Alcohol: Effect on Blood Pressure and Predisposition to Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 373s-375s ◽  
Author(s):  
P. D. Arkwright ◽  
L. J. Beilin ◽  
I. Rouse ◽  
B. K. Armstrong ◽  
R. Vandongen

1. The association between alcohol consumption and blood pressure was studied in 491 Government employees. The men, aged 21–45 years, volunteered to complete a health questionnaire and submitted to standardized measurements of blood pressure, heart rate and body size. 2. Average weekly alcohol consumption correlated with systolic pressure (r = 0.18, P < 0.001) but not with diastolic pressure. Systolic pressure increased progressively with increasing alcohol consumption with no obvious threshold effect. The effect of alcohol was independent of age, obesity (Quetelet's index) or cigarette smoking. 3. Results indicate that alcohol ranks close to obesity as a preventable cause of essential hypertension in the community.

1999 ◽  
Vol 90 (3) ◽  
pp. 681-692 ◽  
Author(s):  
Joel L. Parlow ◽  
Gerard Begou ◽  
Pierre Sagnard ◽  
Jean Marie Cottet-Emard ◽  
Jean Claude Levron ◽  
...  

Background Patients with essential hypertension show altered baroreflex control of heart rate, and during the perioperative period they demonstrate increased circulatory instability. Clonidine has been shown to reduce perioperative circulatory instability. This study documents changes in measures of heart rate control after surgery in patients with essential hypertension and determines the effects of clonidine on postoperative heart rate control in these patients. Methods Using a randomized double-blind placebo-controlled design, 20 patients with essential hypertension (systolic pressure >160 mm Hg or diastolic pressure >95 mm Hg for > or =1 yr) were assigned to receive clonidine (or placebo), 6 microg/kg orally 120 min before anesthesia and 3 microg/kg intravenously over 60 min before the end of surgery. The spontaneous baroreflex ("sequence") technique and analysis of heart rate variability were used to quantify control of heart rate at baseline, before induction of anesthesia, and 1 and 3 h postoperatively. Results Baroreflex slope and heart rate variability were reduced postoperatively in patients given placebo but not those given clonidine. Clonidine resulted in greater postoperative baroreflex slope and power at all frequency ranges compared with placebo (4.9+/-2.9 vs. 2.2+/-2.1 ms/mm Hg for baroreflex slope, 354+/-685 vs. 30+/-37 ms2/Hz for high frequency variability). Clonidine also resulted in lower concentrations of catecholamine, decreased mean heart rate and blood pressure, and decreased perioperative tachycardia and hypertension. Conclusions Patients with hypertension exhibit reduced heart rate control during the recovery period after elective surgery. Clonidine prevents this reduction in heart rate control. This may represent a basis for the improved circulatory stability seen with perioperative administration of clonidine.


1990 ◽  
Vol 2 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Karen L. Nau ◽  
Victor L. Katch ◽  
Robert H. Beekman ◽  
Macdonald Dick

Intraarterial blood pressure (BP) response to bench press weight lifting (WL) was evaluated in 11 children. Aortic systolic and diastolic pressures and heart rate (HR) were measured during WL. Baseline systolic and diastolic pressures were 120 and 81 mmHg, and HR was 86 bpm. Subjects lifted to voluntary fatigue weights equaling 60, 75, 90, and 100% of their predetermined one-repetition maximum (1RM). For each weight lifting condition, BP and HR increased as more repetitions were completed. Peak systolic pressure was 168, 177, 166, and 162 mmHg, peak diastolic pressure was 125, 139, 133, and 130 mmHg, and peak heart rate was 142, 148, 142, and 139 bpm at 60, 75, 90, and 100% 1RM, respectively. Peak BP and HR were greater during WL than rest but did not differ between conditions. The relative BP response to WL in children was similar to adult values. For all conditions, pressures increased as more repetitions were completed. It was concluded that peak pressures occur at voluntary fatigue, independent of the combination of resistance and repetitions used to achieve fatigue.


