scholarly journals Spiritual and Secular Existential Meaning-Making Coping Methods among Japanese Cancer Patients

2019 ◽  
Vol 7 (6) ◽  
pp. 109
Author(s):  
Fereshteh Ahmadi ◽  
Mohammad Rabbani ◽  
Xiaohe Yi ◽  
Hiroko Kase ◽  
Nader Ahmadi
Keyword(s):  
Social Context ◽  
Cancer Patients ◽  
Present Article ◽  
Meaning Making ◽  
International Project ◽  
Sociological Perspective ◽  
Existential Meaning ◽  
Coping Methods ◽  
The Impact

The present article is written on the basis of a sociological international project on meaning-making coping. The aim of the project has been to understand the role of culture in meaning-making coping. The project embarrasses studies among cancer patients in 10 countries. The present article is confined to the results obtained in the study in japan. The main aim was to investigate the impact of culture from a sociological perspective on the choice of coping methods. Twelve participants with various kinds of cancer were interviewed.Several meaning-making coping methods are found in the present study. This study underlines the importance of investigating cultural and social context when investigating into the use of the meaning-making coping methods in different countries.

scholarly journals A Survey Study Among Cancer Patients in Turkey

2017 ◽  
Vol 28 (3) ◽  
pp. 234-254 ◽  
Author(s):  
Fereshteh Ahmadi ◽  
Önver A. Cetrez ◽  
Pelin Erbil ◽  
Asil Ortak ◽  
Nader Ahmadi
Keyword(s):  
Religious Coping ◽  
Cancer Patients ◽  
Meaning Making ◽  
Survey Study ◽  
Spiritual Coping ◽  
Electronic Survey ◽  
Coping Methods ◽  
Quantitative Studies ◽  
The Media

To understand the role of culture on the use of the meaning-making coping among people who have been struck by cancer, qualitative and quantitative studies have been conducted in several countries like Sweden, China, Japan, South Korea, Malaysia, Philippines, and Turkey. This article reports on a quantitative study carried out in Turkey. The aim of the study has been to answer the following question: “Which meaning-making coping method (even nonreligious or spiritual coping methods) is used by informants?” The sample consists of 95 persons, 18+ who had been struck by cancer. The questionnaire was distributed to former/current cancer patients via a web address as an electronic survey through the media page of Cancer Survivors Association. The results of the study show that the most important coping methods used by cancer patients in Turkey are the religious coping (RCOPE) methods, particularly spiritual connection, active religious surrender, passive religious deferral, and pleading for direct intercession. Several RCOPE methods such as spiritual discontent, seeking support from clergy or members, punishing God reappraisal, and demonic reappraisal or self-directing religious coping are not used by the Turkish informants. Nor are non-RCOPE methods highly prevalent among informants.

scholarly journals Molecular and Clinical Characterization of LAG3 in Breast Cancer Through 2994 Samples

2020 ◽  
Author(s):  
Qiang Liu ◽  
Yihang Qi ◽  
Jie Zhai ◽  
Xiangyi Kong ◽  
Xiangyu Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Cancer Immunotherapy ◽  
Cancer Patients ◽  
Immune Cell ◽  
Immune Checkpoints ◽  
Cell Populations ◽  
Potential Biomarker ◽  
The Impact

Abstract Background Despite the promising impact of cancer immunotherapy targeting CTLA4 and PD1/PDL1, a large number of cancer patients fail to respond. LAG3 (Lymphocyte Activating 3), also named CD233, is a protein Coding gene served as alternative inhibitory receptors to be targeted in the clinic. The impact of LAG3 on immune cell populations and co-regulation of immune response in breast cancer remained largely unknown. Methods To characterize the role of LAG3 in breast cancer, we investigated transcriptome data and associated clinical information derived from a total of 2994 breast cancer patients. Results We observed that LAG3 was closely correlated with major molecular and clinical characteristics, and was more likely to be enriched in higher malignant subtype, suggesting LAG3 was a potential biomarker of triple-negative breast cancer. Furthermore, we estimated the landscape of relationship between LAG3 and ten types of cell populations in breast cancer. Gene ontology analysis revealed LAG3 were strongly correlated with immune response and inflammatory activities. We investigated the correlation pattern between LAG3 and immune modulators in pan-cancer, especially the synergistic role of LAG3 with other immune checkpoints members in breast cancer. Conclusions LAG3 expression was closely related to malignancy of breast cancer and might serve as a potential biomarker; LAG3 might plays an important role in regulating tumor immune microenvironment, not only T cells, but also other immune cells. More importantly, LAG3 might synergize with CTLA4, PD1/ PDL1 and other immune checkpoints, thereby lending more evidences to combination cancer immunotherapy by targeting LAG3, PD1/PDL1, and CTLA4 together.

