scholarly journals The Development of Tumor Neoantigen Vaccine Immunotherapy

2019 ◽  
Vol 78 ◽  
pp. 01005
Author(s):  
Wanqiu Wang
Keyword(s):  
Clinical Trial ◽  
Tumor Immunology ◽  
Somatic Mutations ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Normal Cells ◽  
The Core ◽  
The World ◽  
Recent Clinical Trial ◽  
Future Direction

Activating the immune system to fight against cancers has long been a goal in immunology and oncology studies. Recent clinical-trial data proved that boosting the activity of endogenous T cells to destroy cancer cells has great potential in controlling the progression of a variety of human malignancies. In essence, neoantigen is at the core of tumor immunology. Autologous T lymphocytes could distinguish tumor cells from normal cells by recognizing neoantigens, which are tumor specific. Neoantigens are derived from genome somatic mutations of tumors, and there are different approaches to predict and identify them with increasing accuracy. Neoantigens are tumor specific, which are ideal and attractive targets for tumor immunotherapies; many neoantigen-based clinical trials are being carried out around the world. In this review, we will discuss the recent advances of tumor neoantigen vaccine immunotherapy, and present the potential obstacle and future direction of this approach.

scholarly journals Transparency in clinical trials

2021 ◽  
Author(s):  
ChS Pavlov ◽  
DL Varganova ◽  
AA Svistunov ◽  
C Gluud
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Technology Development ◽  
Personal Data ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Positive Effects ◽  
The World ◽  
Information Technology Development ◽  
Meta Analyses

In the age of information technology development, healthcare professionals around the world have the opportunity to simultaneously access advanced scientific developments, modern achievements, and the results of new clinical trials. The clinical guidelines of the international medical communities are based on the results of meta-analyses of clinical trial data. As new medical challenges emerge, clinical trial data are reviewed and re-analyzed. Unfortunately, to date, the results of not all studies are made public, or are presented selectively, indicating the positive effects of a particular technology (intervention), which makes it difficult to critically evaluate the results of work and makes the task of assessing the true effectiveness of the intervention more difficult. The problem of transparency of research data with the preservation of personal data of participants remains relevant for decades. This article is focused on possible ways of solving this problem and the analysis of the current situation in the world.

scholarly journals Recent Updates in Experimental Research and Clinical Evaluation on Drugs for COVID-19 Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Houwen Zou ◽  
Yuqi Yang ◽  
Huiqiang Dai ◽  
Yunchuang Xiong ◽  
Jing-Quan Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Clinical Trial ◽  
Experimental Research ◽  
Clinical Evaluation ◽  
Clinical Studies ◽  
Virus Disease ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Global Public Health ◽  
The World

Since the outbreak of corona virus disease 2019 (COVID-19) in Wuhan (China) in December 2019, the epidemic has rapidly spread to many countries around the world, posing a huge threat to global public health. In response to the pandemic, a number of clinical studies have been initiated to evaluate the effect of various treatments against COVID-19, combining medical strategies and clinical trial data from around the globe. Herein, we summarize the clinical evaluation about the drugs mentioned in this review for COVID-19 treatment. This review discusses the recent data regarding the efficacy of various treatments in COVID-19 patients, to control and prevent the outbreak.

scholarly journals Cannabinoids for the Treatment of Pain: An Update on Recent Clinical Trials

2005 ◽  
Vol 10 (suppl a) ◽  
pp. 27A-30A ◽  
Author(s):  
Mark Ware ◽  
Pierre Beaulieu
Keyword(s):  
Clinical Trial ◽  
Chronic Pain ◽  
Pain Management ◽  
Considerable Increase ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Clinical Use ◽  
The Past ◽  
Pain Syndromes ◽  
Recent Clinical Trial

Over the past five years, there has been a considerable increase in clinical research on cannabinoid use for a range of pain syndromes. Cannabinoid products are becoming available for research and clinical use, and pharmaceutical industry interest in the potential for cannabinoids in therapeutics is also gaining momentum. The present article summarizes recent clinical trial data in the field of pain management and suggests that the potential for cannabinoid therapy for chronic pain states is encouraging. Clinicians working in pain management should be aware of the options becoming available from the cannabinoid class of medications.

scholarly journals Lack of clinical trial data transparency and current solutions

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tabassom Baghai
Keyword(s):  
Clinical Trial ◽  
Clinical Research ◽  
World Health Organization ◽  
Clinical Trial Data ◽  
Trial Data ◽  
World Health ◽  
The World ◽  
Data Transparency ◽  
Health Organization ◽  
The U.S

An ongoing challenge in clinical research is the inaccessibility of clinical trial data, which prevents physicians from making an informed decision with regards to patient care. The U.S. Food and Drug Administration (FDA) as well as the World Health Organization (WHO) recently called for all trial data to be registered and made publically available. However, this issue is still ongoing and there are several measures currently being enforced to rectify these concerns. Potential solutions, such as regulations, campaigns, and possible conse- quences, for increasing transparency in clinical trial data will be discussed. RÉSUMÉ L’inaccessibilité des données provenant d’essais cliniques constitue un défi constant en recherche clinique, puisqu’elle empêche les médecins de prendre des décisions éclairées quant aux soins de leurs patients. Récemment, le Secrétariat américain aux produits alimentaires et pharmaceutiques (FDA) ainsi que l’Organisation mondiale de la Santé (OMS) ont demandé que toutes les données d’essais cliniques soient enregistrées et mises à la disposition du public. Toutefois, ce problème persiste et plusieurs mesures ont été mises en place pour répondre à ces préoccupations. Des solutions possibles dont des réglementations, des campagnes et des sanctions possibles pour améliorer la transparence en ce qui concerne les données d’essais cliniques seront discutées. 

scholarly journals COVID-19 Vaccine Race: An Overview and Update

2021 ◽  
Vol 11 (2) ◽  
pp. 171-177
Author(s):  
Md. Rayhan Chowdhury ◽  
Shirmin Islam ◽  
Mohammad Nurul Matin
Keyword(s):  
Clinical Trial ◽  
Vaccine Development ◽  
Vaccine Candidate ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Phase Iii ◽  
Health Crisis ◽  
Phase Iii Clinical Trials ◽  
Successful Vaccine ◽  
The World

A sudden health crisis has shut down the entire world for almost a year due to a new virus called Covid-19 and thus the WHO has declared the COVID-19 as a pandemic disease. As vaccines stimulate the immune system to fight against future infections, thereby conferring immunity, so far, vaccine development in a race throughout the world. Therefore, disseminating the overview of the vaccine development at present with their critical situation for COVID-19 is the aim of this review. The world is looking eagerly for a potential vaccine candidate that can save every life. Here, we reported the overview of the possible types of vaccines against Covid-19 as well as a glimpse of vaccine race with different phases of clinical trial data, comparison of the rate of success of phase-III clinical trials and their safety, and drawbacks with the present status. We have studied literature from clinical trial data of respective vaccine candidates published in the journals and collected data from databases dedicated to corona vaccine and the vaccine company's website to enrich our review and aiming to focus on clinical trial data stages, how consequences it faces, and how to position it belongs towards a successful vaccine candidate. Keywords: COVID-19, SARS-CoV-2, COVID-19 vaccine, Clinical trial.

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