scholarly journals Wound Healing Effects from 3 Hypericum spp. Essential Oils

2021 ◽  
Vol 8 (02) ◽  
pp. e69-e77
Author(s):  
Maria-Eleni Grafakou ◽  
Aggeliki Diamanti ◽  
Eleytheria Simirioti ◽  
Asimina Terezaki ◽  
Christina Barda ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oils ◽  
Skin Inflammation ◽  
Classical Antiquity ◽  
Extensive Literature ◽  
Traditional Use ◽  
Aerial Parts ◽  
Healing Agent ◽  
Hypericum Species

Abstract Hypericum species have a long-term use as wound healing agents, with the most common preparation being the infused oil from the aerial parts. It contains naphthodianthrones, phloroglucinols, and essential oil. An extensive literature survey shows that, unlike napthodianthrones and phloroglucinols, essential oils from Hypericum spp. have not yet been evaluated for their wound healing efficacy. The present study aims to assess the wound healing efficacy of essential oils from H. perforatum, a plant recognized in European Pharmacopoeia for having wound healing properties, as well from 2 other Hypericum species commonly used in Greece as wound healing agents since classical antiquity, namely, H. empetrifolium and H. triquetrifolium. So far, only the wound healing effects of Hypericum oil are known, which is a different herbal preparation containing nonvolatile compounds, while the essential oils under investigation contain only volatile constituents. The essential oils were subjected to GC-MS analyses. Wounds were created on the upper back of hairless SKH-hr1 mice. Healing was evaluated by clinical, histopathological, and biophysical assessment. The essential oils showed a significantly faster wound healing rate in comparison to the controls and the vehicle-treated groups. H. empetrifolium possessed the most significant healing properties while for H. perforatum and H. triquetrifolium skin inflammation persisted. The essential oils from Hypericum spp. showed promising results as wound healing agents and are likely to contribute to the wound healing efficacy of the Hypericum preparations. H. empetrifolium, being the most potent anti-inflammatory and wound healing agent, confirms the traditional use of this plant in Greece for wounds and skin inflammations.

scholarly journals Compositional Analysis of Lavandula pinnata Essential Oils

2016 ◽  
Vol 11 (3) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Maria Pia Argentieri ◽  
Barbara De Lucia ◽  
Giuseppe Cristiano ◽  
Pinarosa Avato
Keyword(s):  
Essential Oils ◽  
Folk Medicine ◽  
Compositional Analysis ◽  
Mediterranean Area ◽  
Caryophyllene Oxide ◽  
Traditional Use ◽  
Main Compound ◽  
Aerial Parts ◽  
Manufactured Products ◽  
Spring Type

The genus Lavandula includes about thirty species plus a number of intraspecific taxa and hybrids, which are distributed in the Mediterranean area. The traditional use of lavender both as perfume or medicinal plant is known since antiquity. Nowadays several species are extensively cultivated for the extraction of their essential oils (EOs) which are used in manufactured products like cosmetics and perfumes or in phytotherapy. Lavandula pinnata L. f. (syn L. pinnata Lundmark) is a rare species native to the Canary Islands used in folk medicine as relaxant and also a valuable remedy against bites. To the best of our knowledge, EOs from L. pinnata have been very little studied. The present paper reports on the quali- and quantitative compositional profile of the EOs distilled (by a Spring type apparatus) from the aerial parts (flowers and leaves) of this species cultivated in soilless conditions. Chemical analyses by means of GC and GC-MS techniques have indicated that oxygenated monoterpenes are the main constituents of both the flowers (68.30%) and the leaves (83.65%). Carvacrol is the main compound which characterizes the EOs of this species. In addition, discrete amounts of spathulenol (12.22%) and caryophyllene oxide (14.62%) have been detected in flowers EOs, while leaves EOs contained small amounts of carvacrol methyl ether (2.52%).

scholarly journals Histopathological evaluation of latex of Bellaco-Caspi, Himatanthus sucuuba (Spruce) Woodson on wound healing effect in BALB/C mice

