Host–Guest Inclusion System of Scutellarin with Polyamine-β-Cyclodextrin: Preparation, Characterisation, and Anti-cancer Activity

2015 ◽  
Vol 68 (6) ◽  
pp. 946 ◽  
Author(s):  
Xue Ma ◽  
Bo Yang ◽  
Yulin Zhao ◽  
Hudie Xie ◽  
Xiaoshun Gong
Keyword(s):  
Inclusion Complexation ◽  
Two Dimensional ◽  
X Ray Diffraction ◽  
Amino Groups ◽  
X Ray ◽  
Anti Tumour Activity ◽  
Anti Cancer ◽  
Tumour Activity ◽  
Cancer Activity ◽  
Scanning Electron

The inclusion complexation behaviours of scutellarin (SCU) with four polyamine-modified β-cyclodextrins (NH2-βCD, EN-βCD, DETA-βCD, and TETA-βCD; EN = ethylenediamine; DETA = diethylenetriamine; TETA = triethylenetetramine) have been investigated in both solution and solid state by photoluminescence spectroscopy, 1H and two-dimensional NMR spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. The results showed that, with the increase in the number of amino groups, the hosts polyamine-modified β-cyclodextrins (NH2-βCD, EN-βCD, DETA-βCD, TETA-βCD) were able to solubilise SCU to higher levels than native β-CD (9.0 mg mL–1) up to 15.8, 20.4, 44.6, 50.7 mg mL–1 (calculated as SCU), respectively. Besides, the anti-tumour activity of SCU obviously increased after formation of the inclusion complexes. The SCU/CD complexes will be potentially useful for the design of a novel formulation of SCU for clinical treatment.

Novel Hierarchical TiO2/C Nanocomposite with Enhanced Photocatalytic Performance

NANO ◽  
2015 ◽  
Vol 10 (05) ◽  
pp. 1550064 ◽  
Author(s):  
Yupeng Gao ◽  
Hao Chen ◽  
Aiguo Zhou ◽  
Zhengyang Li ◽  
Fanfan Liu ◽  
...  
Keyword(s):  
Photocatalytic Performance ◽  
Photocatalytic Property ◽  
Two Dimensional ◽  
X Ray Diffraction ◽  
Carbon Nanocomposites ◽  
Carbon Nanosheets ◽  
X Ray ◽  
The Hierarchical Structure ◽  
Different Temperatures ◽  
Scanning Electron

Hierarchical TiO 2/carbon nanocomposites were synthesized by oxidation of two-dimensional (2D) Ti 3 C 2 nanosheets at different temperatures. Crystal structures and morphologies of the obtained samples were characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and Raman spectroscopy. The results show that 2D Ti 3 C 2 nanosheets are partially oxidized to form a novel hierarchical nanostructure which is composed of carbon nanosheets and TiO 2 nanoparticles. With the calcination temperature increasing, the crystal structure of TiO 2 nanoparticles changes from anatase to rutile and the hierarchical structure was gradually destroyed. The photodegradation results reveal that the samples obtained at 200°C and 285°C show much better photocatalytic properties than P25. And meanwhile the photocatalytic property will become worse with the increase in calcinations temperature.

Host–Guest Inclusion System of Luteolin with Polyamine-β-cyclodextrin: Preparation, Characterisation, Anti-oxidant and Anti-cancer Activity

2016 ◽  
Vol 69 (2) ◽  
pp. 174 ◽  
Author(s):  
Manshuo Liu ◽  
Rongqiang Liao ◽  
Yulin Zhao ◽  
Bo Yang
Keyword(s):  
Water Solubility ◽  
Inclusion Complexation ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
2D Nmr Spectroscopy ◽  
Binding Ability ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Cancer Activity

