Diabetes mellitus – a devastating metabolic disorder

2015 ◽  
Vol 4 (40) ◽  
pp. 1-7 ◽  
Author(s):  
M.N. Piero
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disorder

scholarly journals THE EFFECT OF CHRONIC HYPERGLYCEMIA ON THE STATE OF MUSCULOSKELETAL SYSTEM (LITERATURE REVIEW)

2021 ◽  
Vol 21 (1) ◽  
pp. 184-187
Author(s):  
A.O. Ponyrko
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Bone Tissue ◽  
Musculoskeletal System ◽  
Metabolic Disorder ◽  
Skeletal System ◽  
Complex Disorders ◽  
Chronic Hyperglycemia ◽  
Wide Range

Diabetes mellitus is a metabolic disorder that today has become a threatening problem for human health. Its prevalence has been constantly increasing throughout the world over the past decades. Diabetes mellitus is regarded as an incurable metabolic disorder characterized by hyperglycemia, which is caused by defects in insulin secretion. This disease annually affects almost 3% of the total population of the planet. Chronic hyperglycemia causes dysfunction of various organs of the body, such as the eyes, kidneys, heart, blood vessels, and nerves. The most common complications of diabetes include lesions of the vessels of the eye, kidneys, lower limbs and nervous system. A high level of glucose in the blood causes the development of a wide range of pathological disorders, which affect bones as well. Recent studies have shown that diseases of the skeletal system are often observed in diabetes mellitus. Speaking about the effect of hyperglycemia on bones, the development of osteopenia and osteoporosis should be noted. In this regard, an important area of research is to study changes in the bone tissue in patients with type 1 diabetes mellitus and the mechanisms that lead to disruption of bone structure and metabolism. The article highlights the pathophysiological mechanisms of hyperglycemia action in type 1 diabetes that explains complex disorders of the organs of the musculoskeletal system. The detrimental effect of hyperglycemia results in marked degenerative changes in bone cells. The pathogenic effect of hyperglycemia on bone tissue is manifested in a decrease in bone mineral density that is due to the lack of insulin and, as a consequence, significant metabolic disorders, a decrease in bone mass, inhibition of bone tissue formation, a significant decrease in the trace element composition of bone. The combination of these factors creates the appropriate pathomorphological basis for the development of diabetic osteopathy. The article highlights the mechanism of action of hyperglycemia on skeletal system in order to stimulate to a more detailed investigation of diabetes mellitus in experimental animals.

Susceptibility of Glutathione--S-Transferase Polymorphism to CVD Development in Type 2 Diabetes Mellitus - A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Santhi Priya Sobha ◽  
Kumar Ebenezar
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Metabolic Disorder ◽  
Vascular Complications ◽  
Clinical Importance ◽  
Diabetic Patients ◽  
Diabetic Vascular Complications ◽  
Metabolic Conditions ◽  
Gst Polymorphism ◽  
Gene Status

Background: Metabolic disorder affects normal homeostasis and can lead to the development of diseases. Diabetes mellitus is the most common metabolic disorder, and a cluster of metabolic conditions can lead to cardiovascular disease (CVD) development. Diabetes mellitus and CVD are closely related, with oxidative stress, playing a major role in the pathophysiology. Glutathione-S-Transferases (GST) potentially play an important role by reducing oxidative stress and is found to be the underlying pathophysiology in the development of diabetes, cardiovascular diseases (CVD), etc. Objectives: In this review, the role of GST genetic variant in the development of diabetes mellitus, CVD and diabetic vascular complications has been focused. Results: Based on the literature, it is evident that the GST can act as an important biochemical tool providing significant evidence regarding oxidative stress predominant in the development of diseases. Analysis of GST gene status, particularly detection of GSTM1 and GSTT1 null mutations and GSTP1 polymorphism, have clinical importance. Conclusion: The analysis of GST polymorphism may help identify the people at risk and provide proper medical management. Genotyping of GST gene would be a helpful biomarker for early diagnosis of CVD development in DM and also in CVD cases. More studies focusing on the association of GST polymorphism with CVD development in diabetic patients will help us determine the pathophysiology better.

scholarly journals Family's Ability to Take Care The Patient of Type 2 Diabetes Mellitus in Tasikmalaya

2020 ◽  
Vol 3 (3) ◽  
pp. 150
Author(s):  
Bayu Brahmantia ◽  
Miftahul Falah ◽  
Lilis Lismayanti ◽  
Vina Erviana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Education ◽  
Blood Sugar ◽  
Metabolic Disorder ◽  
Sampling Method ◽  
The Family

