Light-activated drug release from a hyaluronic acid targeted nanoconjugate for cancer therapy

2019 ◽  
Vol 7 (31) ◽  
pp. 4843-4853 ◽  
Author(s):  
Chun-Yang Sun ◽  
Bei-Bei Zhang ◽  
Jia-Yan Zhou
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Release ◽  
Cancer Cells

A hyaluronic acid targeted nanoconjugate was developed for efficient cancer therapy through phototriggered drug release in CD44-overexpressing cancer cells.

Plasmonic CuS nanodisk assembly based composite nanocapsules for NIR-laser-driven synergistic chemo-photothermal cancer therapy

2018 ◽  
Vol 6 (7) ◽  
pp. 1035-1043 ◽  
Author(s):  
Jian He ◽  
Lisha Ai ◽  
Xin Liu ◽  
Hao Huang ◽  
Yuebin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cancer Cells ◽  
Therapeutic Effects ◽  
Release Behavior ◽  
Sustained Drug Release ◽  
Drug Release Behavior ◽  
Nir Laser

The NIR-laser-driven plasmonic photothermal and sustained drug release behavior of CuS–PTX/SiO2 nanocapsules show great synergistic chemo-photothermal therapeutic effects on cancer cells in vitro and in vivo.

scholarly journals Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 301 ◽  
Author(s):  
Kim ◽  
Choi ◽  
Choi ◽  
Park ◽  
Ryu
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Colloidal Stability ◽  
Inorganic Nanoparticles ◽  
Cancer Targeting ◽  
Anionic Polymer ◽  
Enhanced Permeability And Retention ◽  
Interaction With Receptors

Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, and nanoparticles) can be prepared easily using assembly and modification of its functional groups such as carboxy, hydroxy and N-acetyl groups. Nanometer-sized HA nanomedicines can selectively deliver drugs or other molecules into tumor sites via their enhanced permeability and retention (EPR) effect. In addition, HA can interact with overexpressed receptors in cancer cells such as cluster determinant 44 (CD44) and receptor for HA-mediated motility (RHAMM) and be degraded by a family of enzymes called hyaluronidase (HAdase) to release drugs or molecules. By interaction with receptors or degradation by enzymes inside cancer cells, HA nanomedicines allow enhanced targeting cancer therapy. In this article, recent studies about HA nanomedicines in drug delivery systems, photothermal therapy, photodynamic therapy, diagnostics (because of the high biocompatibility), colloidal stability, and cancer targeting are reviewed for strategies using micelles, nanogels, and inorganic nanoparticles.

Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

2017 ◽  
Vol 62 (1) ◽  
Author(s):  
Ranwei Li ◽  
Tiecheng Liu ◽  
Ke Wang
Keyword(s):  
Lung Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Zirconium Phosphate ◽  
Drug Loading ◽  
Lung Cancer Therapy ◽  
Targeting Ability ◽  
A549 Lung

AbstractNovel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%±4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity

Promising tamoxifen-loaded biocompatible hybrid magnetic nanoplatforms against breast cancer cells: synthesis, characterization and biological evaluation

2021 ◽  
Vol 45 (8) ◽  
pp. 4032-4045
Author(s):  
Diego Cadena Castro ◽  
Gerardo Gatti ◽  
Sandra E. Martín ◽  
Paula M. Uberman ◽  
Mónica C. García
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Evaluation ◽  
Efficacy And Safety ◽  
Breast Cancer Therapy

Improved efficacy and safety of tamoxifen-loaded hybrid nanocarriers based on Fe3O4 nanoparticles, l-cysteine and hyaluronic acid for breast cancer therapy.

Azo modified hyaluronic acid based nanocapsules: CD44 targeted, UV-responsive decomposition and drug release in liver cancer cells

2021 ◽  
Vol 267 ◽  
pp. 118152
Author(s):  
Qi Chen ◽  
Xiaorong Li ◽  
Yuan Xie ◽  
Weicheng Hu ◽  
Zhipeng Cheng ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Liver Cancer ◽  
Drug Release ◽  
Cancer Cells ◽  
Liver Cancer Cells

scholarly journals Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 306 ◽  
Author(s):  
Subin Kim ◽  
Myeong ju Moon ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Biomedical Applications ◽  
Treatment Approach ◽  
Critical Role ◽  
Sulfated Polysaccharide

