Relationship of Plasma Zinc to Human Hypertension

1974 ◽  
Vol 46 (1) ◽  
pp. 137-141
Author(s):  
Gurdarshan S. Thind ◽  
Grace M. Fischer
Keyword(s):  
Inverse Correlation ◽  
Atomic Absorption Spectrophotometry ◽  
Clinical Variable ◽  
Plasma Zinc ◽  
Central Venous ◽  
Control Subjects ◽  
Arterial Blood ◽  
Zinc Levels ◽  
Parenchymal Disease ◽  
Venous Plasma

1. Plasma zinc (μg/100 ml) was determined by atomic absorption spectrophotometry in ninety renal venous, inferior vena caval or peripheral venous specimens obtained from fifteen normal control subjects and thirty hypertensive patients, none of whom had renal failure. 2. Peripheral or central venous plasma zinc levels in ten patients with essential hypertension were not significantly different from those of control subjects. There were, however, significantly lower venous plasma zinc levels found in sixteen patients with renal artery stenosis and four patients with renal parenchymal disease. 3. The only clinical variable found to have a significant inverse correlation with plasma zinc was the mean arterial blood pressure. 4. There were no significant differences in zinc concentrations between central venous and renal venous plasma specimens.

Oral contraceptives, norethindrone and mestranol: effects on tissue levels of minerals

1976 ◽  
Vol 231 (1) ◽  
pp. 98-103 ◽  
Author(s):  
KY Lei ◽  
AS Prasad ◽  
E Bowersox ◽  
D Oberleas
Keyword(s):  
Causative Factor ◽  
Atomic Absorption Spectrophotometry ◽  
Plasma Zinc ◽  
Sprague Dawley ◽  
Liver Iron ◽  
Zinc Intake ◽  
Sprague Dawley Rats ◽  
Plasma Copper ◽  
Zinc Concentrations ◽  
Zinc Levels

The study involved three levels of dietary zinc (deficient, marginal, and adequate) and four hormonal conditions; namely, no steriods, norethindrone, mestranol, and norethindrone plus mestranol. The steroids were incorporated into diets and fed to 11-wk-old female Sprague-Dawley rats. After 10 wk of treatment, various tissues were excised for mineral assays by atomic-absorption spectrophotometry. Both steroids, reduced weight gain. Mestranol depressed plasma zinc, tibia copper and magnesium, and liver iron, but elevated the zinc levels in liver and erythrocytes, plasma copper, liver magnesium and calcium, and iron content of tibia and heart. In general, the effect was most prominent with adequate zinc but diminished in magnitude with the reduction of zinc intake. In addition, norethindrone increased heart iron and tibia calcium. Mestranol appeared to be the main causative factor and may have induced a possible shift of minerals from one pool to another. As expected, zinc deficiency resulted in the reduction of zinc concentrations of plasma, tibia, kidney, and pancreas, and the elevation of copper, iron, magnesium, and calcium concentrations of various tissues.

scholarly journals Reduced Plasma Zinc Levels, Lipid Peroxidation, and Inflammation Biomarkers Levels in Hemodialysis Patients: Implications to Cardiovascular Mortality

Renal Failure ◽  
2013 ◽  
Vol 35 (5) ◽  
pp. 680-685 ◽  
Author(s):  
Julie calixto Lobo ◽  
Milena Barcza Stockler-Pinto ◽  
Najla Elias Farage ◽  
Tanize do Espirito Santo Faulin ◽  
Dulcinéia Saes Parra Abdalla ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Cardiovascular Mortality ◽  
Hemodialysis Patients ◽  
Plasma Zinc ◽  
Zinc Levels

DIFFERENCES IN ACID-BASE LEVELS AND OXYGEN-SATURATION BETWEEN CENTRAL VENOUS AND ARTERIAL BLOOD

The Lancet ◽  
1967 ◽  
Vol 290 (7519) ◽  
pp. 748-751 ◽  
Author(s):  
R.N. Sutton ◽  
R.F. Wilson ◽  
A.J. Walt
Keyword(s):  
Oxygen Saturation ◽  
Central Venous ◽  
Acid Base ◽  
Arterial Blood

scholarly journals Plasma Zinc Levels in Patients with Iron-Deficiency Anemia

2001 ◽  
Vol 47 (2) ◽  
pp. 122-123 ◽  
Author(s):  
Tansu Sipahi ◽  
Nejat Akar ◽  
Nazli Dinçer ◽  
Yonca Eğin ◽  
Şükrü Cin
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Plasma Zinc ◽  
Zinc Levels

scholarly journals Hubungan Kadar Zinc dan Pola Asuh Ibu dengan Kejadian Stunting pada Anak Usia 2 – 5 Tahun di Kecamatan Panti Kabupaten Pasaman

