The effective photocatalysis and antibacterial properties of AgBr/AgVO3 composites under visible-light

With the discharge of large amount of organic pollutants and antibiotics into the water environment, the water cycle has been seriously polluted, and at the same time, various drug-resistant bacteria have emerged in succession, which poses a serious threat to human health.

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Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis

Biomaterials Science ◽

10.1039/d0bm00789g ◽

2020 ◽

Vol 8 (18) ◽

pp. 4975-4996

Author(s):

Pengfei Zou ◽

Wen-Ting Chen ◽

Tongyi Sun ◽

Yuanyuan Gao ◽

Li-Li Li ◽

...

Keyword(s):

Human Health ◽

Antimicrobial Therapy ◽

Bacterial Infections ◽

The Body ◽

Resistant Bacteria ◽

Drug Resistant ◽

Self Assembling ◽

Recent Advances ◽

Drug Resistant Bacteria ◽

Therapy And Diagnosis

Bacterial infections, especially the refractory treatment of drug-resistant bacteria, are one of the greatest threats to human health. Self-assembling peptide-based strategies can specifically detect the bacteria at the site of infection in the body and kill it.

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Analysis of migration of pathogenic drug-resistant bacteria to soils and groundwater after fertilization with sewage sludge

PLoS ONE ◽

10.1371/journal.pone.0256936 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0256936

Author(s):

Ewa Stańczyk-Mazanek ◽

Longina Stępniak

Keyword(s):

Sewage Sludge ◽

Sandy Soil ◽

Pathogenic Bacteria ◽

Water Environment ◽

Intestinal Bacteria ◽

Time Frame ◽

Resistant Bacteria ◽

Drug Resistant ◽

Drug Resistant Bacteria ◽

One Year

The paper discusses the analysis of the effect of using sewage sludge for fertilization on the level of soil and groundwater contamination with drug-resistant bacteria. Other sanitary contaminants in these environments were also analysed. Composted sewage sludge was introduced into the sandy soil over a period of 6 months. The examinations were conducted under conditions of a lysimetric experiment with the possibility of collecting soil leachates (in natural conditions). The following doses of sewage sludge were used: 0, 10, 20, 30 and 40 t/ha calculated per experimental object containing 10 kg of sandy soil. The research were carried out within the time frame of one year. Dactylis glomerata grass was grown on the fertilized soils. In soils and leachates from soils (which may have polluted groundwater) collected from fertilized experimental objects, the sanitary condition and quantity of drug-resistant bacteria (mainly from the families Enterobacteriaceae and Enterococcus) were analysed one year after fertilization. Their drug resistance to selected antibiotics was also analysed based on current recommendations. The study showed that fertilization with sewage sludge (even after stabilization and hygienization) results in contamination of soil and infiltrating waters with many species of drug-resistant pathogenic bacteria. The lowest level of contamination of soil and water environment was found after the application of sewage sludge at a dose of 10 t/ha. The isolated drug-resistant strains of intestinal bacteria were less sensitive to older generations of antibiotics including cefazolin, ampicillin, and co-amoxiclav.

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A Light-Activated Nanotherapeutic with Broad-Spectrum Bacterial Recognition to Eliminate Drug-Resistant Pathogens

Journal of Materials Chemistry B ◽

10.1039/d0tb02583f ◽

2021 ◽

Author(s):

Xiaosong Wei ◽

Yingchao Gao ◽

Yuqing Hu ◽

Yufei Zhang ◽

Xinge Zhang

Keyword(s):

Human Health ◽

Broad Spectrum ◽

Multidrug Resistant ◽

Morbidity And Mortality ◽

Resistant Bacteria ◽

Drug Resistant ◽

Multidrug Resistant Bacteria ◽

Drug Resistant Bacteria

Obstinate infections caused by drug-resistant bacteria severely threaten human health. And the emergence of multidrug-resistant bacteria increases the morbidity and mortality of patients, innovative or alternative therapeutics thus necessitates the...

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Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials

Materials ◽

10.3390/ma13204594 ◽

2020 ◽

Vol 13 (20) ◽

pp. 4594

Author(s):

Rushui Bai ◽

Liying Peng ◽

Qiannan Sun ◽

Yunfan Zhang ◽

Lingyun Zhang ◽

...

Keyword(s):

Antibacterial Agents ◽

Bacterial Resistance ◽

Antibacterial Properties ◽

Surface Treatments ◽

Resistant Bacteria ◽

Drug Resistant ◽

Clinical Issue ◽

Drug Resistant Bacteria ◽

Antibacterial Surface ◽

Orthopedic Materials

The oral cavity harbors complex microbial communities, which leads to biomaterial-associated infections (BAI) during dental and orthopedic treatments. Conventional antibiotic treatments have met great challenges recently due to the increasing emergency of drug-resistant bacteria. To tackle this clinical issue, antibacterial surface treatments, containing surface modification and coatings, of dental and orthopedic materials have become an area of intensive interest now. Among various antibacterial agents used in surface treatments, metallic agents possess unique properties, mainly including broad-spectrum antibacterial properties, low potential to develop bacterial resistance, relative biocompatibility, and chemical stability. Therefore, this review mainly focuses on underlying antibacterial applications and the mechanisms of metallic agents in dentistry and orthopedics. An overview of the present review indicates that much work remains to be done to deepen the understanding of antibacterial mechanisms and potential side-effects of metallic agents.

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Antimicrobial resistance: the 70-year arms race between humans and bacteria

10.1093/oso/9780198789833.003.0006 ◽

2018 ◽

Author(s):

Anne-Laure Bañuls ◽

Thi Van Ahn Nguyen ◽

Quang Huy Nguyen ◽

Thi Ngoc Anh Nguyen ◽

Hoang Huy Tran ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Human Health ◽

Low Income ◽

Arms Race ◽

Low Income Countries ◽

Resistant Bacteria ◽

Drug Resistant ◽

Drug Resistant Bacteria ◽

The World

Antimicrobial resistance started to become a human health issue in the 1940s, following the discovery of the first antibiotics. The golden age of antibiotics (the 1950s through 1970s) marked the beginning of the arms race between humans and bacteria. Antimicrobial resistance is now among the greatest threats to human health; occurring in every region of the world and with the potential to affect anyone, anywhere. We describe the main mechanisms of antimicrobial resistance, as well as how the bacteria evolve into “superbugs.” We detail the role of human activities on the emergence and spread of highly drug-resistant bacteria. Currently, data to identify the specific causes, and to establish the baseline in low-income countries, are lacking. Because of the continual increase of multidrug resistance, the situation is urgent. The chapter ends with a view to the future, with a discussion of the specific problems of low-income countries and initiatives taken.

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