Diabetes mellitus: a primary metabolic disturbance. Metabolomics underlying vascular responses to stress and ischemia?

2021 ◽  
Vol 135 (3) ◽  
pp. 589-591
Author(s):  
Evangelos Oikonomou ◽  
Costas Tsioufis ◽  
Dimitris Tousoulis
Keyword(s):  
Diabetes Mellitus ◽  
Steady State ◽  
Metabolic Disorder ◽  
Point Of View ◽  
Metabolomic Profile ◽  
Vascular Responses ◽  
Energy Substrate ◽  
The Impact ◽  
Shed Light ◽  
Branchial Artery

Abstract Diabetes mellitus (DM) is a primary metabolic disorder and the impact of this entity on maladaptive tissue and organ responses may be mediated through alter metabolomic profile and signatures at steady state or at stress. To this point of view Beckman et al. (Clin. Sci. (Lond.) (2020) 134, 2369–2379), in a hypothesis-generated study, investigated how metabolomic profile is affected following branchial artery ischemia. Interestingly, they found that there is a dynamic and altered change of metabolites associated with energy substrate and with glycolysis/glyconeogenesis in patients with DM. This evidence may shed light on the impaired muscle tolerance in subjects with DM and on impaired vasoreactivity. However, these data lack the ability to be conclusive and further steps should be explored to understand how metabolomic profile is implicated in the response of muscle tissue to ischemia and to the clinical profile of subjects with DM.

scholarly journals Lyα forest power spectrum as an emerging window into the epoch of reionization and cosmic dawn

2020 ◽  
Author(s):  
Paulo Montero-Camacho ◽  
Yi Mao
Keyword(s):  
Power Spectrum ◽  
Hybrid Method ◽  
Point Of View ◽  
Conventional Wisdom ◽  
Cosmological Application ◽  
The Impact ◽  
Shed Light ◽  
Simulation Codes

Abstract Conventional wisdom was that thermal relics from the epoch of reionization (EOR) would vanish swiftly. Recently, however, it was shown that these relics can survive to lower redshifts (z ∼ 2) than previously thought, due to gas at mean density being heated to T ∼ 3 × 104 K by reionization, which is inhomogeneous, and shocks. Given the high sensitivities of upcoming Lyα forest surveys, this effect will be a novel broadband systematic for cosmological application. From the astrophysical point of view, however, the imprint of inhomogeneous reionization can shed light on the EOR and cosmic dawn. We utilize a hybrid method — which includes two different simulation codes capable of handling the huge dynamical range — to show the impact of patchy reionization on the Lyα forest and its dependence on different astrophysical scenarios. We found statistically significant deviations in the 1D Lyα power spectrum at k = 0.14 cMpc−1 that range from $\sim 1\%$ at z = 2 up to almost $\sim 20\%$ at z = 4. The deviations in the 3D Lyα power spectrum, at the same wavenumber, are large and range from a few per cent at z = 2 up to $\sim 50\%$ at z = 4, although these deviations ignore the effect of He ii reionization and AGN feedback at z < 4. By exploiting different k-dependence of power spectrum among various astrophysical scenarios, the effect of patchy reionization on the Lyα forest power spectrum can open a new window into cosmic reionization and possibly cosmic dawn.

The impact of Turkish on the English language – An overview of borrowing in the manifold lexical domains influenced by Turkish over the centuries

2021 ◽  
Vol 17 ◽  
pp. 79-92
Author(s):  
Julia Landmann
Keyword(s):  
Everyday Life ◽  
Present Article ◽  
English Language ◽  
Natural Sciences ◽  
Point Of View ◽  
Oxford English Dictionary ◽  
Close Analysis ◽  
Subject Areas ◽  
The Impact ◽  
Shed Light

The present article sets out to shed light on the Turkish influence on the English vocabulary over the centuries. The results provided by this study rely on a close analysis of a comprehensive lexicographical sample of Turkish borrowings listed in the Oxford English Dictionary Online. This study will provide an overview of the diversity of subject areas and spheres of life influenced by Turkish down the ages, which has as yet been considered little in existing investigations. On the basis of their meanings, the various Turkish-derived items have been grouped into several different semantic domains, ranging from the natural sciences, gastronomy, people and everyday life to faith and religion. A number of typical examples of borrowings will be given, in order to illustrate the impact of Turkish on the English lexicon from a historical point of view.

scholarly journals STEADY-STATE PHARMACOKINETICS OF METFORMIN IN OBESE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A PRELIMINARY STUDY

