First lessons regarding the data analysis of gunshot residue traces at activity level in TTADB

AbstrakNitric oxide merupakan faktor relaksan yang disentesis oleh endotel pembuluh darah yang kadarnya dapat dipengaruhi oleh aktivitas fisik. Penelitian ini bertujuan untuk mengetahui hubungan aktivitas fisik dengan kadar NO plasma pada masyarakat di kota Padang. Penelitian ini merupakan penelitian dengan data sekunder dari penelitian Delmi Sulastri dkk dalam “Pengaruh Asupan Antioksidan terhadap ekspresi Gen eNOS3 pada penderita Hipertensi Etnik Minangkabau”. Subyek penelitian adalah semua responden penelitian Delmi Sulastri dkk dalam “Pengaruh Asupan Antioksidan terhadap ekspresi Gen eNOS3 pada Penderita Hipertensi Etnik Minangkabau” berjumlah 130 orang yang dinilai aktivitas fisiknya dengan menggunakan kuisioner Baecke dkk. dan dilakukan pemeriksaan kadar NO plasma. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat aktivitas fisik ringan dan NO plasma rendah dengan dengan rerata 26,3±15,2 μmol/L. Dari analisis data didapatkan bahwa responden dengan aktivitas fisik ringan lebih banyak memiliki kadar NO plasma rendah (61,7%) dibandingkan kadar NO plasma normal (38,3%). Dari analisis statistik uji Chi-Square didapatkan nilai p = 0,007 yang berarti terdapat hubungan bermakna antara aktivitas fisik dengan kadar NO plasma (p<0,05). Kesimpulan penelitian ini adalah sebagian besar masyarakat di kota Padang memiliki tingkat aktivitas fisik ringan dan kadar NO plasma rendah. Dari uji statistik menunjukkan bahwa terdapat hubungan bermakna antara aktivitas fisik dengan kadar NO plasma pada masyarakat di kota Padang.Kata kunci: Aktivitas fisik, NOAbstractNitric oxide is relaxan factor that is synthesized by endothelial cell of blood vessel. From previous research showed that plasma NO level influenced by physical activity. The purpose of this study is to know correlation between physical activity with plasma NO level to Padang city people. The research is a research with secondary data by Delmi Sulastri et al., in “The Influence Of Antioksidan Intake to eNOS3 Gene Ekspression In Hypertension Patients In Minangkabau Ethnicity”. Participant of this research is all participant of Delmi Sulastri et al. research in “The Influence Of Antioksidan Intake to eNOS3 Gene Ekspression In Hypertension Patients In Minangkabau Ethnicity” with 130 participant. All participant were observed their physical activity using Baecke et al. quitionaire and were examined plasma NO level. Result of this study showed that most of responden have low physical activity level and low NO plasma level,with mean 26,3±15,2 μmol/L. From data analysis shows that subject with mild physical activity more had low plasma NO level (61,7%) than normal plasma NO level (38,3%). Then, from data analysis with Chi-Square test, found p value = 0,007. It mean, there is significant correlation between physical activity with NO plasma level (p<0.05). The summary of this study is most of Padang city people have mild physical activity level and low NO plasma level. From data statistics analysis showed that there is significant correlation betweeen physical activity with NO plasma level to people in Padang city.Keywords:Physical activity, NO

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Data Analysis on Terrorist Activity. Predicting the Terrorist Activity Level

10.1007/978-3-030-90321-3_35 ◽

2021 ◽

pp. 433-442

Author(s):

Roman I. Dzerzhinsky ◽

E. V. Ledovskaya ◽

A. A. Shchenov

Keyword(s):

Data Analysis ◽

Activity Level ◽

Terrorist Activity

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SOCIO-ECONOMIC-GENDER DISBALANCES IN GEORGIA

Globalization and Business ◽

10.35945/gb.2019.07.017 ◽

2019 ◽

Vol 4 (7) ◽

pp. 143-147

Author(s):

NINO ABESADZE ◽

NATALIA ROBITASHVILI ◽

OTAR ABESADZE

Keyword(s):

