On a search of biologically active compounds in bryophytes: Chemical composition and major secondary metabolites

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
L Klavina ◽  
L Arbidans ◽  
V Nikolajeva
Keyword(s):  
Chemical Composition ◽  
Secondary Metabolites ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

scholarly journals A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jelmer Hoeksma ◽  
Tim Misset ◽  
Christie Wever ◽  
Johan Kemmink ◽  
John Kruijtzer ◽  
...  
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
High Resolution Mass Spectrometry ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Therapeutic Drug ◽  
Preparative Hplc ◽  
Active Compounds ◽  
Vis Spectroscopy ◽  
Therapeutic Compounds

AbstractThere is a constant need for new therapeutic compounds. Fungi have proven to be an excellent, but underexplored source for biologically active compounds with therapeutic potential. Here, we combine mycology, embryology and chemistry by testing secondary metabolites from more than 10,000 species of fungi for biological activity using developing zebrafish (Danio rerio) embryos. Zebrafish development is an excellent model for high-throughput screening. Development is rapid, multiple cell types are assessed simultaneously and embryos are available in high numbers. We found that 1,526 fungal strains produced secondary metabolites with biological activity in the zebrafish bioassay. The active compounds from 39 selected fungi were purified by liquid-liquid extraction and preparative HPLC. 34 compounds were identified by a combination of chemical analyses, including LCMS, UV-Vis spectroscopy/ spectrophotometry, high resolution mass spectrometry and NMR. Our results demonstrate that fungi express a wide variety of biologically active compounds, consisting of both known therapeutic compounds as well as relatively unexplored compounds. Understanding their biological activity in zebrafish may provide insight into underlying biological processes as well as mode of action. Together, this information may provide the first step towards lead compound development for therapeutic drug development.

THE CHEMICAL COMPOSITION OF HELIANTHUS ANNUUS L

2021 ◽  
pp. 62-66
Author(s):  
А. Туреханова ◽  
Қ. Тоштай ◽  
М. Дуйсебаева ◽  
Т. Тұрсонжан ◽  
Ж. Жеңіс
Keyword(s):  
Chemical Composition ◽  
Organic Acids ◽  
Helianthus Annuus ◽  
Production Technology ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Helianthus Annuus L ◽  
Soap Production ◽  
Active Substances

Согласно литературным данным, подсолнечное масло богато полезными веществами, однако, в зависимости от степени очистки масла, количество этих компонентов варьируется. В данном исследовании был изучен дистиллят жирных кислот подсолнечного масла. Согласно полученным данным, более 40% состава кислот приходится на линолевую кислоту с F-витаминной активностью. В большом количестве содержатся стерины, составляющие 44% неомыляемого остатка. Токоферолы составляют 9% неомыляемого остатка, 93% из них приходится на a-токоферол. Helianthus annuus L необходим для приготовления натурального мыла, сочетает в себе способ приготовления медицинского мыла с технологией производства. Экстракт из стебля растения. Это свежее натуральное мыло содержит много полезных микро-и макроэлементов, биологически активные соединения и макро - и микроэлементы растения Helianthus annuus L были определены атомно-эмиссионным методом. Основными из них были K (44,9 мг/г), (377,745 мг/г), Na (3,91 мг/г), (7,56 мг/г) и Mg (3,06 мг/г), (1,495 мг/г). Эти элементы полезны для нашего организма и обладают целебными свойствами. Кроме того, в составе растения H. Annuus L. были определены биологически активные вещества, такие как флавоноиды, алкалоиды, органические кислоты, кумарины и витамины. Эти выявленные данные позволяют получать мыло с высоким качеством, а также целебными свойствами. Helianthus annuus L salt, which is necessary for the preparation of natural soap, combines the method of preparation of medical soap production technology. The extract from the stem of the plant. This fresh natural soap contains many useful micro and macronutrients, biologically active compounds and macro - and microelements of the plant Helianthus annuus L were determined by atomicemission method. Main of them were K (44.9 mg/g), (377.745 mg/g), Na (3.91 mg/g), (7.56 mg/g) and Mg (3.06 mg/g), (1.495 mg/g). These elements are useful for our body and have healing properties. In addition, biologically active substances such as fiavonoids, alkaloids, organic acids, coumarins, and vitamins were found in the composition of the plant H. annuus L. These identied data allow us to obtain soap with a high composition and quality and healing properties

scholarly journals Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa

2019 ◽  
Vol 15 ◽  
pp. 2782-2789 ◽  
Author(s):  
Tian Cheng ◽  
Clara Chepkirui ◽  
Cony Decock ◽  
Josphat C Matasyoh ◽  
Marc Stadler
Keyword(s):  
Staphylococcus Aureus ◽  
Secondary Metabolites ◽  
Biofilm Formation ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Fruiting Bodies ◽  
Inhibition Assay ◽  
Active Compounds ◽  
New Compounds ◽  
New Metabolites