2020 ◽  
Vol 13 (6) ◽  
pp. 1045-1049
Author(s):  
Lisbeth Lucia Calero-Armijos ◽  
Oscar Herrera-Calderon ◽  
Jorge Luis Arroyo-Acevedo ◽  
Juan Pedro Rojas-Armas ◽  
Renán Dilton Hañari-Quispe ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Incision ◽  
Control Group ◽  
Histopathological Study ◽  
Traditional Use ◽  
Collagen Formation ◽  
Healing Effect ◽  
Healing Agent ◽  
Wound Healing Effect ◽  
Treatment Of Wounds

Background and Aim: Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) is a medicinal plant known as "Bellaco- Caspi" widely distributed in Loreto, Peru. In the Peruvian traditional medicine, the latex of the plant is used for the treatment of wounds, inflammation, ulcers, and other ailments. This study aims to evaluate the wound healing effect of the latex of H. sucuuba in BALB/C albino mice. Materials and Methods: Thirty BALB/C male mice were used for wound healing study. In the experimental procedures, wound skin incision was performed at 2.0 cm in length until subcutaneous on the paravertebral of each animal. Under locally anesthetized with procaine cream, the treatment was conducted. All the mice were divided into three groups, the control group (A), zinc oxide cream (B), and H. sucuuba latex (C). The entire surface of the wound was treated for all the groups, and the treatments were performed daily for 15 days. The experiments were stopped on days 1, 7, and 15, respectively. Results: The histopathological study of tissues revealed significant changes in wound healing effect in H. sucuuba latex compared to the control and B groups. Consequently, the mice treated with latex showed a significant reduction in epithelialization time and collagen formation. Furthermore, the latex showed a dose-dependent significant reduction of inflammation in the first 24 h of treatment. Conclusion: BALB/C mice treated with the latex of H. sucuuba possess a wound healing effect that can scientifically prove the traditional use of the plant as a wound healing agent.

scholarly journals In Vivo Wound Healing and Anti-Inflammatory Activities of Leaf Latex of Aloe megalacantha Baker (Xanthorrhoeaceae)

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Leake Gebremeskel ◽  
Dayananda Bhoumik ◽  
Gereziher Geremedhin Sibhat ◽  
Kald Beshir Tuem
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Negative Control ◽  
Wound Contraction ◽  
Traditional Use ◽  
Ointment Base ◽  
Healing Agent ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

Background. Aloe megalacantha Baker (Xanthorrhoeaceae) is one of the Aloe species widely distributed in Ethiopia. The leaf latex of the plant is used for treatment of wounds, inflammation, and other multiple ailments in Ethiopian traditional medicine. Purpose. The aim of this study was to evaluate in vivo wound healing and anti-inflammatory activities of the leaf latex of Aloe megalacantha in mice. Methods. The wound healing activity of the leaf latex of the plant was studied topically by incorporating the latex in simple ointment base in a concentration of 5% (w/w) and 10% (w/w) using excision and incision models. In these models, wound contraction, period of epithelialization, and breaking strength of the wounded skin were determined. Carrageenan induced inflammation of paw model was also used to assess the anti-inflammatory activity of the leaf latex at doses of 200 mg/kg, 400mg/kg, and 600 mg/kg. The level of inflammation suppressions were measured at 1, 2, 3, and 4 hrs after carrageenan injection, and then the percentages of inflammation inhibition were computed as compared with the negative control. Result. In both wound models, mice treated with 5% (w/w) and 10% (w/w) latex ointment showed a significant (p<0.05) increment in the rate of wound contraction, reduction in epithelialization time, and higher skin breaking strength. Besides, the latex also exhibited a dose-dependent significant (p<0.05) reductions of inflammation as compared to negative control groups. Conclusion. The overall results of this study demonstrate that the leaf latex of A. megalacantha possesses wound healing and anti-inflammatory activities which can scientifically substantiate the traditional use of the plant as a wound healing agent.

