The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Abstract Aim The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus. Methods This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups. Results Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher disulfide/native thiol and disulfide/total thiol ratios (p<0.05 for all). Disulfide levels were significantly lower in the newly diagnosed group than in other diabetic groups (p<0.05). There were significant associations between glycemic parameters and thiol-disulfide tests (p<0.05). Conclusions A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide levels may contribute to the disease’s severity. Deteriorated thiol-disulfide homeostasis may be relevant to the pathophysiology of type 2 diabetes mellitus.

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Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients

Diabetes and Vascular Disease Research ◽

10.1177/1479164116675493 ◽

2017 ◽

Vol 14 (2) ◽

pp. 116-121 ◽

Cited By ~ 8

Author(s):

Wen-Jia Chen ◽

Yue Liu ◽

Yu-Bin Sui ◽

Bo Zhang ◽

Xiao-Hui Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Plasma Levels ◽

Control Group ◽

Diabetic Patients ◽

Model Assessment ◽

Newly Diagnosed

Background: Musclin is a newly identified skeletal muscle–derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. Materials and methods: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects. Plasma musclin levels were examined by radioimmunoassay. Results: Compared with the control group, musclin plasma levels were significantly higher in untreated type 2 diabetes mellitus patients. Musclin levels in the plasma of newly diagnosed type 2 diabetes mellitus patients were positively correlated with fasting plasma glucose, haemoglobin A1c, serum insulin, triglycerides and homeostasis model assessment of insulin resistance. Furthermore, multivariate logistic regression analysis showed that the level of musclin was associated with the presence of type 2 diabetes mellitus. Receiver operating characteristic curve analysis yielded an area under the curve for musclin of 0.718 in type 2 diabetes mellitus. Conclusion: The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Our results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.

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ASSESSMENT OF INFLAMMATORY STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i9.26733 ◽

2018 ◽

Vol 11 (9) ◽

pp. 133

Author(s):

Priyadharshini S ◽

Savitha Basker G ◽

Vishnupriya V

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Control Group ◽

Healthy Individuals ◽

Major Health Problem ◽

Inflammatory Status ◽

The Mean ◽

Reliable Marker

Objective: The metabolic disorder, Type 2 diabetes mellitus (T2DM), is a major health problem which is the risk factor for the development of cardiovascular disease, cerebrovascular accident, renal failure, and other macrovascular diseases. Inflammation is the major pathogenesis of all the above conditions. Therefore, there is a need to assess the inflammatory status using simple and reliable marker which would help to diagnose the disease and assess the prognosis of the disease. Hence, the aim of the current study is to estimate the level of simple inflammatory marker, C-reactive protein (CRP) in Type 2 diabetes individual.Materials and Method: Fifty patients, reporting to Saveetha Dental College and Hospitals, were enrolled in the study which includes 25 patients with T2DM and 25 healthy individuals. 5 ml of venous blood was collected and centrifuged. Then, it is analyzed for fasting blood sugar (FBS), glycated hemoglobin (HbA1c), and CRP using the standard kit method. The data obtained were subjected to statistical analysis using the SPSS software.Results: The mean FBS, HbA1c, and CRP levels were higher in T2DM patients in comparison to healthy individuals. The serum FBS, HbA1c, and CRP levels in the control group and T2DM group were 85.08±8.47, 4.27±0.63, and 6.51±0.83 and 168, 7.38±0.9, and 27.23±19.06, respectively. There was a significant (p=0.000) difference in the mean CRP levels of the above groups.Conclusion: CRP level were consistently higher in T2DM individuals; hence, it could be a simple and reliable marker to assess the inflammatory status of the diabetic individuals.

