131 CHARACTERISTICS OF PREGNANCIES AND OFFSPRING FOLLOWING TRANSFER OF BOVINE IN VIVO EMBRYOS ASSESSED BY NANORESPIROMETRY

2008 ◽  
Vol 20 (1) ◽  
pp. 146
Author(s):  
A. S. Lopes ◽  
S. E. Madsen ◽  
T. Greve ◽  
H. Callesen
Keyword(s):  
Birth Weight ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Gestation Length ◽  
Newborn Animal ◽  
Respiration Rates ◽  
Stage Of Development ◽  
Newborn Calves ◽  
Chi Square Analysis

It has been speculated whether the metabolism of the pre-implantation embryo may be reflected on the pregnancy and characteristics of the newborn animal. The present study investigated whether respiration rates of individual embryos were correlated with gestation length, type of parturition, birth weight, sex, and viability of the offspring. In-vivo embryos (n = 47) were recovered on day 7 from 11 superovulated and inseminated Holstein-Friesian cows and embryonic respiration rates were measured individually by nanorespirometry. The embryos were classified according to morphological quality (I, II, III), stage of development, and diameter and were subsequently transferred individually (n = 43) to synchronized recipients. Gestation length of the recipients (n = 22) was calculated and the type of parturition (no assistance, light traction, heavy traction, or caesarean section) recorded. Sex, weight, and condition of the calves at birth (weak, normal, or very active) were also assessed. Results were evaluated by chi-square analysis and using a linear mixed model. The pregnancy rate was 60% (26/43), and the respiration rates of individual embryos influenced gestation length as well as the interaction of weight at birth and type of parturition (P < 0.05). Embryos with higher respiration rates tended to be associated with a slightly more difficult type of parturition, which was not affected by sex. When embryos were divided into two even-sized categories according to their respiration rates (high v. low), low embryonic respiration rates were associated with low birth weight in 73% of the newborn calves (Table 1). Neither sex nor condition of the calves was directly affected by the embryonic respiration rates. The diameter and morphology of the embryo affected birth weight (P < 0.05), with quality I embryos associated with heavier calves when compared to quality III embryos. Furthermore, light traction was more frequently used to retrieve heavier animals (P < 0.05), and male calves were 3.2 kg heavier than females (P < 0.05). These results suggest that the metabolism of the embryo might affect the weight of the newborn animal and consequently the type of parturition. However, birth weight is highly influenced by the recipients and season, and thus a more accurate correlation is likely to be established when the weight of the postpubertal offspring is considered. Table 1. Birth weight of newborn calves according to respiratory category of bovine in-vivo embryos

The effect of feeding salmon oil to sows throughout pregnancy on pre-weaning mortality of piglets

2001 ◽  
Vol 73 (3) ◽  
pp. 489-500 ◽  
Author(s):  
J.A. Rooke ◽  
A.G. Sinclair ◽  
S.A. Edwards ◽  
R. Cordoba ◽  
S. Pkiyach ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Birth Weight ◽  
Polyunsaturated Fatty Acids ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Gestation Length ◽  
Nutritional Study ◽  
Pregnancy And Lactation ◽  
And Performance ◽  
Long Chain

