Modulation of gut microbiota by chlorogenic acid pretreatment on rats with adrenocorticotropic hormone induced depression-like behavior

Gut microbiota dysbiosis has been implicated as a vital element in the development or exacerbation of mental disorders, such as major depressive disorder (MDD).

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Integrative Analysis of Long Non-coding RNAs, Messenger RNAs, and MicroRNAs Indicates the Neurodevelopmental Dysfunction in the Hippocampus of Gut Microbiota-Dysbiosis Mice

Frontiers in Molecular Neuroscience ◽

10.3389/fnmol.2021.745437 ◽

2022 ◽

Vol 14 ◽

Author(s):

Lanxiang Liu ◽

Haiyang Wang ◽

Xueyi Chen ◽

Yangdong Zhang ◽

Wenxia Li ◽

...

Keyword(s):

Major Depressive Disorder ◽

Gut Microbiota ◽

Depressive Disorder ◽

Differentially Expressed ◽

Messenger Rnas ◽

Major Depressive ◽

Epigenetic Biomarkers ◽

Non Coding Rnas ◽

Underlying Mechanisms ◽

Gut Microbiota Dysbiosis

Major depressive disorder is caused by gene–environment interactions and the gut microbiota plays a pivotal role in the development of depression. However, the underlying mechanisms remain elusive. Herein, the differentially expressed hippocampal long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), and microRNAs (miRNAs) between mice inoculated with gut microbiota from major depressive disorder patients or healthy controls were detected, to identify the effects of gut microbiota-dysbiosis on gene regulation patterns at the transcriptome level, and in further to explore the microbial-regulated pathological mechanisms of depression. As a result, 200 mRNAs, 358 lncRNAs, and 4 miRNAs were differentially expressed between the two groups. Functional analysis of these differential mRNAs indicated dysregulated inflammatory response to be the primary pathological change. Intersecting these differential mRNAs with targets of differentially expressed miRNAs identified 47 intersected mRNAs, which were mainly related to neurodevelopment. Additionally, a microbial-regulated lncRNA–miRNA–mRNA network based on RNA–RNA interactions was constructed. Subsequently, according to the competitive endogenous RNAs (ceRNA) hypothesis and the biological functions of these intersected genes, two neurodevelopmental ceRNA sub-networks implicating in depression were identified, one including two lncRNAs (4930417H01Rik and AI480526), one miRNA (mmu-miR-883b-3p) and two mRNAs (Adcy1 and Nr4a2), and the other including six lncRNAs (5930412G12Rik, 6430628N08Rik, A530013C23Rik, A930007I19Rik, Gm15489, and Gm16251), one miRNA (mmu-miR-377-3p) and three mRNAs (Six4, Stx16, and Ube3a), and these molecules could be recognized as potential genetic and epigenetic biomarkers in microbial-associated depression. This study provides new understanding of the pathogenesis of depression induced by gut microbiota-dysbiosis and may act as a theoretical basis for the development of gut microbiota-based antidepressants.

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Mental disorders in Australian 4- to 17- year olds: Parent-reported need for help

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867417706032 ◽

2017 ◽

Vol 52 (2) ◽

pp. 149-162 ◽

Cited By ~ 3

Author(s):

Sarah E Johnson ◽

David Lawrence ◽

Michael Sawyer ◽

Stephen R Zubrick

Keyword(s):

Major Depressive Disorder ◽

Mental Disorders ◽

Depressive Disorder ◽

Conduct Disorder ◽

Unmet Need ◽

Household Survey ◽

Conduct Disorders ◽

Major Depressive ◽

Statistical Manual ◽

Diagnostic And Statistical Manual

Objective: To describe the extent to which parents report that 4- to 17-year-olds with symptoms meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for mental disorders need help, the types of help needed, the extent to which this need is being met and factors associated with a need for help. Method: During 2013–2014, a national household survey of the mental health of Australia’s young people (Young Minds Matter) was conducted, involving 6310 parents (and carers) of 4- to 17-year-olds. The survey identified 12-month mental disorders using the Diagnostic Interview Schedule for Children – Version IV ( n = 870) and asked parents about the need for four types of help – information, medication, counselling and life skills. Results: Parents of 79% of 4- to 17-year-olds with mental disorders reported that their child needed help, and of these, only 35% had their needs fully met. The greatest need for help was for those with major depressive disorder (95%) and conduct disorder (93%). Among these, 39% of those with major depressive disorder but only 19% of those with conduct disorder had their needs fully met. Counselling was the type of help most commonly identified as being needed (68%). In multivariate models, need for counselling was higher when children had autism or an intellectual disability, in blended families, when parents were distressed, and in the most advantaged socioeconomic areas. Conclusions: Many children and adolescents meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for mental disorders have a completely unmet need for help, especially those with conduct disorders. Even with mild disorders, lack of clinical assessment represents an important missed opportunity for early intervention and treatment.