scholarly journals Self-concept of cervical cancer patients after chemotheraphy in Yogyakarta

2021 ◽  
Vol 4 (1) ◽  
pp. 37-43
Author(s):  
Nur Azizah Indriastuti ◽  
Riski Oktafia ◽  
Novika Riswanti
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Qualitative Method ◽  
Self Concept ◽  
Social Changes ◽  
The World ◽  
Chemotherapy Patients ◽  
Physical Changes ◽  
The Impact

Cervical cancer is one of the deadliest types of cancer that attacks women in the world. One of the treatment efforts for cancer is chemotherapy. Patients with cervical cancer who receive chemotherapy more than twice will experience impaired self-concept. This study aims to determine self-concept in cervical cancer patients who have undergone chemotherapy in Yogyakarta. This research uses qualitative method with phenomenology approach. Data collection is done with interview and observation. Participants totaling five people were determined by purposive sampling. The validity of the data used source triangulation and checked the data back to the participants. Analysis of data were by comparing among categories, marking and describing descriptively. The results of the study are 6 themes, namely physical changes, emotional changes, changes in sexual relations, changes in relationships with family, changes in the role of parenting and social changes in society. The impact of chemotherapy causes various changes in cervical cancer patients which make the self-concept of cervical cancer patients undergo changes

Individuality and habits in institutional economics

2019 ◽  
Vol 15 (5) ◽  
pp. 791-809
Author(s):  
Heath Spong
Keyword(s):  
Social Context ◽  
Social Environment ◽  
Institutional Economics ◽  
Individual Development ◽  
Self Concept ◽  
Structure Framework ◽  
The Social ◽  
The Impact ◽  
Over Time

AbstractIn this paper a sophisticated conception of individuality is developed that extends beyond simple heterogeneity and is consistent with the approach of institutional economics. Studies of human biological and psychological development are used to illustrate the foundations of human individuality and the impact of the social environment on individual development. The link between the social environment and ongoing agential properties is established through the role of habits, which provide some continuity to individual personalities over time and assist them in navigating the social context they inhabit. Reflexivity is established via an agency-structure framework that endows individuals a changeable self-concept and an ability to interpret their relationship to the social context. The coordination of different individuals is explained not simply through reference to institutional structure, but also through the agent-level properties of shared habits. While reducing differences between individuals to one of degrees, shared habits are shown to be particularly important in the context of agent-sensitive institutions. Finally, the potential for different institutional experiences to impact the reflexivity of individuals is explored.

HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14616-e14616
Author(s):  
Francesco Sclafani ◽  
Amitesh Chandra Roy ◽  
Ian Chau ◽  
Andrew Wotherspoon ◽  
Clare Peckitt ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Therapeutic Target ◽  
Predictive Biomarker ◽  
Secondary Endpoints ◽  
Her 2 ◽  
Low Prevalence ◽  
The Impact