The characterisation, inclusion complexation behaviours, and binding ability of inclusion complexes of luteolin (LU) with four polyamine-modified β-cyclodextrins (NH2-βCD, EN-βCD, DETA-βCD, TETA-βCD; where EN = ethylenediamine; DETA = diethylenediamine; TETA = triethylenetetramine) were investigated in both the solid and solution forms by photoluminescence spectroscopy, 1H and 2D NMR spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. The results showed that the water solubility, and the anti-oxidant activity and anti-cancer activity of LU were significantly increased in the inclusion complex with polyamine-β-cyclodextrin. The LU/CDs complex will be useful for its application as herbal medicine or healthcare product.

scholarly journals ENHANCEMENT OF LORNOXICAM SOLUBILITY BY INCLUSION COMPLEXATION WITH CYCLODEXTRIN: PREPARATION AND CHARACTERIZATION

2016 ◽  
Vol 9 (1) ◽  
pp. 132 ◽  
Author(s):  
Shahira Fawzy El-menshawe ◽  
Essam Eissa ◽  
Adel A. Ali ◽  
Ahmed A. Abderhman
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Freeze Drying ◽  
Inclusion Complexation ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Physical Mixing ◽  
Solid Complexes ◽  
Scanning Electron

<p><strong>Objective: </strong>Lornoxicam is a potent anti-inflammatory drug which has analgesic and antipyretic properties. It is water-insoluble powder. The inclusion complexes of lornoxicam (LOR) with β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPCD) were prepared and characterised in order to improve the solubility of the drug and enhance its bioavailability.</p><p><strong>Methods: </strong>Complexes were prepared by physical mixing and freeze-drying in three different drug/polymer ratios (1:1, 1:2 and 3:2). The solid complexes were characterised through differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray diffraction, nuclear magnetic resonance (NMR) spectroscopy, and Fourier transformed infrared (FTIR) spectroscopy.</p><p><strong>Results: </strong>The data showed that LOR may be complexed with cyclodextrin (CD) forming soluble complexes. The lyophilized 1:2 LOR/HPCD complex is the most soluble.</p><p><strong>Conclusion: </strong>Solubility increases with lyophilization than with physical mixing and by the use of HPCD than βCD in complexation.</p>

scholarly journals Chitosan Grafted Adsorbents for Diclofenac Pharmaceutical Compound Removal from Single-Component Aqueous Solutions and Mixtures

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 497 ◽  
Author(s):  
Areti Tzereme ◽  
Evi Christodoulou ◽  
George Kyzas ◽  
Margaritis Kostoglou ◽  
Dimitrios Bikiaris ◽  
...  
Keyword(s):  
Succinic Anhydride ◽  
Pharmaceutical Compounds ◽  
Aqueous Mixtures ◽  
X Ray Diffraction ◽  
Amino Groups ◽  
X Ray ◽  
Aconitic Acid ◽  
Optimum Ph ◽  
Before And After ◽  
Scanning Electron

The main purpose of this study was to investigate the synthesis of some cross-linked carboxyl-grafted chitosan derivatives to be used as selective adsorbents for diclofenac (DCF) pharmaceutical compounds from aqueous mixtures. Four different materials were synthesized using succinic anhydride (CsSUC), maleic anhydride (CsMAL), itaconic acid (CsITA), and trans-aconitic acid (CsTACON) as grafting agents. After synthesis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were performed before and after DCF adsorption. In addition, a complete adsorption evaluation was carried out for all materials studying some important parameters. The optimum pH was 4; the amino groups of DCF can be protonated at pH = 4 (–NH+), so this groups can easily attract the clear negatively carboxyl moieties (–COO−) of the chitosan adsorbents. The Qm for CsTACON was higher than those of the other materials, at all temperatures studied. By altering the temperature from 25 to 35 °C, an increase (16%) of Qm (from 84.56 to 98.34 mg g−1) was noted, while similar behavior was revealed after a further increase of temperature from 35 to 45 °C, improving by 5% (from 98.34 to 102.75 mg g−1). All isotherms were fitted to Langmuir, Freundlich, and Langmuir-Freundlich (L-F) models). In addition, a kinetic model was proposed taking into account not only the interactions but also the diffusivity of the molecule (DCF) into the polymeric network. The behavior of the prepared chitosan materials in simultaneously removing other compounds (synergetic or antagonistic) was also evaluated by experiments performed in mixtures. DCF presented the highest removal from the mixture in the order: CsTACON (92.8%) > CsITA (89.5%) > CsSUC (80.9%) > CsMAL (66.2%) compared to other pharmaceutical compounds (salicylic acid, ibuprofen and ketoprofen). Desorption was achieved by using different eluants (either water or organic). The highest desorption ability was found for acetone (100% for CsTACON, CsSUC, CsMAL and 77% for CsITA) for all materials.