Diabetes Mellitus is a metabolic disorder disease characterized by a rise of blood sugar due to a decrease of insulin by the pancreas. The role of the family in caring for the patient with type 2 diabetes mellitus is crucial in treatment. this study was aimed to know the ability of family in caring. a purposive sampling method was applied in this research. a total of 31 respondents were selected. the results showed that the majority of family's ability to recognize as a problem was good with 16 people ( 51,6 % ), in taking decisions for treatment was positive as much as 19 people (61.3%), in treatment of type 2 Diabetes Mellitus patients were positive 25 people (80,6%), in modifying the environment for Treatment was negative  18 people (58.1%). therefore, Health education for the family related to modifying the environment for treatment was required to recover the patient.

scholarly journals Bioinformatics Analysis of Key Genes and Pathways for Obesity Associated Type 2 Diabetes Mellitus as a Therapeutic Target

2020 ◽  
Author(s):  
Basavaraj Vastrad ◽  
Anandkumar Tengli ◽  
Chanabasayya Vastrad ◽  
Iranna Kotturshetti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Differentially Expressed Genes ◽  
Regulatory Network ◽  
Metabolic Disorder ◽  
Target Gene ◽  
Bioinformatics Analysis ◽  
Hub Genes

AbstractObesity associated type 2 diabetes mellitus is one of the most common metabolic disorder worldwide. The prognosis of obesity associated type 2 diabetes mellitus patients has remained poor, though considerable efforts have been made to improve the treatment of this metabolic disorder. Therefore, identifying significant differentially expressed genes (DEGs) associated in metabolic disorder advancement and exploiting them as new biomarkers or potential therapeutic targets for metabolic disorder is highly valuable. Differentially expressed genes (DEGs) were screened out from gene expression omnibus (GEO) dataset (GSE132831) and subjected to GO and REACTOME pathway enrichment analyses. The protein - protein interactions network, module analysis, target gene - miRNA regulatory network and target gene - TF regulatory network were constructed, and the top ten hub genes were selected. The relative expression of hub genes was detected in RT-PCR. Furthermore, diagnostic value of hub genes in obesity associated type 2 diabetes mellitus patients was investigated using the receiver operating characteristic (ROC) analysis. Small molecules were predicted for obesity associated type 2 diabetes mellitus by using molecular docking studies. A total of 872 DEGs, including 439 up regulated genes and 432 down regulated genes were observed. Second, functional enrichment analysis showed that these DEGs are mainly involved in the axon guidance, neutrophil degranulation, plasma membrane bounded cell projection organization and cell activation. The top ten hub genes (MYH9, FLNA, DCTN1, CLTC, ERBB2, TCF4, VIM, LRRK2, IFI16 and CAV1) could be utilized as potential diagnostic indicators for obesity associated type 2 diabetes mellitus. The hub genes were validated in obesity associated type 2 diabetes mellitus. This investigation found effective and reliable molecular biomarkers for diagnosis and prognosis by integrated bioinformatics analysis, suggesting new and key therapeutic targets for obesity associated type 2 diabetes mellitus.

scholarly journals PHARMACOLOGICAL EVALUATION OF FICUS RELIGIOSA FOR THEIR INVITRO HYPOGLYCEMIC ACTIVITY

2020 ◽  
pp. 1-2
Author(s):  
Poonam Pandey
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Metabolic Disorder ◽  
Antidiabetic Activity ◽  
Important Criterion ◽  
Ficus Religiosa ◽  
In Vitro Techniques ◽  
Pharmacological Evaluation ◽  
Disease Present

Diabetes mellitus is a metabolic disorder and its management is an important criterion for pharmacotherapy. The medicinal plants play very important role in preventing the progress of the disease. Present study deals with screening of polyherbal extracts using in-vitro techniques for its antidiabetic activity. The plants used in the present study are Ficus religiosa which use traditionally for the treatment of various ailments. In the present study different part of F. religiosa bark showed highest antioxidant and highest antidiabetic activity. This study indicates the curative beneƒOts of F. religiosa in traditional medicinal system.

Magnitude of Bhasmas in handling Madhumeha (Diabetes Mellitus) - A Critical Review.