2016 ◽  
Vol 10 (1) ◽  
pp. 294
Author(s):  
Vitarani Dwi Ananda Ningrum ◽  
Zullies Ikawati ◽  
Ahmad Hamim Sadewa ◽  
M. Robikhul Ikhsan ◽  
S. Saepudin
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Steady State ◽  
High Performance ◽  
Peak Level ◽  
Reversed Phase ◽  
Chromatography Method ◽  
The Impact

ABSTRACTObjective: This study aimed to determine the metformin plasma steady-state concentration (PSSC) either trough and peak level in Type 2 diabetesmellitus patients with obesity and the impact of SLC22A1 gene organic cation transporter 1 (OCT) rs628031 A>G on PSSC of metformin.Methods: Validated reversed-phase high-performance liquid chromatography method with ultraviolet detector was used to determine the metforminPSSC, as well as genotype variation was performed using the restriction fragment length polymorphisms-polymerase chain reaction method.Results: A total of 13 patients were recruited from five Primary Health Centers in Yogyakarta Province of Indonesia. The results showed that themeans of their trough and peak PSSC were 0.285±0.192 and 1.175±0.814 µg/ml, respectively. Only 10 patients (77%) had peak PSSC within theplasma therapeutic level (PTL) of metformin, and 14-fold variability was observed for the peak PSSC. None of the patients achieved the PTL ofmetformin with regard to their trough PSSC. The PSSC of metformin was independent of the OCT1 genotype in rs628031 (A>G) 408M/V SLC22A1.Conclusion: This study found a huge variability in the trough concentration of metformin (>100-fold) and 14-fold for the peak PSSC, and no impactof a variant of rs628013 SLC22A1 OCT1 on metformin PSSC was revealed.Keywords: Metformin, Steady-state pharmacokinetics, Obesity, Type 2 diabetes mellitus.

The Geosciences Applied to Lunar Exploration

1962 ◽  
Vol 14 ◽  
pp. 169-257 ◽  
Author(s):  
J. Green
Keyword(s):  
Lunar Surface ◽  
Probable Mechanism ◽  
Point Of View ◽  
Lunar Exploration ◽  
Geological Model ◽  
Apply Geophysics ◽  
Surface Features ◽  
The Impact

The term geo-sciences has been used here to include the disciplines geology, geophysics and geochemistry. However, in order to apply geophysics and geochemistry effectively one must begin with a geological model. Therefore, the science of geology should be used as the basis for lunar exploration. From an astronomical point of view, a lunar terrain heavily impacted with meteors appears the more reasonable; although from a geological standpoint, volcanism seems the more probable mechanism. A surface liberally marked with volcanic features has been advocated by such geologists as Bülow, Dana, Suess, von Wolff, Shaler, Spurr, and Kuno. In this paper, both the impact and volcanic hypotheses are considered in the application of the geo-sciences to manned lunar exploration. However, more emphasis is placed on the volcanic, or more correctly the defluidization, hypothesis to account for lunar surface features.

МАРКЕТИНГОВІ АСПЕКТИ ФУНКЦІОНУВАННЯ ЛІТЕРАТУРНИХ КОНКУРСІВ ТА ПРЕМІЙ

2020 ◽  
pp. 90
Author(s):  
O. Bondar
Keyword(s):  
Publishing House ◽  
Target Audience ◽  
Point Of View ◽  
Information Support ◽  
Literary Field ◽  
Non Profit ◽  
Functional Aspects ◽  
The Media ◽  
Literary Prizes ◽  
The Impact

<p><em>In this study, I have collected and summarized the functional aspects of a literary prize, contest, and rating, which indicate their affiliation with the marketing complex of the publishing house for the first time. For this purpose, I have analyzed and summarized the common concepts of the functioning of literary prizes and contests as advertising tools for publishing activity. Because the previous studies are only focused on the fact of the impact of the prize on the promotion of editions but do not explain it, these aspects have been considered and introduced by me from the book production’s point of view. I investigated that the prizes and the contests in the literary field are effective marketing tools, which meet many publisher’s needs at the same time and can be considered a non-profit form of capital. I have reviewed the works of other authors, who accept that the economic success of the book is rising if the author is a winner of the literary prize or contest. I have found out that the book prize activates the demand for the book, and the literary contest is a tool to track the reader’s reaction to a future publication. In this way, literary prizes and contests can be considered as a way of conducting a marketing dialogue with the target audience. I have focused on the information support of literary national and international prizes and contests by the media, which attracts attention to the book and forms the reader’s interest. The literary prizes and contests are also considered as a way of exploring trends and their changes, familiarization the popular genres among the target audience and fixation the current choice of modern readers. Literary prizes and contests motivate the authors to improve their literary excellence, are the source of new authors and works, and assist in increasing sales of books. However, further research is recommended.</em></p><strong><em>Key words:</em></strong><em> book prize, book rating, literary contest, literary prize, functions of the literary prizes.</em>

