scholarly journals The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells

2017 ◽  
Vol 15 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Lilya U. Dzhemileva ◽  
Vladimir A. D'yakonov ◽  
Aleksey A. Makarov ◽  
Evgeny N. Andreev ◽  
Milyausha M. Yunusbaeva ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cancer Cells ◽  
Acetylenic Alcohol ◽  
Early Apoptosis

The first gram-scale total synthesis of natural lembehyne B, a selective inducer of early apoptosis in leukemia cancer cells, has been developed.

scholarly journals Cisplatin, glutathione and the third wheel: a copper-(1,10-phenanthroline) complex modulates cisplatin–GSH interactions from antagonism to synergism in cancer cells resistant to cisplatin

RSC Advances ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 5362-5376 ◽  
Author(s):  
Sarah Vascellari ◽  
Elisa Valletta ◽  
Daniela Perra ◽  
Elisabetta Pinna ◽  
Alessandra Serra ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Drug Cocktail ◽  
The Third ◽  
New Drug ◽  
Early Apoptosis ◽  
Phenanthroline Complex ◽  
Resistant Cells

A new drug cocktail is proposed to overcome the cisplatin-resistance due to the presence of glutathione. A2780 cisplatin-resistant cells, treated with the drug cocktail, showed early apoptosis.

Total Synthesis of Isoprekinamycin:  Structural Evidence for Enhanced Diazonium Ion Character and Growth Inhibitory Activity toward Cancer Cells

2007 ◽  
Vol 9 (15) ◽  
pp. 2915-2918 ◽  
Author(s):  
Wei Liu ◽  
Matthew Buck ◽  
Nan Chen ◽  
Muhong Shang ◽  
Nicholas J. Taylor ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Diazonium Ion

scholarly journals Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells

2008 ◽  
Vol 18 (17) ◽  
pp. 4904-4906 ◽  
Author(s):  
Oliver E. Hutt ◽  
Bollu S. Reddy ◽  
Sajiv K. Nair ◽  
Emily A. Reiff ◽  
John T. Henri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Total Synthesis ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mcf 7

scholarly journals Total Synthesis of Phorbazole B

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4848
Author(s):  
Yngve Guttormsen ◽  
Magnus E. Fairhurst ◽  
Sunil K. Pandey ◽  
Johan Isaksson ◽  
Bengt Erik Haug ◽  
...  
Keyword(s):  
Natural Products ◽  
High Resolution ◽  
Secondary Metabolites ◽  
Total Synthesis ◽  
Cancer Cells ◽  
Marine Sponge ◽  
Inhibitory Activity ◽  
Late Stage ◽  
Nmr Techniques

Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B using late stage electrophilic chlorination was developed. The synthesis relied on the use of an oxazole precursor, which was protected with an iodine in the reactive 4-position, followed by complete chlorination of all pyrrole positions. Attempts to prepare phorbazole A and C, which contain a 3,4-dichlorinated pyrrole, were unsuccessful as the desired chlorination pattern on the pyrrole could not be obtained. The identities of the dichlorinated intermediates and products were determined using NMR techniques including NOESY/ROESY, 1,1-ADEQUATE and high-resolution CLIP-HSQMBC.

Modified Panax ginseng Extract Inhibits uPAR-Mediated α5β1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells

2016 ◽  
Vol 44 (05) ◽  
pp. 1081-1097 ◽  
Author(s):  
In-Hu Hwang ◽  
Yong-Kyun Kwon ◽  
Chong-Kwan Cho ◽  
Yeon-Weol Lee ◽  
Jung-Suk Sung ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Herbal Medicine ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Integrin Signaling ◽  
Caspase 8 ◽  
Ginseng Extract ◽  
Caveolin 1 ◽  
Early Apoptosis ◽  
A549 Lung

Urokinase receptor (uPAR) is enhanced in many human cancer cells and is frequently an indicator of poor prognosis. Activation of [Formula: see text]1-integrin requires caveolin-1 and is regulated by uPAR. However, the underlying molecular mechanism responsible for the interaction between uPAR and [Formula: see text]1-integrin remains obscure. We found that modified regular Panax ginseng extract (MRGX) had a negative modulating effect on the uPAR/[Formula: see text]1-integrin interaction, disrupted the uPAR/integrin interaction by modulating caveoline-1, and caused early apoptosis in cancer cells. Additionally, we found that siRNA-mediated caveoline-1 downregulation inhibited uPAR-mediated [Formula: see text]1-integrin signaling, whereas caveoline-1 up-regulation stimulated the signaling, which suppressed p53 expression, thereby indicating negative crosstalk exists between the integrin [Formula: see text]1 and the p53 pathways. Thus, these findings identify a novel mechanism whereby the inhibition of [Formula: see text]1 integrin and the activation of p53 modulate the expression of the anti-apoptotic proteins that are crucially involved in inducing apoptosis in A549 lung cancer cells. Furthermore, MRGX causes changes in the expressions of members of the Bcl-2 family (Bax and Bcl-2) in a pro-apoptotic manner. In addition, MGRX-mediated inhibition of [Formula: see text]1 integrin attenuates ERK phosphorylation (p-ERK), which up-regulates caspase-8 and Bax. Therefore, ERK may affect mitochondria through a negative regulation of caspase-8 and Bax. Taken together, these findings reveal that MRGX is involved in uPAR-[Formula: see text]1-integrin signaling by modulating caveolin-1 signaling to induce early apoptosis in A549 lung-cancer cells and strongly indicate that MRGX might be useful as a herbal medicine and may lead to the development of new herbal medicine that would suppress the growth of lung-cancer cells.

scholarly journals Novel drug isolated from mistletoe (1E,4E)-1,7-bis(4-hydroxyphenyl)hepta-1,4-dien-3-one for potential treatment of various cancers: synthesis, pharmacokinetics and pharmacodynamics

RSC Advances ◽  
2020 ◽  
Vol 10 (46) ◽  
pp. 27794-27804
Author(s):  
Jing Hong ◽  
Lin Meng ◽  
Peipei Yu ◽  
Ceng Zhou ◽  
Zhaoyan Zhang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cancer Cells ◽  
Potential Treatment ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Normal Cells ◽  
Liver And Kidney ◽  
Novel Drug

(1E,4E)-1,7-Bis(4-hydroxyphenyl)hepta-1,4-dien-3-one (DHDK) is a novel curcuminoid analogue isolated from mistletoe. We report the chemical total synthesis, pharmacokinetics, pharmacodynamics, and toxicity on normal cells, cancer cells, liver and kidney.

Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells

2014 ◽  
Vol 24 (15) ◽  
pp. 3373-3376 ◽  
Author(s):  
Shunya Takahashi ◽  
Ayaka Yoshida ◽  
Shota Uesugi ◽  
Yayoi Hongo ◽  
Ken-ichi Kimura ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cancer Cells ◽  
Prolyl Oligopeptidase ◽  
Structural Revision ◽  
Inhibitory Activities
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