Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

2020 ◽  
Vol 8 (22) ◽  
pp. 4841-4845 ◽  
Author(s):  
Lina Gao ◽  
Lei Zhang ◽  
Xuyu Zhu ◽  
Jing Chen ◽  
Meng Zhao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Gold Nanorods ◽  
Copper Complexes ◽  
Therapeutic Agents ◽  
Antitumor Efficacy

Hyaluronic acid functionalized gold nanorods with loading of copper complexes show a unique release manner and synergetic antitumor efficacy.

Dual targeting hyaluronic acid - RGD mesoporous silica coated gold nanorods for chemo-photothermal cancer therapy

2017 ◽  
Vol 81 ◽  
pp. 261-270 ◽  
Author(s):  
Huimin Zhou ◽  
Haixing Xu ◽  
Xin Li ◽  
Yahui Lv ◽  
Tian Ma ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Gold Nanorods ◽  
Dual Targeting

Tumor acidity and CD44 dual targeting hyaluronic acid-coated gold nanorods for combined chemo- and photothermal cancer therapy

2019 ◽  
Vol 226 ◽  
pp. 115281 ◽  
Author(s):  
Yi Li ◽  
Thai Minh Duy Le ◽  
Quang Nam Bui ◽  
Hong Yu Yang ◽  
Doo Sung Lee
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Gold Nanorods ◽  
Dual Targeting ◽  
Tumor Acidity

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Targeting the Ubiquitin Signaling Cascade in Tumor Microenvironment for Cancer Therapy

2021 ◽  
Vol 22 (2) ◽  
pp. 791
Author(s):  
Qi Liu ◽  
Bayonle Aminu ◽  
Olivia Roscow ◽  
Wei Zhang
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Therapeutic Agents ◽  
Biological Processes ◽  
Post Translational Modification ◽  
E3 Ligases ◽  
Tumor Microenvironments ◽  
Cellular Immune ◽  
Ubiquitin Conjugating Enzymes ◽  
Cellular Components

Tumor microenvironments are composed of a myriad of elements, both cellular (immune cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular (extracellular matrix, cytokines, growth factors, etc.), which collectively provide a permissive environment enabling tumor progression. In this review, we focused on the regulation of tumor microenvironment through ubiquitination. Ubiquitination is a reversible protein post-translational modification that regulates various key biological processes, whereby ubiquitin is attached to substrates through a catalytic cascade coordinated by multiple enzymes, including E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes and E3 ubiquitin ligases. In contrast, ubiquitin can be removed by deubiquitinases in the process of deubiquitination. Here, we discuss the roles of E3 ligases and deubiquitinases as modulators of both cellular and non-cellular components in tumor microenvironment, providing potential therapeutic targets for cancer therapy. Finally, we introduced several emerging technologies that can be utilized to develop effective therapeutic agents for targeting tumor microenvironment.

Construction and evaluation of hyaluronic acid-based copolymers as a targeted chemotherapy drug carrier for cancer therapy

2020 ◽  
Vol 31 (30) ◽  
pp. 305702
Author(s):  
Yuting Tang ◽  
Minglong Chen ◽  
Qian Xie ◽  
Lu Li ◽  
Lei Zhu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Targeted Chemotherapy ◽  
Chemotherapy Drug

Hyaluronic acid-based nanogels derived from multicomponent self-assembly for imaging-guided chemo-photodynamic cancer therapy

2021 ◽  
pp. 118257
Author(s):  
Ya-Ting Pan ◽  
Yuan-Fu Ding ◽  
Zhi-Hao Han ◽  
Lihui Yuwen ◽  
Zhan Ye ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Photodynamic Cancer Therapy

Gold Nanorods Stabilized by Biocompatible and Multifunctional Zwitterionic Copolymer for Synergistic Cancer Therapy

2017 ◽  
Vol 15 (1) ◽  
pp. 164-174 ◽  
Author(s):  
Phim-on Khunsuk ◽  
Supatta Chawalitpong ◽  
Pritsana Sawutdeechaikul ◽  
Tanapat Palaga ◽  
Voravee P. Hoven
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods

scholarly journals Bile Acid Conjugates with Anticancer Activity: Most Recent Research

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 25
Author(s):  
Maria Luisa Navacchia ◽  
Elena Marchesi ◽  
Daniela Perrone
Keyword(s):  
Bile Acid ◽  
Cancer Therapy ◽  
Anticancer Activity ◽  
Bile Acids ◽  
Treatment Modality ◽  
Biological Properties ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
Hybrid Functional ◽  
Hybrid Molecules

The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules.

scholarly journals Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

RSC Advances ◽  
2018 ◽  
Vol 8 (47) ◽  
pp. 26517-26522
Author(s):  
Linlin Xie ◽  
Xiaomin Zhi ◽  
Nao Xiao ◽  
Chen-Jie Fang ◽  
Chun-Hua Yan
Keyword(s):  
Aspartic Acid ◽  
Gold Nanorods ◽  
Therapeutic Agents ◽  
Au Nanorods ◽  
Arginine Glycine Aspartic Acid

We demonstrated an easy-to-use strategy to constrain the freedom of an RGD (arginine, glycine, aspartic acid) sequence with gold nanorods.

scholarly journals Developing Picornaviruses for Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 685 ◽  
Author(s):  
Cormac McCarthy ◽  
Nadishka Jayawardena ◽  
Laura N. Burga ◽  
Mihnea Bostina
Keyword(s):  
Cancer Therapy ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Rna Viruses ◽  
Therapeutic Agents ◽  
Oncolytic Viruses ◽  
Wide Range ◽  
Positive Sense

Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including Picornaviridae, have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encode oncogenes, and are easily manipulated as cDNA. This review focuses on the picornaviruses investigated for anticancer potential and the mechanisms that underpin this specificity.

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