scholarly journals Effects of Almaty city ecological factors on students blood indices

2020 ◽  
Vol 169 ◽  
pp. 04005
Author(s):  
Tilek Baidaulet ◽  
Alibek Ydyrys ◽  
Moldir Imanaliyeva ◽  
Zifa Askarova ◽  
Gulziya Srailova ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Foreign Students ◽  
Ecological Factors ◽  
Absolute Number ◽  
Physical Workload ◽  
Absolute Amount ◽  
Blood Indices ◽  
Before And After ◽  
Local Students ◽  
Insight Into

This research gives an insight into the main features of the cardiovascular system’s statistical and dynamic, as well as young local and foreign citizens in Almaty city adaptation indices. 1500 analysis of blood indices was carried out before and after the physical workload. Hematological research were carried out based on N. M. Mykolayiv method and included the erythrocytes and leukocytes count in peripheral blood vessel and absolute number of lymphocytes . Foreign students’ absolute amount of leukocytes and erythrocytes in the peripheral blood vessels and the phagocytic activity of neutrophil were different from local students’ indices.

scholarly journals One-Time Administration of Recombinant Human Erythropoietin Decreases B Cell in Human Peripheral Blood

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 4899-4899
Author(s):  
Tomomi Nagashima ◽  
Akihiko Yokohama ◽  
Kie Nagai ◽  
Rumi Ino ◽  
Noriyuki Takahashi ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Peripheral Blood ◽  
Absolute Number ◽  
Cell Number ◽  
Human Immune System ◽  
Human Erythropoietin ◽  
Before And After ◽  
Human Immune ◽  
B Cell Subsets

Abstract Introduction:Erythropoietin (EPO) is hematopoietic factors participating in red blood cell production by accelerating cell proliferation and inhibition of apoptosis of erythroblast. It is reported that EPO has pleiotropic effects including anti-apoptotic action for some cells, antioxidant action, vascularization action, and promoting cell division in addition to stimulation of erythropoiesis as well, whereas there are conflicting results of small cohorts as to its effect on blood immune cells. We analyzed peripheral white blood cell subsets in patients who received one bolus administration of recombinant human erythropoietin (rHuEPO) to examine the effect of EPO on human immune system. Materials and Methods:One hundred twenty eight autologous blood donors (male/female 64/64) in Gunma University Hospital were enrolled in this study after written informed consent. All the patients had no infections or inflammation. Fifty six patients were administered rHuEPO (Epoetin alpha or Epoetin beta, 24,000 IU) once after blood donation because of low hemoglobin concentration (EPO group) and 72 were not administered (non-EPO group). Peripheral blood samples were obtained at the time of the first phlebotomy and after 7 days from the same patient. We measured the number of WBC, lymphocytes, myeloid dendritic cells (mDC), plasmacytoid dendritic cells (pDC), CD4+ T cells, CD8+ T cells, Natural killer (NK) cells, B cells, monocytes, and neutrophils of peripheral blood before and after rHuEPO administration by flow cytometry. Also we compared EPO group with non-EPO group. Paired and unpaired Student's t-test were used to compare absolute counts and percentages of each cell, P values < 0.05 were considered significant. This study was approved by the research ethics committee of our hospital. Results:In EPO group, absolute number and percentage of lymphocyte in WBC decreased significantly after rHuEPO administration from 1754.9 ± 535.4/µl to 1627.2 ± 467.7/µl, (p<0.01) and from 30.9 ± 8.00% to 28.2 ± 6.77% (p<0.01), respectively. The numbers of whole WBC, mDC, pDC, monocyte and neutrophil did not show significant changes. In regards to lymphocyte subset, absolute number of CD8+ T cell significantly decreased from 358.9 ± 257.0/µl to 311.5 ± 210.9/µl (p=0.04) and that of NK cell from 290.6 ± 157.6/µl to 257.4 ± 141.8/µl (p<0.01), but their percentages did not change. B cells significantly decreased in absolute number from 258.3 ± 154.2 /µl to 221.6 ± 129.2 /µl (p<0.01) and also in percentages from 14.8 ± 6.92% to 13.6 ± 6.07% (p<0.01). Regarding B cell subsets, absolute number of Naïve B cells significantly decreased from 171.3 ± 93.5 /µl to 153.0 ± 84.2 /µl (p<0.01); moreover other B cell subsets, such as transitional B cells, memory B cells and marginal zone B cells, also showed a trend of decrease, so that the percentage of Naïve B cell did not change in total B cells. These suggested that whole B cell decreased, not a specific subset of B cell. In non-EPO group, there was no significant change in any type of immune cells. When compared the rate of change between before and after rHuEPO treatment, B cell number significant decreased in EPO group compared to non-EPO group (0.87 vs 0.98, p<0.01). Multiple regression analysis revealed rHuEPO administration significantly influenced B cell number (p=0.015); however age, sex, disease status and the type of rHuEPO preparations (epoetin alfa or beta) did not influence. Conclusion:These findings suggested that just one administration of rHuEPO influenced human immune system, especially via reduction of B cell in peripheral blood. Disclosures No relevant conflicts of interest to declare.