2022 ◽  
Vol 28 (1) ◽  
pp. 27-30
Author(s):  
Keyin Liu

ABSTRACT Introduction: Basketball can enhance the physical fitness of young people, promote the growth and development of their bodies, and improve health and athletic ability. Objective: To explore the characteristics of basketball players’ cardiac response to increasing load training. Methods: By analyzing 12 juvenile male amateur basketball training athletes, when performing incremental load exercises on the treadmill, using a 12-lead electrocardiograph to record the electrocardiogram, HR, and blood pressure responses for each level of exercise. Results: The mean heart rate of the basketball players before movement was 82.45± 11.44 bpm, slightly higher than the heart rate at rest. Depending on the exercise load, the blood pressure should increase by 5 to 12 mmHg. Under different load training conditions, each level of blood pressure in the Bruce treadmill test procedure should increase 12.5 ~ 44mmHg. The basketball player’s systolic pressure increased by 2.25 ~ 15.7mmHg, diastolic pressure increased by 0.43 to 11.37 mmHg. Conclusions: In basketball players, the psychological stress is less than that of the average person performing the same exercise. The strong ability to adapt to exercise under incremental load training, the contractility of the ventricular muscles and the development of the heart are good. Level of evidence II; Therapeutic studies - investigation of treatment results.


1957 ◽  
Vol 188 (2) ◽  
pp. 383-386 ◽  
Author(s):  
Harold S. Weiss ◽  
Robert K. Ringer ◽  
Paul D. Sturkie

In order to establish the age and manner in which the sex difference in blood pressure of the adult white leghorn chicken develops, periodical blood pressure measurements were made on chicks between 3 and 34 weeks of age. There were no consistent differences in pressure between the sexes under 8 weeks of age. Between the 8th and 13th weeks, pressures began to diverge, and within 4–8 weeks a 26–30-mm sex difference in systolic pressure developed. Significant divergences occurred also in diastolic and pulse pressure. The sex divergence was due primarily to a rise in male pressure, the female level remaining comparatively stable. Net changes in male parameters during the period of rapid development of the sex difference in pressure were: body weight + 219 gm, systolic pressure + 26 mm, diastolic pressure + 16 mm and heart rate –22/ min. The age at which the sex difference in pressure begins and its rate of development appear to be related to sexual maturation in the male. However, no significant correlation between the rising male pressure and testes or comb size could be shown. Normal chick blood pressure values prior to the sex divergence differ within strains of white leghorns and for the two groups used here, between 7 and 9 weeks of age, were 150/130 and 162/136 mm Hg.


1987 ◽  
Vol 63 (1) ◽  
pp. 270-276 ◽  
Author(s):  
J. M. Hagberg ◽  
S. J. Montain ◽  
W. H. Martin

Recently, systolic and diastolic blood pressure have been reported to be significantly lower for several hours after exercise than when measured at rest before exercise in individuals with essential hypertension. We sought to determine the hemodynamic mechanism underlying this reduction in blood pressure. Twenty-four men and women 60–69 yr of age with persistent essential hypertension completed one of the following protocols: exercise at 50% of maximum O2 consumption (VO2 max) followed by 1 h of recovery, exercise at 70% of VO2 max followed by 3 h of recovery, or a 4-h control study. Systolic pressure was significantly lower during recovery after both intensities of exercise, but diastolic pressure was unchanged. The lower blood pressure was primarily due to a reduction in cardiac output, since total peripheral resistance was increased throughout both recovery periods. Cardiac output was reduced in recovery because of a reduction in stroke volume. Heart rate was above, or no different from, that at rest before exercise. Changes in plasma volume could not entirely account for the reduction in stroke volume. Therefore, other mechanisms altering venous return and/or myocardial contractility appear to be responsible for the reduction in systolic blood pressure evident after a single bout of submaximal exercise in individuals with essential hypertension.


