Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice

2021 ◽  
Author(s):  
Chenyang Lu ◽  
Ju Chen ◽  
Congmin Yi ◽  
Jiaojiao Han ◽  
Qiuyue Shi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Gut Microbiota ◽  
Protective Effects ◽  
Collagen Induced Arthritis ◽  
Tuna Oil ◽  
Beneficial Effects ◽  
Chronic Autoimmune Disease

Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the components of tuna oil (TO) were firstly measured, and the beneficial effects of TO on collagen-induced...

scholarly journals Gambaran Pasien Reumatoid Artritis di RSUD Arifin Achmad Riau Province 2015 - 2019

2021 ◽  
Vol 14 (1) ◽  
pp. 45
Author(s):  
Jelita Sri Agustin ◽  
Huriatul Masdar ◽  
Asrizal Asrizal
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Joint Pain ◽  
Pharmacological Therapy ◽  
Age Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Laboratory Examinations ◽  
Chronic Autoimmune Disease

Rheumatoid Arthritis (RA) is a chronic autoimmune disease that causes tissue damage, deformity, and death if not treated immediately. The aim of this study  to description of RA patients in the Regional General Hospital (RSUD) Arifin Achmad Riau Province 2015 – 2019. The results showed that total cases was 55 cases with the more common in female (87,3%) with most age group was 46-55 years (34,5%) and the main complaints were joint pain (85,5%). Rheumatoid arthritis patients with laboratory examinations were non-reactive rheumatoid factor (RF) levels by 20 patients out of 30 patients, levels of Anti-Citrullinated Protei  Antibodies (ACPA) or Immunoglobulin G anti-Cyclic Citrulinated Protein (IgG anti-CCP) reactive by 3 patients out of 4 patients, levels C-Reactive Protein (CRP) abnormal by 18 patients out of 21 patients and levels Erythrocyte Sedimentation Rate (ESR) abnormal by 20 patients out of 23 patients. The results also showed that the most pharmacological therapy given was corticosteroid (87,3%)

scholarly journals Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013−2015

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Rahma Anindya Prathitasari ◽  
Harry Isbagio
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Side Effect ◽  
Normal Limit ◽  
Keywords Rheumatoid Arthritis ◽  
Chronic Autoimmune Disease

Background Rheumatoid arhtirtis (RA) is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate (MTX) which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients' medical records.Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60%. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity (p>0.05).Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX. Keywords: Rheumatoid Arthritis, Methotrexate, Hepatotoxicity

scholarly journals LncRNA: An all-rounder in rheumatoid arthritis

2019 ◽  
Vol 7 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Junyu Liang ◽  
Weiqian Chen ◽  
Jin Lin
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Disease Activity ◽  
Therapeutic Targets ◽  
Non Coding Rnas ◽  
Chronic Autoimmune Disease

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. In addition to working as biomarkers for RA, lncRNAs participate in many specific pathological processes including inflammation, aberrant proliferation, migration, invasion and apoptosis. Further screenings and researches are required to validate the clinical potentials of lncRNAs as diagnostic and therapeutic targets in RA.

scholarly journals Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 763
Author(s):  
Manuela Cassotta ◽  
Tamara Y. Forbes-Hernandez ◽  
Danila Cianciosi ◽  
Maria Elexpuru Zabaleta ◽  
Sandra Sumalla Cano ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Environmental Factors ◽  
Nutritional Factors ◽  
Omics Technologies ◽  
Food Components ◽  
Nutritional Advice ◽  
The Individual ◽  
Chronic Autoimmune Disease ◽  
Nutritional Sciences

Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed.

Autoantibodies in rheumatoid arthritis

2020 ◽  
pp. 65-72
Author(s):  
Tom W.J. Huizinga
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Autoimmune Disease ◽  
Characteristic Feature ◽  
Pathogenic Potential ◽  
Pathogenetic Role ◽  
Autoantibody Response ◽  
Chronic Autoimmune Disease ◽  
Underlying Pathophysiology

Autoantibodies are a characteristic feature of autoimmune diseases. Although the exact pathogenetic role of autoantibodies is in general not known, they are very often useful for diagnostic purposes. Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting the joints. RA is a heterogeneous disease that encompasses several disease subsets with probable differences in underlying pathophysiology. Via a final common inflammatory pathway these different pathophysiological pathways might lead to a similar clinical presentation of arthritis. The best-known subdivision in RA is between autoantibody positive and autoantibody negative RA, which differ in both risk factors and clinical outcomes. This chapter focuses on the role of autoantibodies in the pathophysiology of RA. First, the relation between autoantibodies and known risk factors for RA will be discussed. Thereafter, the specific characteristics of the autoantibody response and the pathogenic potential of the different autoantibodies are reviewed.

Effect of Arthrigia on Adjuvant Arthritis Rats’ IL-12

2011 ◽  
Vol 140 ◽  
pp. 43-47
Author(s):  
Xi Chen ◽  
Cheng Yi Zhang ◽  
Hao Gang Xue
Keyword(s):  
Rheumatoid Arthritis ◽  
Adjuvant Arthritis ◽  
Protective Effects ◽  
Immunological Mechanism ◽  
Rat Models ◽  
Therapeutic Mechanism ◽  
Prevention And Treatment ◽  
Clinical Prevention ◽  
Chronic Autoimmune Disease ◽  
Further Development

Rheumatoid Arthritis （RA） is a systemic chronic autoimmune disease. To study the therapeutic mechanism of effects of Skullcap Brightviolet （SB），glucosamine/chondroitin （GC），and the combination of them (named Arthrigia) on RA. With the adjuvant arthritis (AA) rat models, we observed the protective effects of oral SB, GC and Arthrigia in different concentrations on AA in rats. We further examined the immunological mechanism of the combination of them by testing the rats’ secretion of IL-12. The results showed that Arthrigia inhibited the production and secretion of IL-12 factors in some extent, and its effects are more potent the single SB or GC. The present study provides the experimental evidences for Arthrigia for its further development, clinical prevention and treatment of RA.