Data Analysis ◽

Gender Stereotypes ◽

Statistical Data ◽

Activity Level ◽

Economic Science ◽

Age Group ◽

Percentage Points ◽

Analysis Methods ◽

Rates Of Growth ◽

Data Analysis Methods

Introduction and aim According to the policy towards gender equality, Georgia has become one of the most reformed countries in the Caucasus. Despite the fact that many steps have been taken in this regard, the problems are still in the society. The main objective of the study is to identify and analyze gender imbalances in the country on the background of gender stereotypes in the context of civil cognitive levels. Research methodology: In development of the article, generally accepted qualitative and quantitative data analysis methods of the economic science were employed, among them, statistical data processing, data grouping, inductive deductive data analysis methods. The scientific study employs surveying, observation, as well as comparative, analytical, and graphical methods, which are used by the author to compare and analyze facts and assess solutions to specific issues. Results and implications: The paper considers the gender aspects of Discussion of inequality problems in Georgia. Besides, the trends of unemployment and their reasons are identified and the international instruments of protection of human rights regulating the equality between the men and the women in Georgia are considered. In addition, based on the statistical data, is given the analysis of employment and unemployment in a gender respect; a particular accent is made on the need of International practice of gender protection. Conclusion: Stereotypical views on gender roles still exist in Georgia: the function of women is the care and upbringing of children, doing homework, and man-taking care of family finances. The fact is that more men employed in Georgia than women. The level of inactivity in women is almost twice as high as in men with a similar indicator of 42.0% and 21.8% respectively. In 2017, unemployment rate for women Increased by 1.8 percentage points to 12.7 percent, and for men decreased by 1.6 percentage points and by 15 percent. Changes for to the same period are also indicators of activity level. The level of activity increased realised by 1.5 percentage points for women and decreased by 2.8 percentage points for men and 58.2 percent and 74.6 percent respectively. Interesting trends are shown by employment indicators according to age marks. The number of men employed by the 45-54 age group is significantly higher than the number of women employed for the whole nine years, indicating the employment rate of women, especially in the 15-24 age group where the number of men employed is twice as high as the number of women employed. It is also true that the average level of compensation for women is lower than men. Their rates of growth are also different.

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Do Immune-Mediated TTP Patients Presenting with No Detectable ADAMTS13 Antibody Represent a Unique Clinical Phenotype?

Blood ◽

10.1182/blood-2018-99-111942 ◽

2018 ◽

Vol 132 (Supplement 1) ◽

pp. 3741-3741

Author(s):

Rebecca J Shaw ◽

Ashley Lawrenson ◽

Colin Downey ◽

Kat Moss ◽

Tina Dutt

Keyword(s):

Data Analysis ◽

Significant Proportion ◽

Activity Level ◽

Clinical Relapse ◽

Adamts13 Activity ◽

Negative Group ◽

Positive Group ◽

Detectable Antibody ◽

Presenting Symptoms ◽

Immune Mediated

Abstract Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterised by antibody mediated activity against ADAMTS13. Prompt diagnosis and treatment is critical in this rare condition which has an untreated mortality of around 90%. An ADAMTS13 activity level of <10% is consistent with a diagnosis of TTP and for a significant proportion of patients, ADAMTS13 antibodies can also be demonstrated, confirming iTTP. Recent literature suggests that the sub-group of patients with low ADAMTS13 antigen levels and high ADAMTS13 antibody have the highest mortality (Ferras et al., Blood 2017.); however, the sub-group of patients who have never had a detectable inhibitor remain poorly defined. With therapies becoming increasingly available as adjuvants to plasma exchange, in addition to elective agents for suspected relapsing disease, there is a need to better risk stratify this heterogeneous patient group and identify which patients may benefit most from additional therapies. In most literature to date, patients with low ADAMTS13 inhibitor levels have been excluded from further data analysis and therefore remain an under-represented population. Aim: To define the characteristics of the iTTP patient sub-group where an ADAMTS13 inhibitor has never been demonstrated throughout their clinical course Methods: This was retrospective study of data from a single UK TTP tertiary referral centre from 2011 to 2018. Inclusion criteria for patients with iTTP included ADAMTS13 activity ≤10% at acute presentation. Patients with congenital TTP were excluded from data analysis. A positive ADAMTS13 antibody was defined as >12 U/ml using the Technoclone ADAMTS13 inhibitor ELISA assay. Data collected included patient demographics, presenting symptoms, laboratory markers at first presentation, ADAMTS13 activity and antibody and number of relapses. Clinical relapse was defined as reappearance of clinical manifestations or laboratory parameters consistent with acute TTP and serological relapse was defined as ADAMTS13 activity of <15%. Patients with no detectable antibody were compared with a like group of TTP patients with a detectable ADAMTS13 antibody. Results: A total of 61 patients and 72 acute patient episodes were analysed, of which 7 patients had never demonstrated an ADAMTS13 inhibitor in 10 acute episodes. This sub-group was subsequently compared to an equal sample size of patients with a detectable ADAMTS13 antibody and similar demographics. The average antibody level for the antibody negative group was 5.8 U/ml (range 3 - 10 U/ml) compared to 98.7 U/ml (range 37 - 147U/ml) in the antibody positive group. The respective average ADAMTS13 activity was 4.5% (0-10%), compared with 0.3% (0-1%). 100% of the patients in the antibody positive group had neurological symptoms at presentation compared with 43% of the patients with no detectable antibody. The average presenting platelet count and Troponin T for the antibody negative cohort was 27 x 109/L and 21 ng/L respectively; compared with 10 x 109/L and 206 ng/L in the antibody positive group. 43% of patients in the antibody negative group had multiple acute clinical relapses (1-3) compared with 0% patients presenting with a detectable antibody. 14% of the antibody positive group had a serological relapse treated with elective Rituximab compared with 43% of the patients in the antibody negative group. Conclusion: This data specifically reports the apparent characteristics of patients with ADAMTS13 antibody negative iTTP. Up to 10% of patients may never demonstrate an inhibitor against ADAMTS13 and appear to have a less severe clinical presentation with fewer neurological and cardiac manifestations. This study further suggests that this sub-group may represent a more 'grumbling'/ relapsing phenotype with a tendency for more frequent clinical or serological relapse of TTP. Although TTP is rare, further study of this sub-population of iTTP patients is important in risk stratification, and to support treatment decisions, in particular towards preventing future relapse. Disclosures No relevant conflicts of interest to declare.

