Polyvinyl alcohol (PVA)/chitosan/sodium tripolyphosphate (STPP) hydrogel formulation with freeze-thaw method for anti-tuberculosis drugs extended release

This paper reports a nontoxic, soft and electroactive hydrogel made with polyvinyl alcohol (PVA) and cellulose nanocrystal (CNC). The CNC incorporating PVA-CNC hydrogels were prepared using a freeze–thaw technique with different CNC concentrations. Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy results proved the good miscibility of CNCs with PVA. The optical transparency, water uptake capacity and mechanical properties of the prepared hydrogels were investigated in this study. The CNC incorporating PVA-CNC hydrogels showed improved displacement output in the presence of an electric field and the displacement increased with an increase in the CNC concentration. The possible actuation mechanism was an electrostatic effect and the displacement improvement of the hydrogel associated with its enhanced dielectric properties and softness. Since the prepared PVA-CNC hydrogel is nontoxic and electroactive, it can be used for biomimetic soft robots, actively reconfigurable lenses and active drug-release applications.

Download Full-text

PREPARATION OF CARBOXYMETHYL CELLULOSE AND POLYVINYL ALCOHOL (CMC/PVA) HYDROGELS USING FREEZE−THAW PROCESSES FOR ADSORPTION OF Zn2+ AND Cu2+

Cellulose Chemistry and Technology ◽

10.35812/cellulosechemtechnol.2021.55.36 ◽

2021 ◽

Vol 55 (3-4) ◽

pp. 375-383

Author(s):

NEDA PAVANDI ◽

ELHAM TAGHAVI ◽

NAVIDEH ANARJAN

Keyword(s):

Polyvinyl Alcohol ◽

Carboxymethyl Cellulose ◽

Numerical Optimization ◽

Polynomial Equations ◽

Swelling Ratio ◽

Process Variables ◽

Freeze Thaw ◽

Gel Fraction ◽

Zero Order Kinetics ◽

Order Polynomial

"The preparation of carboxymethyl cellulose and polyvinyl alcohol (CMC/PVA) composites is proposed in the present work. The CMC/PVA hydrogels were prepared using freeze−thaw processes. The effects of freezing time and of the number of freeze−thaw cycles on the swelling ratio and gel fraction of achieved hydrogels were evaluated using response surface methodology. The multiple regression analysis suggested second order polynomial equations as models for predicting changes of the studied hydrogel characteristics by selected process variables, with relatively high coefficients of determination (R2 > 0.82). The numerical optimization suggested that freezing the polymer solutions for 5 h and repeating the freeze−thaw process for 5 times would give the most desirable hydrogels with highest either swelling ratio or gel fraction. Remarkably, the ion adsorption studies showed that the adsorption of Cu2+ and Zn2+ ions by the hydrogels obeys zero order kinetics and the high capability of the produced optimum hydrogels to adsorb selected ions from synthetic waste was confirmed."

Download Full-text

Physical Properties of Polyvinyl Alcohol Prepared from Freeze-Thaw Cycled Gel

Sen i Gakkaishi ◽

10.2115/fiber.72.p-387 ◽

2016 ◽

Vol 72 (8) ◽

pp. P-387-P-392

Author(s):

TAKAHIKO NAKAOKI

Keyword(s):

Polyvinyl Alcohol ◽

Physical Properties ◽

Freeze Thaw

Download Full-text

A freeze–thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties

RSC Advances ◽

10.1039/d1ra04092h ◽

2021 ◽

Vol 11 (48) ◽

pp. 30156-30171

Author(s):

William Xaveriano Waresindo ◽

Halida Rahmi Luthfianti ◽

Dhewa Edikresnha ◽

Tri Suciati ◽

Fatimah Arofiati Noor ◽

...

Keyword(s):

Antibacterial Activity ◽

Polyvinyl Alcohol ◽

Wound Dressing ◽

Leaf Extract ◽

Antibacterial Properties ◽

Freeze Thaw ◽

Good Antibacterial Activity ◽

Potential Applications ◽

Guava Leaf ◽

Pva Hydrogel

A polyvinyl alcohol (PVA) hydrogel loaded with guava leaf extract (GLE) has potential applications as a wound dressing with good antibacterial activity.