REPEATED LONG-TERM SPACE FLIGHTS: PROTEOMIC INVESTIGATIONS OF COSMONAUTS' BLOOD

2020 ◽  
Vol 54 (5) ◽  
pp. 15-22
Author(s):  
I.M. Larina ◽  
◽  
D.N. Kashirina ◽  
K.S. Kireev ◽  
A.I. Grigoriev ◽  
...  
Keyword(s):  
Bone Structure ◽  
Space Station ◽  
The Body ◽  
Coagulation Cascade ◽  
Chemical Components ◽  
Blood Proteins ◽  
Blood Indices ◽  
Before And After ◽  
Biochemical Indices

We performed the first ever comparative analysis of modifications in the proteome, ionogram and some other blood plasma biochemical indices of 18 male cosmonauts (44 ± 6 years of age) before and after maiden or repeated long-term missions to the Russian segment of the International space station (ISS RS). Levels of proteins, substrates and ions as well as chemical components were measured using the LC-MS-based proteomics and routine biochemical techniques. A total of 256 to 281 indices were investigated with the methods of descriptive statistic, regression analysis, and access to bioinformatics resources. It was shown that blood indices recovery from the maiden and repeated missions reflects changes in the body systems and goes at a various speed. The results of measurements made prior to launch and on day 7 after landing are dependent on the number of missions. The bioinformatics techniques showed that after maiden missions both the mediator proteins of alkaline phosphatase (AP) and blood proteins with reliably changing concentrations are associated with the bio-processes including stress, metabolism and DNA reparation, apoptosis, catabolism and proteolysis. During early re-adaptation from repeated missions the AP level was affected by bone remodeling, phosphorylation, angiogenesis and coagulation cascade suggesting a distinct and urgent trigger of the processes of bone structure and mineralization.

scholarly journals AB0017 IMMUNE CHARACTERISTICS OF PERIPHERAL BLOOD IN SECONDARY SJOGREN’S SYNDROME PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1043.1-1043
Author(s):  
R. Su ◽  
Y. Y. Wang ◽  
C. Wang
Keyword(s):  
Sjögren’S Syndrome ◽  
Peripheral Blood ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Absolute Number ◽  
Sjogren's Syndrome ◽  
Secondary Sjögren’S Syndrome ◽  
T Subsets ◽  
Secondary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Background:Secondary Sjogren’s Syndrome (sSS) is diagnosed when symptoms of SS coexist with other systemic connective tissue disease, often secondary to rheumatoid arthritis(RA).The occurrence of SS secondary with RA will worsen the course of disease and increase the high incidence and mortality of RA. At present, the immune characteristics of peripheral blood of sSS with RA are not clear.Objectives:To observe the difference of immune Immune characteristics in peripheral blood between sSS secondary to RA, primary Sjogren’s syndrome(pSS) and RA patients.Methods:20 sSS with RA patients, 20 pSS paients and 20 RA pateints hospitalized in ShanXi medical university the second Hospital were enrolled. The percentage and absolute numbers of lymphocyte phenotypes and CD4+ T subsets in peripheral blood were examined by flow cytometry.Results:As for the percentage and absolute number of total T, B, NK, CD4+T,CD8+ T and the ratio of CD4 + T to CD8+ T cells, there was no significant difference between the sSS with RA, RA, and SS group. There was also no statistical difference in the percentage of CD4+T subsets(Th1,Th2,Th17 and Treg) between the three groups. But the ratio of Th17 and Treg in sSS with RA group was increased than pSS group.About comparison of absolute number of CD4+T subsets, there was no statistical difference among the three groups except that the Th1 cells in RA group was significantly higher than SS group.Conclusion:Elevated Th17/Treg may be an immunological feature that differentiates sSS with RA patients from pSS patients. In addition, in general, peripheral blood of patients with RA and SS have similar immune characteristics.References:[1]Wei W,Ahmad S S, Chi S. From Molecular Mechanism to the Etiology of Sjogren Syndrome.Curr Pharm Des. 2018;24(35):4177-4185.[2]Hajiabbasi A, Masooleh I S,Alizadeh Y, Secondary Sjogren’s Syndrome in 83 Patients With Rheumatoid Arthritis.Acta Med Iran.2016;54(7):448-53.Figure 1.The comparsion about the lymphocyte phenotypes and CD4+ T subsets in peripheral blood of sSS with RA(n=20), pSS(n=20) and RA patients(n=20).(*p<0.05,**p<0.001,*p<0.0001)Disclosure of Interests:None declared

