Role of the Vnn1 pantetheinase in tissue tolerance to stress

2014 ◽  
Vol 42 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Philippe Naquet ◽  
Giuseppina Pitari ◽  
Sylvestro Duprè ◽  
Franck Galland
Keyword(s):  
Present Article ◽  
Mouse Models ◽  
Adaptive Response ◽  
Vitamin B5 ◽  
The Impact

Pantetheinase is an ubiquitous enzyme which hydrolyses D-pantetheine into cysteamine and pantothenate (vitamin B5) on the dissimilative pathway of CoA. Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans. In the present article, we review the results showing the regulation of Vnn1 expression during developmental, repair and inflammatory situations and the impact of a Vnn1 deficiency in mouse models of pathologies. We document the involvement of the Vnn1 pantetheinase in situations of increased tissue needs and propose that Vnn1 through recycling of pantothenate and release of cysteamine in tissues participates in the adaptive response of the tissue to stress.

IMMU-22. THE IMPACT OF MICROGLIA MODULATION ON GBM PROGRESSION IN SYNGENEIC MOUSE MODELS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi96-vi96
Author(s):  
Marie-Françoise Ritz ◽  
Tala Shekarian ◽  
Tomás A Martins ◽  
Philip Schmassmann ◽  
Gregor Hutter
Keyword(s):  
Mouse Models ◽  
Tumor Development ◽  
Adaptive Immune Response ◽  
Tamoxifen Treatment ◽  
Mouse Strains ◽  
Intracerebral Injection ◽  
Adaptive Immune ◽  
Tumor Immune Microenvironment ◽  
The Impact

Abstract BACKGROUND The tumor immune microenvironment (TME) of Glioblastoma consists of almost myeloid-derived macrophages and microglia called TAMs. We have shown that the disruption of CD47-Sirpα-axis induces an antitumor activity of TAMs against GBM in immune-deficient mice, through increases of phagocytosis of tumor cells by TAMs. We have aimed to study the role of microglia and its activation/depletion on GBM progression, in the syngeneic GBM model in immune-competent mice. We have studied the interplay of innate and adaptive immune response after activation and depletion of microglia and the effect on tumor progression and outcome of the mice. MATERIAL AND METHODS We used different colonies of genetically modified immunocompetent mouse strains to genetically activate/deplete microglia in the tumor context. We generated Sall1 CreERT2/fl mice and Cre-negative littermates. The application of Tamoxifen in this constellation leads to the excision of the transcription factor Sall1 and subsequent enhanced microglia activity. Conversely, we generated Sall1 CreERT2 x Csf1r fl/fl animals and the respective heterozygous and Cre-negative littermates in which Tamoxifen treatment leads to inactivation of microglia through the deletion of Csf1r. Glioblastoma tumors were induced by intracerebral injection of GL261, CT2A, or retrovirus-induced PDGF-Akt in pups and Tamoxifen treatment was started once the tumors were detected. RESULTS We observed a survival advantage in tumor-bearing mice after activation of microglia in Sall1 CreERT/fl animals compared to Cre-negative littermates. Genetic depletion of microglia in this model resulted in a shorter lifespan in microglia-depleted animals compared to Cre-negative littermates. Furthermore, the iTME in these tumors is subjected to scRNAseq analysis to identify mechanistic insights. CONCLUSION Microglia are important players in tumor development and progression of glioblastoma in mouse models. These cells may be targeted in future immunotherapeutic approaches for patients.

Functional genetic mouse models: promising tools for investigation of the proteolytic internet

2009 ◽  
Vol 390 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Achim Krüger
Keyword(s):  
Mouse Models ◽  
Knockout Mice ◽  
Gold Standard ◽  
Disease Susceptibility ◽  
Molecular Polymorphism ◽  
Specific Protease ◽  
Molecular Phenotypes ◽  
The Impact ◽  
Genetic Mouse Models

Abstract Knockout mice are the gold standard to probe for the role of a specific protease within the interacting network of proteases, substrates, and inhibitors. This proteolytic network, or protease web, determines cell signaling and organ homeostasis. Therefore, protease deficiency or inhibition is intrinsically tied to alterations within this network, always leading to new molecular phenotypes, which define susceptibility of an organ to disease. Furthermore, recent hints, mainly from research on matrix metalloproteinases, about the impact of the protease web on inter-organ signaling molecules suggest the existence of a proteolytic internet of communicating local organ- or molecular polymorphism-specific networks, thereby defining homeostasis and disease susceptibility in the whole organism.