AbstractSalmon oil (16·5 kg /t), a source of long-chain polyunsaturated n-3 fatty acids, was included in diets offered to multiparous sows during pregnancy and lactation to measure responses in pre-weaning mortality and performance of piglets in two studies. The first study, carried out under commercial conditions, included 196 sows which were offered salmon oil and control diets from immediately post service until weaning. The same diets were also offered to 10 sows per treatment from day 58 of pregnancy in a controlled nutritional study which measured the effects of salmon oil on piglet tissue fatty acid composition. Offering salmon oil to the sow significantly increased gestation length and decreased individual piglet birth weight but had no effect on litter size at birth. Overall, salmon oil reduced pre-weaning mortality from 11·7% to 10·2% mainly by reducing the incidence of deaths from crushing by the sow. More detailed analysis of mortality using a general linear mixed model and 2294 piglet records, demonstrated that the incidence of pre-weaning mortality was significantly decreased with increasing individual piglet birth weight and by inclusion of salmon oil in the diet; the incidence of mortality increased with average piglet birth weight in a litter. Salmon oil inclusion had no effect on weight of litter weaned, sow lactation food intake or subsequent reproductive performance. In both studies, dietary salmon oil increased the proportions of long-chain n-3 polyunsaturated fatty acids in colostrum to a similar extent. In the nutritional study, inclusion of salmon oil reduced the proportions of 20: 4 n-6 in piglet liver and brain at birth and increased the proportions of long-chain n-3 polyunsaturated fatty acids. Therefore, despite reducing piglet birth weight, offering sows salmon oil reduced pre-weaning mortality of piglets. The nutritional study showed that the amount and type of marine oil used may not have been optimal.

scholarly journals Subjective Well-Being in Early Adolescence: Observations from a Five-Year Longitudinal Study

2020 ◽  
Vol 17 (21) ◽  
pp. 8249
Author(s):  
Mònica González-Carrasco ◽  
Marc Sáez ◽  
Ferran Casas
Keyword(s):  
Data Collection ◽  
Longitudinal Studies ◽  
Early Adolescence ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Well Being ◽  
Subjective Well Being ◽  
Cross Sectional ◽  
Additional Information ◽  
Stage Of Development

This article aims to redress the lack of longitudinal studies on adolescents’ subjective well-being (SWB) and highlight the relevance of knowledge deriving from such research in designing public policies for improving their health and wellbeing in accordance with the stage of development they are in. To achieve this, the evolution of SWB during early adolescence (in adolescents aged between 10 and 14 in the first data collection) was explored over a five year period, considering boys and girls together and separately. This involved comparing different SWB scales and contrasting results when considering the year of data collection versus the cohort (year of birth) participants belonged to. The methodology comprised a generalized linear mixed model using the INLA (Integrated Nested Laplace Approximation) estimation within a Bayesian framework. Results support the existence of a decreasing-with-age trend, which has been previously intuited in cross-sectional studies and observed in only a few longitudinal studies and contrasts with the increasing-with-age tendency observed in late adolescence. This decrease is also found to be more pronounced for girls, with relevant differences found between instruments. The decreasing-with-age trend observed when the year of data collection is taken into account is also observed when considering the cohort, but the latter provides additional information. The results obtained suggest that there is a need to continue studying the evolution of SWB in early adolescence with samples from other cultures; this, in turn, will make it possible to establish the extent to which the observed decreasing-with-age trend among early adolescents is influenced by cultural factors.

scholarly journals 15 EFFECT OF SEMEN THAW METHOD ON CONCEPTION RATE IN DAIRY HEIFER HERDS

2005 ◽  
Vol 17 (2) ◽  
pp. 157 ◽  
Author(s):  
M. Kaproth ◽  
H. Rycroft ◽  
G. Gilbert ◽  
G. Abdel-Azim ◽  
B. Putnam ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Mixed Model ◽  
Semen Quality ◽  
Sperm Quality ◽  
Field Trials ◽  
Conception Rate ◽  
Warm Water ◽  
Dairy Heifer

