scholarly journals Manipulation of fertility to enhance productivity of cattle

2018 ◽  
Vol 40 (3) ◽  
pp. 20-25
Author(s):  
Michael K. Holland ◽  
Michael McGowan
Keyword(s):  
Health Status ◽  
Environmental Factors ◽  
Reproductive Biology ◽  
Germ Cells ◽  
Human Population ◽  
Management Practices ◽  
Genetic Factors ◽  
Male And Female ◽  
Key Steps

Fertility is most simply defined as the natural capacity to produce offspring. More technically, it is the ability of male and female animals to produce viable germ cells, mate, conceive, carry and deliver normal living young. Fertility is affected by genetic factors, health status and environmental factors which includes management practices. These factors can affect one or more of the key steps in fertility which are: production of the gametes (the sperm or eggs), ovulation, fertilization, implantation, gestation or parturition. Over the last century, we have learnt to manipulate fertility in cattle by targeting many of these key steps with the goal of producing animals that more efficiently produce meat and milk to meet the demands of the increasing human population. This has required developing and integrating our knowledge in the key disciplines of reproductive biology and genetics, and while much has been achieved, much more is possible.

scholarly journals Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia

Development ◽  
2021 ◽  
pp. dev.199380
Author(s):  
Shengfei Dai ◽  
Shuangshuang Qi ◽  
Xueyan Wei ◽  
Xingyong Liu ◽  
Yibing Li ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Germ Cell ◽  
Somatic Cell ◽  
Cell Fate ◽  
Germ Cells ◽  
Sex Reversal ◽  
Testicular Development ◽  
Antagonistic Action ◽  
Male And Female ◽  
Fate Decision

Germline sexual fate has long been believed to be determined by the somatic environment, but this idea is challenged by recent studies of foxl3 mutants in medaka. Here we demonstrate that the sexual fate of tilapia germline is determined by the antagonistic interaction of dmrt1 and foxl3, which are transcriptionally repressed in male and female germ cells, respectively. Loss of dmrt1 rescued the germ cell sex reversal in foxl3Δ7/Δ7 XX fish, and loss of foxl3 partially rescued germ cell sex reversal but not somatic cell fate in dmrt1Δ5/Δ5 XY fish. Interestingly, germ cells lost sexual plasticity in dmrt1Δ5/Δ5 XY and foxl3Δ7/Δ7 XX single mutants, as aromatase inhibitor and estrogen treatment failed to rescue the respective phenotypes. However, recovery of germ cell sexual plasticity was observed in dmrt1/foxl3 double mutants. Importantly, mutation of somatic cell specific foxl2 resulted in testicular development in foxl3Δ7/Δ7 or dmrt1Δ5/Δ5 mutants. Our findings demonstrate that sexual plasticity of germ cells relies on the presence of both dmrt1 and foxl3. The existence of dmrt1 and foxl3 allows environmental factors to influence the sex fate decision in vertebrates.

Behaviour of germ cells and sexual differentiation in late embryonic and early postnatal mouse chimeras

Development ◽  
1970 ◽  
Vol 23 (2) ◽  
pp. 395-405
Author(s):  
Ewa T. Mystkowska ◽  
Andrzej K. Tarkowski
Keyword(s):  
Environmental Factors ◽  
Germ Cells ◽  
Sexual Differentiation ◽  
Genetic Factors ◽  
Sex Chromosome ◽  
Primordial Germ Cells ◽  
Adult Males ◽  
Genetic Types ◽  
Mouse Chimeras

The purpose of the present study was to trace the fate of primordial germ cells in mouse chimeras of XX/XY constitution. In this type of research one hopes to obtain knowledge of the role of intrinsic genetic factors and of environmental factors (the environment provided by the gonads) in initiating and directing the course of gametogenesis in mammals. Data obtained up to the present show that adult males with sex chromosome chimerism produce spermatozoa only from the genetically male component and that in these individuals XX germ cells are not present among primary spermatocytes in diakinesis (Mystkowska & Tarkowski, 1968). The first of these observations has recently been confirmed by Mintz (1968). Since chimeras formed of components of the same genetic sex can produce gametes of both ‘parental’ genetic types, it seems likely that, in XX/XY individuals also, primordial germ cells of both types are formed and populate the genital ridges, and that the absence of XX germ cells in adult XX/XY males is secondary rather than primary.