2019 ◽  
Vol 19 (3) ◽  
pp. 565
Author(s):  
Elsa Noftalina ◽  
Mayetti Mayetti ◽  
Afriwardi Afriwardi
Keyword(s):  
Simple Random Sampling ◽  
Atomic Absorption Spectrophotometry ◽  
Child Growth ◽  
Chi Square ◽  
Normal Children ◽  
The Past ◽  
West Sumatra ◽  
Long Time ◽  
Zinc Levels ◽  
Inadequate Nutrition

Stunting is a short body condition based on height according to age (TB / U) whose standard deviation is less than -2 and -3 from the z-score calculation of the WHO child growth standard table. Stunting is an irreversible growth disorder due to inadequate nutrition and recurring infections during the first 1000 days of life. Indicators of chronic malnutrition that occur in a long time so that stunting in children under five, especially at the age of 2-5 years stunting will be clearly visible and is one indicator of chronic nutritional status that can provide an overall picture of the disorder in the past. The causes of stunting are lack of nutrition, infectious diseases, poor parenting, poor environmental sanitation and low health services. Zinc deficiency can cause impaired growth and decreased immunity. One of the biomarkers used is the analysis of hair zinc levels because it can describe chronic zinc levels in the past so it is appropriate to measure zinc levels in the stunting condition which is a long-standing condition of malnutrition. The croos sectional research design was carried out in the Panti District of Pasaman Regency and the West Sumatra Regional Health Laboratory in June to July 2019. The study sample were mothers and children aged 2-5 years as many as 60 people divided into two groups which are stunting and normal children, taken by proportional stratified simple random sampling. Zinc levels were measured by atomic absorption spectrophotometry (AAS) while parenting used questionnaires. Statistical test using Mann Whitney test and Chi Square. The results showed the mean zinc levels in stunting children 154.70 (9-387) µg / g and zinc levels in normal children 241.00 (60-933) µg / g with p = 0.018. parental feeding (p = 0.009), hygiene parenting (p = 0.034). health care parenting (p = 0.017), psychosocial stimulation parenting care (0,000). The conclusion of this study is that there is a significant association between zinc levels and parenting with the incidence of stunting.

scholarly journals Desensitization of Adrenaline-Induced Red Blood Cell H+ Extrusion in Vitro After Chronic Exposure of Rainbow Trout to Moderate Environmental Hypoxia

1991 ◽  
Vol 156 (1) ◽  
pp. 233-248 ◽  
Author(s):  
S. THOMAS ◽  
R. KINKEAD ◽  
P. J. WALSH ◽  
C. M. WOOD ◽  
S. F. PERRY
Keyword(s):  
Rainbow Trout ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Whole Blood ◽  
Inverse Correlation ◽  
Adrenergic Stimulation ◽  
Plasma Adrenaline ◽  
Arterial Blood Gas ◽  
Arterial Blood

The sensitivity of red blood cell Na+/H+ exchange to exogenous adrenaline was assessed in vitro using blood withdrawn from catheterized rainbow trout (Oncorhynchus mykiss) maintained under normoxic conditions [water PO2, (PwO2)=20.66 kPa] or after exposure to moderate hypoxia (PwO2=6.67-9.33 kPa) for 48 h, which chronically elevated plasma adrenaline, but not noradrenaline, levels. Peak changes in whole-blood extracellular pH over a 30 min period after adding 50–1000 nmoll−1 adrenaline were employed as an index of sensitivity; the blood was pre-equilibrated to simulate arterial blood gas tensions in severely hypoxic fish (PaO2=2.0 kPa, PaCO2=0.31 kPa). Blood pooled from normoxic fish displayed a dose-dependent reduction in whole-blood pH after addition of adrenaline. Blood pooled from three separate groups of hypoxic fish, however, displayed diminished sensitivity to adrenaline, ranging from complete desensitization to a 60%reduction of the response. Subsequent experiments performed on blood from individual (i.e. not pooled) normoxic or hypoxic fish demonstrated an inverse correlation between the intensity of H+ extrusion (induced by exogenous adrenaline addition) and endogenous plasma adrenaline levels at the time of blood withdrawal. However, acute increases in plasma adrenaline levels in vitro did not affect the responsiveness of the red blood cell to subsequent adrenergic stimulation. The intensity of H+ extrusion was inversely related to the PaO2in vivo between 2.67 and 10.66 kPa, and directly related to the logarithm of the endogenous plasma adrenaline level. The results suggest that desensitization of Na+/H+ exchange in chronically hypoxic fish is related to persistent elevation of levels of this catecholamine. This desensitization can be reversed in vitro as a function of time, but only when blood is maintained under sufficiently aerobic conditions.

