Role of Intercalation on Electrical Properties of Nucleic Acids for use in Molecular Electronics

2021 ◽  
Author(s):  
Hashem Mohammad ◽  
Busra Demir ◽  
Caglanaz Akin ◽  
Binquan Luan ◽  
Joshua Hihath ◽  
...  
Keyword(s):  
Electrical Properties ◽  
Nucleic Acids ◽  
Small Molecules ◽  
Molecular Electronics ◽  
Data Storage ◽  
Single Molecule ◽  
Essential Role ◽  
Transmission Probability ◽  
Electron Transmission

Intercalating ds-DNA/RNA with small molecules can play an essential role in controlling the electron transmission probability for molecular electronics applications such as biosensors, single-molecule transistors, and data storage. However, its...

scholarly journals Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 491 ◽  
Author(s):  
Gurleen Kaur ◽  
Jacob Lewis ◽  
Antoine van Oijen
Keyword(s):  
Mechanical Properties ◽  
Nucleic Acids ◽  
Small Molecules ◽  
Single Molecule ◽  
Single Molecules ◽  
Dna Molecules ◽  
Dna Interactions ◽  
Biochemical Reactions ◽  
Imaging Methods ◽  
Protein Dna Interactions

The ability to watch single molecules of DNA has revolutionised how we study biological transactions concerning nucleic acids. Many strategies have been developed to manipulate DNA molecules to investigate mechanical properties, dynamics and protein–DNA interactions. Imaging methods using small molecules and protein-based probes to visualise DNA have propelled our understanding of complex biochemical reactions involving DNA. This review focuses on summarising some of the methodological developments made to visualise individual DNA molecules and discusses how these probes have been used in single-molecule biophysical assays.

SINGLE-MOLECULE DNA CONDUCTANCE IN WATER SOLUTIONS: ROLE OF EXPLICIT WATER–COUNTERION SHEATH AND CHEMICAL MODIFICATION OF NUCLEOBASES

2009 ◽  
Vol 04 (03) ◽  
pp. 231-243 ◽  
Author(s):  
E. B. STARIKOV ◽  
C. NGANOU ◽  
K. H. LEE ◽  
G. CUNIBERTI ◽  
W. WENZEL
Keyword(s):  
Chemical Modification ◽  
Single Molecule ◽  
Transmission Probability ◽  
Dna Bases ◽  
Electronic Systems ◽  
Specific Charge ◽  
Dna Duplexes ◽  
Water Solutions ◽  
Explicit Water

Dependence of charge transmission through several conventional and extended DNA duplexes on the explicit presence of their water–counterion surrounding has been theoretically studied. We show here that: (a) the latter does not form specific charge transmission channels in addition to those available in DNA duplexes themselves; (b) chemically modifying DNA bases to extend their π-electronic systems does not significantly alter time-averaged charge transmission probability through DNA duplexes.

scholarly journals Simultaneous detection of small molecules, proteins and microRNAs using single molecule arrays

2020 ◽  
Vol 11 (30) ◽  
pp. 7896-7903 ◽  
Author(s):  
Xu Wang ◽  
David R. Walt
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Single Molecule ◽  
Simultaneous Detection ◽  
Multiplexed Detection ◽  
Measurement Methodology

The first example of multiplexed detection of proteins, nucleic acids, and small molecules using single molecule measurement methodology.

scholarly journals Role of solvents in the electronic transport properties of single-molecule junctions

2016 ◽  
Vol 7 ◽  
pp. 1055-1067 ◽  
Author(s):  
Katharina Luka-Guth ◽  
Sebastian Hambsch ◽  
Andreas Bloch ◽  
Philipp Ehrenreich ◽  
Bernd Michael Briechle ◽  
...  
Keyword(s):  
Molecular Electronics ◽  
Single Molecule ◽  
Current Voltage ◽  
Tunnel Barriers ◽  
Single Molecule Junctions ◽  
Level Model ◽  
Current Voltage Characteristics ◽  
Solvent Molecules ◽  
Narrow Gaps

We report on an experimental study of the charge transport through tunnel gaps formed by adjustable gold electrodes immersed into different solvents that are commonly used in the field of molecular electronics (ethanol, toluene, mesitylene, 1,2,4-trichlorobenzene, isopropanol, toluene/tetrahydrofuran mixtures) for the study of single-molecule contacts of functional molecules. We present measurements of the conductance as a function of gap width, conductance histograms as well as current–voltage characteristics of narrow gaps and discuss them in terms of the Simmons model, which is the standard model for describing transport via tunnel barriers, and the resonant single-level model, often applied to single-molecule junctions. One of our conclusions is that stable junctions may form from solvents as well and that both conductance–distance traces and current–voltage characteristics have to be studied to distinguish between contacts of solvent molecules and of molecules under study.

