Clinical outcomes related to either the 1- or 2-hour postprandial glucose level in women with gestational diabetes

2002 ◽  
Vol 187 (3) ◽  
pp. 817-818
Author(s):  
R.G. Moses ◽  
E.M. Lucas
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Varsha Ghadyale ◽  
Shrihari Takalikar ◽  
Vivek Haldavnekar ◽  
Akalpita Arvindekar

Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics.Cymbopogon martinii(CM) (family Poaceae) is used in traditional Indian medicine in treatment of diabetes mellitus. The alpha glucosidase inhibitory action of the plant is studied. The active component was separated using hot water extraction of the whole plant powder, differential solvent extraction, and silica gel column chromatography. The 30 : 70 toluene : ethyl acetate fraction showed optimum activity. The silica gel chromatography fraction demonstrated 98, 98, and 68% inhibition for starch, maltose, and sucrose, respectively, at 5 mg/kg body weight of rats. Intestinal absorption studies using noneverted intestinal sacs, as well as in vivo studies in streptozotocin-induced diabetic rats using oral glucose tolerance with maltose and sucrose load, revealed better inhibition of alpha glucosidase as compared to acarbose. Kinetic studies using Lineweaver Burk plot showed mixed to noncompetitive type of inhibition by CM. In vivo studies with maltose load of 2 mg and 3 mg/gm body weight showed a noncompetitive pattern of inhibition at 5 mg/kg body weight of CM as against 60 mg/kg body weight of acarbose. Thus CM is more effective alpha glucosidase inhibitor and at lower concentration than acarbose.


2013 ◽  
Vol 80 (3) ◽  
pp. 200-210 ◽  
Author(s):  
Makoto Ohara ◽  
Kentaro Watanabe ◽  
Tatsuya Suzuki ◽  
Ken-ichi Sekimizu ◽  
Masayuki Motoyama ◽  
...  

2020 ◽  
Vol 9 (3) ◽  
pp. 811
Author(s):  
Ni Wayan Trisnadewi ◽  
I Made Sudarma Adiputra ◽  
Ni Putu Wiwik Oktaviani ◽  
Putu Aris Suapriyanti ◽  
Ni Luh Gede Intan Saraswati

2019 ◽  
Vol 18 (4) ◽  
pp. 748-752
Author(s):  
N Tyagita ◽  
KP Utami ◽  
FH Zulkarnain ◽  
SM Rossandini ◽  
NP Pertiwi ◽  
...  

Objective: Okra has been known for its properties in improving diabetes markers. Most study used okra extract instead of its infusion water. Okra infusion water (OIW) contains polysaccharide and viscous fiber that delay gastric emptying, and help controlling glucose and HbA1C level. As the glucose low level, so does the inflammation and oxidative stress on hyperglycemic rats. This study aims to investigate the effect of OIW in improving glucose level, HbA1C, SOD and CRP levels. Materials and methods: Posttest only control group design was applied to this experimental study using 15 male wistar rats divided randomly into 3 groups: Control, Streptozotocine (STZ), Streptozotocine+okra (OKRA). STZ, and OKRA groups induced with 65 mg/kg BW Streptozotocine and 110 mg/kg BW Nicotinamide on day 8. After the desirable glucose level achieved, OKRA were given 3.6 ml OIW on day 12-28. Data were analyzed using ANOVA in each variable. Results: Fasting and Postprandial Glucose level of OKRA (137,40±3,57 mg/dL and 154.58±2.71 mg/dL), STZ (251,77±2,30 mg/dL and 270.18±3.03 mg/dL); HbA1C level of OKRA (7.93±0.25), STZ (21.29±0.65); SOD level of OKRA (55.292±3.77%), STZ (16.472±5.298%); CRP level of OKRA (1,540±0,059 mg/dL), STZ (2,230±0,093 mg/dL) Conclusions: OIW able to improve glucose, HbA1C, SOD, and CRP level on hyperglycemic rats. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.748-752


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