensity After Afforestation

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongling Yang ◽  
Yulin Li ◽  
Shaokun Wang ◽  
Jin Zhan ◽  
Zhiying Ning ◽  
...  
Keyword(s):  
Litter Quality ◽  
Agricultural Soils ◽  
Condensed Tannin ◽  
Soluble Sugar ◽  
Fungal Species ◽  
Carbon Accumulation ◽  
Water Soluble ◽  
Farmland Soil ◽  
Litter Mixture ◽  
Soc Mineralization

Afforestation with trees and shrubs around cropland can effectively decrease soil degradation and avoid sand storms, but subsequent modification of litter quality accelerates the degradation of native organic matter via the soil priming effect (PE). Although carbon accumulation in agricultural soils after afforestation was widely studied, little is known about the extent to which soil organic carbon (SOC) mineralization is induced by complex residue input in agro-forest-grass composite ecosystems. Here, we mixed corn field soil and litter of afforestation tree and shrub species together in a micro-environment to quantify the effects of litter-mixture input on farmland soil priming associated with afforestation. Additionally, we studied the responses of bacterial and fungal species to litter chemistry, with the aim to identify the litter and microbial driver of soil priming. The results showed that soil priming was accelerated by different litter addition which varied from 24 to 74% of SOC mineralization, suggesting that priming intensity was relatively flexible and highly affected by litter quality. We also find that the macro-chemistry (including litter carbon, nitrogen, lignin, and cellulose) directly affects priming intensity, while micro-chemistry (including litter soluble sugar, water-soluble phenol, methanol-soluble phenol, and condensed tannin) indirectly influences priming via alteration to dominant bacterial taxa. The stepwise regression analysis suggested that litter nitrogen and cellulose were the critical litter drivers to soil priming (r2 = 0.279), and the combination of bacterial phylum Proteobacteria, Firmicutes, Bacteroidetes, Acidobacteria, and fungal taxa Eurotiomycetes was a great model to explain the priming intensity (r2 = 0.407).

New water-soluble polypyridine silver(i) derivatives of 1,3,5-triaza-7-phosphaadamantane (PTA) with significant antimicrobial and antiproliferative activities

2013 ◽  
Vol 42 (18) ◽  
pp. 6572 ◽  
Author(s):  
Piotr Smoleński ◽  
Sabina W. Jaros ◽  
Claudio Pettinari ◽  
Giulio Lupidi ◽  
Luana Quassinti ◽  
...  
Keyword(s):  
Water Soluble ◽  
Derivatives Of ◽  
Antiproliferative Activities

Near-Infrared Hyperspectral Imaging Rapidly Detects the Decay of Postharvest Strawberry Based on Water-Soluble Sugar Analysis

2019 ◽  
Vol 12 (4) ◽  
pp. 936-946 ◽  
Author(s):  
Qiang Liu ◽  
Kangli Wei ◽  
Hui Xiao ◽  
Sicong Tu ◽  
Ke Sun ◽  
...  
Keyword(s):  
Hyperspectral Imaging ◽  
Near Infrared ◽  
Soluble Sugar ◽  
Water Soluble ◽  
Sugar Analysis

Profiling and relationship of water-soluble sugar and protein compositions in soybean seeds

2016 ◽  
Vol 196 ◽  
pp. 776-782 ◽  
Author(s):  
Xiaomin Yu ◽  
Fengjie Yuan ◽  
Xujun Fu ◽  
Danhua Zhu
Keyword(s):  
Soluble Sugar ◽  
Water Soluble ◽  
Soybean Seeds ◽  
Relationship Of

Synthesis of sugar-organometallic conjugales: ferrocenyl monosaccharide derivatives

1980 ◽  
Vol 58 (12) ◽  
pp. 1188-1197 ◽  
Author(s):  
Michael J. Adam ◽  
Laurance D. Hall
Keyword(s):  
Group Technology ◽  
Chemical Shifts ◽  
Soluble Sugar ◽  
Free Water ◽  
Lattice Relaxation ◽  
Proton Spin ◽  
Water Soluble ◽  
Coupling Constants ◽  
Spin Lattice Relaxation ◽  
Spin Lattice