Protective effects of Paederia scandens extract on rheumatoid arthritis mouse model by modulating gut microbiota

2018 ◽  
Vol 226 ◽  
pp. 97-104 ◽  
Author(s):  
Man Xiao ◽  
Xiaopeng Fu ◽  
Yali Ni ◽  
Jifeng Chen ◽  
Shaoqing Jian ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Protective Effects ◽  
Paederia Scandens

scholarly journals Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 119 ◽  
Author(s):  
Andy W.C. Man ◽  
Huige Li ◽  
Ning Xia
Keyword(s):  
Gut Microbiota ◽  
Cell Cycle Progression ◽  
Vascular Inflammation ◽  
Neointimal Hyperplasia ◽  
Critical Role ◽  
Short Chain Fatty Acids ◽  
Cardiovascular Complications ◽  
Protective Effects ◽  
Vsmc Proliferation ◽  
Beneficial Effects

Arterial remodelling refers to the alteration in the structure of blood vessel that contributes to the progression of hypertension and other cardiovascular complications. Arterial remodelling is orchestrated by the crosstalk between the endothelium and vascular smooth muscle cells (VSMC). Vascular inflammation participates in arterial remodelling. Resveratrol is a natural polyphenol that possesses anti-oxidant and anti-inflammatory properties and has beneficial effects in both the endothelium and VSMC. Resveratrol has been studied for the protective effects in arterial remodelling and gut microbiota, respectively. Gut microbiota plays a critical role in the immune system and inflammatory processes. Gut microbiota may also regulate vascular remodelling in cardiovascular complications via affecting endothelium function and VSMC proliferation. Currently, there is new evidence showing that gut microbiota regulate the proliferation of VSMC and the formation of neointimal hyperplasia in response to injury. The change in population of the gut microbiota, as well as their metabolites (e.g., short-chain fatty acids) could critically contribute to VSMC proliferation, cell cycle progression, and migration. Recent studies have provided strong evidence that correlate the effects of resveratrol in arterial remodelling and gut microbiota. This review aims to summarize recent findings on the resveratrol effects on cardiovascular complications focusing on arterial remodelling and discuss the possible interactions of resveratrol and the gut microbiota that modulate arterial remodelling.

scholarly journals Application of nanomaterials in the treatment of rheumatoid arthritis

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7129-7137
Author(s):  
Miaomiao Zheng ◽  
Huiju Jia ◽  
Huangwei Wang ◽  
Linhong Liu ◽  
Zhesheng He ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Bone Tissue ◽  
Synovial Joints ◽  
Chronic Autoimmune Disease

Rheumatoid Arthritis (RA) is a chronic autoimmune disease, which mainly causes inflammation of the synovial joints and destruction of cartilage and bone tissue.

scholarly journals Dietary Bioactive Peptide Alanyl-Glutamine Attenuates Dextran Sodium Sulfate-Induced Colitis by Modulating Gut Microbiota

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Qingbiao Xu ◽  
Mingyang Hu ◽  
Min Li ◽  
Jinxiu Hou ◽  
Xianghua Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Activity Index ◽  
Intestinal Barrier ◽  
Body Weight Loss ◽  
Community Diversity ◽  
Peptide Transporter ◽  
Protective Effects ◽  
Gut Health ◽  
Beneficial Effects ◽  
Rdna Sequencing

Inflammatory bowel disease (IBD) is a chronic intestinal disorder threatening human health. Di-peptide alanyl-glutamine (Ala-Gln) has various beneficial effects on gut health. However, its role and functional mechanism in treating IBD are still not clear. Therefore, the protective effects of Ala-Gln and glutamine (Gln) on dextran sulfate sodium- (DSS-) induced colitic mice were investigated in this study. The results showed that oral supplementation of Ala-Gln or Gln significantly attenuated the colitis symptoms in mice, including body weight loss, colon length, disease activity index, histological scores, and tissue apoptosis. The concentrations of interleukin- (IL-) 1β, IL-6, tumor necrosis factor-α, and myeloperoxidase were significantly decreased, while the concentrations of immunoglobulins (IgA, IgG, and IgM) and superoxide dismutase were significantly increased by Ala-Gln or Gln supplementation. The expression of occludin and peptide transporter 1 (PepT1) was significantly increased by Ala-Gln or Gln. Interestingly, Ala-Gln had better beneficial effects than Gln in alleviating colitis. In addition, 16S rDNA sequencing showed that the DSS-induced shifts of the microbiome (community diversity, evenness, richness, and composition) in the mouse colon were restored by Gln and Ala-Gln, including Lactobacillus, Bacteroides_acidifaciens, Bacteroidales, Firmicutes, Clostridia, Helicobacter, and Bacteroides. Correspondingly, the functions of the microflora metabolism pathways were also rescued by Ala-Gln, including fatty acid metabolism, membrane transporters, infectious diseases, and immune system. In conclusion, the results revealed that Ala-Gln can prevent colitis through PepT1, enhancing the intestinal barrier and modulating gut microbiota and microflora metabolites.

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