The key role of the central cavity in sodium transport through ligand-gated Two-Pore Channels

2021 ◽  
Author(s):  
Stefan Milenkovic ◽  
Igor V Bodrenko ◽  
Armando Carpaneto ◽  
Matteo Ceccarelli
Keyword(s):  
Sodium Transport ◽  
Central Cavity ◽  
Cellular Life ◽  
Broad Variety ◽  
Basic Level

Subcellular and organellar mechanisms have manifested a prominent importance for a broad variety of processes that maintain cellular life on its most basic level. Mammalian Two-pore channels (TPCs) appear to...

Rola uzasadnienia sądowego w realizacji prawa do rzetelnego procesu sądowoadministracyjnego– standard strasburski

2014 ◽  
pp. 13-31
Author(s):  
Katarzyna Grzelak-Bach
Keyword(s):  
Human Rights ◽  
Legal Reasoning ◽  
Case Law ◽  
Legal Order ◽  
European Court ◽  
Protection Of Human Rights ◽  
Judicial Proceedings ◽  
Court Proceedings ◽  
Basic Level

Following a brief introduction of article 6 of the Convention for the Protection of Human Rights and Fundamental Freedoms, the author begins by analyzing case law from the European Court of Human Rights regarding the legal reasoning in judicial proceedings. The main premise of this paper is to present a formula for preparing legal reasoning in administrative court proceedings. The author draws attention to the role of judges who, in the process of adjudication, should apply creative interpretation of the rules of law, when they see errors or omissions in legislative provisions, or blatant violations of the European legal order. The conclusion of those deliberations finds, that the process of tailoring the approach to meet Strasbourg’s requirements should, on a basic level, be at the discretion of judges rather than the legislators.

scholarly journals Anatomy and Neural Pathways Modulating Distinct Locomotor Behaviors in Drosophila Larva

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 90
Author(s):  
Swetha B. M. Gowda ◽  
Safa Salim ◽  
Farhan Mohammad
Keyword(s):  
Motor Neurons ◽  
Model Systems ◽  
Neural Pathways ◽  
Animal Movements ◽  
Drosophila Larvae ◽  
The Central Nervous System ◽  
Drosophila Larva ◽  
Locomotor Behaviors ◽  
Basic Level

The control of movements is a fundamental feature shared by all animals. At the most basic level, simple movements are generated by coordinated neural activity and muscle contraction patterns that are controlled by the central nervous system. How behavioral responses to various sensory inputs are processed and integrated by the downstream neural network to produce flexible and adaptive behaviors remains an intense area of investigation in many laboratories. Due to recent advances in experimental techniques, many fundamental neural pathways underlying animal movements have now been elucidated. For example, while the role of motor neurons in locomotion has been studied in great detail, the roles of interneurons in animal movements in both basic and noxious environments have only recently been realized. However, the genetic and transmitter identities of many of these interneurons remains unclear. In this review, we provide an overview of the underlying circuitry and neural pathways required by Drosophila larvae to produce successful movements. By improving our understanding of locomotor circuitry in model systems such as Drosophila, we will have a better understanding of how neural circuits in organisms with different bodies and brains lead to distinct locomotion types at the organism level. The understanding of genetic and physiological components of these movements types also provides directions to understand movements in higher organisms.

Affect and iconicity in phonological variation

2020 ◽  
pp. 1-23
Author(s):  
Annette D'Onofrio ◽  
Penelope Eckert
Keyword(s):  
Experimental Evidence ◽  
Empirical Evidence ◽  
Essential Role ◽  
Sound Symbolism ◽  
Linguistic Variation ◽  
Phonological Variation ◽  
Sociolinguistic Variation ◽  
Production Studies ◽  
Basic Level

Abstract The study of iconic properties of language has been marginalized in linguistics, with the assumption that iconicity, linked with expressivity, is external to the grammar. Yet iconicity plays an essential role in sociolinguistic variation. At a basic level, repetition and phonetic intensification can intensify the indexicality of variables. Iconicity plays a further role in variation in the form of sound symbolism, linking properties of sounds with attributes or objects. Production studies have shown some phonological variables exhibiting sound symbolism, particularly in the expression of affect. In some cases, the observation of sound symbolism has been largely interpretive. But in others, stylistic variability as a function of speaker affect has provided empirical evidence of iconicity. This article examines the role of iconicity and performativity in transcending the limits of reference, reviews iconicity in production studies, and provides experimental evidence that sound symbolism influences how listeners attribute affect to linguistic variation. (Variation, iconicity, affect)

scholarly journals Playing with Fire: Analysing the Role of Fire in Architecture

2021 ◽  
Author(s):  
◽  
Joanita Goei
Keyword(s):  
Case Studies ◽  
Modern Science ◽  
Living Organism ◽  
Architectural Elements ◽  
Greco Roman ◽  
Architectural Element ◽  
Contemporary Architecture ◽  
Basic Level ◽  
Living Being