During the course of screening for new metabolites from basidiomycetes, we isolated and characterized five previously undescribed secondary metabolites, skeletocutins M–Q (1–5), along with the known metabolite tyromycin A (6) from the fruiting bodies of the polypore Skeletocutis sp. The new compounds did not exhibit any antimicrobial, cytotoxic, or nematicidal activities. However, compound 3 moderately inhibited the biofilm formation of Staphylococcus aureus (S. aureus), while compounds 3 and 4 performed moderately in the ʟ-leucine-7-amido-4-methylcoumarin (ʟ-Leu-AMC) inhibition assay. These compounds represent the first secondary metabolites reported to occur in the fruiting bodies by Skeletocutis. Interestingly, tyromycin A (6) was found to be the only common metabolite in fruiting bodies and mycelial cultures of the fungus, and none of the recently reported skeletocutins from the culture of the same strain were detected in the basidiomes.

scholarly journals THE INFLUENCE OF ULTRASONIC TREATMENT ON THE EXTRACTION OF BIOLOGICALLY ACTIVE COMPOUNDS OF PLANTS OF THE FAMILY CARYOPHYLLACEAE

2018 ◽  
pp. 145-151
Author(s):  
Лариса (Larisa) Николаевна (Nikolaevna) Зибарева (Zibareva) ◽  
Елена (Elena) Сергеевна (Sergeevna) Филоненко (Filonenko)
Keyword(s):  
Secondary Metabolites ◽  
Ultrasonic Treatment ◽  
High Performance ◽  
Control Level ◽  
Extraction Process ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Destructive Effect ◽  
Active Compounds ◽  
The Family

The influence of ultrasonic irradiation on extraction of secondary metabolites from plants of the family Caryophyllaceae was study. It is shown that while carrying out extraction and the effects of ultrasound observed acceleration of the extraction process such biologically active compounds as ecdysteroids and flavonoids. The time of extraction of ecdysteroids from the aerial part of Silene viridiflora, Silene sendtneri, Silene roemeri, colpophylla Silene, Silene frivaldszkyana and Lychnis chalcedonica decreased by 6–12 times. Found that ultrasound has a different effect on the process of extraction of compounds from different plant species. Lychnis chalcedonica, with an average level of ecdysteroids, after 60 minutes of exposure is achieved by the extraction of the ecdysteroids is equal to the control, and after 90 min, exceeding its level by 49%. From Silene frivaldszkyana - species with high content of ecdysteroids control level were achieved after 120 min of ultrasonic treatment. High-intensity ultrasound accelerates the process, reduces the volume of solvents and increases the yield of flavonoids in 28–41% in comparison with the control. The destructive effect of ultrasound on the secondary metabolites not observed, as confirmed by UV-spectra and high performance liquid chromatography.

Nickel(0)-Catalyzed Linear-Selective Hydroarylation of Unactivated Alkenes and Styrenes with Arylboron Acids

2018 ◽  
Author(s):  
Honggui Lv ◽  
Li-Jun Xiao ◽  
Dongbing Zhao ◽  
Qi-Lin Zhou
Keyword(s):  
Butyric Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Highly Efficient ◽  
Organoboronic Acids

Herein, we realized the first linear-selective hydroarylation of unactivated alkenes and styrenes with organoboronic acids by introducing directing groupon alkenes. Our method is highly efficient and scalable, and provides a modular route to assemble structurally diverse alkylarenes, especially for γ-aryl butyric acid derivatives, which have been widely utilized as chemical feedstocks to access multiple marketed drugs, and biologically active compounds.<br>

SOME DIRECTIONS IN THE MODIFICATION OF AZOLES

2020 ◽  
Vol 5 (443) ◽  
pp. 85-91
Author(s):  
Ibrayev M.K., ◽  
◽  
Takibayeva A.T., ◽  
Fazylov S.D., ◽  
Rakhimberlinova Zh.B., ◽  
...  
Keyword(s):  
13C Nmr Spectroscopy ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Synthesis Conditions ◽  
Alkaloid Cytisine ◽  
Azole Ring ◽  
Cyclic Compounds ◽  
New Compounds ◽  
Derivatives Of