e14616 Background: HER-2 is a well established therapeutic target in breast and gastric cancer. The role of HER-2 in rectal cancer is unclear, as conflicting data on prevalence of HER-2 expression have been reported. Preclinical data indicate a potential role of HER-2 in mediating resistance of rectal cancer to chemoradiotherapy and cetuximab. This analysis evaluates the prevalence of HER-2 and its impact on the outcome of high risk rectal cancer patients treated with neoadjuvant CAPOX and CRT ± cetuximab in EXPERT-C. Methods: Eligible patients with available tumour tissue for HER-2 analysis were included. HER-2 expression was determined by immunohistochemistry (IHC) in biopsy and/or surgical specimens (score 0 to 3+). Tumours with equivocal IHC result (2+) were tested for HER-2 amplification by B-DISH. Tumours with IHC 3+ or B-DISH ratio ≥2.0 were classified as HER-2 positive. The impact of HER-2 on primary (CR) and secondary endpoints (RR, PFS, OS) of the study was analyzed. Results: Of 164 eligible study patients, 104 (63%) biopsy and 114 (69%) surgical specimens were available for analysis. Only 3/104 (2.9%) and 3/114 (2.6%) were HER-2 positive, respectively. In 77 patients with paired specimens, concordance for HER-2 status was found in 74 (96%). Overall 141 patients were assessable for HER-2; 6/141 (4.3%) had a HER-2 positive tumour in at least 1 specimen. The median follow-up was 58.7 months. HER-2 expression or amplification was not associated with a difference in outcome for any of the study endpoints, including in the subset of 90 KRAS/BRAF wild type patients treated ± cetuximab. In an exploratory analysis, 44 IHC 0/1+ random specimens were tested by B-DISH and HER-2 amplification was found in 3/38 (7.9%, insufficient material in 6 cases). Conclusions: Based on the low prevalence of expression (according to the classical criteria for defining HER-2 positivity) as recorded in EXPERT-C, HER-2 does not appear to represent a useful therapeutic target for high risk rectal cancer. We did not confirm the role of HER-2 as prognostic factor or potential predictive biomarker for cetuximab-based treatment.

Role of the Vnn1 pantetheinase in tissue tolerance to stress

2014 ◽  
Vol 42 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Philippe Naquet ◽  
Giuseppina Pitari ◽  
Sylvestro Duprè ◽  
Franck Galland
Keyword(s):  
Present Article ◽  
Mouse Models ◽  
Adaptive Response ◽  
Vitamin B5 ◽  
The Impact

Pantetheinase is an ubiquitous enzyme which hydrolyses D-pantetheine into cysteamine and pantothenate (vitamin B5) on the dissimilative pathway of CoA. Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans. In the present article, we review the results showing the regulation of Vnn1 expression during developmental, repair and inflammatory situations and the impact of a Vnn1 deficiency in mouse models of pathologies. We document the involvement of the Vnn1 pantetheinase in situations of increased tissue needs and propose that Vnn1 through recycling of pantothenate and release of cysteamine in tissues participates in the adaptive response of the tissue to stress.

scholarly journals “The concentration of power, represented by current prevailing media conditions, is and ought to be open to challenge.” An interview with Peter Golding.

2017 ◽  
Vol 15 (1) ◽  
pp. 305-327
Author(s):  
Jernej Amon Prodnik ◽  
Sašo Slaček Brlek
Keyword(s):  
Political Economy ◽  
Cultural Studies ◽  
Sociological Perspective ◽  
Emeritus Professor ◽  
Critical Scholarship ◽  
The Impact

Interview with Peter Golding, Emeritus Professor at Northumbria University, Visiting Professor in the School of Arts and Cultures at Newcastle University and one of the crucial figures in Critical Political Economy of Communication. In the interview we discuss the role of critical scholarship, the sometimes troubled relationship between cultural studies and critical political economy of communication, the importance of a sociological perspective in studying media, and the impact of broader socio-political trends on academia.

scholarly journals Probiotics and Periodontal Disease: A Current Update

2010 ◽  
Vol 4 (Spl) ◽  
pp. 35-37
Author(s):  
Vivek Gupta ◽  
Bhavana Gupta
Keyword(s):  
Oral Health ◽  
Periodontal Disease ◽  
Present Article ◽  
Periodontal Health ◽  
Health And Disease ◽  
Systemic Health ◽  
Micro Organisms ◽  
The Impact ◽  
A Current

ABSTRACT Probiotics are live micro-organisms that when administered in adequate amounts confer health benefits upon the host. Although a lot of work has been done regarding the effects of probiotic applications on systemic health particularly gastro-intestinal, the impact of probiotics on oral health is relatively new with lots of research going on; the area of probiotics and periodontal disease is still in its infancy. The present article summarizes the role of probiotics in periodontal health and disease and its effectiveness in periodontal therapy.

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