A Pediatric Case of Benign Episodic Unilateral Mydriasis with Clinical Characteristics Resembling Tadpole Pupil

2021 ◽  
Author(s):  
Rebecca Lise Gammelgaard Henneberg ◽  
Pernille Kure Vandborg ◽  
Jonas Kjeldbjerg Hansen
Keyword(s):  
Clinical Characteristics ◽  
Autonomic Failure ◽  
Clinical Spectrum ◽  
Pediatric Case ◽  
New Knowledge ◽  
Unilateral Mydriasis ◽  
The Given

AbstractBenign episodic unilateral mydriasis is an episodic disturbance with dilatation of the entire pupil, often lasting for hours. It occurs most frequently in women aged between 20 and 50 years and is closely associated with migraines. Only a few pediatric cases have been reported. The demographics of benign unilateral mydriasis correspond to another episodic disturbance of the pupil, the tadpole pupil. Also, the clinical similarities between the two conditions are numerous. However, tadpole pupil is an irregular distortion of the pupil lasting from seconds to minutes and occurring in clusters. We present a 16-year-old girl with benign unilateral mydriasis and migraine. Her episodes of mydriasis lasted from seconds to minutes, occurred in clusters, and were thus like episodes of tadpole pupil. Benign unilateral mydriasis presenting this way has not been reported previously. This observation links the phenotypes of benign unilateral mydriasis and tadpole pupil closer together. The given case provides new knowledge as it (i) expands the clinical spectrum of benign episodic unilateral mydriasis, (ii) links the phenotypes of benign unilateral mydriasis and tadpole pupil together, and (iii) in comparison with knowledge about autonomic failure in migraine patients may add to hypotheses on pathophysiology in both pupillary disorders.

Towards The New Episteme

2013 ◽  
pp. 45-59
Author(s):  
Zbigniew Król
Keyword(s):  
Knowledge Management ◽  
Tacit Knowledge ◽  
Philosophy Of Language ◽  
Explicit Knowledge ◽  
Professional Collaboration ◽  
Science Knowledge ◽  
Types Of Knowledge ◽  
New Knowledge ◽  
Definition Of ◽  
The Given

The usual horizon of knowledge science is limited to nominalism, empiricism, and naturalistic and evolutionary epistemologies. I propose to broaden this horizon by applying some other philosophical attitudes, such as a non-nominalistic philosophy of language. A basic methodology for the new episteme, including (non-nominalistic) typology and a definition of knowledge and of tacit knowledge, is proposed. Several types of knowledge and the corresponding tacit knowledge are discussed within a broadened philosophical context. There are many types of knowledge and tacit knowledge using different methods of sharing. The main problem with the effective sharing of tacit knowledge is sharing knowledge relevant to the given problem. The transfer, change and transformation of tacit knowledge into explicit knowledge are possible. An example of such a transition, which I call conceptualization, is described. Conceptualization exemplifies how new knowledge can be created with the use of tacit knowledge. A need also exists for a professional collaboration between knowledge science, knowledge management and philosophy.

scholarly journals ARMC5 Primary Bilateral Macronodular Adrenal Hyperplasia Associated with a Meningioma: A Family Report

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
M. J. Ferreira ◽  
J. Pedro ◽  
D. Salazar ◽  
C. Costa ◽  
J. Aragão Rodrigues ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Germline Mutations ◽  
Pathogenic Variant ◽  
Clinical Spectrum ◽  
Genetic Mutations ◽  
Cortisol Secretion ◽  
Adrenal Hyperplasia ◽  
Familial Clustering ◽  
Armadillo Repeat

Primary bilateral adrenal macronodular hyperplasia is characterized by functioning adrenal macronodules and variable cortisol secretion. Familial clustering suggests a genetic cause that has been confirmed with the identification of some genetic mutations, including inactivating germline mutations, in armadillo repeat containing 5 (ARMC5) gene. The identification of the pathogenic variant enables the physician to identify and treat these patients earlier and more effectively. It has also been noticed that patients with germline causative variants show a different clinical spectrum, presenting specific clinical characteristics, as the association with the presence of meningiomas.

Towards The New Episteme

2010 ◽  
Vol 1 (1) ◽  
pp. 43-57
Author(s):  
Zbigniew Król
Keyword(s):  
Knowledge Management ◽  
Tacit Knowledge ◽  
Philosophy Of Language ◽  
Explicit Knowledge ◽  
Professional Collaboration ◽  
Science Knowledge ◽  
Types Of Knowledge ◽  
New Knowledge ◽  
Definition Of ◽  
The Given

The usual horizon of knowledge science is limited to nominalism, empiricism, and naturalistic and evolutionary epistemologies. I propose to broaden this horizon by applying some other philosophical attitudes, such as a non-nominalistic philosophy of language. A basic methodology for the new episteme, including (nonnominalistic) typology and a definition of knowledge and of tacit knowledge, is proposed. Several types of knowledge and the corresponding tacit knowledge are discussed within a broadened philosophical context. There are many types of knowledge and tacit knowledge using different methods of sharing. The main problem with the effective sharing of tacit knowledge is sharing knowledge relevant to the given problem. The transfer, change and transformation of tacit knowledge into explicit knowledge are possible. An example of such a transition, which I call conceptualization, is described. Conceptualization exemplifies how new knowledge can be created with the use of tacit knowledge. A need also exists for a professional collaboration between knowledge science, knowledge management and philosophy.

scholarly journals Critique of the reflexive-referential analysis of phenomenal knowledge

