PENGARUH EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) TERHADAP GLUKOSA DARAH MENCIT (Mus musculus L.) JANTAN YANG DIINDUKSI SUKROSA

BioScience ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 61
Author(s):  
Elsa Yuniarti
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Negative Control ◽  
State University ◽  
Betel Leaf ◽  
Randomized Design ◽  
The Subject ◽  
Effective Drugs ◽  
Zoology Department

Patients withdiabetes mellitus (DM) continues to grow because prosperity and people's lifestyles.Treatment of diabetes often usei njections of insulin and oral antidiabetic drugs. Thetreatment has no side effects. Therefore, it is necessary to find effective drugs using plants thatred betel leaf (Piper crocatum Ruiz & Pav.). Red betel leaf contains flavonoids which are antioxidants. This study aims to determine the effect and dose of extract of red betel leaf (Piper crocatum Ruiz & Pav.) The most effective agains blood glucose in mice(Mus musculusL.) male induced sucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.

scholarly journals PENGARUH EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) TERHADAP GLUKOSA DARAH MENCIT (Mus musculus L.) JANTAN YANG DIINDUKSI SUKROSA

2018 ◽  
Vol 19 (1) ◽  
pp. 43-55
Author(s):  
Ramadhan Sumarmin
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Negative Control ◽  
State University ◽  
Betel Leaf ◽  
Randomized Design ◽  
The Subject ◽  
Completely Randomized Design ◽  
Zoology Department

Patients withdiabetes mellitus(DM) continues to grow becauseprosperityandpeople's lifestyles.Treatment of diabetesoften useinjectionsof insulinandoralantidiabeticdrugs. Thetreatmenthas no side effects. Therefore, it isnecessary to findeffective drugsusing plantsthatred betelleaf(Piper crocatumRuiz&Pav.). Red betel leafcontains flavonoidswhichare antioxidants. This study aimsto determine the effectand dose ofextractof redbetel leaf(Piper crocatumRuiz&Pav.) The mosteffectiveagainstbloodglucosein mice(Mus musculusL.) maleinducedsucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.

scholarly journals PEMANFAATAN INFUSA DAUN SIRIH MERAH (Piper crocatum) SEBAGAI ANTI-OBESITAS PADA MENCIT (Mus musculus)

2020 ◽  
Vol 10 ◽  
pp. 50-57
Author(s):  
Desty Apritya ◽  
Miarsono Sigit ◽  
Retina Yunani ◽  
Fuji Lestari
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Experimental Animals ◽  
Betel Leaf ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Randomized Design ◽  
Obesity In Mice ◽  
Sugar Levels ◽  
The Relationship

The purpose of this research is to know the effectiveness of red betel leaf infusion (Piper crocatum) as anti-obesity in mice (Mus musculus). Other parameters of this study to know the relationship between changes in blood glucose levels to obesity in experimental animals. Experimental animals used were 24 male mice. The design of this research is completely randomized design (CRD) with 4 treatments 6 repetitions. There are four treatmens P0 (Control), P1 (6 mice by giving a betel leaf infusion with a concentration of 5%), P2 (6 mice by giving a betel leaf infusion with a concentration of 10%), and P3 (6 mice by giving a betel leaf infusion with a concentration of red 15%). The treatment is carried out once every day for 21 days. Before treatment, initial weight was weighed and blood glucose level examination continued on the 7th day, on the 14th day, and on the 21st day. Data obtained from the results of weighing and checking blood sugar levels were further analyzed using the ANOVA test which statistically showed no significant changes (P> 0.05) of body weight and blood glucose levels in mice (Mus musculus) given infusion red betel leaf (Piper crocatum).

scholarly journals Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)

WARTA FARMASI ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 43-52
Author(s):  
Muhammad Azdar Setiawan ◽  
Muhammad Syaiful Saehu ◽  
Kartini Kartini
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose ◽  
Albizia Saman

ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosin 150 mg/kgBB secara Intraperitonial. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: Ekstrak dosis 25 mg/kgBB, 50 mg/kgBB, 100  mg/kgBB, sebagai kontrol positif Glibenclamid 5 mg dan kontrol negatif suspensi Na.CMC 0,5%. Data yang diperoleh dianalisis dengan uji ANOVA. Hasil analisa statistik menunjukan pada konsentrasi ekstrak 100 mg/kgBB memberikan efek yang optimum dengan perlakuan kontrol positif Glibenklamid.  Kata Kunci  : Ekstrak Daun Trembesi, Antidiabetik.  ABSTRACT Trembesi leaf (Albizia saman (Jacq.) Merr) is one of the efficacious plants to reduce blood glucose levels where the chemical content has the potential to reduce blood glucose levels, among others, flavonoids that work by stimulating beta cells of the island langerhans, so that insulin secretion is increased. It aims to determine the antidiabetic effect of trembesi leaf extract (Albizia saman (Jacq.) Merr) in mice (Mus musculus). This research method is an experimental study in which as many as 20 mice were made diabetic using Streptozotosin 150 mg / kgBW intraperitonially. Then divided into 5 treatment groups, namely: Extract dose 25 mg / kg body weight, 50 mg / kg body weight, 100 mg / kg body weight, as positive control Glibenclamid 5 mg and negative control suspension Na.CMC 0.5%. The data obtained were analyzed by ANOVA test. The results of statistical analysis showed that the extract concentration of 100 mg / kgBB gave the optimum effect with the positive control of Glibenclamide. Keywords: Trembesi Leaf Extract, Antidiabetic.

