Waste derived biomaterials as building blocks in the biomedical field

2022 ◽  
Author(s):  
Sonali Jana ◽  
Piyali Das ◽  
Joydeep Mukherjee ◽  
Dipak Banerjee ◽  
Prabal Ranjan Ghosh ◽  
...  
Keyword(s):  
Building Blocks ◽  
Bioactive Molecules ◽  
Fish Meat ◽  
Recent Developments ◽  
Biomedical Field ◽  
Biological Wastes

Recent developments in the biomedical arena have led to the progress of several biomaterials by utilizing bioactive molecules from biological wastes arising from the fish, meat, and poultry industries. These...

Recent Advances in the Synthesis and Chemistry of Nitronates

Synthesis ◽  
2017 ◽  
Vol 49 (15) ◽  
pp. 3255-3268 ◽  
Author(s):  
Andrey Tabolin ◽  
Alexey Sukhorukov ◽  
Sema Ioffe ◽  
Alexander Dilman
Keyword(s):  
Carbon Atom ◽  
Stereoselective Synthesis ◽  
Building Blocks ◽  
Short Review ◽  
Bioactive Molecules ◽  
Silyl Nitronates ◽  
Recent Advances ◽  
Recent Developments

Due to their availability and versatile reactivity, nitronates have become important building blocks in the stereoselective synthesis of bioactive molecules. This short review provides a summary of recent developments on the synthesis, chemistry and applications of O-alkyl and O-silyl nitronates.1 Introduction2 Approaches to the Synthesis of Nitronates2.1 Synthesis of Six-Membered Cyclic Nitronates2.1.1 Formal [4+2] Approaches2.1.2 Formal [3+3] Approaches2.1.3 Other Approaches2.2 Synthesis of Five-Membered Cyclic Nitronates2.2.1 Formal [3+2] Approaches2.2.2 Formal [4+1] Approaches2.2.3 Oxidation Approaches3 Chemistry of Nitronates3.1 Nitronates as α-C-Nucleophiles3.2 Nitronates as α-C-Electrophiles3.3 Nitronates in [3+n]-Annulation Reactions3.4 Reactions Involving the β-Carbon Atom of Nitronates3.5 Miscellaneous Transformations4 Conclusion

Combinatorial Peptide Libraries for Selecting Inorganic-Binding Proteins: A Step in Molecular Biomimetics

2003 ◽  
Vol 773 ◽  
Author(s):  
C. Tamerler ◽  
S. Dinçer ◽  
D. Heidel ◽  
N. Karagûler ◽  
M. Sarikaya
Keyword(s):  
Binding Proteins ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Inorganic Materials ◽  
Combinatorial Peptide Libraries ◽  
Self Assembling ◽  
Complex Functions ◽  
Recent Developments ◽  
Specific Proteins ◽  
Molecular Biomimetics

AbstractProteins, one of the building blocks in organisms, not only control the assembly in biological systems but also provide most of their complex functions. It may be possible to assemble materials for practical technological applications utilizing the unique advantages provided by proteins. Here we discuss molecular biomimetic pathways in the quest for imitating biology at the molecular scale via protein engineering. We use combinatorial biology protocols to select short polypeptides that have affinity to inorganic materials and use them in assembling novel hybrid materials. We give an overview of some of the recent developments of molecular engineering towards this goal. Inorganic surface specific proteins were identified by using cell surface and phage display technologies. Examples of metal and metal oxide specific polypeptides were represented with an emphasis on certain level of specificities. The recognition and self assembling characteristics of these inorganic-binding proteins would be employed in develeopment of hybrid multifunctional materials for novel bio- and nano-technological applications.

scholarly journals Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

2020 ◽  
Vol 21 (24) ◽  
pp. 9759
Author(s):  
Agnieszka Arthur ◽  
Stan Gronthos
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Genetic Manipulation ◽  
Bioactive Molecules ◽  
Long Bone ◽  
Differentiation Potential ◽  
Skeletal Tissue ◽  
Recent Developments ◽  
Multipotent Differentiation ◽  
Craniofacial Defects

There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.

scholarly journals The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1357
Author(s):  
Andreea-Mariana Negrescu ◽  
Anisoara Cimpean
Keyword(s):  
Foreign Bodies ◽  
Structural Characteristics ◽  
Critical Role ◽  
Fibrous Tissue ◽  
Bioactive Molecules ◽  
New Bone Formation ◽  
Recent Developments

