Amorphous silica nanoparticle-induced perturbation of cholesterol homeostasis as a function of surface area highlights safe-by-design implementation: an integrated multi-OMICS analysis

The systems toxicology approach revealed that the alterations of cholesterol biosynthesis were directly proportional with the surface area of amorphous silica nanoparticles (aSiNPs); the larger the surface area the higher the cholesterol level.

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Emerging investigator series: Long-term exposure of amorphous silica nanoparticles disrupts the lysosomal and cholesterol homeostasis in macrophages

Environmental Science Nano ◽

10.1039/d1en00696g ◽

2021 ◽

Author(s):

Ronglin Ma ◽

Xiaoming Cai ◽

Ye Zhou ◽

Xi Liu ◽

Di Wu ◽

...

Keyword(s):

Acute Toxicity ◽

Silica Nanoparticles ◽

Amorphous Silica ◽

Cholesterol Homeostasis

Amorphous silica nanoparticles (ASiNPs) are generally considered to be biocompatible with limited acute toxicity. These nanoparticles were therefore exploited in diverse nanoproducts (e.g. foods and cosmetics) and may be released...

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Influence of size, surface area and microporosity on thein vitrocytotoxic activity of amorphous silica nanoparticles in different cell types

Nanotoxicology ◽

10.3109/17435390.2010.482749 ◽

2010 ◽

Vol 4 (3) ◽

pp. 307-318 ◽

Cited By ~ 98

Author(s):

Virginie Rabolli ◽

Leen C. J. Thomassen ◽

Catherine Princen ◽

Dorota Napierska ◽

Laetitia Gonzalez ◽

...

Keyword(s):

Silica Nanoparticles ◽

Surface Area ◽

Amorphous Silica ◽

Cell Types ◽

Different Cell Types

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Synthesis and characterization of mesalamine silica nanoparticles

Current Drug Therapy ◽

10.2174/1574885516666211207100200 ◽

2021 ◽

Vol 16 ◽

Author(s):

Balaji Maddiboyina ◽

Ramya Krishna Nakkala ◽

Prasanna Kumar Desu ◽

Vikas Jhawat

Keyword(s):

Particle Size ◽

Silica Nanoparticles ◽

Surface Area ◽

High Surface ◽

High Surface Area ◽

Silica Nanoparticle ◽

Water Soluble ◽

Infrared Spectrometry ◽

Burst Release ◽

Wide Range

Background: Nanoparticles made of silica are new materials that can be used in a wide range of drug delivery methods because they are biocompatible and biodegradable. Mesalamine, a classic water-soluble medication, remains loaded into the synthesized silica nanoparticle and is considered for sustained release proficiency. Precipitation approach using high surface area and pore volume tetraethyl orthosilicate yielded mesalamine-loaded silica nanoparticles. Methods: The drug-loaded nanoparticle was created and produced using two different techniques. Fourier transform infrared spectrometry, differential scanning calorimetry, X-ray powder diffraction, Brauer Emmett teller, scanning electron microscopy, particle size measurements, and dissolution investigations have all been used to analyse the substance in some way or another. Results: Because of the high surface area, well-known results like the complete silica nanoparticle created using method-2 remained mesoporous. The onset peak of the method-2 formulation's DSC was 182.27°c, and the offset peak was 192.14°c, consistent with the DSC results. The particle size range varies from 205-225nm. The results demonstrate that the uptake of the mesalamine by burst release it for 30 minutes initial, followed by sustained maintenance of dose even after 240 minutes. The results indicate that the loading process has an effect on the extent of loading. When silica nanoparticles were impregnated with mesalamine, the amount of the drug contained was significantly higher than when they were wetted. Conclusion: In addition, the XRD results show that both the pure mesalamine and the formulation did not show any polymorphic deviation.

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Biomass Fly Ash as an Alternative Approach for Synthesis of Amorphous Silica Nanoparticles with High Surface Area

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2018.14548 ◽

2018 ◽

Vol 18 (5) ◽

pp. 3329-3334 ◽

Cited By ~ 2

Author(s):

Nguyen Dang Mao ◽

Soon Young Lee ◽

Hee Jae Shin ◽

Lee Ku Kwac ◽

Sang Cheol Ko ◽

...

Keyword(s):

Fly Ash ◽

Silica Nanoparticles ◽

Surface Area ◽

Amorphous Silica ◽

High Surface ◽

High Surface Area ◽

Alternative Approach ◽

Biomass Fly Ash

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Cytokine production by co-cultures exposed to monodisperse amorphous silica nanoparticles: The role of size and surface area

Toxicology Letters ◽

10.1016/j.toxlet.2012.03.002 ◽

2012 ◽

Vol 211 (2) ◽

pp. 98-104 ◽

Cited By ~ 36

Author(s):

Dorota Napierska ◽

Leen C.J. Thomassen ◽

Bart Vanaudenaerde ◽

Katrien Luyts ◽

Dominique Lison ◽

...