1977 ◽  
Vol 5 (4) ◽  
pp. 236-242 ◽  
Author(s):  
V H Yajnik ◽  
J S Nandi ◽  
S C Patel ◽  
H V Doshi ◽  
S H Patel

A pilot single-blind placebo controlled crossover within-patient study was undertaken in essential hypertension. In ten patients single daily doses of 25 mg and 50 mg and in two patients 25 mg, 50 mg and 100 mg were used. Satisfactory reductions in both systolic and diastolic blood pressure in the supine and erect postures were observed. Reduction in heart rate was of the order of 6·32%, there being no correlation between reductions in blood pressure and decrements in heart rate. Three patients were dropped from the final analyses. Seventy-eight per cent (7/9) of patients had a final diastolic pressure (lying) of 90 mm Hg or less. Single doses of penbutolol controlled blood pressure for at least twenty-four hours. At the end of two weeks on placebo medication, following nine weeks of active drug medication, blood pressure had reverted to near pre-treatment levels. Penbutolol was well tolerated.


2015 ◽  
Vol 7 ◽  
pp. OED.S20960 ◽  
Author(s):  
Kyriakoula Merakou ◽  
Georgia Varouxi ◽  
Anastasia Barbouni ◽  
Eleni Antoniadou ◽  
Georgios Karageorgos ◽  
...  

Introduction Music has been proposed as a safe, inexpensive, nonpharmacological antistress intervention. The purpose of this study was to determine whether patients undergoing cataract surgery while listening to meditation music experience lower levels of blood pressure and heart rate. Methods Two hundred individuals undergoing cataract surgery participated in the study. Hundred individuals listened to meditation music, through headphones, before and during the operation (intervention group) and 100 individuals received standard care (control group). Patients stress coping skills were measured by the Sense of Coherence Scale (SOC Scale). Systolic and diastolic blood pressure and heart rate were defined as outcome measures. Results According to the SOC Scale, both groups had similar stress coping skills (mean score: 127.6 for the intervention group and 127.3 for the control group). Before entering the operating room (OR) as well as during surgery the rise in systolic and diastolic pressures was significantly lower in the intervention group ( P < 0.001). Among patients receiving antihypertensive therapy, those in the intervention group presented a lower increase only in systolic pressure ( P < 0.001) at both time recordings. For those patients in the intervention group who did not receive antihypertensive treatment, lower systolic blood pressure at both time recordings was recorded ( P < 0.001) while lower diastolic pressure was observed only during entry to the OR ( P = 0.021). Heart rate was not altered between the two groups in any of the recordings. Conclusions Meditation music influenced patients' preoperative stress with regard to systolic blood pressure. This kind of music can be used as an alternative or complementary method for blood pressure stabilizing in patients undergoing cataract surgery.


2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Mary Gheller ◽  
Erica Bender ◽  
Anna Thalacker-Mercer

Abstract Objectives Histidine is an essential amino acid found in the diet through protein-rich foods. Previous research demonstrated benefits of histidine due to anti-inflammatory, anti-oxidant, and glucoregulatory properties. To date, histidine requirement for adults has not be established; current expert opinion for histidine is 8 and 12 mg/(kg body weight × day), an estimate that was extrapolated from the infant requirement for histidine. Further, the clinical safety of histidine supplementation above the average dietary intake has not been determined. Objective: To determine the safety of graded-doses of histidine in a healthy adult population. Methods Our preliminary study includes 30 adults (n = 12 males and n = 18 females, aged 21–50 y). Following the completion and review of a health history questionnaire, vitals, and a biochemical panel, participants were deemed healthy and able to participate. After baseline measures were obtained, participants consumed encapsulated histidine pills daily for four weeks followed by a three-week washout period between each dose. Participants consumed one of three doses (4 g, 8 g, and 12 g) of histidine during each of the four-week supplement periods. A complete biochemical panel was run at baseline, week 2 and 4 of supplement, as well as washout. Anthropometric, body composition, sleep patterns, dietary intake, and urine samples were also collected throughout the study (analyses underway). Results Baseline descriptive statistics are as follows for females [males]: body weight 65 ± 0.55 kg [62.91 ± 3.17 kg], systolic pressure 113 ± .54 mmHg [125 ± 2.93 mmHg], diastolic pressure 70 ±.48 mmHg [74 ± 3.22 mmHg], and heart rate 74 ± 0.56 bpm [63 ±3.17 bpm]. There were no observed differences between baseline and measurements taken at any of the three doses for body weight, systolic blood pressure, diastolic blood pressure, and heart rate. There was no effect of histidine dose on the biochemical measures of aspartarte amino transferase (U/L, P = 0.096), alanine amino transferase (U/L, P = 0.47), creatinine (mg/dL, P = 0.79), glucose (mg/dL, P = 0.06), insulin (μIU/ml, P = 0.48), or c-reactive protein (mg/L, P = 0.19). Conclusions In our current analyses, we observe no deleterious effects of taking up to 12 grams of histidine in healthy young adults. Funding Sources International Council on Amino Acid Science.