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Divya P. ◽  
Medikeri Surekha ◽  
Hiremath Shobha G.
Keyword(s):  
Diabetes Mellitus ◽  
Critical Review ◽  
Metabolic Disorder ◽  
Similar Condition ◽  
Therapeutic Efficacy ◽  
Scientific Evidence ◽  
The Body ◽  
Growing Population

India is being estimated with fastest growing population of Diabetes. Diabetes is a metabolic disorder which is either due to Pancreas not producing enough insulin or the cells of the body not responding to the insulin produced. Diabetes refers “To run through siphon” and Mellitus means “Honey”, Similar condition Madhumeha “Prayo Madviva Mehanti” (Honey like urine) has been explained in the Ayurvedic classics long centuries ago in an apparent way. Rasashastra emphasize the usage of various Rasoushadhis in the management of Madhumeha. Various researches conducted in last few decades on the Rasa Bhasmas and Rasayogas mentioned in literature for Madhumeha have shown phenomenal Antidiabetic property. In this article, review of therapeutic efficacy of 5 Rasa Bahasmas Viz Naga, Vanga, Yashada, Swarna Makshika, and Abhraka Bhasmas with the scientific evidence and rationality have been compiled. Target conditions choosing of these Rasa Bhasmas in Madhumeha have been discussed.

Diabetes Mellitus

2021 ◽  
pp. 1-31
Author(s):  
Ruksar Salim Damji ◽  
Shamiha Chowdhury ◽  
Zaib-Un-Nisa Munawar Hussain
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
21St Century ◽  
Economic Burden ◽  
Metabolic Disorder ◽  
Pancreatic Beta Cells ◽  
Herbal Medicines ◽  
Drug Reactions ◽  
Healthcare Expenditures ◽  
Autoimmune Destruction

Diabetes mellitus is a chronic metabolic disorder which is at present rapidly growing to an alarming epidemic level. Various pathogenic processes are involved in the development of diabetes mellitus. This spectrums from autoimmune destruction of pancreatic beta cells with consequent deficiency of insulin to abnormalities that lead to resistance to the action of insulin. In the 21st century, the astounding rise in obesity, poor diet, and inactive lifestyles have increased the prevalence dramatically. Although several therapies are in use, Western medications are associated with adverse drug reactions and high cost of treatment. Therefore, there is currently a growing interest in herbal medicines to replace or supplement the Western medications. Extensive research is essential to enhance diagnoses, treatment, and to lessen healthcare expenditures. This chapter provides an overview of the classification, diagnosis, symptoms, complications, and economic burden of diabetes mellitus. Additionally, the authors discuss the current and upcoming therapies to treat this metabolic disorder.

scholarly journals Risk Factors and Early Detection of Diabetes Mellitus in Early Rheumatoid Arthritis WomenBackground: Patients with rheumatoid arthritis show predominance of metabolic disorder characterized by overweight, central obesity, dyslipidemia and impaired glucose

2018 ◽  
Vol 60 (1) ◽  
pp. 74-76
Author(s):  
Mohammad H. Ali ◽  
Abeer J. Hassan ◽  
Enas J. Hasan
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Early Rheumatoid Arthritis ◽  
Metabolic Disorder ◽  
Central Obesity ◽  
Rheumatoid Arthritis Group ◽  
Control Group ◽  
Fasting Insulin ◽  
Healthy Control

