Bacteria-activated chlorin e6 ionic liquid based on cation and anion dual-mode antibacterial action for enhanced photodynamic efficacy

2019 ◽  
Vol 7 (4) ◽  
pp. 1399-1410 ◽  
Author(s):  
Chaoli Wang ◽  
Peng chen ◽  
Youbei Qiao ◽  
Yuan Kang ◽  
Songyan Guo ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ionic Liquid ◽  
Antibiotic Resistance ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Chlorin E6 ◽  
Antibacterial Action ◽  
Dual Mode

With the increase in antibiotic resistance, photosensitizers ionic liquid with no detectable resistance and broad-spectrum antimicrobial activity are promising antimicrobial agents.

The Chemistry Of Antibiofilm Phytocompounds.

2020 ◽  
Vol 20 ◽  
Author(s):  
Dibyajit Lahiri ◽  
Moupriya Nag ◽  
Sayantani Garai ◽  
Rina Rani Ray
Keyword(s):  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Antibiotic Therapy ◽  
Antimicrobial Agents ◽  
Chemical Nature ◽  
Rapid Development ◽  
Wide Spread ◽  
Chronic Infections ◽  
Therapeutic Uses

: Phytocompounds are long known for their therapeutic uses due to their competence as antimicrobial agents. The antimicrobial activity of these bioactive compounds manifests their ability as an antibiofilm agent and is thereby proved to be competent to treat the wide spread of biofilm-associated chronic infections. Rapid development of antibiotic resistance in bacteria has made the treatment of these infections almost impossible by conventional antibiotic therapy, which forced in the switch over to the use of phytocompounds. The present overview deals with the classification of the huge array of phytocompounds according to their chemical nature, detection of their target pathogen, and elucidation of their mode of action.

scholarly journals Antimicrobial Activity of Biosynthesized Silver Nanoparticles Compared to Standard Antibiotics Used in ORL Infections

2019 ◽  
Vol 70 (7) ◽  
pp. 2571-2573
Author(s):  
Alina Andreea Tischer (Tucuina) ◽  
Delia Berceanu Vaduva ◽  
Nicolae Balica ◽  
Alina Heghes ◽  
Adelina Cheveresan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Antibiotic Resistance ◽  
Adverse Effects ◽  
Infectious Diseases ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
New Antibiotics ◽  
Recorded Data

In recent years, bacterial infections in hospitals have grown particularly due to the development of antibiotic resistance. Recent research targets the discovery of new antibiotics that exhibit broad spectrum of action without adverse effects or minimizing adverse effects. In this study, the activity of biosynthesized silver nanoparticles against three bacteria commonly found in infectious diseases in the ORL sphere was evaluated. The recorded data revealed an activity comparable to that of the standard antibiotics used in these types of infections, with the observation that the activity of the nanoparticles could also be observed in the particular cases of antibiotic resistance.

scholarly journals Peptidomic Analysis of Skin Secretions of the Caribbean Frogs Leptodactylus insularum and Leptodactylus nesiotus (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 718 ◽  
Author(s):  
Gervonne Barran ◽  
Jolanta Kolodziejek ◽  
Laurent Coquet ◽  
Jérôme Leprince ◽  
Thierry Jouenne ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Therapeutic Potential ◽  
Multidrug Resistant ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Peptidomic Analysis ◽  
Skin Secretions ◽  
Long Acting

Ocellatins are peptides produced in the skins of frogs belonging to the genus Leptodactylus that generally display weak antimicrobial activity against Gram-negative bacteria only. Peptidomic analysis of norepinephrine-stimulated skin secretions from Leptodactylus insularum Barbour 1906 and Leptodactylus nesiotus Heyer 1994, collected in the Icacos Peninsula, Trinidad, led to the purification and structural characterization of five ocellatin-related peptides from L. insularum (ocellatin-1I together with its (1–16) fragment, ocellatin-2I and its (1–16) fragment, and ocellatin-3I) and four ocellatins from L. nesiotus (ocellatin-1N, -2N, -3N, and -4N). While ocellatins-1I, -2I, and -1N showed a typically low antimicrobial potency against Gram-negative bacteria, ocellatin-3N (GIFDVLKNLAKGVITSLAS.NH2) was active against an antibiotic-resistant strain of Klebsiella pneumoniae and reference strains of Escherichia coli, K. pneumoniae, Pseudomonas aeruginosa, and Salmonella typhimurium (minimum inhibitory concentrations (MICs) in the range 31.25–62.5 μM), and was the only peptide active against Gram-positive Staphylococcus aureus (MIC = 31.25 μM) and Enterococcus faecium (MIC = 62.5 μM). The therapeutic potential of ocellatin-3N is limited by its moderate hemolytic activity (LC50 = 98 μM) against mouse erythrocytes. The peptide represents a template for the design of long-acting, non-toxic, and broad-spectrum antimicrobial agents for targeting multidrug-resistant pathogens.