Genetic Influence on Risk of Divorce

1992 ◽  
Vol 3 (6) ◽  
pp. 368-373 ◽  
Author(s):  
Matt McGue ◽  
David T. Lykken
Keyword(s):  
Environmental Factors ◽  
Strong Influence ◽  
Genetic Factors ◽  
Family Background ◽  
Familial Resemblance ◽  
Male And Female ◽  
Adjustment Difficulties ◽  
Increased Risk ◽  
Genetic And Environmental Factors ◽  
Divorce Risk

Although it has long been recognized that there is increased risk of divorce among the children of divorced parents, the extent to which genetic and environmental factors contribute to this familial resemblance has been a matter of speculation only. In order to resolve the separate influence of genetic and environmental factors on risk of divorce, divorce status of 1,516 same-sex twin pairs (722 monozygotic. MZ, and 794 dizygotic. DZ), their parents, and their spouses' parents was determined. Concordance for divorce was significantly higher in MZ than DZ twins; this was true overall, in both the male and female samples, for both younger and older twin pairs, and both when the twins' parents had been divorced and when they had not been divorced. The robustness and magnitude of the MZ-DZ difference in divorce concordance indicates a strong influence of genetic factors in the etiology of divorce. Moreover, family background of both spouses contributed independently to couples' divorce risk, suggesting that, in many cases, divorce may be largely the result of characteristics the two spouses bring to the union rather than to interaction effects. These results also suggest that the adjustment difficulties seen with some children of divorced parents may be due to an interaction between genetic and environmental factors rather than environmental influences alone, as is assumed in many theories of divorce's effects.

Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)

2016 ◽  
Vol 88 (8) ◽  
pp. 713-830
Author(s):  
John H. Duffus ◽  
Michael Schwenk ◽  
Douglas M. Templeton
Keyword(s):  
Risk Assessment ◽  
Reproductive Biology ◽  
Environmental Risk ◽  
Environmental Risk Assessment ◽  
Primary Objective ◽  
Human Reproduction ◽  
Reproductive Systems ◽  
Teratogenic Effects ◽  
Male And Female ◽  
Medical Practitioners

Abstract The primary objective of this glossary is to give clear definitions for those who contribute to studies relevant to these disciplines, or who must interpret them, but are not themselves reproductive physiologists or physicians. This applies especially to chemists who need to understand the literature of reproductive and teratogenic effects of substances without recourse to a multiplicity of other glossaries or dictionaries. The glossary includes terms related to basic and clinical reproductive biology and teratogenesis, insofar as they are necessary for a self-contained document, particularly terms related to diagnosing, measuring, and understanding the effects of substances on the embryo, the fetus, and on the male and female reproductive systems. The glossary consists of about 1200 primary alphabetical entries and includes Annexes of common abbreviations and examples of chemicals with known effects on human reproduction and development. The authors hope that toxicologists, pharmacologists, medical practitioners, risk assessors, and regulatory authorities are among the groups who will find this glossary helpful, in addition to chemists. In particular, the glossary should facilitate the worldwide use of chemical terminology in relation to occupational and environmental risk assessment.

scholarly journals Reproductive Isolation and Morphogenetic Evolution in Drosophila Analyzed by Breakage of Ethological Barriers

Genetics ◽  
1997 ◽  
Vol 147 (1) ◽  
pp. 231-242 ◽  
Author(s):  
Lucas Sánchez ◽  
Pedro Santamaria
Keyword(s):  
Reproductive Isolation ◽  
Germ Cells ◽  
Morphological Analysis ◽  
Seminal Fluid ◽  
Germ Line ◽  
Regulatory Gene ◽  
Motile Sperm ◽  
Male And Female ◽  
Drosophila Yakuba

Abstract This article reports the breaking of ethological barriers through the constitution of soma-germ line chimeras between species of the melanogaster subgroup of Drosophila, which are ethologically isolated. Female Drosophila yakuba and D. teissieri germ cells in a D. melanogaster ovary produced functional oocytes that, when fertilized by D. melanogaster sperm, gave rise to sterile yakuba-melanogaster andteissieri-melanogaster male and female hybrids. However, the erecta-melanogaster and orena-melanogaster hybrids were lethal, since female D. erecta and D. orena germ cells in a D. melanogaster ovary failed to form oocytes with the capacity to develop normally. This failure appears to be caused by an altered interaction between the melanogaster soma and the erecta and orena germ lines. Germ cells of D. teissieri and D. orena in a D. melanogaster testis produced motile sperm that was not stored in D. melanogaster females. This might be due to incompatibility between the teissieri and orena sperm and the melanogaster seminal fluid. A morphological analysis of the terminalia of yakuba-melanogaster and teissieri-melanogaster hybrids was performed. The effect on the terminalia of teissieri-melanogaster hybrids of a mutation in doublesex, a regulatory gene that controls the development of the terminalia, was also investigated.

scholarly journals Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans

Leukemia ◽  
2021 ◽  
Author(s):  
Geffen Kleinstern ◽  
J. Brice Weinberg ◽  
Sameer A. Parikh ◽  
Esteban Braggio ◽  
Sara J. Achenbach ◽  
...  
Keyword(s):  
Environmental Factors ◽  
B Cell ◽  
Risk Score ◽  
Genetic Factors ◽  
Strong Predictor ◽  
Lymphocytic Leukemia ◽  
European Ancestry ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
C Statistic

AbstractMonoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry(EA). Here, we evaluate these variants, the PRS, and environmental factors for MBL risk. We also evaluate these variants and the CLL-PRS among African-American (AA) and EA-CLL cases and controls. Our study included 560 EA MBLs, 869 CLLs (696 EA/173 AA), and 2866 controls (2631 EA/235 AA). We used logistic regression, adjusting for age and sex, to estimate odds ratios (OR) and 95% confidence intervals within each race. We found significant associations with MBL risk among 21 of 41 variants and with the CLL-PRS (OR = 1.86, P = 1.9 × 10−29, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53, P = 4.0 × 10−63, c-statistic = 0.77) and AA-CLL risk (OR = 1.76, P = 5.1 × 10−5, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population.

scholarly journals Applicability of human-specific STR systems, GlobalFiler™ PCR Amplification Kit, Investigator 24plex QS Kit, and PowerPlex® Fusion 6C in chimpanzee (Pan troglodytes)

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Abhishek Singh ◽  
Vivek Sahajpal ◽  
Mukesh Thakur ◽  
Lalit Kumar Sharma ◽  
Kailash Chandra ◽  
...  
Keyword(s):  
Population Genetics ◽  
Pan Troglodytes ◽  
Human Population ◽  
Pcr Amplification ◽  
Forensic Analysis ◽  
Cross Reactivity ◽  
Allele Size ◽  
Male And Female ◽  
Successful Amplification ◽  
Human Specific

Abstract Objectives Human identification systems based on STRs are widely used in human population genetics and forensic analysis. This study aimed to validate the cross-reactivity of three widely known human-specific STR identification systems i.e. GlobalFiler™ PCR Amplification Kit, Investigator 24plex QS Kit, and PowerPlex® Fusion 6C in chimpanzee. Results The present study revealed the successful amplification of 18 loci using GlobalFiler™ PCR Amplification Kit, 18 loci using Investigator 24plex QS Kit, and 20 loci using PowerPlex® Fusion 6C system. The marker Amelogenin (AMEL) showed differential allele size between male and female revealing the gender identity of chimpanzees and thus validates their application concerning forensic examination, population estimation, and genetic analysis.

scholarly journals Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yisong Huang ◽  
Shaoyong Su ◽  
Harold Snieder ◽  
Frank Treiber ◽  
Gaston Kapuku ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Young Adulthood ◽  
Ethnic Differences ◽  
Genetic Factors ◽  
Pulse Wave ◽  
Environmental Influences ◽  
Genetic Effects ◽  
Over Time

AbstractIncreased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability might be driven by genetic factors that are expressed consistently over time. We aimed to illustrate the relative contributions of genetic and environmental factors to the stability of carotid-distal PWV from youth to young adulthood. We also examined potential ethnic differences. For this purpose, carotid-distal PWV was measured twice in 497 European American (EA) and African American (AA) twins, with an average interval time of 3 years. Twin modelling on PWV showed that heritability decreased over time (62–35%), with the nonshared environmental influences becoming larger. There was no correlation between the nonshared environmental factors on PWV measured at visit 1 and visit 2, with the phenotypic tracking correlation (r = 0.32) completely explained by shared genetic factors over time. Novel genetic influences were identified accounting for a significant part of the variance (19%) at the second measurement occasion. There was no evidence for ethnic differences. In summary, novel genetic effects appear during development into young adulthood and account for a considerable part of the variation in PWV. Environmental influences become larger with age for PWV.

scholarly journals Research on the Relationship between Shared Leadership and Individual Creativity-Qualitative Comparative Analysis on the Basis of Clear Set

2021 ◽  
Vol 13 (10) ◽  
pp. 5445
Author(s):  
Muyun Sun ◽  
Jigan Wang ◽  
Ting Wen
Keyword(s):  
Comparative Analysis ◽  
Environmental Factors ◽  
Shared Leadership ◽  
Management Practices ◽  
Qualitative Comparative Analysis ◽  
Necessary Condition ◽  
The Individual ◽  
The Impact ◽  
The Relationship ◽  
Sufficient And Necessary Condition

Creativity is the key to obtaining and maintaining competitiveness of modern organizations, and it has attracted much attention from academic circles and management practices. Shared leadership is believed to effectively influence team output. However, research on the impact of individual creativity is still in its infancy. This study adopts the qualitative comparative analysis method, taking 1584 individuals as the research objects, underpinned by a questionnaire-based survey. It investigates the influence of the team’s shared leadership network elements and organizational environmental factors on the individual creativity. We have found that there are six combination of conditions of shared leadership and organizational environmental factors constituting sufficient combination of conditions to increase or decrease individual creativity. Moreover, we have noticed that the low network density of shared leadership is a sufficient and necessary condition of reducing individual creativity. Our results also provide management suggestions for practical activities during the team management.

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