scholarly journals Volatile Constituents of Two Hypericum Species from Tunisia

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Karim Hosni ◽  
Kamel Msaâda ◽  
Mouna Ben taârit ◽  
Thouraya Chahed ◽  
Brahim Marzouk
Keyword(s):  
Chemical Composition ◽  
Genetic Variability ◽  
Essential Oils ◽  
Hypericum Perforatum ◽  
Qualitative And Quantitative ◽  
Aerial Parts ◽  
Branched Hydrocarbons ◽  
Chemical Variability ◽  
Germacrene D ◽  
Hypericum Species

The chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of the Tunisian Hypericum perforatum and H. ericoides ssp. roberti was elucidated by a combination of GC and GC-MS analyses. The main constituents of the oil of H. perforatum were α-pinene (11.8%), α-ylangene (10.4%), germacrene-D (9.5%), n-octane (6.5%) and α-selinene (5.9%). The oil of H. ericoides ssp. roberti exhibited a higher amount of aliphatic and branched hydrocarbons and the main constituents were n-octane (29.1%), α-pinene (10.9%), pulegone (7.7%) and acetophenone (7%). Both qualitative and quantitative differences were observed between the studied oils. This chemical variability seems likely to result from the genetic variability, since samples of both species were collected at the same location and processed under the same conditions.

Preliminary results: essential oils from Hypericum spp. growing wild in Greece and their wound healing effects

2019 ◽  
Author(s):  
ME Grafakou ◽  
A Diamanti ◽  
E Simirioti ◽  
A Terezaki ◽  
C Barda ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oils ◽  
Preliminary Results

The Undiscovered Potential of Essential Oils for Treating SARS-CoV-2 (COVID-19)

2020 ◽  
Vol 26 (41) ◽  
pp. 5261-5277
Author(s):  
Peter J. Wilkin ◽  
Minnatallah Al-Yozbaki ◽  
Alex George ◽  
Girish K. Gupta ◽  
Cornelia M. Wilson
Keyword(s):  
Essential Oils ◽  
Clinical Symptoms ◽  
Synergistic Effects ◽  
World Health Organisation ◽  
Diagnostic Techniques ◽  
World Health ◽  
Clinical Aspects ◽  
Traditional Use ◽  
In Silico Studies ◽  
The World

On 11th March 2020, the World Health Organisation (WHO) announced a pandemic caused by a novel beta-coronavirus SARS-CoV-2, designated COVID-19. The virus emerged in December 2019 in Wuhan, China, has spread across the world as a global pandemic. The traditional use of medicines from plants can be traced back to 60,000 years. Global interest in the development of drugs from natural products has increased greatly during the last few decades. Essential oils (EOs) have been studied through the centuries and are known to possess various pharmaceutical properties. In the present review, we have highlighted the current biology, epidemiology, various clinical aspects, different diagnostic techniques, clinical symptoms, and management of COVID-19. An overview of the antiviral action of EOs, along with their proposed mechanism of action and in silico studies conducted, is described. The reported studies of EOs&#039; antiviral activity highlight the baseline data about the additive and/or synergistic effects among primary or secondary phytoconstituents found in individual oils, combinations or blends of oils and between EOs and antiviral drugs. It is hoped that further research will provide better insights into EOs&#039; potential to limit viral infection and aid in providing solutions through natural, therapeutically active agents.

Nanostructured Lipid Carriers (NLCs) for drug delivery: Role of Liquid lipid (oil)

2020 ◽  
Vol 17 ◽  
Author(s):  
Anisha D’Souza ◽  
Ranjita Shegokar
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Drug Carrier ◽  
Drug Loading ◽  
Performance Criteria ◽  
Long Term Stability ◽  
Natural Oils ◽  
Optimal Drug

: In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oils are broadly classified in two categories: Natural oils and Essential oils. NLCs offer range advantages in drug delivery due to the formation of imperfect matrix owing to the presence of oil. The type and percentage of oil used determines optimal drug loading and stability. Literature shows that variety of oils is used in NLCs mainly as matrix, which is from natural origin, triglycerides class. On the other hand, essential oils not only serve as a matrix but as an active. In short, oil is the key ingredient in formation of NLCs, hence needs to be selected wisely as per the performance criteria expected.