scholarly journals Extracellular probiotic lipase capped silver nanoparticles as highly efficient broad spectrum antimicrobial agents

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31358-31365 ◽  
Author(s):  
Imran Khan ◽  
Nivetha Sivasankaran ◽  
Ravikiran Nagarjuna ◽  
Ramakrishnan Ganesan ◽  
Jayati Ray Dutta
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Ag Nps ◽  
Highly Efficient

A series of Ag NPs capped with different concentrations of probiotic lipase have been synthesized. The obtained Ag NPs exhibited efficient broad spectrum antimicrobial activity at concentrations much lower than the LC50values of zebrafish.

scholarly journals Antimicrobial Activity of Polyphenols and Natural Polyphenolic Extracts on Clinical Isolates

Antibiotics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 46
Author(s):  
Tamara Manso ◽  
Marta Lores ◽  
Trinidad de Miguel
Keyword(s):  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Antimicrobial Agents ◽  
Fungal Infections ◽  
Clinical Isolates ◽  
World Health ◽  
Supporting Evidence ◽  
Promising Alternative ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities

Antibiotic resistance is a growing global problem that affects people, animals, the environment, and the economy. Many clinically relevant bacteria have become resistant to antibiotics, and this fact is emerging as one of the major threats to public health. The lack of new antibiotics, which is due to their time-consuming and costly development, exacerbates the problem. Therefore, it is necessary to identify new antimicrobial agents to treat bacterial and fungal infections. Plant extracts, which are valuable sources of bioactive compounds, mainly polyphenols, play an important role as a new strategy to combat pathogenic microorganisms. There is an extensive body of supporting evidence for the potent antibacterial and antifungal activities of polyphenols. Furthermore, some polyphenols show a synergistic effect when combined with antibiotics and antifungals, suggesting a promising alternative for therapeutic strategies against antibiotic resistance. However, only a few articles are found when searching the antibacterial or antifungal activities of polyphenols employing clinical isolates. Hence, this review focuses on the antimicrobial activity of polyphenols and extracts rich in polyphenols on clinical isolates, organized according to the World Health Organization priority pathogens classification.

Antimicrobial Activity of Actinomycetes Isolated from Paya Maga, Sarawak

2013 ◽  
Vol 62 (2) ◽  
Author(s):  
Ng Yik Han Han ◽  
Ting Jen Yi ◽  
Yeo Tiong Chia
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Micrococcus Luteus ◽  
Culture Method ◽  
Inhibition Zone ◽  
Yeast Saccharomyces Cerevisiae ◽  
Gram Positive Bacteria ◽  
Rdna Sequences ◽  
16S Rdna Sequences

A study was carried out to evaluate the antimicrobial activity of 51 actinomycetes strains isolated from environmental samples collected during an expedition at Paya Maga, located in Ulu Trusan, Lawas, Sarawak. These actinomycetes strains were isolated from 20 soil and 15 plant samples. Their ability to inhibit the growth of Gram positive bacteria (Staphylococcus aureus, Micrococcus luteus), Gram negative bacteria (Escherichia coli) and yeast (Saccharomyces cerevisiae) were tested by using co-culture method. Twenty five percent of the isolates (13 out of 51) were active against at least one bacteria or one yeast standard strain while 18 (35%) were active against at least two standard strains, indicating broad spectrum activities. The results also showed that 23% (7 strains) of the positive isolates with single or broad spectrum activities were able to show better result in comparison to 100 mg/L of Chloramphenicol and Nystatin used (by forming inhibition zone more than 20 mm in diameter). The 31 inhibitory strains were sequenced and partial 16S rDNA sequences were derived for taxonomic identification. The majority of these strains (27 out of 31) belong to the family of Streptomycetaceae, followed by 2 strains from Streptosporangiaceae and 1 strain each from Nocardiaceae and Pseudonocardiaceae. Sixteen of the isolates can only be classified up to the genus level so they are potentially novel species which are targets for further study to isolate antimicrobial agents.

scholarly journals Antiseptics and Disinfectants: Activity, Action, and Resistance

1999 ◽  
Vol 12 (1) ◽  
pp. 147-179 ◽  
Author(s):  
Gerald McDonnell ◽  
A. Denver Russell
Keyword(s):  
Health Care ◽  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Broad Spectrum ◽  
Mode Of Action ◽  
Clinical Implications ◽  
Microbial Resistance ◽  
Health Care Settings ◽  
Chemical Agents ◽  
Active Chemical