scholarly journals Plasma zinc levels in normal and malnourished children with lower respiratory tract infection from 2 months to 5 years of age

2019 ◽  
Vol 6 (3) ◽  
pp. 1285
Author(s):  
Dinesk Kumar E. ◽  
Thumjaa Annamalai ◽  
Shafath Ahmed M. ◽  
Sundari S.
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Zinc Level ◽  
Plasma Zinc ◽  
Malnourished Children ◽  
Zinc Levels ◽  
Age And Sex

Background: Acute Lower Respiratory Tract Infection (ALRI) is an important cause of morbidity and mortality in the developing world. Pneumonia is a severe form of ALRI that cause over 2 million deaths annually among children younger than 5 years of age. About 19% of all deaths, pneumonia is the leading cause of child mortality. Malnutrition is known to be associated with greater intensity of lower respiratory tract infections, higher the frequency of complications, longer episodes of infections. This study is to assess the plasma zinc levels in normal and malnourished children with LRI aged 2 months to 5 years.Methods: This is a case control study, which was carried out in the Department of Paediatrics, Sree Balaji Medical College and Hospital, the study period is one year from July 2016 to July 2017. 100 children between 2 months to 5 years of age with LRI was included in the study and children less than 2 months and more than 5 years. 50 Children with normal nutrition were taken as controls and 50 children with moderate and severe malnutrition were taken as cases. Age and sex were matched among cases and controls. Blood samples were collected for zinc estimation in both the cases and controls. All children were investigated and treated as per the department protocol for the particular condition. All statistical procedures were performed using SPSS v 21.0.Results: In present study, 66% of children had normal zinc levels, 34% of children had low zinc levels. The mean zinc level in our cases was 54.84±18.31 and in controls was 76.84±15.2, which was statistically significant (p = 0.000). Mean plasma zinc levels with respect to age and sex were not significant.Conclusions: Total 34% of children with LRI had low plasma zinc levels. Plasma zinc level were significantly low in malnourished children than normally nourished children with LRI, which is one of the most important cause of high childhood mortality in developing countries.

scholarly journals Role and effects of zinc supplementation in HIV-infected patients with immunovirological discordance: A randomized, double blind, case control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244823
Author(s):  
Macarena Silva ◽  
Carmen G. Montes ◽  
Andrea Canals ◽  
Maria J. Mackenna ◽  
Marcelo Wolff
Keyword(s):  
Zinc Supplementation ◽  
Group Versus ◽  
Cd4 Count ◽  
Control Group ◽  
Immune Recovery ◽  
Plasma Zinc ◽  
Absolute Increase ◽  
Number Of Patients ◽  
Significant Difference ◽  
Zinc Levels

Introduction It has been estimated that between 15% and 18% of patients who start antiretroviral therapy (ART) do not achieve a successful immune recovery despite complete virological suppression. In the literature this phenomenom is known as poor immune recovery or immunovirological discordance (IVD). Zinc has an immunomodulatory role associated with T lymphocytes and its supplementation could enhance immune recovery. Objective To determine if zinc supplementation on IVD patients prevents immune failure after 12 months of supplementation. Secondary objectives were to determine serum zinc levels in HIV patients with and without IVD and the frequency of hypozincemia in discordant patients. Method We reviewed the historical record of patients under care at Arriarán Foundation. Following inclusion criteria were defined: 1) age ≥ 18 years, 2) standard ART (three effective drugs) for at least 18 months, 3) virologically suppressed for 12 months, 3) persistence of CD4 count ≤200 cells/mm3 and/or increase ≤ 80 cells/mm3 after one year of viral undetectability. A control group was assigned paired 1:1 by sex, age (± 2 years) that did achieved an increase of CD4> 350 cells/ mm3. In both groups plasma zinc levels were determined. In a later phase, patients with IVD were randomized to receive zinc (15 mg daily) versus placebo. Patients were followed for 12 months with CD4 count, viral load and zinc levels determinations every 4–6 months. Results A total of 80 patients, 40 patients with IVD criteria and 40 controls were included. 92.5% were men, and age average was 47.5 years. The median baseline CD4 was 189 cells/mm3 (71–258) in the cases vs. 552.5 cells/ mm3 (317–400) in the control group with a median increase at the end of the study of 39 cell/mm3 and 19 cell/mm3 respectively. There was no difference in baseline plasma zinc levels between both groups (81.7 + 18.1 in cases versus 86.2 + 11.0 in controls). In the 40 patients with IVD, the median absolute increase in CD4 after annual zinc supplementation was 31.5 cells/mm3 in the treated group versus 50 cells/mm3 in the placebo group, this difference being statistically not significant (p = 0.382). Conclusions Patients with IVD have plasma zinc levels similar to those who achieve adequate immune recovery. Zinc supplementation in IVD patients showed a statistically non-significant difference in in CD4 levels between cases and controls. The results warrant a comparative study with a larger number of patients.