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Microchemical imaging in biomedical research

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100130225 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1118-1119

Author(s):

P. Ingram

Keyword(s):

Data Analysis ◽

Electron Probe ◽

The Other ◽

X Ray ◽

Cell Element ◽

Physiological Information ◽

Functional States ◽

Elemental Maps ◽

Electron Energy Loss ◽

Secondary Ion

It is well established that unique physiological information can be obtained by rapidly freezing cells in various functional states and analyzing the cell element content and distribution by electron probe x-ray microanalysis. (The other techniques of microanalysis that are amenable to imaging, such as electron energy loss spectroscopy, secondary ion mass spectroscopy, particle induced x-ray emission etc., are not addressed in this tutorial.) However, the usual processes of data acquisition are labor intensive and lengthy, requiring that x-ray counts be collected from individually selected regions of each cell in question and that data analysis be performed subsequent to data collection. A judicious combination of quantitative elemental maps and static raster probes adds not only an additional overall perception of what is occurring during a particular biological manipulation or event, but substantially increases data productivity. Recent advances in microcomputer instrumentation and software have made readily feasible the acquisition and processing of digital quantitative x-ray maps of one to several cells.

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Pyrotechnic Residues in Gunshot Residue Analysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100117649 ◽

1985 ◽

Vol 43 ◽

pp. 128-129

Author(s):

H. M. Sagara ◽

S. A. Schliebe ◽

M. C. Kong

Keyword(s):

Law Enforcement ◽

Residue Analysis ◽

Gunshot Residue ◽

Particle Analysis ◽

Dry Skin ◽

X Ray ◽

Skin Cells ◽

Smokeless Powder ◽

Carbon Coated ◽

Detailed List

Particle analysis by scanning electron microscopy with energy-dispersive x- ray analysis is one of the current methods used in crime laboratories to aid law enforcement in identifying individuals who have recently fired or handled a firearm. During the discharge of a firearm, the high pressure caused by the detonation of the cartridge materials forces a portion of the generated gases through leaks in the firing mechanism of the weapon. These gases contain residues of smokeless powder, primer mixture, and contributions from the projectile itself. The condensation of these hot gases form discrete, micrometer-sized particles, which can be collected, along with dry skin cells, salts, and other hand debris, from the hands of a shooter by a simple adhesive lift technique. The examination of the carbon-coated adhesive lifts consist of time consuming systematic searches for high contrast particles of spherical morphology with the characteristic elemental composition of antimony, barium and lead. A detailed list of the elemental compositions which match the criteria for gunshot residue are discussed in the Aerospace report.