Semen processed with procedures permitting a flexible thaw method is used to breed millions of cows yearly. “Pocket thawing” is widely used as an alternative to warm-water thawing with such semen. To pocket thaw, a straw is retrieved from cryostorage, immediately wrapped in a folded paper towel, and moved to a thermally protected pocket for 2 to 3 min of thawing within the pocket before AI gun loading. Published field data are lacking for comparisons of such a thaw method with those for semen prepared to permit flexible-thawing. We measured the effect of warm-water or pocket thaw on conception rate in four dairy heifer herds using semen prepared with methods previously optimized for flexible-thawing success. Semen processing (Anderson S et al. 1994 J. Dairy Sci. 77, 2302–2307) includes two-step whole-milk extension, static vapor tank freezing (0.5-mL straws), and IMV Digitcool mechanical freezing (0.25-mL straws). It is unclear which specific processing steps permit flexible thawing. These procedures have been developed using breeding results from decades of field trials by professional inseminators using both pocket and warm-water thaw. Semen prepared from each of 12 sires produced equal straw units at 10 and 15 million total sperm per straw, in both 0.5- and 0.25-mL straw packages. Professional inseminators used each combination evenly over 16 months. Additional commercial semen (55% of total) from the same source was used. The thaw methods alternated weekly. Thaw effect on conception status, from 70 day non-return data for 11,215 services (67.6% conception rate), was estimated by a generalized linear mixed model. Neither thaw method nor total sperm per straw significantly affected conception rate (P = 0.658, 0.769, respectively). Bull, herd, inseminator within herd, year, season, and straw size did significantly affect conception rate (P < 0.05). No thaw method interactions with herd, sperm number, season, and straw package size were significant (P = 0.297, 0.526, 0.365, 0.723, respectively). This suggests that if semen has been prepared with procedures specific to flexible-thawing, it can be either pocket thawed or warm-water thawed within a range of herdsman or inseminator practices, season, or straw packaging choices. Even at 10 million, the lowest total sperm per straw, pocket thaw was equally as successful as warm-water thaw. We generally observe that in vitro sperm quality, as expected, is maximal for rapidly thawed straws, with slower thawing resulting in lower values. However, while it appears that conventional measures of in vitro semen quality are improved with fast thaw rates, these measures do not appear to correspond to higher in vivo fertility for semen prepared intentionally to be flexibly thawed. We conclude that, for semen prepared with procedures that permit flexible thawing, the thaw method, whether pocket or warm-water thaw, does not affect conception under commercial conditions and with routine semen handling methods. We thank the herd owners and their staff, the inseminators, and Hap Allen, Ron Hunt, Gordon Nickerson, and Bryan Krick of Genex for their help and cooperation.

scholarly journals Evaluation of gestation length and birth weight of offspring of Polish native cattle breeds in context of estimating genetic parameters

2018 ◽  
Vol 63 (No. 8) ◽  
pp. 323-330
Author(s):  
Nienartowicz-Zdrojewska Anna ◽  
Sobek Zbigniew ◽  
Różańska-Zawieja Jolanta
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Gestation Length ◽  
Black And White ◽  
Research Material ◽  
Native Cattle ◽  
Newborn Calves ◽  
Calving Season ◽  
Calving Difficulty ◽  
Birth Body Weight

Research material included data on gestation length of 15 436 cows of Polish native breeds. These were: White Backed (BG; 324 records), Polish Red (RP; 5396 records), Polish Black and White (ZB; 3508 records), and Polish Red and White (ZR; 6208 records). The calvings took place in 2005–2009, and we analysed two calving seasons, lactation number, the degree of calving difficulty, sex, and body weight of newborn calves. The effect of birth year on gestation length and birth weight of offspring was statistically significant, whereas calving season had statistically highly significant effect on both. Gestation length in the analysed breeds was 281.02, 283.35, 280.5, 281.53 for BG, RP, ZB, and ZR, respectively. The birth body weight heritability was 0.13 (RP), 0.33 (ZB) and 0.40 (ZR).

scholarly journals BREED OF DAM, AGE OF DAM AND SEX OF CALF EFFECTS IN THE CANADIAN SIMMENTAL YOUNG SIRE PROVING PROGRAM

1984 ◽  
Vol 64 (1) ◽  
pp. 1-8
Author(s):  
R. A. KEMP ◽  
L. R. SCHAEFFER ◽  
J. W. WILTON
Keyword(s):  
Birth Weight ◽  
Key Words ◽  
Mixed Model ◽  
Genetic Relationships ◽  
Residual Effects ◽  
Gestation Length ◽  
Calving Ease ◽  
Sire Evaluation ◽  
Unbiased Estimates ◽  
Best Linear Unbiased