Hyaluronic acid (HA) is a non-sulfated polysaccharide polymer with the properties of biodegradability, biocompatibility, and non-toxicity. Additionally, HA specifically binds to certain receptors that are over-expressed in cancer cells. To maximize the effect of drug delivery and cancer treatment, diverse types of nanomaterials have been developed. HA-based nanomaterials, including micelles, polymersomes, hydrogels, and nanoparticles, play a critical role in efficient drug delivery and cancer treatment. Hyperthermic cancer treatment using HA-based nanomaterials has attracted attention as an efficient cancer treatment approach. In this paper, the biomedical applications of HA-based nanomaterials in hyperthermic cancer treatment and combined therapies are summarized. HA-based nanomaterials may become a representative platform in hyperthermic cancer treatment.

scholarly journals Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells

2011 ◽  
Vol 71 (12) ◽  
pp. 4085-4095 ◽  
Author(s):  
Anaid Benitez ◽  
Travis J. Yates ◽  
Luis E. Lopez ◽  
Wolfgang H. Cerwinka ◽  
Ashraf Bakkar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Prostate Cancer Cells

scholarly journals Targeted Delivery of Paclitaxel in Liver Cancer Using Hyaluronic Acid Functionalized Mesoporous Hollow Alumina Nanoparticles

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Yu Gao ◽  
Lili Hu ◽  
Ying Liu ◽  
Xiaoyan Xu ◽  
Chao Wu
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Drug Release ◽  
Targeted Delivery ◽  
Amorphous State ◽  
Alumina Nanoparticles ◽  
Sustained Drug Release ◽  
Scanning Calorimetry ◽  
Adsorption Method

Hyaluronic acid functionalized mesoporous hollow alumina nanoparticles (HMHA) were used as a tumor-targeted delivery carrier for liver cancer therapy. Paclitaxel (PAC) incorporated in the carrier by the adsorption method was analyzed by X-ray diffraction and differential scanning calorimetry. PAC was found to be in an amorphous state. The hyaluronic acid coated on the surface of mesoporous hollow alumina nanoparticles (MHA) regulated the drug release rate and the loaded samples obtained a sustained drug release. In vitro experiments demonstrated that paclitaxel-hyaluronic acid functionalized mesoporous hollow alumina nanoparticles (PAC-HMHA) had a high cellular uptake, which increased the drug level in tumor tissues and was beneficial to promote apoptosis. An in vivo tumor inhibition rate study demonstrated that PAC-HMHA (64.633 ± 4.389%) had a better antitumor effect than that of paclitaxel-mesoporous alumina nanoparticles (PAC-MHA, 56.019 ± 6.207%) and pure PAC (25.593 ± 4.115%). Therefore it can be concluded that PAC-HMHA are a prospective tumor-targeted delivery medium and can be useful for future cancer therapy.

A pH sensitive polymeric micelle for co-delivery of doxorubicin and α-TOS for colon cancer therapy

2017 ◽  
Vol 5 (29) ◽  
pp. 5870-5880 ◽  
Author(s):  
Tilahun Ayane Debele ◽  
Kuan-Yi Lee ◽  
Ning-Yu Hsu ◽  
Yi-Ting Chiang ◽  
Lu-Yi Yu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Drug Release ◽  
Cancer Cells ◽  
Polymeric Micelle ◽  
Ph Sensitive ◽  
Normal Cells

pH-Sensitive rod-like micelles were designed to improve drug release, to increase cytotoxicity towards cancer cells, and to reduce cytotoxicity towards normal cells.

Dually folate/CD44 receptor-targeted self-assembled hyaluronic acid nanoparticles for dual-drug delivery and combination cancer therapy

2017 ◽  
Vol 5 (33) ◽  
pp. 6835-6846 ◽  
Author(s):  
Liang Song ◽  
Zhou Pan ◽  
Huabing Zhang ◽  
Yanxiu Li ◽  
Yinying Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Anticancer Effect ◽  
Cd44 Receptor ◽  
Dual Targeting ◽  
Combination Cancer Therapy ◽  
Self Assembled ◽  
Dual Drug

Self-assembled methotrexate-hyaluronic acid-octadecylamine nanoparticles loaded with curcumin have dual-targeting and combinational anticancer effect to folate and CD44 receptors overexpressed cancer cells.

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