New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats

2020 ◽  
Vol 11 (3) ◽  
pp. 1958-1965
Author(s):  
Mariam I. Gamal El-Din ◽  
Fadia S. Youssef ◽  
Mohamed L. Ashour ◽  
Omayma A. Eldahshan ◽  
Abdel Nasser B. Singab
Keyword(s):  
Gastric Ulcer ◽  
Methanol Extract ◽  
Protective Activity ◽  
Gastroprotective Activity ◽  
Phytochemical Investigation ◽  
Ulcer Model

Phytochemical investigation of the methanol extract of Pachira glabra leaves led to the isolation of a new γ-pyrone glycoside namely 7-hydroxy maltol-3-O-β-d-glucoside (HMGlu) that demonstrated promising gastro-protective activity.

scholarly journals Antioxidant and gastroprotective effects of the ethyl acetate extract from Stemodia maritima L. in ethanol-induced gastric ulcer model

2021 ◽  
Vol 10 (15) ◽  
pp. e195101522548
Author(s):  
Rayane Siqueira de Sousa ◽  
Jéssica de Andrade Gomes Silva ◽  
Elizabeth Fernanda de Oliveira Borba ◽  
Katharina Rodrigues de Lima Porto Ramos ◽  
Camila Joyce Alves da Silva ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Gastric Ulcer ◽  
Acute Toxicity ◽  
Cell Viability ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Control Group ◽  
Gastroprotective Activity ◽  
Ulcer Model ◽  
Phytochemical Profile

Stemodia maritima L., is a shrub of the Plantaginaceae family, with some biological activities already described, such as: larvicide, antimicrobial, and anti-inflammatory. Thus, the objective of this work was to evaluate the antioxidant, and gastroprotective activities of the ethyl acetate extract from S. maritima. The phytochemical profile was investigated through the quantification of total phenolic compounds, flavonoids, and CCD analysis. The toxicity of the extract was performed through cell viability using L929 line cell, and acute toxicity by the OECD Guide 423. The antioxidant activity was analyzed by the methods of reduction of the ferric ion (FRAP), total antioxidant activity (TAA), and the gastroprotective activity by the absolute ethanol-induced gastric ulcer model, with analysis of NO, MDA, GSH and MPO levels in the stomach tissues. In the phytochemical profile it was possible to identify the presence of flavonoids, triterpenes, steroids, mono, and sesquiterpenes. The extract was not cytotoxic against L929 lineage, maintaining cell viability above 70% at the doses tested, and in acute toxicity it did not show physiological changes indicative of toxicity compared to the control group. The extract presented antioxidant activity of 157.3 ± 9.7 mg equivalent of Trolox/g of extract in the FRAP method, and 50.0 ± 1.1 % by TAA. The ethyl acetate extract of S. maritima, at the doses tested, reduced the ulcerative lesion index compared to the injured control group, increased the levels of NO and GSH, and was able to decrease the concentrations of MDA and MPO, enhancing their gastroprotective activity.

scholarly journals SCREENING OF WILD FRUIT TREES WITH GASTROPROTECTIVE ACTIVITY IN DIFFERENT EXPERIMENTAL MODELS

2017 ◽  
Vol 54 (2) ◽  
pp. 135-138 ◽  
Author(s):  
Luciane Angela Nottar NESELLO ◽  
Adriana CAMPOS ◽  
Roseane Leandra da ROSA ◽  
Sérgio Faloni de ANDRADE ◽  
Valdir CECHINEL FILHO
Keyword(s):  
Gastric Ulcer ◽  
Fruit Trees ◽  
Experimental Models ◽  
Gastrointestinal Disorders ◽  
Gastroprotective Activity ◽  
Lesion Area ◽  
Wild Fruit ◽  
Ulcer Model ◽  
Different Parts

ABSTRACT BACKGROUND Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach. OBJECTIVE The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models. METHODS The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg/kg. Subsequently, the total lesion area (mm2) and relative lesion area (%) were determined. RESULTS The results showed significant gastroprotective activity against the aggressive agents used - ethanol and indomethacin - for all the extracts tested. CONCLUSION It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties.

scholarly journals The gastroprotective effect of Memora nodosa roots against experimental gastric ulcer in mice

2016 ◽  
Vol 88 (3 suppl) ◽  
pp. 1819-1828 ◽  
Author(s):  
DAYANE M. SILVA ◽  
JOSÉ L.R. MARTINS ◽  
IZIARA F. FLORENTINO ◽  
DANILLO R. OLIVEIRA ◽  
JAMES O. FAJEMIROYE ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Food Restriction ◽  
Previous Treatment ◽  
Control Group ◽  
Gastroprotective Activity ◽  
Gastric Mucus ◽  
Ulcer Model ◽  
Cold Restraint Stress ◽  
Intraduodenal Administration ◽  
Cold Restraint

ABSTRACT Memora nodosa is popularly known as "caroba" and widely found in the Cerrado regions of Brazil. In traditional medicine, the leaves and stems are used for the healing of external ulcer and the roots for abdominal pain. This study investigated the effect of ethanolic roots extract of Memora nodosa (EMN) on the gastric mucosa of mice. In the indomethacin induced gastric ulcer model, the treatments of the animals with EMN at doses of 100, 300 and 1000 mg/kg, p.o., markedly reduced the index of lesions. In the gastric ulcer models induced by ethanol and cold restraint-stress the previous treatment with EMN at dose of 300 mg/kg showed 69% and 43% of protection, respectively. Seven days after food-restriction, the animals treated with EMN (300 mg/kg p.o.) showed reduction in the index of lesion by 65% as compared to control group. The intraduodenal administration of EMN (300 mg/kg) did not alter the gastric acid secretion parameters. The treatment with EMN (300 mg/kg p.o.) did not alter glutathione levels (GSH), but showed an increase of adhered gastric mucus as compared to the control group with lesion. These results showed that EMN has gastroprotective activity probably due with an increase of adhered gastric mucus.