The critical role of the immune system in host defense against foreign bodies and pathogens has been long recognized. With the introduction of a new field of research called osteoimmunology, the crosstalk between the immune and bone-forming cells has been studied more thoroughly, leading to the conclusion that the two systems are intimately connected through various cytokines, signaling molecules, transcription factors and receptors. The host immune reaction triggered by biomaterial implantation determines the in vivo fate of the implant, either in new bone formation or in fibrous tissue encapsulation. The traditional biomaterial design consisted in fabricating inert biomaterials capable of stimulating osteogenesis; however, inconsistencies between the in vitro and in vivo results were reported. This led to a shift in the development of biomaterials towards implants with osteoimmunomodulatory properties. By endowing the orthopedic biomaterials with favorable osteoimmunomodulatory properties, a desired immune response can be triggered in order to obtain a proper bone regeneration process. In this context, various approaches, such as the modification of chemical/structural characteristics or the incorporation of bioactive molecules, have been employed in order to modulate the crosstalk with the immune cells. The current review provides an overview of recent developments in such applied strategies.

Droplet-microfluidics towards the assembly of advanced building blocks in cell mimicry

Nanoscale ◽  
2016 ◽  
Vol 8 (47) ◽  
pp. 19510-19522 ◽  
Author(s):  
Adam Armada-Moreira ◽  
Essi Taipaleenmäki ◽  
Fabian Itel ◽  
Yan Zhang ◽  
Brigitte Städler
Keyword(s):  
Building Blocks ◽  
Droplet Microfluidics ◽  
Spherical Particles ◽  
Recent Developments

This minireview outlines recent developments in droplet microfluidics regarding the assembly of nanoparticles, Janus-shaped and other non-spherical particles, and cargo-loaded particles which could potentially be employed as building blocks in cell mimicry.

Nano-Sized and Nanocrystalline Calcium Orhophosphates in Biomedical Engineering

2009 ◽  
Vol 3 ◽  
pp. 59-92 ◽  
Author(s):  
Sergey V. Dorozhkin
Keyword(s):  
Bone Repair ◽  
Dental Enamel ◽  
Building Blocks ◽  
Research Area ◽  
Future Research ◽  
Biological Origin ◽  
Current State ◽  
Calcium Orthophosphates ◽  
Recent Developments ◽  
Hard Tissue Engineering

There has been much recent activity in the research area of nanoparticles and nanocrystalline materials, in many fields of science and technology. This is due to their outstanding and unique physical, mechanical, chemical and biological characteristics. Recent developments in biomineralization have demonstrated that nano-sized particles play an important role in the formation of the hard tissues of animals. It is well established that the basic inorganic building blocks of bones and teeth of mammals are nano-sized and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds of nanocrystals of biological apatite are found to combine into self-assembled structures under the control of bio-organic matrixes. It was also confirmed experimentally that the structure of both dental enamel and bones could be mimicked by an oriented aggregation of nano-sized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nano-sized and nanocrystalline calcium orthophosphates for clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various cells were detected on smaller crystals of calcium orthophosphates. Furthermore, studies revealed that the differentiation of various cells was promoted by nano-sized calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have the potential to revolutionize the field of hard tissue engineering, in areas ranging from bone repair and augmentation to controlled drug delivery devices. This paper reviews the current state of knowledge and recent developments of various nano-sized and nanocrystalline calcium orthophosphates, covering topics from the synthesis and characterization to biomedical and clinical applications. This review also provides possible directions of future research and development.

Cybersecurity in Israel

2021 ◽  
pp. 630-648
Author(s):  
Lior Tabansky
Keyword(s):  
Soft Power ◽  
Intelligent Systems ◽  
Critical Infrastructure ◽  
Building Blocks ◽  
Strategic Choices ◽  
Innovation Ecosystem ◽  
Policy Goals ◽  
Recent Developments ◽  
Innovation Capacity ◽  
Economic Boom