<p>This research addresses the four inherent themes within fire. Fire has an association with myth due to its complexity in nature and existence long before modern science. Even today these myths live on as a way to describe the characteristics of fire as an architectural element. Bachelard’s book The Psychoanalysis of Fire looks at how fire connects with our primitive self through reverie. Fire’s contemplative character allows us to escape the surrounding world, and transport us to a kind of subconscious level. An extension of the reverie of fire is fire’s relation to the primitive. Although we have evolved into advance species, at a basic level we are all still animals. There are certain primal needs inherent within us such as sense of safety and community. Fire fulfils these needs architecturally by providing the setting for ‘primitive experiences.’ The last theme I will look at has to do with fire’s association with living beings. Even though fire is not scientifically a living organism, it is often compared to a living being due to its complexity in character. Moreover, it often symbolises life in many levels of society such as the civic hearth during the Greco-Roman era. Several case studies are looked at to see the application of the ideas represented within the themes of fire. A range of contemporary architecture is chosen to show how the ideals associated with fire are still applicable in architecture even today. In the case studies fire has either been excluded physically but present symbolically, or its presence has been reduced to the bare minimum. The case studies aim to show how fire can be addressed architecturally using other architectural elements that are traditionally associated with fire, such as chimneys and hearth. Due to current issues such as sustainability, having fire physically within a space is becoming more difficult. Many places around the world have banned open fires. An option to continue celebrating fire within architecture is through the symbolic representation of the element. This can be done by using other architectural elements that we traditionally associate with fire ...</p>

scholarly journals CopR, a global regulator of transcription to maintain copper homeostasis in Pyrococcus furiosus

2020 ◽  
Author(s):  
Felix Grünberger ◽  
Robert Reichelt ◽  
Ingrid Waege ◽  
Verena Ned ◽  
Korbinian Bronner ◽  
...  
Keyword(s):  
Essential Role ◽  
Pyrococcus Furiosus ◽  
Copper Homeostasis ◽  
Negative Stain ◽  
Cellular Life ◽  
Transmission Electron ◽  
Genome Wide ◽  
Binding Data ◽  
Differential Gene

AbstractAlthough copper is in many cases an essential micronutrient for cellular life, higher concentrations are toxic. Therefore, all living cells have developed strategies to maintain copper homeostasis. In this manuscript, we have analysed the transcriptome-wide response of Pyrococcus furiosus to increased copper concentrations and described the essential role of the putative copper-sensing metalloregulator CopR in the detoxification process.To this end, we employed biochemical and biophysical methods to characterise the role of CopR. Additionally, a copR knockout strain revealed an amplified sensitivity in comparison to the parental strain towards increased copper levels, which designates an essential role of CopR for copper homeostasis. To learn more about the CopR-regulated gene network, we performed differential gene expression and ChIP-seq analysis under normal and 20 μM copper-shock conditions. By integrating the transcriptome and genome-wide binding data, we found that CopR binds to the upstream regions of many copper-induced genes. Negative-stain transmission electron microscopy and 2D class averaging revealed an octameric assembly formed from a tetramer of dimers for CopR, similar to published crystal structures from the Lrp family. In conclusion, we propose a model for CopR-regulated transcription and highlight the complex regulatory network that enables Pyrococcus to respond to increased copper concentrations.

Why Do National Cybersecurity Awareness Programmes Often Fail?