scholarly journals Evidence for abnormal deformational reserve in hypertrophic obstructive cardiomyopathy on exercise: is this a true fingerprint?

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Halmai ◽  
M Ward ◽  
A Kardos ◽  
A Nemes ◽  
S Neubauer ◽  
...  
Keyword(s):  
Valsalva Maneuver ◽  
Coupling Efficiency ◽  
Inverse Correlation ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
University Hospital ◽  
Funding Source ◽  
Peak Strain ◽  
Additional Information ◽  
Control Subjects ◽  
Twist Ratio

Abstract   Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by muscle hypertrophy and fibrosis, interfering with force generation and relaxation. Abnormal ventricular (LV) myocardial deformation have been demonstrated in patients with HOCM at rest, but there is lack of data regarding the deformational mechanics in exercise in obstructive HCM. Aims To assess the adaptability of LV deformational behaviour to physical exercise in HOCM patients as compared to healthy controls and to examine if Deformational Imaging (DMI) can provide additional information. Methods 28 obstructive HOCM (age 51.2±14.2yrs; 16 men, LVOT-obstruction 56±19mmHg at rest or on Valsalva maneuver) and 32 control subjects (50.9±6.8 yrs, 19 men from the MAGYAR-PATH Registry) underwent bicycle stress Echo (ESE) with full conventional 2D- and Doppler TTE, 2D- and 3D-Speckle Tracking Analysis (DMI) and 3D-Full Volume assessment both at rest and on submaximal ESE. Results At rest, the HOCM group had lower GLS (−14.6±4.5 vs 18.4±2.6%, p<0.01) but higher CS (−32.9±5.1 vs 28.8±2.3%) and Twist (9.9±2.6 vs 6.1±2.2°) than in control subjects. Exercise induced an increase in all strains in control subjects but less in HOCM (GLS: −21.4±3.5 vs 15.1±3.0% and CS: −33.9±3.6 vs 34.1±4.2% in controls). The increase of LV twist was blunted in HOCM (Δ1.2 vs Δ3.6° in controls). The PSS was more pronounced in HOCM on ESE (46.6±12.0 vs 21.2±9.6%, AUC: 0.71 for predicting HOCM), the UTR was slower (118±2.1 vs 133.1±14.1°/s) and occurred later in HOCM. The MD of Strain increased in HOCM on ESE (Δ85.1 vs Δ8.1ms in controls). The Twist had positive correlation with LVOT-obstruction (R2=0.54, p<0.01) and inverse correlation with UTR (R2=−0.72, p<0.02). The UTR/Twist ratio diminished only in HOCM on exercise (−6.0±0.8 vs −13.1±2.5 1/s). The MD, the PSS on ESE and the UTR/Twist ratio predicted the HOCM deformation phenotype accurately (AUC: 0.72, cut-off 6.0 1/s). Conclusions The HOCM patients had attenuated Strain and Rotational response on exercise implying impaired deformational adaptability with post-systolic shortening and pronounced mechanical dispersion of peak Strain on exercise which was more accurate to identify the HOCM phenotype than other Echo-indices. These findings support evidence for reduced systolic-diastolic coupling efficiency in HOCM patients on exercise which can contribute to the development of exercise-related breathlessness, dynamic LVOT-obstruction and arrhythmias in patients with HOCM. These distinct deformational patterns on exercise can help in the differential diagnosis of patients with LV hypertrophy of unknown aetiology with good sensitivity and specificity and can also aid in the risk stratification workup in HOCM. DMI Predictors for HOCM Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): Milton Keynes University Hospital Research Founding

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