Download Full-text

Characteristics and Cell Growth Behavior of Gelatin/Polyvinyl Alcohol Porous Scaffolds

Science of Advanced Materials ◽

10.1166/sam.2021.3977 ◽

2021 ◽

Vol 13 (5) ◽

pp. 883-888

Author(s):

Soyeun Kim ◽

Deuk Yong Lee ◽

Bae-Yeon Kim ◽

Jung In Yoon

Keyword(s):

Mechanical Properties ◽

Compressive Strength ◽

Cell Growth ◽

Polyvinyl Alcohol ◽

Growth Behavior ◽

Porous Scaffolds ◽

Freeze Thaw ◽

Swelling Rate ◽

G Ratio ◽

Acetal Group

Gelatin/polyvinyl alcohol (PVA) (g/P) porous scaffolds with a glutaraldehyde/g ratio of 3 were synthesized by freeze/thaw and lyophilization to evaluate the effect of the g/P ratio (10/0 to 7/3) on the mechanical properties and cell growth behavior of the scaffolds. Fourier transform infrared spectroscopy results showed that the g/P scaffolds exhibited good crosslinking between gelatin and gelatin (imine), PVA and PVA (acetal group), and gelatin and PVA (imine). The pore size decreased gradually from 170±63 μm, to 140±60 μm, 129±64 μm, and 74 ±23 μm by varying the g/P ratio from 10/0, to 9/1, 8/2, and 7/3, respectively. As the g/P ratio was changed from 10/0 to 7/3, the compressive strength and swelling rate increased gradually from 150± 17 kPa to 290 ±28 kPa and 1268± 11% to 1640 ±35%, respectively. Among the scaffolds, 7/3 g/P scaffolds with tailored properties are suitable for wound healing.

Download Full-text

Citric acid crosslinked carboxymethylcellulose-polyvinyl alcohol hydrogel films for extended release of water soluble basic drugs

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.05.013 ◽

2019 ◽

Vol 52 ◽

pp. 421-430 ◽

Cited By ~ 16

Author(s):

Vishwajeet Sampatrao Ghorpade ◽

Remeth Jacky Dias ◽

Kailas Krishnat Mali ◽

Safina Ismail Mulla

Keyword(s):

Citric Acid ◽

Polyvinyl Alcohol ◽

Extended Release ◽

Water Soluble ◽

Basic Drugs ◽

Hydrogel Films

Download Full-text

Synthesis of Chitosan-Polyvinyl Alcohol Biopolymers to Eliminate Fluorides from Water

Biomolecules ◽

10.3390/biom10010156 ◽

2020 ◽

Vol 10 (1) ◽

pp. 156 ◽

Cited By ~ 3

Author(s):

Cecilia Judith Valdez-Alegría ◽

Rosa María Fuentes-Rivas ◽

José Luis García-Rivas ◽

Rosa Elvira Zavala Arce ◽

María de la Luz Jiménez Núñez ◽

...

Keyword(s):

Polyvinyl Alcohol ◽

Sodium Tripolyphosphate ◽

Diglycidyl Ether ◽

Point Of Zero Charge ◽

Fluoride Adsorption ◽

Zero Charge ◽

Freundlich Adsorption Isotherm ◽

Equilibrium Data ◽

Adsorption Equilibrium Data ◽

Solid Liquid Interface

The fluoride content in groundwater varies depending on geological configuration. Fluoride problems tend to occur in places where these minerals are most abundant in rocks. The objective of the present work was to synthesize four biopolymers based on chitosan-polyvinyl alcohol (Ch-PVA) cross-linked with sodium tripolyphosphate pentabasic (TPP) and ethylene glycol diglycidyl ether (EGDE) and determine their ability to remove fluoride from water. The characterization of the Ch-PVA beads was performed by way of Scanning Electron Microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). The percentage of humidity and the point of zero charge were determined. The Ch-PVA beads showed a surface area of 63.87 m2 g−1, a pore size of 7.6 nm, a point of zero charge of 7.4, and 98.6% humidity. The kinetic adsorption study was adjusted to the pseudo-second-order model and the adsorption equilibrium data were adjusted to the Freundlich adsorption isotherm, showing a maximum fluoride adsorption capacity of 12.64 mg g−1 at pH 7 and 30 °C, for the beads of Ch-PVA-NaOH-TPP. According to the thermodynamic parameters: −∆G°, +∆H° and −∆S°, fluoride adsorption is spontaneous, endothermic in nature and there is no random energy change in the solid/liquid interface during the adsorption process.

Download Full-text