Background: Patients with rheumatoid arthritis show predominance of metabolic disorder characterized by overweight, central obesity, dyslipidemia, and impaired glucose tolerance, specifically, few studies have explained insulin resistance in this disease.Objective: The aim of the present study is to examine insulin resistance and the risk of developing diabetes mellitus in middle age Iraqi women with early rheumatoid arthritis.Patients and methods: This work involved seventy female with early rheumatoid arthritis. Who was attending to the National Diabetic Center (NDC) of Al-Mustansiriya University and 35 healthy subjects as a control group. From all subjects blood sample was drawn in fasting state to measure the biochemical parameters which including plasma glucose level and fasting insulin concentrations. Other measurements (RF and anti-CCP) were made by routine methods. Homeostasis model of assessment insulin resistance (HOMA-IR) by using the formula HOMA model Insulin sensitivity was calculated in RA patients and healthy control.Results: Results revealed a highly significant in the level of the rheumatoid factor (RF), anti-CCP and fasting insulin, and HOMA-IR when compared the patient group with the control group. While a significant increase in the level of FBG in the RA group than the control group. Also, there was a positive correlation with high significance among, Anti-CCP, and RF with HOMA-IR in the rheumatoid arthritis group. Conclusions: This study shows that patient with rheumatoid arthritis have abnormal insulin secretion with a high value of IR than a group of healthy control and these patients may be at risk of diabetic mellitus.  عوامل الخطر والتشخيص المبكر لداء السكري للنساء حديثات الاصابة بألتهاب المفاصل الروماتويدي محمد حسن علي  د.عـبير جبـار حسن أيناس جبار حسن  الخلاصة: خلفية البحث:يكون المرضى الذين يعانون من التهاب المفاصل الروماتويدي عرضة للاصابة بمتلازمة التمثيل بالغذائي والعوامل المرتبطة بها مثل زيادة الوزن، وقلة دهون الدم أو ضعف تحمل الجلوكوز، وهناك بعض الدراسات بينت ان هولاء المرضى يكونون معرضون لمقاومة الانسولين . الهدف: صممت هذه الدراسة لفحص مقاومة الانسولين وخطر الإصابة بداء السكري عند النساء العراقيات المصابات حديثا بالتهاب المفاصل الروماتويدي. طرق العمل: شملت الدراسة سبعين أنثى مصابات حديثا بالتهاب المفاصل الروماتويدي و 35 من النساء المتطوعات كمجموعة ضابطة. تم سحب عينة الدم من الجميع في حالة الصيام لقياس المعلمات البيوكيميائية بما في ذلك مستوى الجلوكوز ، تركيزالأنسولين وقياسات أخرى مثل (RF and anti-CCP). وايضا تم حساب المقاومة للانسولين (HOMA-IR). النتائج أظهرت النتائج وجود زيادة معنوية في مستوى العامل الروماتويدي (RF) وتركيز الانسولين مقاومة الانسولين (HOMA-IR) عند مقارنة مجموعة المرضى مع مجموعة السيطرة. في حين أن زيادة كبيرة في مستوى السكر الصائم  في مجموعة المرضى مقارنة بالمجموعة الضابطة. أيضا كان هناك علاقة إيجابية  مؤثرة بين، Anti-CCP, and RF  و HOMA-IR في مجموعة مرضى التهاب المفاصل الروماتويدي. الاستنتاجات: اظهرت نتائج هذه الدراسة أن المرضى بالتهاب المفاصل الروماتويدي يكون لديهم إفراز الأنسولين غير طبيعي وبالتالي تظهر لديهم مقاومة للانسولين ويكونون عرضة لخطر الاصابة بمرض السكري. الكلمات المفتاحية: مقاومة الانسولين,  داء السكري, التهاب المفاصل الروماتويدي.

scholarly journals A Review on Anti-diabetic Activity of Medicinal Spices

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Ramya P ◽  
Lavanya Krishnadhas
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Human Body ◽  
Metabolic Disorder ◽  
Well Being ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Treatment Of Diabetes

Diabetes mellitus is a common metabolic disorder in which the human body does not produce insulin hormone, this leads to the increase in blood glucose levels. Diabetes infects more than 387 million individuals globally, posing a significant threat to both personal well-being and global economies. Normally, medicinal plants are highly used for the treatment of diabetes mellitus but some spices also have the efficiency to treat diabetes. Still, spices which we are using as ingredients plays important role in foods also have the ability to treat diabetes. This article describes the anti-diabetic activity of those medicinal spices.

scholarly journals THE RELATION OF 25-HYDROXYVITAMIN D LEVEL WITH METABOLIC SYNDROME IN TYPE 2 DIABETES MELITUS PATIENTS

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Medityas Winda Krissinta ◽  
M.I. Diah Pramudianti ◽  
Dian Ariningrum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Disorder ◽  
Hydroxyvitamin D ◽  
Type 2 Dm ◽  
25 Hydroxyvitamin D

Background: Type 2 diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia. Metabolic syndrome (MS) is a complex metabolic disorder like hyperglycemia, obesity, dyslipidemia, and hypertension. Vitamin D controls genes associated with regulation of insulin and renin production. The aim of this study was to analyze the relation between total levels of 25-hydroxyvitamin D [25(OH)D] and the incidence of MS in  type 2 DM patients.Methods: This case control study was conducted from October to November 2018 in Dr Moewardi Hospital Surakarta in 84 people with type 2 diabetes mellitus. All subjects were 34-75 years old. The research data were analyzed with a 2x2 test table to determine the odd ratio (OR) of each study variable, then multivariate analysis with logistic regression then continued.Results: The mean total level of 25(OH)D is 18.01 ± 6.10 ng/dl. Bivariate and multivariate OR analysis showed that poor glycemic control with the incidence of MS (OR: 11.154; 95% Cl: 3.933-31.631; p = 0.001); female sex (OR : 1.788; 95% Cl: 0.750-4.261; p = 0.188); age < 50 year (OR: 1.644; 95% Cl: 0.614-4.404; p = 0.321); and  total  25(OH)D deficiency (OR: 1.250; 95% Cl: 0.317-2.022; p = 0.637).Conclusion: total 25(OH)D level is not associated with the incidence of MS in the type 2 DM patients. Further study was needed using by healthy group control to explain the role of vitamin D in type 2 DMKeywords: type 2 DM, metabolic syndrome, 25(OH)D

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