scholarly journals Probiotics and Periodontal Disease: A Current Update

2010 ◽  
Vol 4 (Spl) ◽  
pp. 35-37
Author(s):  
Vivek Gupta ◽  
Bhavana Gupta
Keyword(s):  
Oral Health ◽  
Periodontal Disease ◽  
Present Article ◽  
Periodontal Health ◽  
Health And Disease ◽  
Systemic Health ◽  
Micro Organisms ◽  
The Impact ◽  
A Current

ABSTRACT Probiotics are live micro-organisms that when administered in adequate amounts confer health benefits upon the host. Although a lot of work has been done regarding the effects of probiotic applications on systemic health particularly gastro-intestinal, the impact of probiotics on oral health is relatively new with lots of research going on; the area of probiotics and periodontal disease is still in its infancy. The present article summarizes the role of probiotics in periodontal health and disease and its effectiveness in periodontal therapy.

scholarly journals Sociedades patogénicas y locura colectiva: una mirada crítica a la normalidad

2020 ◽  
Author(s):  
Enric Garcia Torrents
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Mental Health Care ◽  
Present Article ◽  
Health Care Services ◽  
Biomedical Model ◽  
Care Services ◽  
Socioeconomic System ◽  
The Impact

The present article addresses the need to rethink mental health care services from a social perspective, highlighting the impact of inequality and other determinants on people's suffering, while posing a critique of the role of the current biomedical model in controlling the population and maintaining a socioeconomic system that is both unhinged and unhinging.

scholarly journals Trade Unionism and Compensation Dynamics: A Research Overview

2018 ◽  
Vol 17 (2) ◽  
pp. 1-12
Author(s):  
Indranil Bose ◽  
Baisakhi Mitra Mustaphi
Keyword(s):  
Present Article ◽  
Trade Unions ◽  
Work Life ◽  
Minimum Wages ◽  
Wage Determination ◽  
Decent Work ◽  
Cost Of Living ◽  
Trade Unionism ◽  
The Impact

Over the years, government’s enacted laws and enunciated policies to provide for decent work life, guarantee minimum wages, cushion against rise in cost of living, ensure equal remuneration and deter employers from making unfair and arbitrary deductions from wages has led to a change in the impact trade unions had on wage determination. The present article discusses different aspects of trade union’s role in wage and salary administration in terms of choices and options for trade unions, unions’ impact on general wage levels, unions’ impact in terms of spill-over effect, role of trade unions in wage and salary policies and practices and so on.

The Impact of War on the Russian Liberals in 1904–5

1965 ◽  
Vol 1 (1) ◽  
pp. 85-109 ◽  
Author(s):  
S. Galai
Keyword(s):  
Present Article ◽  
Historical Writing ◽  
Detailed Treatment ◽  
The Impact

It is of course a commonplace that the defeat of Russia by Japan in the war of 1904–5 ushered in the revolutionary year of 1905. The role of the frankly revolutionary Russian illegal parties has been frequently studied, but the part played by the various groups of more or less moderate public men who are often loosely designated as ‘liberals’ in preparing the climate of revolution has received less detailed treatment in historical writing. The present article therefore proposes to examine the stages by which these groups moved to a progressively more radical position under the impact of an unpopular and unsuccessful war.

scholarly journals Spiritual and Secular Existential Meaning-Making Coping Methods among Japanese Cancer Patients

2019 ◽  
Vol 7 (6) ◽  
pp. 109
Author(s):  
Fereshteh Ahmadi ◽  
Mohammad Rabbani ◽  
Xiaohe Yi ◽  
Hiroko Kase ◽  
Nader Ahmadi
Keyword(s):  
Social Context ◽  
Cancer Patients ◽  
Present Article ◽  
Meaning Making ◽  
International Project ◽  
Sociological Perspective ◽  
Existential Meaning ◽  
Coping Methods ◽  
The Impact

The present article is written on the basis of a sociological international project on meaning-making coping. The aim of the project has been to understand the role of culture in meaning-making coping. The project embarrasses studies among cancer patients in 10 countries. The present article is confined to the results obtained in the study in japan. The main aim was to investigate the impact of culture from a sociological perspective on the choice of coping methods. Twelve participants with various kinds of cancer were interviewed.Several meaning-making coping methods are found in the present study. This study underlines the importance of investigating cultural and social context when investigating into the use of the meaning-making coping methods in different countries.