SUMMARY Antiseptics and disinfectants are extensively used in hospitals and other health care settings for a variety of topical and hard-surface applications. A wide variety of active chemical agents (biocides) are found in these products, many of which have been used for hundreds of years, including alcohols, phenols, iodine, and chlorine. Most of these active agents demonstrate broad-spectrum antimicrobial activity; however, little is known about the mode of action of these agents in comparison to antibiotics. This review considers what is known about the mode of action and spectrum of activity of antiseptics and disinfectants. The widespread use of these products has prompted some speculation on the development of microbial resistance, in particular whether antibiotic resistance is induced by antiseptics or disinfectants. Known mechanisms of microbial resistance (both intrinsic and acquired) to biocides are reviewed, with emphasis on the clinical implications of these reports.

scholarly journals Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency

2019 ◽  
Vol 20 (6) ◽  
pp. 1417 ◽  
Author(s):  
Changxuan Shao ◽  
Weizhong Li ◽  
Peng Tan ◽  
Anshan Shan ◽  
Xiujing Dou ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibiotic Resistance ◽  
Multidrug Resistance ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Therapeutic Index ◽  
Antimicrobial Activities ◽  
Effective Strategy ◽  
Gram Negative ◽  
Gram Positive Bacteria

Antimicrobial peptides (AMPs) have emerged as a promising class of antimicrobial agents that could potentially address the global antibiotic resistance. Generating mirror-like peptides by minimizing dermaseptin family sequences is an effective strategy for designing AMPs. However, the previous research still had some limitations such as lower effectiveness and a narrow spectrum of antibacterial activity. To further expand and hone this strategy, we designed a series of AMPs consisting of the WXMXW-NH2 motif (X represents V, I, F, and W; M represents KAAAKAAAK). The peptides formed α-helices and displayed broad-spectrum antimicrobial activities against eleven types of clinical bacteria including both Gram-negative and Gram-positive bacteria. The optimized peptide WW exhibited high physical rupture by inducing membrane shrinkage, disruption, and lysis. Moreover, WW effectively neutralized endotoxins and inhibited the inflammatory response while having the highest therapeutic index. In conclusion, these results indicated that the peptide WW has potential as a broad-spectrum antimicrobial agent or preservative for overcoming the risk of multidrug resistance in localized or external therapeutic applications.

Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents

MedChemComm ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 202-211 ◽  
Author(s):  
Doaa A. E. Issa ◽  
Nargues S. Habib ◽  
Abeer E. Abdel Wahab
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Compound 9a showed dual anticancer and antimicrobial activity and compound 16 showed a broad spectrum antimicrobial activity.

scholarly journals Review of Rifaximin: A Summary of the Current Evidence and Benefits Beyond Licensed Use

2021 ◽  
pp. 94-100
Author(s):  
Rooshi Nathwani ◽  
Benjamin Mullish ◽  
David Kockerling ◽  
Alexander Cole ◽  
Nowlan Selvapatt ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Current Evidence ◽  
Disease Mortality ◽  
Microbial Products ◽  
Traveller’S Diarrhoea ◽  
The Uk ◽  
Made In

Antibiotic resistance in patients with cirrhosis continues to draw significant attention. With a propensity to frequent hospitalisations, patients with cirrhosis are subject to frequent antibiotic prescription. This increases their risk of developing resistance to one or more antimicrobial agents, making management of their condition particularly challenging. Despite advancements being made in the management of liver disease, mortality rates continue to rise: almost 5-fold in those <65 years of age while remaining the leading cause of death in those 35–49 years of age. Alternative therapeutic options to prevent disease progression and cirrhosis-associated complications are urgently required; rifaximin is one such example. The medication use in patients with cirrhosis demonstrates additional benefits beyond current licensed use in the UK, that being for the prevention of hepatic encephalopathy and traveller’s diarrhoea; rifaximin has especially been explored beyond current licensed use in the context of enteric-driven pathologies. Through the therapy’s key central action as a broad-spectrum antimicrobial, rifaximin has the ability to modulate the gut–liver axis via removal of gut microbial products associated with the progression of cirrhosis and its sequalae. The benefits of rifaximin use continues to gather momentum, given its non-absorbable nature and well-tolerated side-effect profile, and these require consideration. With broad-spectrum antimicrobial properties, its use may assist in overcoming the conundrum posed of antibiotic resistance amongst patients with cirrhosis. This literature review discusses the chemical and antimicrobial properties of rifaximin, its licenced indication for use, and its reported benefits beyond this, as well as concerns regarding rifaximin resistance.

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