scholarly journals Effectiveness of Graptophyllum pictum (L.) Griff leaf extraction on blood glucose level in alloxan-induced Wistar rat

Food Research ◽  
2020 ◽  
Vol 4 (S3) ◽  
pp. 123-126
Author(s):  
A. Leonoreza ◽  
T. Excelinda ◽  
J. Elnitiarta ◽  
H.S. Heri-Nugroho ◽  
M. Hendrianingtyas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Group ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Negative Control ◽  
Normal Group ◽  
Treatment Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes mellitus is a metabolic disease that always increasing in prevalence. Excessive glucose intake and oxidative stress that can lead to damage to the pancreatic cell or insulin resistance, are such factors that influence the occurrence of diabetes mellitus. Graptophyllum pictum (L.) Griff leaf contains active metabolites such as flavonoid which able to decrease free radical levels. This study aimed to prove the effectiveness of Graptophyllum pictum (L.) Griff leaves extract on blood glucose levels in alloxan-induced Wistar rats. In this study, twenty-five male Wistar rats were divided into five groups. On day 0, the negative control and each treatment group injected with 125 mg/kg dose of alloxan and would be checked on 4th day. On the 4th day after the rats had diabetes, normal group (K-1) was given only standard feed, Negative control (K-2) was given only alloxan intraperitoneally on day 0, first treatment group (K-3) was given 50 mg/kg dose of Graptophyllum pictum (L.) Griff, second treatment group (K-4) was given 100 mg/kg dose of the leaf extract, and the third treatment group (K-5) was given the leaf 200 mg/kg dose of the leaf extract. On the 10th day, fasting blood glucose was taken from the rats. Post-test only group design was used to be the experimental design. There were significant differences in the treatment groups (K-3, K-4, and K-5) compared to the negative control group (K-2) after treatment. The mean of blood glucose levels decreased with the increased doses of Graptophyllum pictum (L.) Griff leaf extract treatment. The treatment groups (K-3, K-4, and K-5) were not significant compared to the normal group (K-1).

scholarly journals Analisis Daya Hambat Ekstrak Daun Sirih Hijau (Piper betle L.) terhadap Mikroorganisme Indikator Mastitis

2020 ◽  
Vol 4 (2) ◽  
pp. 230-236
Author(s):  
Dicky Rizaldi Rambe ◽  
Allaily Allaily ◽  
Cut Intan Novita
Keyword(s):  
Leaf Extract ◽  
Agricultural Product ◽  
Piper Betle ◽  
Product Analysis ◽  
E Coli ◽  
Betel Leaf ◽  
Randomized Design ◽  
Inhibitory Analysis ◽  
Analysis Laboratory ◽  
Range Test

Abstrak. Penelitian tentang Analisis Daya Hambat Ekstrak Daun Sirih Hijau (Piper betle L.) terhadap Mikroorganisme Indikator Mastitis telah dilaksanakan di Laboratorium Ilmu dan Teknologi Pengolahan Susu dan Laboratorium Analisis Pangan dan Hasil Pertanian yang dilaksanakan pada 7 September sampai dengan 10 November 2018. Penelitian ini terdiri dari 4 perlakuan dan 5 ulangan. Data yang diperoleh selanjutnya akan diolah menggunakan Rancangan Acak Lengkap, jika didapatkan hasil yang berbeda maka akan dilanjutkan dengan uji Duncan. Perlakuan R1 yaitu penambahan ekstrak daun sirih hijau 15%, R2 yaitu penambahan ekstrak daun sirih hijau 30%, R3 yaitu penambahan ekstrak daun sirih hijau 45% dan R4 yaitu penambahan ekstrak daun sirih hijau 60%. Hasil penelitian menunjukkan bahwa ekstrak daun sirih hijau dengan konsentrasi 15%, 30%, 45% dan 60% mampu menghambat E. coli dan S. aureus. Berdasarkanhasil penelitian ini dapat disimpulkan bahwa ekstrak daun sirih hijau mampu menghambat pertumbuhan E. coli dan S. aureus.Inhibiting Power Analysis of Green Betel Leaf Extract (Piper betle L.) against Microorganism Indicator MastitisAbstract. Research on Inhibitory Analysis of Green Betel Leaf Extract (Piper betle L.) against Mastitis causing Microorganism has been conducted in Milk Processing Science and Technology Laboratory and  Food and Agricultural Product Analysis Laboratory held on September 7 to November 10, 2018. This research consisted of 4 treatments and 5 replications. The data obtained will then be processed using a Completely Randomized Design, if different results are obtained it will be followed by the Duncan Multiple Range Test. The treatment of R1 is the addition of 15% green betel leaf extract, R2, which is the addition of 30% green betel leaf extract, R3, namely the addition of 45% green betel leaf extract and R4 which is the addition of 60% green betel leaf extract. The results showed that green betel leaf extract with a concentration of 15%, 30%, 45% and 60% was able to inhibit E. coli and S. aureus. Based on the results of this study it can be concluded that green betel leaf extract can inhibit the growth of E. coli and S. aureus.

