Systems-level feedback in cell-cycle control
2010 ◽
Vol 38
(5)
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pp. 1242-1246
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Keyword(s):
Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)–CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations are always well-conserved. The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism).
Keyword(s):
2000 ◽
Vol 20
(12)
◽
pp. 4627-4634
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Keyword(s):
1999 ◽
Vol 354
(1389)
◽
pp. 1551-1557
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Keyword(s):
2021 ◽
Vol 22
(24)
◽
pp. 13423