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Prevention Of Coronary Heart Disease And Stroke Complications In Type 2 Diabetes Mellitus: An Observational, Prospective Study

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.1515/rjdnmd-2015-0022 ◽

2015 ◽

Vol 22 (2) ◽

pp. 175-185

Author(s):

Ramona Maria Ştefan ◽

Cristina Niţă ◽

Anca Crăciun ◽

Adriana Rusu ◽

Nicolae Hâncu

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Control Group ◽

Newly Diagnosed ◽

Intensive Group

AbstractBackground and Aims: We assessed the effect of intensive therapy on modifiable cardiovascular (CV) risk factors and CV risk as compared to conventional therapy in patients with newly diagnosed type 2 diabetes mellitus (T2DM).Material and Methods: This was an observational, prospective study, conducted in Romania. During 1-year follow-up period the enrolled participants received either multi-factorial pharmacotherapy associated with intensive therapeutic education (Intensive group), or conventional therapy (Control group). Current analysis included data (anthropometric measurements, blood pressure and biochemical parameters) recorded at months (M) 0, 6 and 12. CV risk was calculated at M1 and M12 using the UK Prospective Diabetes Study Risk Engine.Results: 138 patients aged 57.02±10.05 years were included in this analysis (69 in each group). At M6 and M12 a significant improvement of the majority of the modifiable risk factors in the Intensive group compared to the Control group was observed. At M12, coronary heart disease (CHD)/fatal-CHD risks were significantly lower in the Intensive (7.5%/3.1%) than in the Control (17.95%/10.3%) group (p<0.05). A similar trend was observed for the stroke/fatal-stroke risks.Conclusions: CHD/fatal-CHD and stroke/fatal-stroke risk burden decreased in newly diagnosed diabetic patients following multi-factorial pharmacotherapy association with intensive lifestyle changes during 1-year follow-up.

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The Relationship Between Serum Vitamin D Level and Type 2 Diabetes Mellitus

Medical Science and Discovery ◽

10.36472/msd.v8i2.472 ◽

2021 ◽

Vol 8 (2) ◽

pp. 79-85

Author(s):

Habibe İnci ◽

Fatih İnci

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Logistic Regression ◽

Risk Factor ◽

Control Group ◽

Healthy Individuals ◽

The Relationship

Objective: Vitamin D (VD) could play a role in pathogenesis of Type 2 Diabetes Mellitus (T2DM) by affecting either insulin sensitivity or pancreatic β-cell function. This article is about the relationship between T2DM and VD levels. Material and Methods: The 4678 individuals were included in the study. Of these, 1764 were T2DM patients and 2914 were healthy individuals. Correlation analysis was carried out between VD, age, Body Mass Index (BMI), Hemoglobin A1c (HbA1c), and duration of illness in the T2DM patients. Logistic regression analysis was used to determine the independent predictors. Results: VD levels were significantly lower in the T2DM patients compared to the control group. The VD level of T2DM patients with HbA1c >7% was lower than those with HbA1c <7%. The VD level of T2DM patients using insulin was found to be significantly lower compared to those not using insulin. Among the T2DM patients, VD level was found to be the highest in those without complications and the lowest in those with nephropathy. The cut-off value for VD was calculated as 16.95 ng/mL. According to the logistic regression test, low serum VD levels were found to be an independent risk factor for the development of T2DM and its complications. Conclusion: VD deficiency may be a risk factor for the development of T2DM. In our study, VD levels were significantly lower in the T2DM patients and those having complications of T2DM than the healthy individuals.

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ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i8.456 ◽

2019 ◽

Vol 3 (8) ◽

Author(s):

Shah Namrata Vinubhai ◽

Pardeep Agarwal ◽

Bushra Fiza ◽

Ramkishan Jat

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Sugar ◽

Serum Ferritin ◽

Inflammatory Marker ◽

Control Group ◽

Diabetic Patients ◽

Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

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Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v4i2.36358 ◽

2018 ◽

Vol 4 (2) ◽

pp. 58-62

Author(s):

Roksana Yeasmin ◽

MA Muttalib ◽

Kazi Nazneen Sultana ◽

Nizamul Hoque Bhuiyan ◽

Md Jamil Hasan Karami ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Rheumatoid Factor ◽

Serum Uric Acid ◽

Control Group ◽

Healthy Male ◽

Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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