scholarly journals A freeze–thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 30156-30171
Author(s):  
William Xaveriano Waresindo ◽  
Halida Rahmi Luthfianti ◽  
Dhewa Edikresnha ◽  
Tri Suciati ◽  
Fatimah Arofiati Noor ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Leaf Extract ◽  
Antibacterial Properties ◽  
Freeze Thaw ◽  
Good Antibacterial Activity ◽  
Potential Applications ◽  
Guava Leaf ◽  
Pva Hydrogel

A polyvinyl alcohol (PVA) hydrogel loaded with guava leaf extract (GLE) has potential applications as a wound dressing with good antibacterial activity.

scholarly journals Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3109 ◽  
Author(s):  
Andres Bernal-Ballen ◽  
Jorge Lopez-Garcia ◽  
Martha-Andrea Merchan-Merchan ◽  
Marian Lehocky
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Statistical Significance ◽  
Antibacterial Properties ◽  
Intermolecular Forces ◽  
Polymeric System ◽  
Bacterial Strains ◽  
Natural Polymers ◽  
The Matrix ◽  
The Individual

Bio-artificial polymeric systems are a new class of polymeric constituents based on blends of synthetic and natural polymers, designed with the purpose of producing new materials that exhibit enhanced properties with respect to the individual components. In this frame, a combination of polyvinyl alcohol (PVA) and chitosan, blended with a widely used antibiotic, sodium ampicillin, has been developed showing a moderate behavior in terms of antibacterial properties. Thus, aqueous solutions of PVA at 1 wt.% were mixed with acid solutions of chitosan at 1 wt.%, followed by adding ampicillin ranging from 0.3 to 1.0 wt.% related to the total amount of the polymers. The prepared bio-artificial polymeric system was characterized by FTIR, SEM, DSC, contact angle measurements, antibacterial activity against Staphylococcus aureus and Escherichia coli and antibiotic release studies. The statistical significance of the antibacterial activity was determined using a multifactorial analysis of variance with ρ < 0.05 (ANOVA). The characterization techniques did not show alterations in the ampicillin structure and the interactions with polymers were limited to intermolecular forces. Therefore, the antibiotic was efficiently released from the matrix and its antibacterial activity was preserved. The system disclosed moderate antibacterial activity against bacterial strains without adding a high antibiotic concentration. The findings of this study suggest that the system may be effective against healthcare-associated infections, a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.

scholarly journals SYNTHESIS OF POLYVINYL ALCOHOL-CHITOSAN HYDROGEL AND STUDY OF ITS SWELLING AND ANTIBACTERIAL PROPERTIES

2013 ◽  
Vol 7 (1) ◽  
pp. 1 ◽  
Author(s):  
Thamrin Wikanta ◽  
Mr Erizal ◽  
Mr Tjahyono ◽  
Mr Sugiyono
Keyword(s):  
Polyvinyl Alcohol ◽  
Irradiation Dose ◽  
Gamma Ray ◽  
Antibacterial Properties ◽  
Positive Control ◽  
Negative Control ◽  
Initial Time ◽  
Water Evaporation ◽  
Combination Technique ◽  
Pva Hydrogel

The aim of this research was to synthesize a hydrogel for wound dressing by mixing of polyvinyl alcohol (PVA) and chitosan (CTS) and processed by combination technique of freezing-thawing and irradiation by gamma ray, and to study of its properties. PVA aqueous solution 10% (w/v) was mixed with 2% (w/v) chitosan (CTS) solution and homogenized. The PVA-CTS mixture was processed by freezing-thawing up to 3 cycles, and then irradiated by gamma rays at the doseranged of 20-50 kGy  (dose rate was 10 kGy/hour). Result showed that PVA-CTS hydrogel with the gel fraction of 83%, 87%, 90%, and 83% were obtained at the irradiation dose of 20 kGy, 30 kGy, 40 kGy, and 50 kGy, respectively. Increasing of irradiation dose caused increasing of water absorption of hydrogel, i.e. 1.700 %, 1.715 %, 1.913 %, and 2.036 %, respectively, and the hydrogel reached the equilibrium in 25 hours. The hydrogel showed very slow water evaporation rate (~ 2%) at the initial time (1 hour) and then increased very fast (up ~50 %) at 24 h, i.e. 43%, 39.13%, 44%, and 53%, respectively. The elongation at break of hydrogels were obtained 245%, 322%, 322%, and 205% with the maximum value were obtained at irradiation dose ranged of 30-40 kGy. The presence of chitosan in the PVA hydrogel made it having higher antibacterial properties with the inhibitionzone value of 8 mm at irradiation dose of 30-40 kGy compared to PVA hydrogel as a negative control (6 mm) and to chloramphenicol as a positive control (8 mm).

scholarly journals Evaluation of Polyvinyl Alcohol/Cobalt Substituted Hydroxyapatite Nanocomposite as a Potential Wound Dressing for Diabetic Foot Ulcers

2020 ◽  
Vol 21 (22) ◽  
pp. 8831
Author(s):  
Wei-Chun Lin ◽  
Cheng-Ming Tang
Keyword(s):  
Polyvinyl Alcohol ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
E Coli ◽  
Accelerate Wound Healing ◽  
Persistent Infections ◽  
Electrochemically Deposited ◽  
Potential Applications