scholarly journals Systemic Lupus Erythematosus before and after COVID-19 Lockdown: How the Perception of Disease Changes through the Lenses of Narrative Medicine

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 726
Author(s):  
Fulvia Ceccarelli ◽  
Venusia Covelli ◽  
Giulio Olivieri ◽  
Francesco Natalucci ◽  
Fabrizio Conti
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Narrative Medicine ◽  
Good Control ◽  
Final Analysis ◽  
Point Of View ◽  
Systemic Lupus ◽  
Before And After ◽  
Text Content ◽  
Insight Into

Background: The COVID-19 pandemic contributes to the burden of living with different diseases, including Systemic Lupus Erythematosus (SLE). We described, from a narrative point of view, the experiences and perspectives of Italian SLE adults during the COVID-19 emergency, by distinguishing the illness experience before and after the lockdown. Methods: Fifteen patients were invited to participate. Illness narratives were collected between 22 and 29 March 2020 using a written modality to capture patients’ perspectives before and after the COVID-19 lockdown. We performed a two-fold analysis of collected data by distinguishing three narrative types and a qualitative analysis of content to identify the relevant themes and sub-themes reported. Results: Eight narratives included in the final analysis (mean length 436.9 words) have been written by eight females (mean age 43.3 ± 9.9 years, mean disease duration 13.1 ± 7.4 years). Six patients provided a quest narrative, one a chaos and the remaining one a restitution narrative. By text content analysis, we identified specific themes, temporally distinct before and after the lockdown. Before COVID-19, all the patients referred to a good control of disease, however the unexpected arrival of the COVID-19 emergency broke a balance, and patients perceived the loss of health status control, with anxiety and stress. Conclusions: We provided unique insight into the experiences of people with SLE at the time of COVID-19, underlining the perspective of patients in relation to the pandemic.

Small rodent communities (Muridae) in Gabonese savannas: species diversity and biogeographical affinities

Mammalia ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jean-François Mboumba ◽  
Maxime R. Hervé ◽  
Véronique Guyot ◽  
Frederic Ysnel
Keyword(s):  
Ecological Factors ◽  
Abundant Species ◽  
Small Rodent ◽  
Small Rodents ◽  
South West ◽  
New Information ◽  
Different Types ◽  
Mus Minutoides ◽  
Insight Into ◽  
Coastal Basin

Abstract The study contributes to the knowledge of species composition and biogeographical affinities of savannas rodent in Gabon. Unlike small rodents in Gabonese forests, there is little data on the diversity of small rodents in Gabonese savannas. The diversity and distribution of rodent murid communities was studied in four different types of savanna in Gabon: Coastal Basin (South-West), Lopé/Okanda (in the Center), Batéké Plateaux (Southeastern) and Ngougnié/ N’yanga (in the South). A total of 428 individuals representing six species were captured over 11,920 trap nights. Trap success was highly variable (2.2–6.9 %). The most abundant species were Mus minutoides (69%) followed by Lemniscomys striatus (21.5%). Indices of species richness varied from 2 to 5 and diversity (Shannon and Weaver) was low in the four savannas with the highest value at Ngougnié/N’yanga (H′ = 1.2). Species distributions show that Gabonese savanna small rodents conform to four distribution types, with one species known from Zambesian savannas exhibiting austral affinities (Pelomys campanae: occurs in three southern savannas). This new information provides important insight into the biogeography of small rodents at a local and regional level. Moreover, the correspondence analysis highlighted an influence of local ecological factors on population abundance.