scholarly journals The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

2020 ◽  
Author(s):  
Xinglei Liu ◽  
Lu Rao ◽  
Arne Gennerich
Keyword(s):  
Optical Tweezers ◽  
Single Molecule ◽  
Essential Role ◽  
Cytoplasmic Dynein ◽  
Regulatory Function ◽  
Atpase Domain ◽  
Single Molecule Fluorescence ◽  
Mechanochemical Cycle ◽  
Aaa Atpases

AbstractCytoplasmic dynein is the primary motor for microtubule minus-end-directed transport and is indispensable to eukaryotic cells. Although each motor domain of dynein contains three active AAA+ ATPases (AAA1, 3, and 4), only the functions of AAA1 and 3 are known. Here, we use single-molecule fluorescence and optical tweezers studies to elucidate the role of AAA4 in dynein’s mechanochemical cycle. We demonstrate that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimerizing tail of the motor to the AAA+ ring. Before ATP binds to AAA4, dynein remains incapable of generating motion. However, when AAA4 is bound to ATP, the gating of AAA1 by AAA3 prevails and dynein motion can occur. Thus, AAA1, 3, and 4 work together to regulate dynein function. Our work elucidates an essential role for AAA4 in dynein’s stepping cycle and underscores the complexity and crosstalk among the motor’s multiple AAA+ domains.

Properties of Single Molecule Magnet Ni4Mo12

2012 ◽  
Vol 190 ◽  
pp. 490-493
Author(s):  
Victor V. Kostyuchenko
Keyword(s):  
Magnetic Properties ◽  
Symmetry Breaking ◽  
Single Molecule ◽  
Essential Role ◽  
Exchange Interactions ◽  
Spin Models ◽  
Single Molecule Magnet ◽  
Heisenberg Exchange ◽  
Additional Level

At the present time two models can more or less describe the magnetic properties ofNi4Mo12. The rst one is based on the assumption of essential role of non-Heisenberg exchangeinteractions. The key feature of the second model is the symmetry breaking of exchange inter-actions. The present work is focused on the forecasting power of these spin models. Mechanismresponsible for non-Heisenberg exchange interactions is the same as mechanism resulting in in-teraction of spin chirality with external magnetic eld. An additional level splitting in magnetic eld can be observed in this case. The symmetry breaking of exchange interactions inevitablyleads to nonzero toroidal moment and related to it magnetoelectric phenomena.

scholarly journals The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinglei Liu ◽  
Lu Rao ◽  
Arne Gennerich
Keyword(s):  
Optical Tweezers ◽  
Single Molecule ◽  
Essential Role ◽  
Cytoplasmic Dynein ◽  
Regulatory Function ◽  
Atpase Domain ◽  
Single Molecule Fluorescence ◽  
Mechanochemical Cycle ◽  
Aaa Atpases

AbstractCytoplasmic dynein is the primary motor for microtubule minus-end-directed transport and is indispensable to eukaryotic cells. Although each motor domain of dynein contains three active AAA+ ATPases (AAA1, 3, and 4), only the functions of AAA1 and 3 are known. Here, we use single-molecule fluorescence and optical tweezers studies to elucidate the role of AAA4 in dynein’s mechanochemical cycle. We demonstrate that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimerizing tail of the motor to the AAA+ ring. Before ATP binds to AAA4, dynein remains incapable of generating motion. However, when AAA4 is bound to ATP, the gating of AAA1 by AAA3 prevails and dynein motion can occur. Thus, AAA1, 3, and 4 work together to regulate dynein function. Our work elucidates an essential role for AAA4 in dynein’s stepping cycle and underscores the complexity and crosstalk among the motor’s multiple AAA+ domains.

Transmission Electron Microscopy of Evaporated Perylene Thin Films

1990 ◽  
Vol 48 (2) ◽  
pp. 336-337
Author(s):  
C. Ewins ◽  
J.R. Fryer
Keyword(s):  
Electron Microscopy ◽  
Thin Films ◽  
Transmission Electron Microscopy ◽  
Molecular Electronics ◽  
High Vacuum ◽  
Amorphous Layer ◽  
Electric Heater ◽  
Transmission Electron ◽  
Polycyclic Aromatic

The preparation of thin films of organic molecules is currently receiving much attention because of the need to produce good quality thin films for molecular electronics. We have produced thin films of the polycyclic aromatic, perylene C10H12 by evaporation under high vacuum onto a potassium chloride (KCl) substrate. The role of substrate temperature in determining the morphology and crystallography of the films was then investigated by transmission electron microscopy (TEM).The substrate studied was the (001) face of a freshly cleaved crystal of KCl. The temperature of the KCl was controlled by an electric heater or a cold finger. The KCl was heated to 200°C under a vacuum of 10-6 torr and allowed to cool to the desired temperature. The perylene was then evaporated over a period of one minute from a molybdenum boat at a distance of 10cm from the KCl. The perylene thin film was then backed with an amorphous layer of carbon and floated onto copper microscope grids.

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