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Toward a transdiagnostic tool to evaluate depressive symptoms across mental disorders: Validation of the Calgary depression rating scale in patients with major depressive disorder

Psychiatry Research ◽

10.1016/j.psychres.2018.06.062 ◽

2018 ◽

Vol 268 ◽

pp. 68-71 ◽

Cited By ~ 3

Author(s):

Jean-Arthur Micoulaud-Franchi ◽

Mélanie Faugere ◽

Sebastien Weibel ◽

Catherine Faget ◽

Christophe Lancon ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Symptoms ◽

Mental Disorders ◽

Depressive Disorder ◽

Rating Scale ◽

Major Depressive

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Associations Between Burnout and Mental Disorder Symptoms Among Nurses in Canada

Canadian Journal of Nursing Research ◽

10.1177/0844562120974194 ◽

2020 ◽

pp. 084456212097419

Author(s):

Andrea M. Stelnicki ◽

Laleh Jamshidi ◽

Andréanne Angehrn ◽

Heather D. Hadjistavropoulos ◽

R. Nicholas Carleton

Keyword(s):

Major Depressive Disorder ◽

Mental Disorders ◽

Depressive Disorder ◽

Mental Disorder ◽

Stress Disorder ◽

Demographic Variables ◽

Early Career ◽

Depression Symptoms ◽

Major Depressive ◽

Clinically Significant

Background Nurses appear to be at a greater risk of burnout compared to other medical professionals. Higher levels of burnout are significantly associated with higher levels of anxiety, stress, and depression symptoms. Purpose The current study was designed to estimate levels of burnout among Canadian nurses, examine the association between burnout and mental disorder symptoms, and identify characteristics that may increase the risk for reporting symptoms of burnout. Method Canadian nurses ( n = 3257; 94.3% women) were surveyed online in both English and French. The survey assessed current symptoms of burnout and mental disorders (i.e., Posttraumatic Stress Disorder, Major Depressive Disorder, Generalized Anxiety Disorder, Panic Disorder). Results Most nurses (63.2%) reported at least some symptoms of burnout and many (29.3%) reported clinically significant levels of burnout. Age and years of service were the only demographic variables that explained burnout rates. Participants reporting clinically significant levels of burnout were significantly more likely than participants with no burnout to screen positive for all mental disorders, but particularly for Major Depressive Disorder. Conclusions Monitoring burnout may be an effective way to identify nurses at risk of developing symptoms of mental disorders. Younger and early-career nurses are an important group to target for prevention programs.

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Lifetime prevalence and inter-cohort variation in DSM-IV disorders in metropolitan China

Psychological Medicine ◽

10.1017/s0033291706008993 ◽

2006 ◽

Vol 37 (1) ◽

pp. 61-71 ◽

Cited By ~ 101

Author(s):

SING LEE ◽

ADLEY TSANG ◽

MING-YUAN ZHANG ◽

YUE-QIN HUANG ◽

YAN-LING HE ◽

...

Keyword(s):

Major Depressive Disorder ◽

Mental Disorders ◽

Depressive Disorder ◽

Age Of Onset ◽

Lifetime Risk ◽

Lifetime Prevalence ◽

Major Depressive ◽

Cross Sectional ◽

Dsm Iv ◽

Prospective Longitudinal

Background. This is the first study to examine variation across cohorts in lifetime risk of DSM-IV mental disorders in metropolitan China.Method. Face-to-face household interviews of 2633 adults in Beijing and 2568 adults in Shanghai were conducted from November 2001 to February 2002 using a multi-stage household probability sampling method. The Chinese World Mental Health (WMH) Survey Initiative version of the WHO Composite International Diagnostic Interview (WMH-CIDI) was used for assessment.Results. Lifetime prevalence of any disorder was 13·2%. Alcohol abuse (4·7%), major depressive disorder (3·5%), and specific phobia (2·6%) were the most common disorders. The median age of onset was later for mood (43 years) than anxiety (17 years) and substance use (25 years) disorders. Compared to observed lifetime prevalence, the projected lifetime risk as of age 75 years increased by 106% for major depressive disorder (7·2%), and was uniformly higher for all disorders. Relative odds of any lifetime disorder were 4·7 in the most recent cohorts (ages 18–34) compared to the eldest cohorts (ages [ges ]65).Conclusions. The findings of this cross-sectional study tally with the view that rapid socioeconomic changes may bring about increasing incidence of mental disorders in China. However, prospective longitudinal studies are needed to confirm if the increase is real. Because of the huge size of the Chinese population, any increase in projected lifetime risk of mental disorders represents an enormous increase in the number of affected individuals.

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