2020 ◽  
Vol 9 (2) ◽  
pp. 18-27
Author(s):  
Eva NAGYFEJEO ◽  
Basie Von SOLMS
Keyword(s):  
Civil Society ◽  
Best Practice ◽  
National Level ◽  
The Public ◽  
Awareness Campaigns ◽  
Cyber Space ◽  
Awareness Raising ◽  
The Government ◽  
Basic Level

Nowadays, many cyber users do not understand how to protect themselves and their information within cyber space. One reason is that cyber users are unaware of possible cyber risks and threats that may occur within cyber space. The second reason is that citizens, businesses and users within the public sector may be aware of relevant cyber risks but do not really understand the seriousness of such risks and the consequences if they do realise. Therefore, cybersecurity awareness campaigns are an integral part of improving cybersecurity awareness. Based on in-country reviews conducted as part of the Global Cybersecurity Capacity Centre (GCSCC) programme, we observed that the campaigns to raise cybersecurity awareness throughout the country are often led by different ‘owners’ without co-ordination and adequate resources therefore creating fragmentation in the national cybersecurity awareness raising programme. This paper suggests that the development of a coordinated and coherent national cybersecurity awareness program is critical for building a basic level of aware-ness at the national level. We will examine the requirements needed to develop a coordinated national awareness raising programme by reviewing the existing literature, best practice approaches and the role of different stakeholders such as the government, private sector and civil society. We will draw conclusions on the main obstacles to ensure overall coherence between the actions of stakeholders and the efforts countries should prioritise in order to increase awareness of cyber risks at the national level.

Thinks tanks and their role in policy making in ireland

2021 ◽  
pp. 157-170
Author(s):  
Chris McInerney
Keyword(s):  
Public Policy ◽  
Civil Society ◽  
Policy Making ◽  
International Experience ◽  
Think Tanks ◽  
Think Tank ◽  
Complex Issue ◽  
Recent Developments ◽  
Broad Variety

This chapter reviews the role of think tanks in policy making. Like most modern democracies, Ireland relies on a range of sources to influence the choices and designs of public policy. Apart from political and administrative influences, a broad variety of civil society, academic and private sector actors seek to access, influence, advise, inform and sometimes embarrass those in power. The chapter focuses on ‘think tanks’, defining them, reviewing international experience, examining different types and considering the complex issue of assessing think tank influence. It maps out Ireland’s limited think tank landscape and examines recent developments. Think tanks’ influence on Irish policymaking is assessed across a number of indicators.

The Role of the Attorney in a Private Practice

2017 ◽  
pp. 199-205 ◽  
Author(s):  
A. Steven Frankel
Keyword(s):  
Private Practice ◽  
Vital Role ◽  
Insurance Companies ◽  
Critical Importance ◽  
Legal Professionals ◽  
Private Practitioners ◽  
Fee Structure ◽  
Broad Variety

This chapter addresses the broad variety of legal professionals that private practitioners may need to consult. Topics include pre-practice concerns for unlicensed individuals and the issues that arise when one builds, maintains, and enhances a private practice. Attorneys can be of critical importance in the areas of marketing, establishing a fee structure and payment practices, adding colleagues, and responding to difficult and/or threatening clients. Other situations in which attorneys can play a vital role include responding to licensing board complaints, malpractice lawsuits, and criminal complaints, as well as interactions with insurance companies and planning for practice transition and termination. Suggestions are provided for how to locate good attorneys, how to work with attorneys, and how to stop working with them when necessary.

Role of adult input in young children's category evolution: II an experimental study

1988 ◽  
Vol 15 (3) ◽  
pp. 493-504 ◽  
Author(s):  
Rae L. Banigan ◽  
Carolyn B. Mervis
Keyword(s):  
Experimental Study ◽  
Relative Effectiveness ◽  
Verbal Description ◽  
Effective Strategy ◽  
Mutual Exclusivity ◽  
Object A ◽  
Basic Level

ABSTRACTYoung children's initial categories often are not identical to the adult category labelled by the same word. Eventually, children's categories must evolve to correspond to the adult standard. The purpose of this study was to consider the relative effectiveness of four input strategies in inducing the child to learn the adult-appropriate label and begin to form a new category. Fifty-six children aged 2;0 were taught new labels for objects that they included in categories labelled by different names. Comprehension and production post-tests were then administered. As expected, the most effective strategy involved labelling an object and providing both a physical demonstration and a verbal description of important attributes that made the object a member of the adult-appropriate category. The label plus physical demonstration strategy was next most effective. Neither the label plus verbal description strategy nor the label only strategy was effective for children of this age. Results also indicated that these 24 month olds did not yet honour the convention of mutual exclusivity of basic level categories.

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