Computer Assistance in the Clinical Investigation of Pulmonary Function Studies

1973 ◽  
Vol 12 (02) ◽  
pp. 102-107 ◽  
Author(s):  
D. J. Protti ◽  
Nancy Craven ◽  
A. Naimark ◽  
R. M. Cherniack
Keyword(s):  
Information System ◽  
Pulmonary Function ◽  
Additional Data ◽  
Normal Values ◽  
Clinical Investigation ◽  
Regression Equations ◽  
Beneficial Effects ◽  
Computer Assistance ◽  
Manual Methods

A previously described comprehensive respiratory information system (CRIS) has been changed to introduce new spirometric tests which are sensitive to minor abnormalities, revise on the basis of additional data the regression equations which define normal values to various parameters of pulmonary function and refine the system’s interpretation scheme. The beneficial effects of transferring the system from a large IBM 360/65 to a small CDC 1700 are presented. An analysis of the costs of processing routine pulmonary function studies reveals that a 40°/o saving is realized when a computer is used in comparison to the use of the usual manual methods.

scholarly journals Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 210
Author(s):  
Yanyan Wang ◽  
Yun-Ling Tai ◽  
Derrick Zhao ◽  
Yuan Zhang ◽  
Junkai Yan ◽  
...  
Keyword(s):  
Bile Acid ◽  
Mouse Model ◽  
Disease Progression ◽  
Nonalcoholic Steatohepatitis ◽  
Noncoding Rna ◽  
Metabolic Diseases ◽  
Immune Cell ◽  
Stellate Cell ◽  
Clinical Investigation ◽  
Beneficial Effects

Background and Aims: The disease progression of nonalcoholic fatty liver disease (NAFLD) from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is driven by multiple factors. Berberine (BBR) is an ancient Chinese medicine and has various beneficial effects on metabolic diseases, including NAFLD/NASH. However, the underlying mechanisms remain incompletely understood due to the limitation of the NASH animal models used. Methods: A high-fat and high-fructose diet-induced mouse model of NAFLD, the best available preclinical NASH mouse model, was used. RNAseq, histological, and metabolic pathway analyses were used to identify the potential signaling pathways modulated by BBR. LC–MS was used to measure bile acid levels in the serum and liver. The real-time RT-PCR and Western blot analysis were used to validate the RNAseq data. Results: BBR not only significantly reduced hepatic lipid accumulation by modulating fatty acid synthesis and metabolism but also restored the bile acid homeostasis by targeting multiple pathways. In addition, BBR markedly inhibited inflammation by reducing immune cell infiltration and inhibition of neutrophil activation and inflammatory gene expression. Furthermore, BBR was able to inhibit hepatic fibrosis by modulating the expression of multiple genes involved in hepatic stellate cell activation and cholangiocyte proliferation. Consistent with our previous findings, BBR’s beneficial effects are linked with the downregulation of microRNA34a and long noncoding RNA H19, which are two important players in promoting NASH progression and liver fibrosis. Conclusion: BBR is a promising therapeutic agent for NASH by targeting multiple pathways. These results provide a strong foundation for a future clinical investigation.

scholarly journals New Perspectives on Dystonia

2003 ◽  
Vol 30 (S1) ◽  
pp. S34-S44 ◽  
Author(s):  
Mélanie Langlois ◽  
Francois Richer ◽  
Sylvain Chouinard
Keyword(s):  
Age Of Onset ◽  
Clinical Investigation ◽  
Genetic Data ◽  
Therapeutic Agents ◽  
Anatomical Distribution ◽  
Beneficial Effects ◽  
Physiological Abnormalities ◽  
Primary Torsion ◽  
Primary Torsion Dystonia ◽  
Deep Brain

Dystonia is a syndrome of sustained muscular contractions with numerous underlying etiologies. This review examines the varied phenomenology of dystonias, its evolving classification including recent genetic data as well as its clinical investigation and treatment. Although age of onset, anatomical distribution and family history are key elements of the investigation of dystonia, classification increasingly relies on etiologic and genetic criteria. Physiological abnormalities in striatocortical circuits are common in dystonia but the pathophysiology is still unclear. In recent years, a great deal has been learned on the more common primary dystonias such as primary torsion dystonia and on dystonia-plus syndromes such as dopamine responsive dystonia. Treatment of dystonia has also evolved and there are now a number of therapeutic agents with clear beneficial effects including anticholinergics, benzodiazepines, and botulinum toxin and there is growing interest in neurofunctional surgery including deep brain stimulation.

