Role of proteolysis in copper homoeostasis
2002 ◽
Vol 30
(4)
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pp. 688-691
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The cop operon of Enterococcus hirae controls cytoplasmic copper levels. It encodes two copper ATPases, a repressor, and the CopZ metallo-chaperone. Transcription of these genes is induced by copper. However, at higher copper concentrations, CopZ is degraded by a copper-activated proteolytic activity. This specific proteolysis of CopZ can also be demonstrated in vitro with E. hirae extracts. Growth of the cells in copper increases the copper-inducible proteolytic activity in extracts. Zymography reveals the presence of a copper-dependent protease in crude cell lysates. Copper-stimulated proteolysis of CopZ appears to play an important role in copper homoeostasis by E. hirae.
2006 ◽
Vol 24
(18_suppl)
◽
pp. 10103-10103
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1990 ◽
Vol 45
(7-8)
◽
pp. 823-828
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1990 ◽
Vol 48
(3)
◽
pp. 826-827
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Keyword(s):
1999 ◽
Vol 81
(06)
◽
pp. 951-956
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Keyword(s):