Diabetic foot ulcers (DFUs) caused by diabetes are prone to serious and persistent infections. If not treated properly, it will cause tissue necrosis or septicemia due to peripheral blood vessel embolism. Therefore, it is an urgent challenge to accelerate wound healing and reduce the risk of bacterial infection in patients. In clinical practice, DFUs mostly use hydrogel dressing to cover the surface of the affected area as an auxiliary treatment. Polyvinyl alcohol (PVA) is a hydrophilic hydrogel polymer widely used in dressings, drug delivery, and medical applications. However, due to its weak bioactivity and antibacterial ability, leads to limited application. Filler adding is a useful way to enhance the biocompatibility of PVA. In our study, cobalt-substituted hydroxyapatite (CoHA) powder was prepared by the electrochemically-deposited method. PVA and PVA-CoHA nanocomposite were prepared by the solvent casting method. The bioactivity of the PVA and composite was evaluated by immersed in simulated body fluid for 7 days. In addition, L929 cells and E. coli were used to evaluate the cytotoxicity and antibacterial tests of PVA and PVA-CoHA nanocomposite. The results show that the addition of CoHA increases the mechanical properties and biological activity of PVA. Biocompatibility evaluation showed no significant cytotoxicity of PVA-CoHA composite. In addition, a small amount of cobalt ion was released to the culture medium from the nanocomposite in the cell culture period and enhanced cell growth. The addition of CoHA also confirmed that it could inhibit the growth of E. coli. PVA-CoHA composite may have potential applications in diabetic trauma healing and wound dressing.

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16940-16949 ◽  
Author(s):  
Rui Zhao ◽  
Xiang Li ◽  
Bolun Sun ◽  
Yan Tong ◽  
Ziqiao Jiang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Fiber Mats ◽  
Good Antibacterial Activity ◽  
Nanofiber Mats ◽  
Layer Fiber

Dual-layer nitrofurazone-loaded nanofiber mats are fabricated by electrospinning with good antibacterial activity and the mats perform well in wound healing.

scholarly journals Synthesis, Characterization and Antibacterial Activity of Carbamate Derivatives of Isatin

2018 ◽  
Vol 34 (4) ◽  
pp. 2026-2030 ◽  
Author(s):  
Sarrah Sattar Jabbar
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Antibacterial Agent ◽  
Antibacterial Properties ◽  
E Coli ◽  
Good Antibacterial Activity ◽  
Diffusion Technique ◽  
Derivatives Of ◽  
Isatin Derivatives

In search of novel antibacterial agent, a series of new isatin derivatives (3a-d) have been synthesized by condensation isatin (2,3-indolinendione) with piperidine (hexahydropyridine), hydrazine hydrate and Boc-amino acids respectively. Compounds synthesized have been characterized by IR spectroscopy and elemental analysis. In addition, the in vitro antibacterial properties have been tested against E. coli, P. aeruginosa, and Bacillus cereus, S. aureus by employing the well diffusion technique. A majority of the synthesized compounds were showing good antibacterial activity and from comparisons of the compounds, compound 3d has been determined to be the most active compound.

scholarly journals Physically crosslinked PVA/graphene-based materials/aloe vera hydrogel with antibacterial activity

RSC Advances ◽  
2021 ◽  
Vol 11 (46) ◽  
pp. 29029-29041
Author(s):  
Wildan Hanif ◽  
Andri Hardiansyah ◽  
Ahmad Randy ◽  
Lia A. T. W. Asri
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Aloe Vera ◽  
Freeze Thaw ◽  
3T3 Fibroblasts ◽  
Physically Crosslinked ◽  
Nih 3T3

PVA/GBM/Av hydrogels were synthesized using a freeze-thaw process. It has antibacterial activity against Staphylococcus aureus and cytocompatibility to NIH 3T3 fibroblasts, showing its potential for wound dressing application.

scholarly journals Uji Antibakteri Sediaan Masker Peel Off Ekstrak Etanol Daun Alpukat (Persea ameicana Mill.) terhadap Bakteri Staphylococcus epidermidis sebagai Antijerawat

Jurnal MIPA ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 101
Author(s):  
Esterlina Aldora Puluh ◽  
Hosea Jaya Edy ◽  
Jainer Pasca Siampa
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Leaf Extract ◽  
Antibacterial Properties ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Persea Americana ◽  
Inhibition Zone Diameter ◽  
Inhibitory Ability ◽  
Activity Test