1982 ◽  
Vol 63 (s8) ◽  
pp. 455s-458s ◽  
Author(s):  
Bonita Falkner ◽  
Gaddo Onesti ◽  
Melton B. Affrime ◽  
David T. Lowenthal

1. The effects of clonidine and hydrochlorothiazide on the cardiovascular responses to mental stess were compared in 29 adolescents with essential hypertension. 2. Clonidine therapy was associated with lower diastolic pressures, heart rate and noradrenaline in response to mental stress. By contrast, hydrochlorothiazide resulted in the reduction of systolic pressure only. The mental stress testing produced a greater absolute diastolic pressure response and higher plasma noradrenaline on hydrochlorothiazide therapy. 3. Juveniles with essential hypertension may be more sensitive to central control of blood pressure and more resistant to diuretics. 4. The reduced diastolic pressure and heart rate response to central stimuli during clonidine therapy may be related to decreased adrenergic activity, as indicated by lower plasma noradrenaline.


2019 ◽  
Vol 27 (4) ◽  
pp. 219
Author(s):  
Leonando Pedro Pereira Da Costa ◽  
Gabriela Dos santos ◽  
Patrícia Haas ◽  
Renato Claudino ◽  
Ana Inês Gonzáles

Objetivo: levantar na literatura atual, estudos relevantes que identifiquem as possíveis respostas hemodinâmicas encontradas em indivíduos hipertensos praticantes do Método Pilates. Materiais e Métodos: Pesquisa de revisão sistemática conduzida conforme as recomendações PRISMA em cinco bases de dados eletrônicas (PEDro, PubMed, SciELO, LILACS e Cochrane), disponibilizado desde o início das bases até Março de 2019, com descritores do dicionário MESH conforme segue: [(“Adult” OR “Young adult” OR “Middle Aged” OR “Aged” OR “Elderly”) AND (“exercise movement techniques” OR “Pilates-Based Exercises” OR “Pilates Training”) AND (“Hemodynamics” OR “Heart Rate” OR “Cardiac Chronotropy” OR “Heart Rate Control” OR “hypertension” OR “Blood Pressure” OR “High Blood Pressure” OR “Systolic Pressure” OR “Diastolic Pressure” OR “High Blood Pressure” OR “Pulse Rate Determination”)], posteriormente ajustado para as demais bases. Busca complementar manual nas referências dos artigos incluídos na pesquisa e no Google Scholar. Foram incluídos estudos de intervenção, com indivíduos de idade maior ou igual a 18 anos; diagnóstico de hipertensão arterial sistêmica (HAS); que tenham sido submetidos a exercícios de pilates solo e/ou pilates aparelhos como método de intervenção e incluído a descrição de análise das variáveis hemodinâmicas de pressão arterial (PA), frequência cardíaca (FC) e duplo produto (DP). Resultados: Após processo de seleção foi selecionado apenas um único estudo que tenha contemplado todos os critérios de elegibilidade, totalizando 44 indivíduos do sexo feminino, com média de idade de 50,5 anos (±6,3 anos), hipertensas com utilização de medicação, onde 22 foram submetidas ao pilates solo e 22 permaneceram no grupo controle. O estudo apresentou resultados positivos na frequência cardíaca (FC), pressão arterial (PA) e no duplo-produto (DP) em comparação ao grupo controle. Conclusão: O Mat pilates pode ser um método aplicável e hemodinamicamente em pacientes com HAS, entretanto, novos estudos devem ser realizados para a confirmação dos achados.


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