Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy

Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, and nanoparticles) can be prepared easily using assembly and modification of its functional groups such as carboxy, hydroxy and N-acetyl groups. Nanometer-sized HA nanomedicines can selectively deliver drugs or other molecules into tumor sites via their enhanced permeability and retention (EPR) effect. In addition, HA can interact with overexpressed receptors in cancer cells such as cluster determinant 44 (CD44) and receptor for HA-mediated motility (RHAMM) and be degraded by a family of enzymes called hyaluronidase (HAdase) to release drugs or molecules. By interaction with receptors or degradation by enzymes inside cancer cells, HA nanomedicines allow enhanced targeting cancer therapy. In this article, recent studies about HA nanomedicines in drug delivery systems, photothermal therapy, photodynamic therapy, diagnostics (because of the high biocompatibility), colloidal stability, and cancer targeting are reviewed for strategies using micelles, nanogels, and inorganic nanoparticles.

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Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

Biomedical Engineering / Biomedizinische Technik ◽

10.1515/bmt-2015-0238 ◽

2017 ◽

Vol 62 (1) ◽

Cited By ~ 3

Author(s):

Ranwei Li ◽

Tiecheng Liu ◽

Ke Wang

Keyword(s):

Lung Cancer ◽

Hyaluronic Acid ◽

Cancer Therapy ◽

Cancer Cells ◽

Tumor Targeting ◽

Zirconium Phosphate ◽

Drug Loading ◽

Lung Cancer Therapy ◽

Targeting Ability ◽

A549 Lung

AbstractNovel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%±4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity

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Illuminating the cancer-targeting potential of near-infrared photoimmunotherapy

The Biochemist ◽

10.1042/bio03806016 ◽

2016 ◽

Vol 38 (6) ◽

pp. 16-19

Author(s):

Hisataka Kobayashi

Keyword(s):

Stem Cells ◽

Cancer Therapy ◽

Cancer Stem Cells ◽

Cancer Cells ◽

Immune Cells ◽

Distant Metastasis ◽

Near Infrared ◽

Host Immunity ◽

Cancer Targeting ◽

Vascular Cells

Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cell-selective cancer therapy with enormous potential for treating cancer in a variety of ways. NIR-PIT not only kills cancer cells, but can also eliminate other unfavourable cells including cancer stem cells and immunosuppressor cells, among others, without damaging favourable cells such as immune cells, vascular cells and tissue stem cells. This technique can efficiently activate anti-tumour host immunity in a way that can even cure untreated distant metastasis.

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Hyaluronic Acid-Conjugated Carbon Nanomaterials for Enhanced Tumour Targeting Ability

Molecules ◽

10.3390/molecules27010048 ◽

2021 ◽

Vol 27 (1) ◽

pp. 48

Author(s):

Oisin Kearns ◽

Adalberto Camisasca ◽

Silvia Giordani

Keyword(s):

Drug Delivery ◽

Hyaluronic Acid ◽

Cancer Therapy ◽

Photothermal Therapy ◽

Near Infrared ◽

Carbon Nanomaterials ◽

Graphene Quantum Dots ◽

Tumour Volume ◽

The Novel ◽

Targeting Ability

Hyaluronic acid (HA) has been implemented for chemo and photothermal therapy to target tumour cells overexpressing the CD44+ receptor. HA-targeting hybrid systems allows carbon nanomaterial (CNM) carriers to efficiently deliver anticancer drugs, such as doxorubicin and gemcitabine, to the tumour sites. Carbon nanotubes (CNTs), graphene, graphene oxide (GO), and graphene quantum dots (GQDs) are grouped for a detailed review of the novel nanocomposites for cancer therapy. Some CNMs proved to be more successful than others in terms of stability and effectiveness at removing relative tumour volume. While the literature has been focused primarily on the CNTs and GO, other CNMs such as carbon nano-onions (CNOs) proved quite promising for targeted drug delivery using HA. Near-infrared laser photoablation is also reviewed as a primary method of cancer therapy—it can be used alone or in conjunction with chemotherapy to achieve promising chemo-photothermal therapy protocols. This review aims to give a background into HA and why it is a successful cancer-targeting component of current CNM-based drug delivery systems.