This article presents studies on the targeted search for new derivatives of azoles, such as benzthiazole, 3,5-dimethylpyrazole, 1,3,4-oxadiazole-2-thione, 1,3,4-thiadiazole. The possibility of combining in one molecule of the azole ring with other cyclic compounds: the alkaloid cytisine, morpholine, furan and some arenes has been studied. To obtain new compounds, the reactions of bromination, acylation, and interaction with isothiocyanates were studied. Optimal synthesis conditions were studied for all reactions. It was found that the reaction of 4-bromo-3,5-dimethylpyrazole with isothiocyanates, in contrast to the previously written derivatives of anilines, takes a longer time and requires heating the reaction mixture. The combination of a pirasol fragment with halide substituents often results in an enhanced therapeutic effect. The synthesized 2-bromine-N-(6-rodanbenzo[d]thiazole-2-yl)acetamide, due to the alkylbromide group, is an important synth in the synthesis of new benzthiazole derivatives. Its derivatives combine in one molecule the rest of rhodanbenzthiazole with alkaloid cytisine and biogenic amine morpholine and are potentially biologically active compounds, since the molecule structure contains several pharmacophoric fragments: benzthiazole and alkaloid (amine) heterocycles, rhodane and urea groups. The mechanism of formation of 1,3,4-oxadiazole-2-tyons from hydrazides under action on them by carbon disulfide was studied and assumed. It was shown that dithiocarbamates in acidic medium decompose with the release of hydrogen sulfide and the formation of highly reactive isothiocyanate group. Then, intra-molecular cyclization occurs, with the formation of end products - 1,3,4-oxadiazole-2-thions. The structures of the synthesized compounds were studied by 1H and 13C NMR spectroscopy. All synthesized substances are potentially biologically active compounds, since they contain several pharmacophore fragments in their structure.

Lactoferrin in Bone Tissue Regeneration

2020 ◽  
Vol 27 (6) ◽  
pp. 838-853 ◽  
Author(s):  
Madalina Icriverzi ◽  
Valentina Dinca ◽  
Magdalena Moisei ◽  
Robert W. Evans ◽  
Mihaela Trif ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Bone Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Bone Tissue Regeneration ◽  
Bone Homeostasis ◽  
Active Compounds

: Among the multiple properties exhibited by lactoferrin (Lf), its involvement in bone regeneration processes is of great interest at the present time. A series of in vitro and in vivo studies have revealed the ability of Lf to promote survival, proliferation and differentiation of osteoblast cells and to inhibit bone resorption mediated by osteoclasts. Although the mechanism underlying the action of Lf in bone cells is still not fully elucidated, it has been shown that its mode of action leading to the survival of osteoblasts is complemented by its mitogenic effect. Activation of several signalling pathways and gene expression, in an LRPdependent or independent manner, has been identified. Unlike the effects on osteoblasts, the action on osteoclasts is different, with Lf leading to a total arrest of osteoclastogenesis. : Due to the positive effect of Lf on osteoblasts, the potential use of Lf alone or in combination with different biologically active compounds in bone tissue regeneration and the treatment of bone diseases is of great interest. Since the bioavailability of Lf in vivo is poor, a nanotechnology- based strategy to improve the biological properties of Lf was developed. The investigated formulations include incorporation of Lf into collagen membranes, gelatin hydrogel, liposomes, loading onto nanofibers, porous microspheres, or coating onto silica/titan based implants. Lf has also been coupled with other biologically active compounds such as biomimetic hydroxyapatite, in order to improve the efficacy of biomaterials used in the regulation of bone homeostasis. : This review aims to provide an up-to-date review of research on the involvement of Lf in bone growth and healing and on its use as a potential therapeutic factor in bone tissue regeneration.

Diverse thiophenes as scaffolds in anti-cancer drug development: A concise review

2020 ◽  
Vol 20 ◽  
Author(s):  
Neha V. Bhilare ◽  
Pratibha B. Auti ◽  
Vinayak S. Marulkar ◽  
Vilas J. Pise
Keyword(s):  
Drug Development ◽  
Anticancer Agents ◽  
Heterocyclic Ring ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Cancer Drug ◽  
Active Compounds ◽  
Natural Origin ◽  
Concise Review ◽  
Anti Cancer

: Thiophenes are one among the abundantly found heterocyclic ring systems in many biologically active compounds. Moreover various substituted thiophenes exert numerous pharmacological actions on account of their isosteric resemblance with compounds of natural origin thus rendering them with diverse actions like antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, antiallergic, hypotensives etc.. In this review we specifically explore the chemotherapeutic potential of variety of structures consisting of thiophene scaffolds as prospective anticancer agents.

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