On the Impact of Aptness, Conventionality and Familiarity on Metaphor Processing from a Meta-analytical Point of View

2020 ◽  
Vol 6 (1) ◽  
pp. 55-106
Author(s):  
Csilla Rákosi
Keyword(s):  
Meta Analysis ◽  
Point Of View ◽  
Psycholinguistic Research ◽  
Analytical Point ◽  
Metaphor Processing ◽  
The Impact

Psycholinguistic research into metaphor processing is burdened with empirical problems as experiments provide diverging evidence on the impact of conventionality, familiarity and aptness, and with conceptual issues as the interpretation and operationalization of the three concepts mentioned, as well as the related predictions which can be drawn from theories of metaphor processing, are controversial in the literature. This paper uses tools of statistical meta-analysis in order to bring us closer to the solution of these problems and reveal future lines of research.

The Impact of Obesity on Incidence of Type 2 Diabetes Mellitus (T2DM) among Women with Polycystic Ovary Syndrome (PCOS)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1612-P
Author(s):  
NADIRA SULTANA KAKOLY ◽  
ARUL EARNEST ◽  
HELENA TEEDE ◽  
LISA MORAN ◽  
DEBORAH LOXTON ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
The Impact

Wacana Kolonial dalam Novel Max Havelaar: Sebuah Kajian Poskolonial

Metahumaniora ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 411
Author(s):  
Abu Bakar Ramadhan Muhamad
Keyword(s):  
Point Of View ◽  
The Other ◽  
The Novel ◽  
Colonial Discourse ◽  
The Impact ◽  
The Voice

AbstrakHegemoni kolonialisme dalam budaya poskolonial merupakan alasan penelitian inikemudian mengkaji wacana kolonial dalam novel Max Havellar (MH) khususnya dampakditimbulkannya. Dampak dimaksud adalah posisi keberpihakan pemikiran tersirat darikarya tersebut. Hasil pembahasan menunjukkan, secara temporal maupun permanen MHmenyuarakan ketidakadilan dalam kondisi-kondisi kolonial menyangkut penindasan sangpenjajah terhadap terjajah. Hanya saja, upaya mengatasnamakan atau mewakili suarakaum terjajah terbukti mengimplikasikan ciri ideologis statis kerangka kolonialisme(orientalisme); yakni cara pandang Eropasentris, di mana “Barat” sebagai self adalah superior,dan “Timur” sebagai other adalah inferior. Dalam konteks poskolonialisme, MH dengan sifatkritisnya yang berupaya “menyuarakan” nasib pribumi terjajah, justru menampilkan stigmapenguatan kolonialitas itu sendiri secara hegemonik. Artinya, “menyuarakan” nasib pribumidimaknai sebagai keberpihankan kolonial yang kontradiktif, di mana stigma penguatankolonialitas justru lebih terasa, ujung-ujungnya melanggengkan hegemoni kolonial. Tidakmembela yang terjajah, tetapi memperhalus cara kerja mesin kolonial.AbstractThe hegemony of colonialism in the culture of postcolonial society is the reason this studythen examines the colonial discourse in the novel Max Havellar (MH) in particular the impactit brings. The impact in question is the implied position of thought in the work. The resultsof the discussion show that, temporarily or permanently, MH voiced injustice in the colonialconditions regarding the oppression of the colonist against the colonized. However, the effort toname or represent the voice of the colonized has proven to imply a static ideological characterin the framework of colonialism (orientalism); ie Eropacentric point of view, in which “West” asself is superior, and “East” as the other is the inferior. In the context of postcolonialism, MH withits critical nature that seeks to “voice” the fate of the colonized natives, actually presents thestigma of strengthening coloniality itself hegemonicly. That is, “voicing” the fate of the pribumiis interpreted as a contradictory colonial flare, where the stigma of strengthening colonialityis more pronounced, which ultimately perpetuates the hegemony of colonialism. No longerdefending the colonized, but refining the workings of the colonial machinery.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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