scholarly journals UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 44-53
Author(s):  
Andri Priyoherianto ◽  
◽  
Panji Ratih Suci ◽  
Putri Rizki Cahya Fatimah ◽  
Atik Nur Wijayanti
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Water Hyacinth ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Normal Limits ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

scholarly journals Blood glucose and total cholesterol content of hyperglycemic white male rat (Rattus norvegicus L.) after orally intakes of methanol meniran (Phyllanthus niruri L.) root extract

2005 ◽  
Vol 3 (1) ◽  
pp. 1-6 ◽  
Author(s):  
CHASBI FAHRI ◽  
SUTARNO SUTARNO ◽  
SHANTI LISTYAWATI
Keyword(s):  
Blood Glucose ◽  
Total Cholesterol ◽  
White Male ◽  
Cholesterol Content ◽  
Positive Control ◽  
Negative Control ◽  
Male Rat ◽  
Root Extract ◽  
Phyllanthus Niruri ◽  
Randomized Design

The aims of this research were to study the effect of methanol meniran (Phyllanthus niruri L.) root extract given to the blood glucose and total cholesterol content, and which level of concentration giving significant effect alloxan treatment. Meniran root contains ellagic acid as antioxidant which provides hypoglycemic capability to reduce diabetic blood glucose. This research was done by using completely randomized design (CRD) including eight treatments as follow: negative control (CMC 1%, 2 mL/200 g bw), positive control (glibenclamide 0,126 mg/200 g bw), normal control, meniran root extract in various concentration (2; 4; 6; 8; 10 mg/200 g bw). Data were elucidated until 15 day of treatment and analyzed using ANOVA followed by DMRT at 5% confidence level. The result indicated that meniran root extract giving significant effect on the reduction of blood glucose, however, it does not appear to have the same result to total cholesterol content. At various concentration of meniran root extract, the total cholesterol of rat remains stable. The optimum concentration to provide hypoglycemic activity raised at 10 mg/200 b bw dose. 

scholarly journals THE PERCENTAGE OF CARCASS PARTS OF MEAL LOCAL DUCKS GIVEN BETEL LEAF SOLUTION INCLUDED IN RATIO

2017 ◽  
Vol 3 (1) ◽  
pp. 41
Author(s):  
Maria Sale ◽  
Ristika Handarini ◽  
Elis Dihansih
Keyword(s):  
Leaf Extract ◽  
Animal Husbandry ◽  
Piper Betle ◽  
Betel Leaf ◽  
Extract Solution ◽  
Randomized Design ◽  
Commercial Feed ◽  
Period Data ◽  
Test Result ◽  
Average Body

This study was aimed at assessing the effects of inclusion of betel leaf extract solution in ration on the percentage of carcass parts of male local ducks. The study was conducted at the Poulty Farm of department of Animal Husbandry, Faculty of Agriculture, Djuanda University, Bogor from June to August 2016. Twenty-four male local ducks aged 2 weeks with average body weight of 450 g were used. The ducks were alocated into battery pens (150 cm x 40 cm) and fed BR-21E ration and betel leaf extract solution. Drinking water was given ad libitum. A completly randomized design with 4 treatments and 3 replicates was used. Treatments consisted of 100% comercial feed (R1) , comercial feed +2.5% piper betel solution (R2), commercial feed+5.0% piper betel solution (R3), and commercial feed + 7,5% piper betel solution (R4). Treatments were given at the second week following the adaption period. Data were subjected to an analysis of variance and a Duncan test. Result showed that the inclusion of betel leaf extract of 2.5, 5, 7.5% in the ration gave significant effects (P<0.05) on the percentage of carcass, wing, and tigh meat but not (P>0,05) on the percentage of back, breast and its parts, thigh, skin and femur. It was recommended that the inclusion of betel leaf extract in the ration be done by 5% in order to obtain high percentage of and more economical carcass, wing and thigh.Keywords : percentage of carcass part, male local duck, piper betle linn leaf solution

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