scholarly journals X-Ray Structure and In Vitro Anti-Tumoural Activity of the Dimeric Bis[(2-Phenyl-1,2-Dicarba-Closo-Dodecaborane-1-Carboxylato)-Di-n-Butyltin] Oxide

1997 ◽  
Vol 4 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Edward R. T. Tiekink ◽  
Marcel Gielen ◽  
Abdeslam Bouhdid ◽  
Rudolph Willem ◽  
Vladimir I. Bregadze ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carboxylate Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
Anti Tumour Activity ◽  
Common Motif ◽  
The Common ◽  
Tumour Activity ◽  
Oxygen Atoms

X-ray diffraction studies reveal the structure of {[(2-C6H5-1,2-C2B10H10-1-COO)Bu2Sn]2O}2, 1, to conform to the common motif found for {[(R′COO)R2Sn]2O}2 compounds. The dimer features a central Bu4Sn2O2 unit (two-fold symmetry) with the two Bu2Sn groups being linked via bridging oxygen atoms, each of which also carries an exocyclic Bu2Sn moiety. The two pairs of exo- and endo-cyclic tin atoms are each linked via an almost symmetrically bridging carboxylate ligand and the two remaining ligands coordinate an exocyclic tin atom only, in the monodentate mode. The in vitro anti-tumour activity of 1, determined against a variety of cell lines, is compared with those of the corresponding 2-methylcarboranylacetate, derivative 2, and with clinically used compounds.

Synthesis and catalytic performance of MCM-41 modified with tetracarboxylphthalocyanine

2013 ◽  
Vol 67 (4) ◽  
Author(s):  
Ya-Ping Zhang ◽  
Ke-Chuang Xue ◽  
Wei-Ping Zhang ◽  
Chao Song ◽  
Rong-Lan Zhang ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Catalytic Performance ◽  
Conversion Ratio ◽  
X Ray Diffraction ◽  
Amino Groups ◽  
N2 Adsorption ◽  
X Ray ◽  
Adsorption Desorption ◽  
Mcm 41 ◽  
Scanning Electron

AbstractA series of tetracarboxylphthalocyanines (MPc(COOH)4, M = H, Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)) were anchored onto MCM-41 by the following procedures: functionalization of MCM-41 with (EtO)3SiCH2CH2CH2NH2 reacting with surface Si-OH, and anchoring MPc(COOH)4 onto MCM-41 with a substitution reaction between chloroformyl and amino groups. The samples were characterized by infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy, N2 adsorption-desorption, and X-ray photoelectron spectroscopy. Catalytic activity of oxidation was tested using solutions of ethanethiol in petroleum ether and thiophene in octane; CoPc-CONH-MCM-41 displayed the highest conversion ratio of 90.15 % and 93.79 %, respectively.