The Unkempt Heritage: On the Role of Latin in the Arabic-Islamic Sphere

Arabica ◽  
2016 ◽  
Vol 63 (5) ◽  
pp. 419-493
Author(s):  
Daniel G. König
Keyword(s):  
Twentieth Century ◽  
Present Article ◽  
Arabic Language ◽  
Latin Language ◽  
The Status ◽  
Arabic Speaking ◽  
The Impact ◽  
Exhaustive List

As linguistic systems, Latin and Arabic have interacted for centuries. The article at hand aims at analysing the status of the Latin language in the Arab and Arabic-Islamic sphere. Starting out from the observation that Latin-Christian and Arabic-Islamic scholarship dedicated a very different degree of attention to the study of the respective ‘other’ language in the course of the centuries, the article traces the impact of Latin on an emerging Arabic language in Antiquity, provides an overview on the various references to Latin found in works of Arabic-Islamic scholarship produced in the medieval and modern periods, and provides an exhaustive list of Arabic translations of Latin texts. A description of the role played by Latin in the Arabic-speaking world of our times is followed by a discussion of several hypotheses that try to explain why Latin was rarely studied systematically in the Arabic-Islamic sphere before the twentieth century. Le latin et l’arabe, en tant que systèmes linguistiques, furent en interaction pendant des siècles. Le présent article a pour objectif d’analyser le statut de la langue latine dans le monde arabe et arabo-musulman. Partant de l’observation que les érudits latins chrétiens et arabo-musulmans se consacrèrent à différents degrés à l’étude de la langue de « l’Autre », l’article retrace l’impact du latin sur une langue arabe émergeant dans l’Antiquité, donne un aperçu des références à la langue latine dans les œuvres des érudits arabo-musulmans produites aux époques médiévale et moderne, et fournit une liste exhaustive des traductions des textes latins en arabe. Après avoir esquissé le statut actuel de la langue latine dans le monde arabophone de nos jours, l’article aborde plusieurs hypothèses qui essaient d’expliquer pourquoi le latin n’a guère été un objet d’études systématiques dans le monde arabo-musulman avant le xxe siècle. This article is in English.

Task Groups: “How They Work in One Vocational Assessment Unit”

1978 ◽  
Vol 45 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Avrum Green ◽  
Leslie Gould ◽  
Mildred Mailer ◽  
Karen Otto ◽  
Rhoda Henderson
Keyword(s):  
Present Article ◽  
Group Leader ◽  
Vocational Assessment ◽  
Task Groups ◽  
Valuable Addition ◽  
Client Group ◽  
Assessment Unit ◽  
Il Y A ◽  
The Impact

The Vocational Assessment Unit at Chedoke Hospitals in Hamilton, Ontario, incorporated the use of weekly client group meetings approximately eighteen months ago. These groups proved themselves to be a valuable addition to the program. “Task Groups: How They Work in One Vocational Assessment Unit”, was co-authored by five people involved with the conception and evolution of the groups. The paper described the group, elaborated on the role of the group leader and the issues and themes which emerge in groups. Finally, it discusses the impact and influences which have been observed on the clients and the therapists. Il y a environ dix-huit mois, l'Unité d'Evaluation au Travail du Chedoke Hospital de Hamilton, a instauré des discussions de groupe hebdomadaires pour ses clients. Ces réunions se sont avérées une addition trés valable au programme thérapeutique. Le présent article a été écrit par cinq personnes impliquées dans la conception et l'évolution de ces groupes. On y décrit les groupes, le rôle du meneur et les questions et thémes abordés dans les réunions. Enfin, une discussion de l'impact et des influences observés chez les clients et les thérapeutes est présentée.

scholarly journals “Things” and Recovery From Trauma in Joukhader’s A Map of Salt and Stars

2022 ◽  
Vol 12 (1) ◽  
pp. 177-184
Author(s):  
Hayat Louati ◽  
Yousef Abu Amrieh
Keyword(s):  
Present Article ◽  
Close Association ◽  
Healing Process ◽  
Psychological Trauma ◽  
Traumatic Experiences ◽  
Thing Theory ◽  
Theoretical Frameworks ◽  
American Author ◽  
The Impact

The present article explores the impact of “Things” on the healing journeys of the characters in Syrian American author Jennifer Zeynab Joukhader’s novel A Map of Salt and Stars (2018). It highlights the role of certain “Things” in Nour’s family’s healing process from the traumatic experiences of the Syrian war. The article also sheds light on the war’s reshaping of the objects and the individuals’ relationship with them. The objects that this article investigates are as varied as mundane utensils (a shattered plate), cherished souvenirs (Zahra’s bracelet), and even magical objects (Nour’s stone). Particularly, the article examines the establishment of the close association between the characters and these objects and the impact of this association on the family’s journey towards safety and recovery. For this reason, the present study is situated within the theoretical frameworks of the “Thing” theory and psychological trauma. This article argues that the close association that the characters establish with certain “Things” accompanies them during their grief and traumatic experiences, and subsequently initiates and facilitates their recovery.

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