Chemical Composition, Antibacterial, Insecticidal and Anti-Oxidant Activities of Three Acantholimon Species (A. atropatanum, A. gilliatii and A. tragacanthium)

2020 ◽  
Vol 10 (3) ◽  
pp. 272-278
Author(s):  
Ardalan Pasdaran ◽  
Satyajit D. Sarker ◽  
Lutfun Nahar ◽  
Azadeh Hamedi
Keyword(s):  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Main Compound ◽  
Aerial Parts ◽  
Anti Oxidant ◽  
Gas Chromatography Mass Spectroscopy

Background: The essential oil from the Acantholimon genus have been an integral part of the traditional food additive in Middle East. Most of the plants in Acantholimon genus have not been studied scientifically. The aim of this study is to investigate the chemical composition, antibacterial, insecticidal and anti-oxidant activities of three Acantholimon species including Acantholimon atropatanum, A. gilliatii and A. tragacanthium. Method: The essential oils of the aerial parts were extracted by hydrodistillation. Chemical constitutions were identified by gas chromatography- mass spectroscopy technique, also their toxicities were assessed against the two important grain products pests, Oryzeaphilus mercator and Tribolium castaneum. Antibacterial activity was assessed against the three foodborne bacteria that include Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus based on the disc diffusion assay. Free-radical-scavenging property was identified based on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Results: 2-hexahydrofarnesyl acetone was the main compound in A. gilliatii and A. tragacanthium, whilst farnesyl acetone, heptacosane and germacrene D were the principal components of A. atropatanum essential oil. These oils exhibited 40-90% mortality of O. mercator and/or T. castaneum at a dose of 12 μl/l air after 48h of exposure, and exhibited significant free-radicalscavenging property (RC50 = 3.7 × 10-3 - 8.3 × 10-3 mg/ml). The oils of A. tragacanthium and A. gilliatii showed a weaker antibacterial activity compared to A. atropatanum. Conclusion: A. atropatanum, A. gilliatii and A. tragacanthium essential oils had significant insecticidal and anti-oxidant properties. They also showed week to moderate antibacterial activity against P. aeruginosa and S. aureus.

scholarly journals Foeniculum vulgare Essential Oils: Chemical Composition, Antioxidant and Antimicrobial Activities

2010 ◽  
Vol 5 (2) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Maria Graça Miguel ◽  
Cláudia Cruz ◽  
Leonor Faleiro ◽  
Mariana T. F. Simões ◽  
Ana Cristina Figueiredo ◽  
...  
Keyword(s):  
Essential Oils ◽  
Radical Scavenging ◽  
Antimicrobial Activities ◽  
Point Of View ◽  
Diffusion Method ◽  
Foeniculum Vulgare ◽  
Aerial Parts ◽  
Scavenging Capacity ◽  
Dpph Method ◽  
Main Components

The essential oils from Foeniculum vulgare commercial aerial parts and fruits were isolated by hydrodistillation, with different distillation times (30 min, 1 h, 2 h and 3 h), and analyzed by GC and GC-MS. The antioxidant ability was estimated using four distinct methods. Antibacterial activity was determined by the agar diffusion method. Remarkable differences, and worrying from the quality and safety point of view, were detected in the essential oils. trans-Anethole (31-36%), α-pinene (14-20%) and limonene (11-13%) were the main components of the essentials oil isolated from F. vulgare dried aerial parts, whereas methyl chavicol (= estragole) (79-88%) was dominant in the fruit oils. With the DPPH method the plant oils showed better antioxidant activity than the fruits oils. With the TBARS method and at higher concentrations, fennel essential oils showed a pro-oxidant activity. None of the oils showed a hydroxyl radical scavenging capacity >50%, but they showed an ability to inhibit 5-lipoxygenase. The essential oils showed a very low antimicrobial activity. In general, the essential oils isolated during 2 h were as effective, from the biological activity point of view, as those isolated during 3 h.

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