Daun Alpukat memiliki kandungan antara lain saponin, alkaloid, flavonoid, polifenol, quersetin yang bersifat sebagai antibakteri.  Penelitian ini bertujuan untuk mendapatkan konsentrasi terbaik dari ekstrak etanol daun alpukat (Persea americana Mill.) yang diformulasikan sebagai sediaan masker gel peel off berdasarkan uji aktivitas antibakteri terhadap bakteri Staphylococcus epidermidis. Penelitian ini menggunakan metode ekperimental laboratorium. Formula sediaan masker gel peel off ekstrak daun Alpukat dibuat dengan variasi konsentrasi 0.1%; 0.15%; 0.2%; 0.25% dan 0.3%. Ekstrak tanaman daun alpukat diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Pengujian antibakteri dengan metode sumuran diameter zona hambat yang paling besar yaitu pada konsentrasi 0,3% dengan diameter zona hambat 3 mm ± 0,32 dan kemampuan daya hambat dikategorikan lemah. Dapat disimpulkan bahwa konsentrasi terbaik dari ekstrak etanol daun Alpukat (Persea americana Mill.) yang diformulasikan sebagai sediaan masker gel peel off yaitu pada konsentrasi 0.3% dan dikategorikan kemampuan daya hambat lemahAvocado leaves contains saponins, alkaloids, flavonoids, polyphenols, quercetin which are as antibacterial properties. This study aims to obtain the best concentration of ethanol extract of avocado leaves (Persea americana Mill.) which is formulated as a gel peel off mask preparation based on antibacterial activity test against Staphylococcus epidermidis bacteria. This study uses a laboratory experimental method. Avocado leaf extract peel off mask gel formula is made with a concentration variation of 0.1%; 0.15%; 0.2%; 0.25% and 0.3%. Avocado leaf extract is obtained by maceration using 96% ethanol solvent. Antibacterial testing with the largest inhibition zone diameter wells method is at a concentration of 0.3% with a diameter of inhibition zone 3 mm ± 0.32 and the ability of inhibition is categorized as weak. It can be concluded that the best concentration of ethanol extract of avocado leaves (Persea americana Mill.) Which is formulated as a gel peel off mask preparation is at a concentration of 0.3% and categorized as weak inhibitory ability

Bi-Layered Disulfiram-Loaded Fiber Membranes With Antibacterial Properties for Wound Dressing

2021 ◽  
Author(s):  
Chenchen Xie ◽  
Jin Yan ◽  
Siyuan Cao ◽  
Ri Liu ◽  
Baishun Sun ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Wound Dressing ◽  
Polyvinylidene Fluoride ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Plasma Modification ◽  
Bottom Surface ◽  
Chemical Compositions ◽  
Fiber Membranes ◽  
Loaded Fiber

Abstract In this study, the bi-layered disulfiram-loaded fiber membranes with antibacterial activity and different surface wettabilities are prepared using electrospinning technology. In the application of wound dressing, the hydrophilic surface of fiber membranes is beneficial for the cell adhesion and drug release to heal the wound, meanwhile the hydrophobic outside surface is able to block water penetration to reduce the probability of wound infection. The obtained bi-layered drug-loaded fiber membranes are composed of polyvinylidene fluoride (PVDF) bottom surface and disulfiram (DSF)/polylactic acid (PLA) top surface. To modify the top surface wettability, the oxygen plasma modification of bi-layered membranes was carried out. We analyzed the morphology, wettability and chemical compositions of bi-layered drug-loaded fiber membranes by various techniques. And the bi-layered disulfiram-loaded membranes showed potent antibacterial activity in vitro against both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Thus, the obtained bi-layered disulfiram-loaded fiber membranes are very suitable for wound dressings application.

Antibacterial Activities of Biosynthesized ZnO Nanoparticles Using Leaf and Fruit Extracts of Neolamarckia cadamba

2021 ◽  
Vol 21 (12) ◽  
pp. 6168-6182
Author(s):  
Saee Gharpure ◽  
Rachana Yadwade ◽  
Shuana Mehmood ◽  
Balaprasad Ankamwar
Keyword(s):  
Antibacterial Activity ◽  
Zno Nanoparticles ◽  
Leaf Extract ◽  
Antibacterial Properties ◽  
Fruit Extract ◽  
E Coli ◽  
Fruit Extracts ◽  
Before And After ◽  
Micro Organisms ◽  
Antibacterial Potential

Zinc oxide nanoparticles have been biosynthesized with the help of Neolamarckia cadamba leaf and fruit extracts. ZnO nanoparticles were tested for antibacterial activity before and after calcination against Gram positive (Staphylococcus aureus, Bacillus subtilis) as well as Gram negative micro-organisms (Escherichia coli, Pseudomonas aeruginosa) within the concentration range 0.625–10 mg/mL with the help of well diffusion technique. Higher antibacterial potential has been observed in ZnO nanoparticles synthesized using leaf extract in comparison with those synthesized using fruit extract. Increased antibacterial activity was observed before calcination as compared to after calcination. ZnO synthesized using leaf extract were observed to show significant antibacterial potential against E. coli, S. aureus along with P. aeruginosa before calcination as well as against E. coli after calcination. Similarly, ZnO nanoparticles synthesized using fruit extract exhibited antibacterial activity against E. coli and P. aeruginosa before calcination and against E. coli after calcination. Both the ZnO nanoparticles before and after calcination did not show any antibacterial activity against B. subtilis. Thus, ZnO nanoparticles can serve a dual purpose by its application as an antibacterial agent against susceptible micro-organisms as well as biocompatible carrier system for drug delivery applications in case of non-antibacterial properties by virtue of its inertness as well as easy disposal.

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