Computer Assistance in Food Analysis

1986 ◽  
Vol 69 (5) ◽  
pp. 754-756
Author(s):  
Laurence R Dusold ◽  
John A G Roach
Keyword(s):  
Pattern Recognition ◽  
Information System ◽  
Laboratory Data ◽  
Chemical Information ◽  
Laboratory Computer ◽  
Food Adulteration ◽  
Pattern Recognition Techniques ◽  
Computer Assistance ◽  
Multivariate Problems ◽  
Chemical Information System

Abstract Laboratory computer links are a key part of acquisition, movement, and interpretation of certain types of data. Remote information retrieval from databases such as the Chemical Information System provides the analyst with structural and toxicologicai information via a laboratory terminal. Remote processing of laboratory data by large computers permits the application of pattern recognition techniques to the solution of complex multivariate problems such as the detection of food adulteration.

scholarly journals 1790 Use of a Spreadsheet Program to Calculate Pediatric Pulmonary Function Normal Values

1985 ◽  
Vol 19 (4) ◽  
pp. 409A-409A
Author(s):  
Donald E Lighter ◽  
William G Perkins ◽  
Sachchida N Sinha
Keyword(s):  
Pulmonary Function ◽  
Normal Values ◽  
Spreadsheet Program

scholarly journals INVENTORY INFORMATION SYSTEM ON WELDING TECHNIQUES WORKSHOP

2020 ◽  
Vol 1 (2) ◽  
pp. 73-80
Author(s):  
Fadli Muhlisin ◽  
Safaruddin H. Al Ikhsan ◽  
Fitrah S. Fajar Kusuma
Keyword(s):  
Information System ◽  
Life Cycle ◽  
System Development ◽  
Object Oriented ◽  
Laboratory Equipment ◽  
Object Oriented Design ◽  
Development Life Cycle ◽  
Manual Methods ◽  
Inventory Number

In managing laboratory equipment at SMK Negeri 1 Gunungputri, they still use manual methods and the toolman or head of the workshop does not collect data continuously, causing data and goods in the field to be incompatible, then there is no inventory number that causes lost items cannot be identified, therefore needed an Information System Inventory of Welding Engineering Workshop. This system uses the System Development Life Cycle method with Object Oriented Design modeling, with an Information System Inventory Workshop Welding Techniques can make it easier to identify every item in the field, reduce errors in terms of storage of goods, search for data and can facilitate the search for goods, especially in the Engineering workshop Welding.

scholarly journals Pulmonary Function of Young Muslim Males During the Month of Ramadan

2016 ◽  
Vol 12 (4) ◽  
pp. 828-836 ◽  
Author(s):  
Anindita Singha Roy ◽  
Amit Bandyopadhyay
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Demographic Data ◽  
Body Height ◽  
Simple Random Sampling ◽  
Intermittent Fasting ◽  
Regression Equations ◽  
Normal Range ◽  
History Of ◽  
And Function

During the month of Ramadan intermittent fasting (RIF), both dietary and sleep patterns are adversely affected to cope with the rituals of Ramadan. Literature suggests that sleep deprivation and alteration of dietary pattern and nutritional impairment affect the pulmonary structure and function. Pulmonary function during RIF was not explored earlier. The present study aimed to investigate the effects of RIF on pulmonary function tests (PFTs) in healthy young Muslim males. Fifty sedentary nonsmoking healthy young Muslim male individuals of 20 to 25 years of age without any history of pulmonary or other major diseases were recruited by simple random sampling from different parts of Kolkata, India. Participants completed the American Thoracic Society questionnaire to record their personal demographic data, health status, and consent to participate in the study. Expirograph and peak flow meter were used to record the pulmonary function parameters (PFTs). PFTs were within the normal range and did not show any significant variation during the RIF. Body height and body mass depicted significant correlation ( p < .05, p < .001) with PFTs. Tidal volume, vital capacity, and peak expiratory flow rate had significant correlation ( p < .05, p < .01, p < .001) with age. Simple and multiple regression equations were computed to predict PFTs in the studies population. RIF did not affect the normal range of PFTs in young Muslim males of Kolkata, India. Standard errors of estimate of the computed regression equations were substantially small enough to recommend these equations as norms to predict the PFTs in the studied population.

Evaluation of the Bergen Cephalometric Norms: A Radiological and Statistical Appraisal

1987 ◽  
Vol 14 (2) ◽  
pp. 95-100
Author(s):  
Seppo Järvinen
Keyword(s):  
Additional Data ◽  
Normal Values ◽  
Young Male ◽  
Class I ◽  
Population Estimates ◽  
Clinical Use ◽  
Original Sample ◽  
Orthodontic Patients ◽  
Cephalometric Measurements

The normal values of the angular radiographic cephalometric measurements in the Bergen analysis, the so called orthognathic combinations, were compared with the associations between these measurements obtained from two population samples. The original sample of the study consisted of 55 untreated orthodontic patients aged 7–14 years and with Angle's Class I malocclusion. Additional data were obtained from Solow's study on young male adults. The comparison indicated differences between the Bergen acceptable combinations and the population estimates. The Bergen norms seemed to be constructed partly on the basis of solely topographical correlations. Therefore, it can he claimed that Bergen cephalometric norms are more artificial than biological, because of which the clinical use of the Bergen analysis requires special caution.

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