2009 ◽  
Vol 52 (2) ◽  
pp. 53-67
Author(s):  
Miljana Milojevic
Keyword(s):  
Subject Matter ◽  
Semantic Theory ◽  
Main Concern ◽  
Basic Assumptions ◽  
Phenomenal Knowledge ◽  
New Knowledge ◽  
The Subject ◽  
The Given

The main concern of this paper is John Perry's attempt to analyze phenomenal knowledge in a way that avoids the objection which states that the non-deducibility of this kind of knowledge leads to the ontological conclusion that physicalism must be false. The attempt in question determines the content of phenomenal knowledge with a help of the reflexive-referential semantic theory which enables us to explain a growth in knowledge without introducing new (non-physical) facts on the subject matter level as the object of this new knowledge. I will argue that even on the assumption that the case of phenomenal knowledge is just another case of recognition knowledge, as Perry argues, the end result of the analysis suffers from unavoidable inconsistencies and the given analysis of the content of phenomenal knowledge proves to be incompatible with the basic assumptions of the central argumentation.

Teaching Slovak as a foreign language through the prism of project teaching

2021 ◽  
Vol 3/2021 (2) ◽  
pp. 1-10
Author(s):  
Andrea Babiarová
Keyword(s):  
Foreign Language ◽  
Teaching Methods ◽  
Communication Competence ◽  
Educational Process ◽  
School Activities ◽  
New Knowledge ◽  
Language Communication ◽  
The Individual ◽  
The Given ◽  
Communication Culture

The paper reflects on the issue of the educational process, in which it is necessary to apply such teaching methods that will arouse students' interest in learning and acquiring new knowledge. The principles of communication in teaching Slovak as a foreign language should also be placed in the given context aiming to develop students' communication competence. The paper also seeks to justify that, while teaching Slovak as a foreign language, the balance of the individual components (language – communication – culture) needs to be ensured, while the latter is not always given due attention. This unfavourable phenomenon can be eliminated by (out-of)school activities through project teaching, which encourages students to actively participate in the teaching process and enriches their knowledge of culture.

Clinical Characteristics of Noncritical Patients with Coronavirus Disease 2019 (COVID-19): Lessons from Bangladesh

2020 ◽  
Vol 37 (2) ◽  
pp. 42-46
Author(s):  
Md Shahed Morshed ◽  
Abdullah Al Mosabbir ◽  
Prodipta Chowdhury ◽  
Sheikh M Ashadullah ◽  
Mohammad Sorowar Hossain
Keyword(s):  
South Asian ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Clinical Spectrum ◽  
Severe Illness ◽  
Cross Sectional ◽  
Co Morbidity ◽  
Critical Patients ◽  
Loss Of Appetite

The scientific literatures on clinical manifestations of coronavirus disease 2019 (COVID-19) patients from South Asian countries including Bangladesh are limited. Documentation of clinical spectrum from various geographic locations is vital for future scientific studies and clinical management. This study is aimed to report the sociodemographic and clinical characteristics of noncritical patients with COVID-19 in Bangladesh. We conducted a cross-sectional study at three dedicated COVID-19 hospitals of Bangladesh. The severity of the COVID-19 cases was assessed based on the WHO interim guidance. Data were collected only from non-critical COVID-19 patients as critical patients required immediate management. A total of 103 real-time polymerase chain reaction (RT-PCR) confirmed noncritical COVID- 19 patients were included. Most of the patients (71.8%) were male. Mild, moderate and severe illness were assessed in 74.76%, 9.71% and 15.53% of patients respectively. Nearly 52.4% patients had a co-morbidity, with hypertension being the most common (34%), followed by diabetes mellitus (21.4%) and ischemic heart disease (9.7%). Fever (78.6%), weakness (68%) and cough (44.7%) were the most common clinical manifestations. Other common symptoms included loss of appetite (37.9%), difficulty in breathing (37.9%), loss of taste or smell (35.0%), headache (32%) and body ache (32%). The median time from onset of the first symptom to attending hospitals was 7 days (interquartile range: 4 - 10). This study will help both the clinicians and epidemiologists to understand the magnitude and clinical spectrum of COVID-19 patients in South Asian perspective including Bangladesh. Bangladesh J Microbiol, Volume 37 Number 2 December 2020, pp 42-46

The Structure Principle of Knowledge Mesh and its Application

2012 ◽  
Vol 433-440 ◽  
pp. 4428-4433 ◽  
Author(s):  
Ren Zi Yang ◽  
Hong Sen Yan
Keyword(s):  
Topological Space ◽  
Manufacturing Systems ◽  
Transitive Closure ◽  
Basic Knowledge ◽  
New Knowledge ◽  
Inherent Structure ◽  
Complex Relationships ◽  
Knowledgeable Manufacturing ◽  
Essential Mapping ◽  
The Given

Aiming at the rationality of new knowledge mesh, which is obtained from the self-reconfiguration of knowledgeable manufacturing systems, the inherent structure principle of the knowledge mesh is studied. Firstly, the sets of the knowledge points are classified by the equivalent relations, and the function topological space is constructed. The relationships between the sets of the knowledge points and the function topological space are established by the real set. In the function topological space, the conclusions of the base are given, which show the essential mapping relationships of the knowledge mesh, the topological space and the base. After knowing the principle, the structure of the knowledge mesh is reduced by using the equivalent relations, the base and the basic knowledge points. The completeness of the complex relationships in the knowledge mesh is studied by the transitive closure. These conclusions can reduce the structure and enhance the rationality of the knowledge mesh. Finally the given example shows that these theories are effective.

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