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Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy

Chemical Communications ◽

10.1039/c9cc04098f ◽

2019 ◽

Vol 55 (67) ◽

pp. 9904-9914 ◽

Cited By ~ 25

Author(s):

Jinggong Liu ◽

Haoqiang Lai ◽

Zushuang Xiong ◽

Bolai Chen ◽

Tianfeng Chen

Keyword(s):

Targeted Therapy ◽

Cancer Therapy ◽

Photothermal Therapy ◽

Ruthenium Complex ◽

Ruthenium Complexes ◽

Cancer Targeting ◽

Bio Imaging

Herein, the functionalized Ruthenium complex applied for bio-imaging, photodynamic/photothermal therapy, precise targeted therapy and theranostics application have been discussed.

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A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Journal of Materials Chemistry B ◽

10.1039/c9tb00398c ◽

2019 ◽

Vol 7 (24) ◽

pp. 3856-3864 ◽

Cited By ~ 4

Author(s):

Mengxue Liu ◽

Jiulong Zhang ◽

Xin Li ◽

Chao Cai ◽

Xueyan Cao ◽

...

Keyword(s):

Iron Oxide ◽

Sialic Acid ◽

Magnetic Resonance ◽

Cancer Therapy ◽

Cancer Cells ◽

Photothermal Therapy ◽

Multimodal Imaging ◽

Photoacoustic Imaging

A novel targeted theranostic nanoplatform (LAP–Fe3O4@PDA–PEG–PBA) is constructed for magnetic resonance and photoacoustic imaging-guided photothermal therapy of cancer cells overexpressing sialic acid.

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Light-activated drug release from a hyaluronic acid targeted nanoconjugate for cancer therapy

Journal of Materials Chemistry B ◽

10.1039/c9tb01115c ◽

2019 ◽

Vol 7 (31) ◽

pp. 4843-4853 ◽

Cited By ~ 3

Author(s):

Chun-Yang Sun ◽

Bei-Bei Zhang ◽

Jia-Yan Zhou

Keyword(s):

Hyaluronic Acid ◽

Cancer Therapy ◽

Drug Release ◽

Cancer Cells

A hyaluronic acid targeted nanoconjugate was developed for efficient cancer therapy through phototriggered drug release in CD44-overexpressing cancer cells.

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Promising tamoxifen-loaded biocompatible hybrid magnetic nanoplatforms against breast cancer cells: synthesis, characterization and biological evaluation

New Journal of Chemistry ◽

10.1039/d0nj04226a ◽

2021 ◽

Vol 45 (8) ◽

pp. 4032-4045

Author(s):

Diego Cadena Castro ◽

Gerardo Gatti ◽

Sandra E. Martín ◽

Paula M. Uberman ◽

Mónica C. García

Keyword(s):

Breast Cancer ◽

Hyaluronic Acid ◽

Cancer Therapy ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Biological Evaluation ◽

Efficacy And Safety ◽

Breast Cancer Therapy

Improved efficacy and safety of tamoxifen-loaded hybrid nanocarriers based on Fe3O4 nanoparticles, l-cysteine and hyaluronic acid for breast cancer therapy.

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Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy

Pharmaceutics ◽

10.3390/pharmaceutics11070306 ◽

2019 ◽

Vol 11 (7) ◽

pp. 306 ◽

Cited By ~ 7

Author(s):

Subin Kim ◽

Myeong ju Moon ◽

Suchithra Poilil Surendran ◽

Yong Yeon Jeong

Keyword(s):

Drug Delivery ◽

Hyaluronic Acid ◽

Cancer Therapy ◽

Cancer Treatment ◽

Cancer Cells ◽

Biomedical Applications ◽

Treatment Approach ◽

Critical Role ◽

Sulfated Polysaccharide

Hyaluronic acid (HA) is a non-sulfated polysaccharide polymer with the properties of biodegradability, biocompatibility, and non-toxicity. Additionally, HA specifically binds to certain receptors that are over-expressed in cancer cells. To maximize the effect of drug delivery and cancer treatment, diverse types of nanomaterials have been developed. HA-based nanomaterials, including micelles, polymersomes, hydrogels, and nanoparticles, play a critical role in efficient drug delivery and cancer treatment. Hyperthermic cancer treatment using HA-based nanomaterials has attracted attention as an efficient cancer treatment approach. In this paper, the biomedical applications of HA-based nanomaterials in hyperthermic cancer treatment and combined therapies are summarized. HA-based nanomaterials may become a representative platform in hyperthermic cancer treatment.

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