Canadian Simmental Association Young Sire Proving Program records (1978–1982) were used to estimate breed of dam by age of dam by sex of calf effects for several traits. Two models were used. Model 1 included fixed herd-years, breed of dam by age of dam by sex of calf (BAX) plus random sire and residual effects. Model 2 included fixed herd-year by sex of calf and breed of dam by age of dam (BA) plus random sire and residual effects. Both models included additive genetic relationships among sires and maternal grandsires. Traits used with Model 1 were gestation length (GL), calving ease (CE), birth weight (BW), gain on dam (GD) and 200-day weight (WW). Model 2 was used for gain on test (GT) and 365-day weight (YW). Mixed model techniques were used to obtain best linear unbiased estimates of BAX and BA from models 1 and 2, respectively. Hypothesis tests were conducted using two breed of dam groups ([Formula: see text] Simmental (S) and [Formula: see text] British breeds (B)) and four age of dam groups (2, 3, 4 and 5 + yr which correspond to < 31, 31–42, 43–54 and > 54 mo, respectively). Three-way subclasses (BAX) were significant (P < 0.01) for GL, CE, BW, GD and WW as were two-way subclasses (BA) for YW. Estimated differences for breed of dam by age of dam by six of calf subclasses (for GL, CE, BW, GD, WW) and breed of dam by age of dam subclasses (for YW) generally increased as age of dam increased. Accounting for breed of dam, age of dam, sex of calf and interaction effects are important in sire evaluation. Estimated differences of these effects, a by-product of sire evaluation, can be used to increase the accuracy of procedures for individual and dam evaluation. Key words: Breed of dam by age of dam by sex of calf effects, sire evaluation, mixed model techniques

scholarly journals Assessment of Pelvic-Lumbar-Thigh Biomechanics to Optimize The Childbirth Position: An “In Vivo” Innovative Biomechanical Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
David Desseauve ◽  
Fabrice Pierre ◽  
Anna Fernandez ◽  
Henri Panjo ◽  
Arnaud Decatoire ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Mixed Model ◽  
Three Dimensional ◽  
Biomechanical Study ◽  
Joint Laxity ◽  
Future Research ◽  
Lumbar Curve ◽  
Hip Abduction ◽  
Hip Flexion

Abstract The study aimed to assess the associations between the pelvis orientation, lumbar curve and thigh postures throughout pregnancy in a population of healthy women. Additionally, optimal mechanical birth conditions in terms of the pelvic inlet and lumbar curve were researched. The individuals’ posture was assessed with three-dimensional motion analysis and the lumbar curve with the Epionics SPINE system. The association between the hip joint angles (flexion and abduction), the pelvis external conjugate, and lumbar curve position was assessed with a generalized linear mixed model (GLMM) adjusted to individuals’ characteristics. Joint laxity was assessed with a modified Jobbin’s extensometer. For all of the subjects, hip flexion and hip abduction were significantly associated with the angle between the external conjugate and spine, with higher correlation in the multivariate regression model. The association between hip flexion and the lumbar curve was less significant in multivariate than univariate regression analysis. Optimal birth conditions were never reached. The findings contribute to the understanding of the association between the hip position (flexion and abduction), pelvic orientation, and lumbar curve adjusted for joint laxity in healthy pregnant women. They lay the groundwork for future research in the field of obstetrical biomechanics.

scholarly journals Evaluation of gestation length and birth weight of offspring of Polish native cattle breeds in context of estimating genetic parameters

2018 ◽  
Vol 63 (No. 8) ◽  
pp. 323-330
Author(s):  
Nienartowicz-Zdrojewska Anna ◽  
Sobek Zbigniew ◽  
Różańska-Zawieja Jolanta
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Gestation Length ◽  
Black And White ◽  
Research Material ◽  
Native Cattle ◽  
Newborn Calves ◽  
Calving Season ◽  
Calving Difficulty ◽  
Birth Body Weight