Suitably blocked carbohydrates containing free thio 4, amino 5, and hydroxyl 10, 19 nucleophilic functionalities have been treated with (a) ferrocenecarbonyl chlorides 2 and 3, (b) N,N-dimethylaminomethylferrocene methiodide 12, and (c) ferrocenyl tosylate 16 to form the ferrocenyl sugar derivatives 6, 7, 8, 9, 11, 13, 14, 15, and 20. Direct conjugation of a free, water-soluble sugar to ferrocene was achieved by the formation of a Schiff's base between glucosamine hydrochloride 25 and ferrocene carboxaldehyde 24. The synthesis of ferrocenyl sugars using bridging group technology is exemplified by the conjugation of the thio sugar 4 to ferrocene via the versatile coupling reagent cyanuric chloride 21 to form the s-triazine compound 23. These products have been studied by 1H nmr spectroscopy: chemical shifts, coupling constants, and proton spin–lattice relaxation measurements.

Effect of Multiple Gas Media Package on Preservation of Fresh Sweet Corn at Room Temperature

2013 ◽  
Vol 477-478 ◽  
pp. 1354-1358
Author(s):  
Jian Qing Meng ◽  
Xiao Yu Jia ◽  
Wei Qiao Yang ◽  
Xi Hong Li
Keyword(s):  
High Temperature ◽  
Water Content ◽  
Room Temperature ◽  
Sweet Corn ◽  
Sugar Content ◽  
Soluble Sugar ◽  
Water Soluble ◽  
Plate Count ◽  
Aerobic Plate Count

Effects of different methods of gas package on freshness of harvested fresh Sweet Corn, at room temperature in its shelf life were investigated. The harvested fresh Sweet Corn were packaged under vacuum, air, N2 or CO2, respectively, and then stored 90 days at 30°Cafter the high temperature sterilization. After the sterilization and during storage, the changes of aerobic plate count, water content, soluble sugar content, and TPA were determined. The results showed that compared with others, the package with N2 could inhibit the growth of microorganisms, kept the content of water, soluble sugar and fat. After 90 days, TPA showed that the package in nitrogen could improve the quality of sweet corns.

Solute leakage from susceptible and tolerant cultivars of Phaseolus vulgaris following ozone exposure

1982 ◽  
Vol 60 (1) ◽  
pp. 73-78 ◽  
Author(s):  
B. D. McKersie ◽  
P. Hucl ◽  
W. D. Beversdorf
Keyword(s):  
Amino Acids ◽  
Phaseolus Vulgaris ◽  
Soluble Sugar ◽  
Amino Acid Content ◽  
Water Soluble ◽  
Ozone Exposure ◽  
Leaf Discs ◽  
Solute Leakage ◽  
Phloem Translocation ◽  
Reduced Rate

The leakage of total electrolytes, potassium, calcium, sugars, and amino acids from primary leaf discs of Phaseolus vulgaris L. cv. Seafarer (ozone susceptible) and cv. Goldcrop (ozone tolerant) was monitored following exposure to 40 parts per hundred million (pphm) ozone for 4 h. Significant differences in cultivar response were not detected until 24 h after exposure. At that time, leakage from cv. Seafarer leaves was 220% for total electrolytes, 230% for calcium, 260% for potassium and sugars, and 400% for amino acids relative to controls, whereas the leakage from cv. Goldcrop leaves remained at control levels. The water-soluble sugar and free amino acid content of a leaf homogenate also increased at the 24-h sampling time. These accumulations may result from a reduced rate of phloem translocation. Rates of leakage and leaf-solute contents returned to control levels by 48 and 72 h after exposure.Kinetic analysis of solute efflux from leaf discs sampled from both cultivars immediately after ozone exposure indicated that these leaves contained an increased quantity of solutes which could be rapidly leached within 0.5 h. However, the subsequent linear rate of leakage between 0.5 and 4 h did not increase except in leaf discs sampled from cv. Seafarer 24 h after exposure. The results are discussed in relation to the mechanism of ozone injury in cv. Seafarer and the basis of ozone tolerance in the cv. Goldcrop.

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