Comparative antiulcer effect of curcumin and tetrahydrocurcumin in a gastric ulcer model system

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
S Mahattanadul ◽  
S Nima ◽  
S Tewtrakul ◽  
P Tansakul
Keyword(s):  
Gastric Ulcer ◽  
Model System ◽  
Ulcer Model

scholarly journals Development of new gastric ulcer model induced by ischemia-reperfusion and its application to evaluate the efficacy.

1996 ◽  
Vol 71 ◽  
pp. 202
Author(s):  
Kouichirou Wada ◽  
Yoshinori Kamisaki ◽  
Masayuki Kitano ◽  
Yosuke Kishimoto ◽  
Kentaro Nakamoto ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Ischemia Reperfusion ◽  
Ulcer Model

scholarly journals The potential effects of Centella asiatica ethanolic extracts as an anti-inflammatory agent through decreasing TNF-α expression in indomethacin-induced gastric ulcer model rats

2021 ◽  
Author(s):  
Priscilla Maiselina Sriepindonnta ◽  
Fatimah Nur Fitriani ◽  
Savannah Quila Thirza ◽  
Made Dinda Pratiwi ◽  
Dwi Evan Prima Putra Noviardi ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Centella Asiatica ◽  
Inflammatory Agent ◽  
Tnf Α ◽  
Ethanolic Extracts ◽  
Ulcer Model ◽  
Anti Inflammatory

scholarly journals Evaluation of a poly-herbal preparation for the treatment of peptic ulcer

2017 ◽  
Vol 12 (2) ◽  
pp. 11
Author(s):  
Zaman Hayat ◽  
Mueen Ahmad Chaudhry ◽  
. Alamgeer
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Treated Group ◽  
Ulcer Formation ◽  
Ulcer Index ◽  
Herbal Formulation ◽  
High K ◽  
Ulcer Model ◽  
Dose Dependent ◽  
Gross Examination

<p class="Abstract">The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percentage cure through gross examination and histopathological evaluation. A significant (p&lt;0.001) dose-dependent anti-ulcerant effect was observed in ulcerene (50 and 100 mg/kg)-treated group with highest effectiveness against ethanol-induced ulcer. The concentration-dependent spasmolytic effect was seen in spontaneously contracting, high K<sup>+</sup> (80 mM) and carbachol (1 µM)-induced jejunum contractions (10, 0.3 and 1 mg/mL), similar to dicyclomine (10, 1 and 3 µM), indicated non-specific spasmolytic mechanism behind the effect. By considering these results, ulcerene can be suggested for the treatment of peptic ulcer.</p>

GASTRO-PROTECTIVE POTENTIAL OF FLOWERS OF HIBISCUS ROSA-SINENSIS (L.) IN MUCOSAL LESION ON RATS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 25-31
Author(s):  
K. K Agrawal ◽  
A. Verma ◽  
K Singh ◽  
Keyword(s):  
Wistar Rats ◽  
Gastric Volume ◽  
Control Group ◽  
Phytochemical Screening ◽  
Protective Activity ◽  
Ulcer Index ◽  
Hibiscus Rosa Sinensis ◽  
Pylorus Ligation ◽  
Ethanolic Extracts ◽  
Ulcer Model

study was conducted to evaluate the gastro-protective activity of aqueous (HAE) and ethanolic (HEE) extracts of Hibiscus rosa-sinensis Linn. (Malvaceae) flowers in experimental animals. Aqueous and ethanolic extracts were investigated for pylorus ligation and indomethacin induced ulcer models in albino wistar rats. The pH, gastric volume, ulcer index, ulcer score and free and total acidity were determined by pylorus ligation induced ulcer model and ulcer score, ulcer index and percentage protection were determined by Indomethacin induced ulcer model. Phytochemical screening of aqueous and ethanolic extracts were conducted for and it showed that extracts have alkaloids, glycosides, tannins, flavonoids and mucilage. Both the extracts at dose of 200 and 400mg/kg showed significant (P<0.05) reduction in gastric volume (1.20±0.17, 0.83±0.20, 0.90±0.12, 0.96±0.17) and ulcer index (1.50±0.19, 1.33±0.11, 2.16±0.03, 0.75±0.17, 0.92±0.22, 0.31±0.04, 0.42±0.06, 0.19±0.04) as compared to the control group (1.47±0.15, 3.00±0.21, 1.64±0.13) in both of the models. It can be concluded that both the extracts possess gastro-protective activity that might be due the presence of flavanoids, tannins and/or mucilage.

Sign in / Sign up

Export Citation Format

Share Document