Keyword(s):

Silica Nanoparticles ◽

Surface Area ◽

Amorphous Silica ◽

Cytokine Production

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The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation

Toxicology Letters ◽

10.1016/j.toxlet.2011.07.013 ◽

2011 ◽

Vol 206 (2) ◽

pp. 197-203 ◽

Cited By ~ 59

Author(s):

Virginie Rabolli ◽

Leen C.J. Thomassen ◽

Francine Uwambayinema ◽

Johan A. Martens ◽

Dominique Lison

Keyword(s):

Cytotoxic Activity ◽

Silica Nanoparticles ◽

Surface Area ◽

Amorphous Silica

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Application of Silica Nanoparticles in the Determination of Herbicides in Environmental Water Samples Using Liquid Chromatography-Mass Spectroscopy

Current Nanoscience ◽

10.2174/1573413716666191224113231 ◽

2020 ◽

Vol 16 (5) ◽

pp. 748-756

Author(s):

Mir Waqas Alam ◽

Tentu Nageswara Rao ◽

Yarasani Prashanthi ◽

Vourse Sridhar ◽

Adil Alshoaibi ◽

...

Keyword(s):

Aqueous Solution ◽

Liquid Chromatography ◽

Silica Nanoparticles ◽

Solid Phase ◽

Silica Nanoparticle ◽

Environmental Water ◽

Phase Extraction ◽

Functionalized Nanoparticles ◽

Supporting Material

Background: Herbicides are very beneficial in the crop yield with the aid of controlling weeds within the agriculture, but several herbicides are chronic in soil. Objective: In this study, nanoparticles and the packages of synthesized novel silica nanoparticles were studied for the preconcentration of herbicides. Methods: These nanoparticles prepared by the Stöber mechanism were purified and functionalized. Nanoparticles thus prepared successfully were used as supporting material for the preconcentration of residues of herbicides in the water. Results: Preconcentration was achieved by preparing the silica-based solid-phase-extraction cartridges. Nanoparticles used for this purpose were within the range of 50-250 nm. An SPE cartridge was prepared by packing 200 mg of silica nanoparticle in the empty cartridge of diameter 5.5 cm and length 0.6 cm in between PTFE frits. Aqueous solutions of 0.1 μg/ml of herbicides were prepared separately, and 10 ml of the solution was passed through the cartridge at the rate of 0.2 ml/min. After passing 10 ml volume of the aqueous solution, residues adsorbed on the cartridge were eluted using 2 ml of acetonitrile. The eluate was injected to determine the herbicide residue adsorbed on the SPE cartridge. Conclusion: In the study, it was found that greater than 90% of the herbicide residues were trapped on silica nanoparticle-based SPE cartridge. An analytical method was developed for the simultaneous determination of these herbicides. The residues were quantified by LC-MS/MS with ESI mode.

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Mesoporous Silica Nanoparticles of Hydroxyurea: Potential

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681210999200430010457 ◽

2020 ◽

Vol 10 ◽

Author(s):

Kumar Nishchaya ◽

Swatantra K.S. Kushwaha ◽

Awani Kumar Rai

Keyword(s):

Drug Release ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Release Kinetics ◽

Average Particle Size ◽

Silica Nanoparticle ◽

Average Particle ◽

Independent Variables ◽

Lower Temperature

Background: Present malignant cancer medicines has the advancement of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer medication in malignant growth tissue. Aim: In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent and independent variables. Method: In this study, microporous silica nanoparticle stacked with neoplastic medication had been prepared through emulsification followed with solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations were prepared with varying ratio of polymer, lipid and surfactant which affects drug release and kinetics of drug release pattern. The obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, stability testing in order to investigate the nanoparticle characteristics. Results: The percentage drug entrapment of the drug for the formulations F1, F2, F3, was found to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours. Conclusion: From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of cancer due to its sustained release and less side effects.

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Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice

Scientific Reports ◽

10.1038/s41598-019-52001-2 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Peter Dornbos ◽

Amanda Jurgelewicz ◽

Kelly A. Fader ◽

Kurt Williams ◽

Timothy R. Zacharewski ◽

...

Keyword(s):

Liver Injury ◽

Aryl Hydrocarbon Receptor ◽

Cholesterol Biosynthesis ◽

Competitive Inhibitor ◽

Cholesterol Homeostasis ◽

Hepatic Glycogen ◽

Alcoholic Fatty Liver ◽

Female Mice ◽

Aryl Hydrocarbon ◽

The Impact

Abstract The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. The prototypical ligand of the AHR is an environmental contaminant called 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD exposure is associated with many adverse health outcomes in humans including non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that AHR ligands alter cholesterol homeostasis in mice through repression of genes involved in cholesterol biosynthesis, such as Hmgcr, which encodes the rate-limiting enzyme of cholesterol biosynthesis called 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR). In this study, we sought to characterize the impact of HMGCR repression in TCDD-induced liver injury. C57BL/6 mice were exposed to TCDD in the presence or absence of simvastatin, a competitive inhibitor of HMGCR. Simvastatin exposure decreased TCDD-induced hepatic lipid accumulation in both sexes, but was most prominent in females. Simvastatin and TCDD (S + T) co-treatment increased hepatic AHR-battery gene expression and liver injury in male, but not female, mice. In addition, the S + T co-treatment led to an increase in hepatic glycogen content that coincides with heavier liver in female mice. Results from this study suggest that statins, which are amongst the most prescribed pharmaceuticals, may protect from AHR-mediated steatosis, but alter glycogen metabolism and increase the risk of TCDD-elicited liver damage in a sex-specific manner.

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