Dual-responsive click-crosslinked micelles designed for enhanced chemotherapy for solid tumors

2020 ◽  
Vol 8 (9) ◽  
pp. 2507-2513 ◽  
Author(s):  
Rong Jin ◽  
Jing Sun ◽  
Liefu Zhou ◽  
Xuelian Guo ◽  
Aoneng Cao
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Solid Tumors ◽  
Anticancer Drugs ◽  
Dual Responsive ◽  
Crosslinked Micelles

Core-crosslinked dual-responsive micelles can be readily constructed from a pair of clickable copolymers and applied for controlled release of anticancer drugs in cancer therapy.

Novel dual‐responsive semi‐interpenetrating polymer network hydrogels for controlled release of anticancer drugs

2019 ◽  
Vol 107 (10) ◽  
pp. 2327-2339 ◽  
Author(s):  
Seyed Mohammad Reza Dadfar ◽  
Saeed Pourmahdian ◽  
Mohammad Mehdi Tehranchi ◽  
Seyed Mohammadali Dadfar
Keyword(s):  
Controlled Release ◽  
Anticancer Drugs ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Dual Responsive

Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (13) ◽  
pp. 5859-5868 ◽  
Author(s):  
Zhigang Xu ◽  
Shiying Liu ◽  
Yuejun Kang ◽  
Mingfeng Wang
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Silica Matrices

Stimuli-responsive nonporous silica prodrug nanoparticles are developed by covalently encapsulating anticancer drugs camptothecin (CPT) and doxorubicin (DOX) into silica matrices through glutathione (GSH)-responsive disulfide and pH-responsive hydrazone bonds.

Acid- and reduction-sensitive micelles for improving the drug delivery efficacy for pancreatic cancer therapy

2018 ◽  
Vol 6 (5) ◽  
pp. 1262-1270 ◽  
Author(s):  
Pu Wang ◽  
Jinxiu Wang ◽  
Haowen Tan ◽  
Shanfan Weng ◽  
Liying Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Solid Tumors ◽  
Anticancer Drugs ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
The Poor ◽  
Pancreatic Cancer Therapy

One of the major challenges in anticancer therapy is the poor penetration of anticancer drugs into tumors, especially in solid tumors, resulting in decreased therapeutic efficacy in vivo.

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

scholarly journals Bioinformatic Analysis of the Nicotinamide Binding Site in Poly(ADP-Ribose) Polymerase Family Proteins

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1201
Author(s):  
Garri Manasaryan ◽  
Dmitry Suplatov ◽  
Sergey Pushkarev ◽  
Viktor Drobot ◽  
Alexander Kuimov ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Binding Site ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Bioinformatic Analysis ◽  
Parp Inhibitors ◽  
Functional Region ◽  
D Loop

The PARP family consists of 17 members with diverse functions, including those related to cancer cells’ viability. Several PARP inhibitors are of great interest as innovative anticancer drugs, but they have low selectivity towards distinct PARP family members and exert serious adverse effects. We describe a family-wide study of the nicotinamide (NA) binding site, an important functional region in the PARP structure, using comparative bioinformatic analysis and molecular modeling. Mutations in the NA site and D-loop mobility around the NA site were identified as factors that can guide the design of selective PARP inhibitors. Our findings are of particular importance for the development of novel tankyrase (PARPs 5a and 5b) inhibitors for cancer therapy.

scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

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