SELF-ASSEMBLY OF BISMUTH SELENIDE TWO-DIMENSIONAL SUPERSTRUCTURE FROM HEXAGONAL NANOSHEETS

2011 ◽  
Vol 04 (03) ◽  
pp. 245-248
Author(s):  
JUNJIE SHEN ◽  
QIAN SUN ◽  
TIEJUN ZHU ◽  
XINBING ZHAO
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Two Dimensional ◽  
X Ray Diffraction ◽  
Facile Hydrothermal Method ◽  
Lattice Match ◽  
X Ray ◽  
Good Lattice ◽  
Self Assembled ◽  
Scanning Electron

A kind of novel superstructure array composed of hexagonal Bi2Se3 nanosheets were fabricated via a facile hydrothermal method. The structure was characterized by X-ray diffraction and field emission scanning electron micrioscopy. It is suggested that the two dimensional superstructure was self-assembled by sheet-like Bi2Se3 building blocks on naturally-formed Bi2SeO2 precusor template. The present result indicates one promising way in design and growth of self-assembled superstructures by controllable crystal growth from deoxided substrates with good lattice match.

The Use of Advanced Analytical Techniques for Characterization of the Chemical, Physical, and Crystallographic Nature of a Surface

1973 ◽  
Vol 31 ◽  
pp. 132-133 ◽  
Author(s):  
R. E. Herfert
Keyword(s):  
Surface Characterization ◽  
Analytical Techniques ◽  
X Ray Diffraction ◽  
Depth Of Penetration ◽  
X Ray ◽  
The Past ◽  
Transmission Electron ◽  
Scanning Electron

Studies of the nature of a surface, either metallic or nonmetallic, in the past, have been limited to the instrumentation available for these measurements. In the past, optical microscopy, replica transmission electron microscopy, electron or X-ray diffraction and optical or X-ray spectroscopy have provided the means of surface characterization. Actually, some of these techniques are not purely surface; the depth of penetration may be a few thousands of an inch. Within the last five years, instrumentation has been made available which now makes it practical for use to study the outer few 100A of layers and characterize it completely from a chemical, physical, and crystallographic standpoint. The scanning electron microscope (SEM) provides a means of viewing the surface of a material in situ to magnifications as high as 250,000X.

Identification of calcium oxalate crystals in dried or fixed tobacco leaf

1984 ◽  
Vol 42 ◽  
pp. 288-289
Author(s):  
Vicki L. Baliga ◽  
Mary Ellen Counts
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Calcium Oxalate ◽  
Growth And Development ◽  
Polarized Light ◽  
Calcium Oxalate Crystals ◽  
X Ray Diffraction ◽  
X Ray ◽  
Transmission Electron ◽  
Scanning Electron

Calcium is an important element in the growth and development of plants and one form of calcium is calcium oxalate. Calcium oxalate has been found in leaf seed, stem material plant tissue culture, fungi and lichen using one or more of the following methods—polarized light microscopy (PLM), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and x-ray diffraction.Two methods are presented here for qualitatively estimating calcium oxalate in dried or fixed tobacco (Nicotiana) leaf from different stalk positions using PLM. SEM, coupled with energy dispersive x-ray spectrometry (EDS), and powder x-ray diffraction were used to verify that the crystals observed in the dried leaf with PLM were calcium oxalate.

Sem and X-Ray Analysis of Renal and Biliary Calculi

1976 ◽  
Vol 34 ◽  
pp. 306-307
Author(s):  
R. J. Narconis ◽  
G. L. Johnson
Keyword(s):  
Chemical Constituents ◽  
Natural State ◽  
X Ray Diffraction ◽  
Chemical Methods ◽  
X Ray ◽  
Additional Dimension ◽  
Biliary Calculi ◽  
Calculus Formation ◽  
Scanning Electron

Analysis of the constituents of renal and biliary calculi may be of help in the management of patients with calculous disease. Several methods of analysis are available for identifying these constituents. Most common are chemical methods, optical crystallography, x-ray diffraction, and infrared spectroscopy. The application of a SEM with x-ray analysis capabilities should be considered as an additional alternative.A scanning electron microscope equipped with an x-ray “mapping” attachment offers an additional dimension in its ability to locate elemental constituents geographically, and thus, provide a clue in determination of possible metabolic etiology in calculus formation. The ability of this method to give an undisturbed view of adjacent layers of elements in their natural state is of advantage in determining the sequence of formation of subsequent layers of chemical constituents.

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