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Specificity determinants of phosphoprotein phosphatases controlling kinetochore functions

Essays in Biochemistry ◽

10.1042/ebc20190065 ◽

2020 ◽

Vol 64 (2) ◽

pp. 325-336 ◽

Cited By ~ 1

Author(s):

Dimitriya H. Garvanska ◽

Jakob Nilsson

Keyword(s):

Spindle Assembly Checkpoint ◽

Activity Level ◽

Phosphorylation Sites ◽

Binding Affinities ◽

Mitotic Kinases ◽

Anaphase Onset ◽

Phosphoprotein Phosphatases ◽

Linear Motifs ◽

Temporal And Spatial ◽

Kinetochore Function

Abstract Kinetochores are instrumental for accurate chromosome segregation by binding to microtubules in order to move chromosomes and by delaying anaphase onset through the spindle assembly checkpoint (SAC). Dynamic phosphorylation of kinetochore components is key to control these activities and is tightly regulated by temporal and spatial recruitment of kinases and phosphoprotein phosphatases (PPPs). Here we focus on PP1, PP2A-B56 and PP2A-B55, three PPPs that are important regulators of mitosis. Despite the fact that these PPPs share a very similar active site, they target unique ser/thr phosphorylation sites to control kinetochore function. Specificity is in part achieved by PPPs binding to short linear motifs (SLiMs) that guide their substrate specificity. SLiMs bind to conserved pockets on PPPs and are degenerate in nature, giving rise to a range of binding affinities. These SLiMs control the assembly of numerous substrate specifying complexes and their position and binding strength allow PPPs to target specific phosphorylation sites. In addition, the activity of PPPs is regulated by mitotic kinases and inhibitors, either directly at the activity level or through affecting PPP–SLiM interactions. Here, we discuss recent progress in understanding the regulation of PPP specificity and activity and how this controls kinetochore biology.

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Perceptions of a Collaborative Professional Learning Program: Seeing the “Bigger Picture”

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2019_persp-19-00041 ◽

2020 ◽

Vol 5 (1) ◽

pp. 290-303

Author(s):

P. Charlie Buckley ◽

Kimberly A. Murza ◽

Tami Cassel

Keyword(s):

Data Analysis ◽

Professional Learning ◽

Social Communication ◽

Special Educators ◽

Service Providers ◽

Integrative Approach ◽

Theory Approach ◽

Learning Program ◽

Speech Language Pathologists ◽

Related Service

Purpose The purpose of this study was to explore the perceptions of special education practitioners (i.e., speech-language pathologists, special educators, para-educators, and other related service providers) on their role as communication partners after participation in the Social Communication and Engagement Triad (Buckley et al., 2015 ) yearlong professional learning program. Method A qualitative approach using interviews and purposeful sampling was used. A total of 22 participants who completed participation in either Year 1 or Year 2 of the program were interviewed. Participants were speech-language pathologists, special educators, para-educators, and other related service providers. Using a grounded theory approach (Glaser & Strauss, 1967 ) to data analysis, open, axial, and selective coding procedures were followed. Results Three themes emerged from the data analysis and included engagement as the goal, role as a communication partner, and importance of collaboration. Conclusions Findings supported the notion that educators see the value of an integrative approach to service delivery, supporting students' social communication and engagement across the school day but also recognizing the challenges they face in making this a reality.

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Communicative Performance of Adolescents with Severe Speech Impairment

Journal of Speech and Hearing Disorders ◽

10.1044/jshd.5403.403 ◽

1989 ◽

Vol 54 (3) ◽

pp. 403-421 ◽

Cited By ~ 7

Author(s):

Beth M. Dalton ◽

Jan L. Bedrosian

Keyword(s):

Data Analysis ◽

Peer Interactions ◽

Consistent Pattern ◽

Clinical Implications ◽

Speech Impairment ◽

Communication Mode ◽

Mode Function ◽

Communicative Performance ◽

Therapy Room ◽

Communication Board

The communicative performance of 4 preoperational-level adolescents, using limited speech, gestures, and communication board techniques, was examined in a two-part investigation. In Part 1, each subject participated in an academic interaction with a teacher in a therapy room. Data were transcribed and coded for communication mode, function, and role. Two subjects were found to predominantly use the speech mode, while the remaining 2 predominantly used board and one other mode. The majority of productions consisted of responses to requests, and the initiator role was infrequently occupied. These findings were similar to those reported in previous investigations conducted in classroom settings. In Part 2, another examination of the communicative performance of these subjects was conducted in spontaneous interactions involving speaking and nonspeaking peers in a therapy room. Using the same data analysis procedures, gesture and speech modes predominated for 3 of the subjects in the nonspeaking peer interactions. The remaining subject exhibited minimal interaction. No consistent pattern of mode usage was exhibited across the speaking peer interactions. In the nonspeaking peer interactions, requests predominated. In contrast, a variety of communication functions was exhibited in the speaking peer interactions. Both the initiator and the maintainer roles were occupied in the majority of interactions. Pertinent variables and clinical implications are discussed.

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