Research material included data on gestation length of 15 436 cows of Polish native breeds. These were: White Backed (BG; 324 records), Polish Red (RP; 5396 records), Polish Black and White (ZB; 3508 records), and Polish Red and White (ZR; 6208 records). The calvings took place in 2005–2009, and we analysed two calving seasons, lactation number, the degree of calving difficulty, sex, and body weight of newborn calves. The effect of birth year on gestation length and birth weight of offspring was statistically significant, whereas calving season had statistically highly significant effect on both. Gestation length in the analysed breeds was 281.02, 283.35, 280.5, 281.53 for BG, RP, ZB, and ZR, respectively. The birth body weight heritability was 0.13 (RP), 0.33 (ZB) and 0.40 (ZR).

scholarly journals Functional Disability in Adolescents with Chronic Pain: Comparing an Interdisciplinary Exposure Program to Usual Care

Children ◽  
2020 ◽  
Vol 7 (12) ◽  
pp. 288
Author(s):  
Carolien Dekker ◽  
Mariëlle Goossens ◽  
Bjorn Winkens ◽  
Silvia Remerie ◽  
Caroline Bastiaenen ◽  
...  
Keyword(s):  
Usual Care ◽  
Pain Intensity ◽  
Mixed Model ◽  
Functional Disability ◽  
Linear Mixed Model ◽  
Pain Catastrophizing ◽  
Controlled Trial ◽  
Outpatient Rehabilitation ◽  
Multicenter Rct

(1) Background: Chronic musculoskeletal pain (CMP) in adolescents can negatively affect physical, psychological, and social functioning, resulting in functional disability. This randomized controlled trial (RCT) aimed to evaluate the effectiveness of an outpatient rehabilitation program based on graded exposure in vivo (EP) compared with care as usual (CAU: interdisciplinary outpatient rehabilitation care). Both EP and CAU aim to improve functional ability in adolescents with CMP. (2) Methods: Pragmatic multicenter RCT with 12-month follow-up. Adolescents (12–21 years) with CMP were invited to participate. Primary outcome: functional disability; secondary outcomes: perceived harmfulness; pain catastrophizing; pain intensity. Data analysis: intention-to-treat linear mixed model. (3) Results: Sixty adolescents (mean 16 years) were randomized; data for 53 were analyzed. Adolescents in EP showed relevant and significant decreases in functional disability (estimated mean difference at least −8.81, p ≤ 0.01) compared with CAU at all times. Significant differences in favor of EP were found for perceived harmfulness at all times (p ≤ 0.002), for pain catastrophizing at 2 months (p = 0.039) and for pain intensity at 4 and 10 months (p ≤ 0.028). (4) Conclusion: EP leads to a significant and clinically relevant decrease in functional disability compared with usual care.

scholarly journals A Moderate-Fat Diet with One Avocado per Day Increases Plasma Antioxidants and Decreases the Oxidation of Small, Dense LDL in Adults with Overweight and Obesity: A Randomized Controlled Trial

2019 ◽  
Vol 150 (2) ◽  
pp. 276-284 ◽  
Author(s):  
Li Wang ◽  
Ling Tao ◽  
Lei Hao ◽  
Todd H Stanley ◽  
Kuan-Hsun Huang ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Mixed Model ◽  
Oxidized Ldl ◽  
Controlled Trial ◽  
Overweight And Obesity ◽  
Healthy Diet ◽  
Small Dense Ldl ◽  
Ldl Particles ◽  
Increased Risk