The long-standing pillars in the grand strategy of Israel—namely, the qualitative edge principle and self-reliance in defence—enabled considerable cybersecurity achievements. Israel, the sole developed nation facing existential threats, has carried out audacious cyberspace operations yet never suffered material damage from cyberattacks. ‘Made in Israel’ inventions have long been embedded in building blocks of the global digital technologies, and drive much of the economic boom. As high-technology innovation flourishes, strategic choices taken over many decades created the foundations of Israel’s vibrant innovation ecosystem. Power, the currency of international relations, undergoes technology-driven change. Innovation capacity grows in importance in periods of profound change. Cyber power must be smart, integrating hard and soft power. The official Israel now shares sensitive cybersecurity expertise with foreign stakeholders, aiming to advance a range of foreign policy goals from counterterrorism to sustainable development. The milestones in Israel’s national cybersecurity evolution include the 2002 state-guided Critical Infrastructure Protection (CIP); the 2011 official national cybersecurity strategy with ambitious goals and comprehensive scope; and the most recent developments in the Israel National Cyber Directorate (INCD) and the Israel Defence Forces (IDF). However, Israel’s cybersecurity journey is far from complete. Harnessing digital transformation, in particular narrow artificial intelligence and intelligent systems, requires further profound innovation in national security. This chapter outlines four guiding principles and forces shaping Israel’s cybersecurity, and sketches three long-term policy challenges for Israel. As long as a coherent strategy guides innovation, Israel as well as other small nations can gain and utilize ample cyber power.

Towards Macro-Economic Convergence in SACU: The Position of Botswana

2020 ◽  
Vol 41 (2) ◽  
Author(s):  
Mabutho Shangase
Keyword(s):  
Economic Policy ◽  
Regional Integration ◽  
Secondary Data ◽  
Free Trade Area ◽  
Building Blocks ◽  
Customs Union ◽  
Economic Convergence ◽  
Trade Area ◽  
Recent Developments

In light of recent developments such as the African Continental African Free Trade Area agreement (AfCFTA), incrementalist approaches to regional inte gration that focus on sub-regions seems to have been pushed to the backburner as more focus puts the entire African continent at the centre of integration processes. With all its potential, gradual macro-economic convergence has accordingly been neglected. Discussions on macro-economic convergence have on the other hand been cast over the broader sub-region such as the Southern African Development Community (SADC) where a number of indicators and targets have been identified and pursued closely. Whilst looking at Botswana as a point of departure, this paper argues that incremental macro-economic convergence is pivotal to broader regional integration and the Southern African Customs Union (SACU) provides an ideal stepping-stone. An incrementalist approach to macro-economic convergence as well as broader regional integration should begin with identifying key formal institutions that serve as custodians of macro-economic policy such as the central banks and departments of finance or treasuries. Using secondary data sources, with Botswana as a case study, this paper foregrounds macro-economic convergence, macro-economic policy making institutions, and SACU as critical building blocks for broader regional integration.

2. Criminalizaton: historical, legal, and criminological perspectives

2017 ◽  
Author(s):  
Nicola Lacey ◽  
Lucia Zedner
Keyword(s):  
Criminal Law ◽  
Criminal Liability ◽  
Building Blocks ◽  
Historical Contingency ◽  
England And Wales ◽  
Close Relationship ◽  
Recent Developments ◽  
Shifting Boundaries ◽  
The Relationship ◽  
Over Time

This chapter examines the relationship between legal and criminological constructions of crime and explores how these have changed over time. The chapter sets out the conceptual framework of criminalization within which the two dominant constructions of crime—legal and criminological—are situated. It considers their respective contributions and the close relationship between criminal law and criminal justice. Using the framework of criminalization, the chapter considers the historical contingency of crime by examining its development over the past 300 hundred years. It analyses the normative building blocks of contemporary criminal law to explain how crime is constructed in England and Wales today and it explores some of the most important recent developments in formal criminalization in England and Wales, not least the shifting boundaries and striking expansion of criminal liability. Finally, it considers the valuable contributions made by criminology to understanding the scope of, and limits on, criminalization.

scholarly journals Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4906
Author(s):  
Jurriën W. Collet ◽  
Thomas R. Roose ◽  
Bram Weijers ◽  
Bert U. W. Maes ◽  
Eelco Ruijter ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Building Blocks ◽  
Insertion Reactions ◽  
Chemical Reagents ◽  
The Past ◽  
Recent Advances ◽  
Recent Developments ◽  
Palladium Catalyzed ◽  
Made In ◽  
Rapid Incorporation

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

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