scholarly journals Effect of red betel leaf extract (Piper crocatum) against interleukin-1 beta (IL-1β) levels and thickness of feet oedema in Mus musculus (swiss strain) rheumatoid arthritis model

2020 ◽  
Author(s):  
Lisa Savitri ◽  
Siti Imroatul Maslikah ◽  
Susilowati
Keyword(s):  
Rheumatoid Arthritis ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Arthritis Model ◽  
Betel Leaf ◽  
Swiss Strain

PENGARUH EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) TERHADAP GLUKOSA DARAH MENCIT (Mus musculus L.) JANTAN YANG DIINDUKSI SUKROSA

BioScience ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 61
Author(s):  
Elsa Yuniarti
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Negative Control ◽  
State University ◽  
Betel Leaf ◽  
Randomized Design ◽  
The Subject ◽  
Effective Drugs ◽  
Zoology Department

Patients withdiabetes mellitus (DM) continues to grow because prosperity and people's lifestyles.Treatment of diabetes often usei njections of insulin and oral antidiabetic drugs. Thetreatment has no side effects. Therefore, it is necessary to find effective drugs using plants thatred betel leaf (Piper crocatum Ruiz & Pav.). Red betel leaf contains flavonoids which are antioxidants. This study aims to determine the effect and dose of extract of red betel leaf (Piper crocatum Ruiz & Pav.) The most effective agains blood glucose in mice(Mus musculusL.) male induced sucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.

Levels of interleukin-1 beta can predict response to tocilizumab therapy in rheumatoid arthritis: the PETITE (predictors of effectiveness of tocilizumab therapy) study

2015 ◽  
Vol 36 (3) ◽  
pp. 349-357 ◽  
Author(s):  
Tadashi Okano ◽  
Kentaro Inui ◽  
Masahiro Tada ◽  
Yuko Sugioka ◽  
Kenji Mamoto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 1 ◽  
Interleukin 1 Beta

scholarly journals The Effect of Green Betel Leaves (Piper betle L.) Extract on Wounding Healing in Mice (Mus musculus L.)

2021 ◽  
Vol 21 (1) ◽  
pp. 103
Author(s):  
Nurul Atika Zar’ah ◽  
Syachruddin Syachruddin ◽  
Kusmiyati Kusmiyati
Keyword(s):  
Wound Healing ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Block Design ◽  
Average Diameter ◽  
Control Group ◽  
P Value ◽  
Piper Betle ◽  
Betel Leaf ◽  
The One

Green betel leaf (Piper betle L.) contains secondary metabolites, namely alkaloids, flavonoids, steroids, terpenoids, saponins, tannins. Green betel leaf (Piper betle L.) is widely used for wound healing, especially in rural Indonesians. This study aims to determine the effect of green betel leaves extract (Piper betle L.) on wound healing in mice (Mus musculus L.). The samples were determined using a randomized block design (RBD) using mice (Mus musculus L.) which consisted of three treatment groups using a concentration of 20%, 30%, 40% and one control group. The Measure of the average diameter of the wound was using a ruler on each side of the diameter. The data measurement for the average diameter of wound restriction was analyzed by using the one way. The one way Anova test showed that the sig or p-value is 0.000 <0.05 (at the alpha level of 5%) so that Ho is rejected which indicates that there is an effect of giving green betel leaf extract (Piper betel L.) on wound healing in mice (Mus musculus L.). Based on the results of the LSD or LSD test, it shows that it is not significant / the same because the sig value is 0.074> 0.05, which means that no change occurs in mice when given 30% or 40% extract. Green betel leaf extract (Piper betle L.) has an effect on wound healing in mice (Mus musculus L.).  

Decreased Interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids

1992 ◽  
Vol 11 (3) ◽  
pp. 393-395 ◽  
Author(s):  
G. T. Espersen ◽  
N. nGrunnet ◽  
H. H. Lervang ◽  
G. L. Nielsen ◽  
B. S. Thomsen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Interleukin 1 ◽  
Dietary Supplementation ◽  
Interleukin 1 Beta

scholarly journals PENGARUH EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) TERHADAP GLUKOSA DARAH MENCIT (Mus musculus L.) JANTAN YANG DIINDUKSI SUKROSA

2018 ◽  
Vol 19 (1) ◽  
pp. 43-55
Author(s):  
Ramadhan Sumarmin
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Negative Control ◽  
State University ◽  
Betel Leaf ◽  
Randomized Design ◽  
The Subject ◽  
Completely Randomized Design ◽  
Zoology Department

Patients withdiabetes mellitus(DM) continues to grow becauseprosperityandpeople's lifestyles.Treatment of diabetesoften useinjectionsof insulinandoralantidiabeticdrugs. Thetreatmenthas no side effects. Therefore, it isnecessary to findeffective drugsusing plantsthatred betelleaf(Piper crocatumRuiz&Pav.). Red betel leafcontains flavonoidswhichare antioxidants. This study aimsto determine the effectand dose ofextractof redbetel leaf(Piper crocatumRuiz&Pav.) The mosteffectiveagainstbloodglucosein mice(Mus musculusL.) maleinducedsucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.

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