scholarly journals Discoloration of Historical Plastic Objects: New Insight into the Degradation of β-Naphthol Pigment Lakes

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2278
Author(s):  
Anna Micheluz ◽  
Eva Mariasole Angelin ◽  
João Almeida Lopes ◽  
Maria João Melo ◽  
Marisa Pamplona
Keyword(s):  
Light Exposure ◽  
Molecular Structures ◽  
Conservation Science ◽  
Organic Pigment ◽  
Organic Pigments ◽  
Before And After ◽  
The Individual ◽  
Determining Factor ◽  
Insight Into ◽  
Historical Samples

Light is a determining factor in the discoloration of plastics, and photodegradation processes can affect the molecular structures of both the polymer and colorants. Limited studies focused on the discoloration of heritage plastics in conservation science. This work investigated the discoloration of red historical polyethylene (PE) objects colored with PR 48:2 and PR 53:1. High-density and low-density PE reference polymers, neat pigment powders, and historical samples were assessed before and after accelerated photoaging. The applied methodology provided insight into the individual light-susceptibility of polyethylenes, organic pigment lakes, and their combined effect in the photoaging of historical plastic formulations. After light exposure, both PE references and historical samples yellowed, PR53:1 faded, and PR 48:2 darkened; however, both organic pigments faded severely in the historical samples. This highlights the role played by the plastic binder likely facilitating the pigment photofading. Fourier transform infrared spectroscopy and mass spectrometry techniques—EGA-MS, PY-GC/MS, and TD-GC/MS—were successfully employed for characterizing the plastic formulations and degradation. The identification of phthalic compounds in both aged β-naphthol powders opens new venues for studies on their degradation. This work’s approach and analytical methods in studying the discoloration of historical plastics are novel, proving their efficacy, reliability, and potentiality.

Changes of lymphocyte subsets in peripheral blood before and after operation of patients with advanced ovarian carcinoma

1990 ◽  
Vol 116 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Yoshihiro Kikuchi ◽  
Ichiro Iwano ◽  
Tsunekazu Kita ◽  
Munenori Miyauchi ◽  
Eiichi Kuki ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Advanced Ovarian Carcinoma ◽  
Before And After

Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps

2011 ◽  
Vol 6 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Erkan Vuralkan ◽  
Cem Saka ◽  
Istemihan Akin ◽  
Sema Hucumenoglu ◽  
Binnur Uzmez Unal ◽  
...  
Keyword(s):  
Recurrence Rate ◽  
Nasal Spray ◽  
Peripheral Blood ◽  
Nasal Polyposis ◽  
Mometasone Furoate ◽  
Significant Difference ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Snot 22

Background: The aim of our study was to compare the effects of montelukast and mometasone furoate nasal spray on the postoperative course of patients with nasal polyposis. Patients and methods: Fifty patients diagnosed with nasal polyposis between March 2006 and August 2007 were included in the study. All patients underwent bilateral endoscopic sphenoethmoidectomy and were randomized postoperatively into two groups. Group A ( n = 25) received 10 mg montelukast per day and group B ( n = 25) received 400 µg mometasone furoate nasal spray twice daily. All patients were followed up for 6 months. Sino-Nasal Outcome Test (SNOT)-22 scores, polyp grades, computerized tomography (CT) scores (Lund–Mackay), eosinophils in peripheral blood and polyp tissue were evaluated before and after surgery. Results: There was a significant reduction in SNOT-22 scores in both groups throughout the study period. There was a significant difference in the recurrence rate between both groups with a marginal advantage of mometasone furoate nasal spray. Eosinophils in peripheral blood were found to be effective on the recurrence rate ( p < 0.05). Conclusions: In conclusion, both drugs seem to have a complementary action and further studies are needed to determine which patients should receive which treatment.

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