ABSTRACT Background Avocados are a nutrient-dense source of MUFAs and are rich in antioxidants. Avocados have an additional LDL cholesterol (LDL-C) lowering effect beyond that observed when their MUFAs are substituted for SFAs, especially on small, dense LDL (sdLDL) particles, which are susceptible to in vivo oxidation and associated with increased risk of cardiovascular disease (CVD). Objectives We investigated whether a healthy diet with 1 avocado daily decreased the following secondary outcomes: circulating oxidized LDL (oxLDL) and related oxidative stress markers. Methods A randomized, crossover, controlled feeding trial was conducted with 45 men and women, aged 21–70 y, with overweight or obesity and elevated LDL-C (25th–90th percentile). Three cholesterol-lowering diets were provided (5 wk each) in random sequences: a lower-fat (LF) diet (24% calories from fat—7% SFAs, 11% MUFAs, 6% PUFAs) and 2 moderate-fat (MF) diets (34% calories from fat—6% SFAs, 17% MUFAs, 9% PUFAs): the avocado (AV) diet included 1 Hass avocado (∼136 g) per day, and the MF diet used high oleic acid oils to match the fatty acid profile of 1 avocado. A general linear mixed model was used to analyze the treatment effects. Results Compared with baseline, the AV diet significantly decreased circulating oxLDL (−7.0 U/L, –8.8%, P = 0.0004) and increased plasma lutein concentration (19.6 nmol/L, 68.7%, P &lt; 0.0001), and both changes differed significantly from that after the MF and LF diets (P ≤ 0.05). The change in oxLDL caused by the AV diet was significantly correlated with the changes in the number of sdLDL particles (r = 0.32, P = 0.0002) but not large, buoyant LDL particles. Conclusions One avocado a day in a heart-healthy diet decreased oxLDL in adults with overweight and obesity, and the effect was associated with the reduction in sdLDL. This trial was registered at http://www.clinicaltrials.gov as NCT01235832.

29 Effects of Recent and Ancient Inbreeding on Growth in American Angus Cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 14-14
Author(s):  
Emmanuel A Lozada-Soto ◽  
Francesco Tiezzi ◽  
Duc Lu ◽  
Stephen P Miller ◽  
John B Cole ◽  
...  
Keyword(s):  
Birth Weight ◽  
Inbreeding Depression ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Economic Losses ◽  
Weaning Weight ◽  
Mixed Model Approach ◽  
Males And Females ◽  
Genomic Inbreeding ◽  
Effect On Growth

Abstract The accumulation of inbreeding can lead to an unfavorable change in the phenotypic value of individuals for traits related to fitness, also known as inbreeding depression. However, inbreeding accumulated at a more distant past (ancient inbreeding) is expected to have a smaller depressive effect than that accumulated more recently due to the loss of detrimental alleles caused by purifying selection. Therefore, the aim of this study was to quantify the inbreeding depression caused by recent and ancient inbreeding for birth weight, weaning weight, and post-weaning gain. Pedigree and genomic information were obtained from Angus Genetics, Inc. (St. Joseph, MO) for 569,364 individuals from the American Angus breed. Pedigree inbreeding and genomic inbreeding based on runs of homozygosity (ROH) were estimated using the SNP1101 software. Model-based genomic inbreeding based on the probability a marker is part of a homozygous-by-descent segment (HBD) was estimated using the RZooROH in R. The generational cutoffs for designating inbreeding as recent was that acquired 5 generations ago or sooner for pedigree, 6.25 generations ago or sooner for ROH, and 8 generations ago or sooner for HBD inbreeding. The effect of a 1% increase in inbreeding was modeled in males and females using a linear mixed model approach. Recent pedigree inbreeding was found to decrease birth weight by 0.04 and 0.03 kg, decrease weaning weight by 0.50 and 0.48 kg, and decrease post-weaning gain by 0.62 and 0.32 kg, in males and females respectively. Ancient pedigree inbreeding was generally found to have no effect on growth. For genomic inbreeding, when both recent and ancient inbreeding had a detrimental effect on growth, recent inbreeding generally had a larger effect. The results of this study demonstrate that inbreeding accumulated recently should be quantified and managed in beef cattle populations to avoid economic losses.

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