Optimal follow-up policies for monitoring chronic diseases based on virtual age

Author(s):  
Mei Li ◽  
Zixian Liu ◽  
Yiliu Liu ◽  
Xiaopeng Li ◽  
Ling Lv
Keyword(s):  
BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e024073 ◽  
Author(s):  
Maria Tellez-Plaza ◽  
Laisa Briongos-Figuero ◽  
Gernot Pichler ◽  
Alejandro Dominguez-Lucas ◽  
Fernando Simal-Blanco ◽  
...  

PurposeThe Hortega Study is a prospective study, which investigates novel determinants of selected chronic conditions with an emphasis on cardiovascular health in a representative sample of a general population from Spain.ParticipantsIn 1997, a mailed survey was sent to a random selection of public health system beneficiaries assigned to the University Hospital Rio Hortega’s catchment area in Valladolid (Spain) (n=11 423, phase I), followed by a pilot examination in 1999–2000 of 495 phase I participants (phase II). In 2001–2003, the examination of 1502 individuals constituted the Hortega Study baseline examination visit (phase III, mean age 48.7 years, 49% men, 17% with obesity, 27% current smokers). Follow-up of phase III participants (also termed Hortega Follow-up Study) was obtained as of 30 November 2015 through review of health records (9.5% of participants without follow-up information).Findings to dateThe Hortega Study integrates baseline information of traditional and non-traditional factors (metabolomic including lipidomic and oxidative stress metabolites, genetic variants and environmental factors, such as metals), with 14 years of follow-up for the assessment of mortality and incidence of chronic diseases. Preliminary analysis of time to event data shows that well-known cardiovascular risk factors are associated with cardiovascular incidence rates, which add robustness to our cohort.Future plansIn 2020, we will review updated health and mortality records of this ongoing cohort for a 5-year follow-up extension. We will also re-examine elder survivors to evaluate specific aspects of ageing and conduct geolocation to study additional environmental exposures. Stored biological specimens are available for analysis of new biomarkers. The Hortega Study will, thus, enable the identification of novel factors based on time to event data, potentially contributing to the prevention and control of chronic diseases in ageing populations.


2020 ◽  
Vol 26 (4) ◽  
pp. 2625-2636 ◽  
Author(s):  
Claudio Urrea ◽  
Daniel Venegas

This article presents the development and implementation of a monitoring system for patients with chronic hypertension. Technological advances in wireless communication are increasingly used today to send and receive information through smartphones. This also applies to devices for measuring blood pressure, which can be efficiently integrated with smartphones. Telemedicine is used in a variety of health fields, and in the past 5 years, it has extended its reach to the online monitoring of patients. The objective of this study is to create an integrated system capable of conducting the follow-up, through mobile communication (smartphones), of patients with chronic diseases such as hypertension. An iHealth equipment certified by the Food and Drug Administration is used. The blood pressure values from users are uploaded via Internet and stored in an integral system for processing. The monitoring system developed not only informs users about their disease status but also sends them alerts generated during monitoring. This work uses the telecommunication technology existing through smartphones. The integrated system developed ensures the follow-up of the blood pressure of a large number of users. In addition, this system can be further applied to diseases such as diabetes and metabolic syndrome. The system developed was easy to use and efficient to monitor patients with chronic diseases such as high blood pressure.


2019 ◽  
Vol 110 (3) ◽  
pp. 666-674 ◽  
Author(s):  
Dong Hoon Lee ◽  
Meng Yang ◽  
Edward L Giovannucci ◽  
Qi Sun ◽  
Jorge E Chavarro

ABSTRACT Background Mushrooms are good dietary sources of important vitamins, minerals, and bioactive compounds which may be important in the prevention of chronic diseases. However, studies have not prospectively evaluated the potential health effects of mushrooms with respect to major cardiometabolic diseases. Objectives The aim of this study was to examine the association of mushroom consumption with major cardiometabolic diseases and mediating biomarkers in 2 large prospective US cohorts. Methods We followed 67,139 women from the Nurses’ Health Study (1986–2012) and 43,541 men from the Health Professionals Follow-up Study (1986–2012) who were free of chronic diseases. Mushroom consumption was assessed at baseline through the use of a food-frequency questionnaire. Cardiometabolic biomarkers were collected in subpopulations of the 2 cohorts. Cox proportional hazards models were used to estimate HRs and 95% CIs of cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke, and type 2 diabetes (T2D), associated with mushroom consumption. Results We identified total 11,894 CVD (7,616 CHD; 4,278 stroke), and 10,206 T2D cases in >2 million person-years of follow-up. In the pooled multivariable-adjusted analysis, participants who consumed ≥5 servings of mushrooms per week had no significantly different risk of total CVD (HR: 1.02; 95% CI: 0.91, 1.14), CHD (HR: 1.00; 95% CI: 0.87, 1.16), stroke (HR: 1.05; 95% CI: 0.87, 1.25), or T2D (HR: 1.04; 95% CI: 0.93, 1.16) than participants who consumed mushrooms <1 time/mo. We consistently found no association between mushroom consumption and the aforementioned cardiometabolic diseases, in subgroups of sex, lifestyle factors, and medical conditions. Moreover, mushroom consumption was not associated with plasma biomarkers of lipids, insulin, and inflammation. Conclusions We found no association of mushroom consumption with biomarkers and risks of CVD and T2D in US adults. More large prospective cohort studies are warranted to investigate this association in other racial/ethnic groups.


1986 ◽  
Vol 15 (2) ◽  
pp. 263-267 ◽  
Author(s):  
CHITR SITTHI-AMORN ◽  
S TUSSANIYOM ◽  
S SOONTRAPA ◽  
V VONGSANGNAK ◽  
N SONPANYA

2012 ◽  
Vol 5 (5) ◽  
pp. 318-320
Author(s):  
Prasad Ellanti ◽  
Nikos Davarinos ◽  
Thomas E. Burke ◽  
Lester G. D’Souza

Bilateral simultaneous ruptures are rare comprising less than 1% of all Achilles tendon ruptures. Risk factors for bilateral ruptures include chronic diseases and medications such as corticosteroids and fluoroquinolones. There is little in the literature on the long-term functional outcome of bilateral Achilles tendon ruptures. This article present a series of 3 cases of simultaneous and spontaneous bilateral Achilles tendon ruptures with a minimum of 5-year follow up suggesting a good functional outcome. Level of Evidence: Therapeutic Level IV


2017 ◽  
Vol 30 (5) ◽  
pp. 715-726 ◽  
Author(s):  
Anne Hiance-Delahaye ◽  
Florence Muller de Schongor ◽  
Laurent Lechowski ◽  
Laurent Teillet ◽  
Jean-Jacques Arvieu ◽  
...  

ABSTRACTBackground:The increasing use of antidepressants (ADs) has raised concerns about their inappropriate use in old people.Objective:To examine the prevalence of potentially inappropriate prescribing (PIP) of ADs, their associated factors, and their impact on mortality in a sample of old people in France.Methods:The analysis used data from the SIPAF study, a cross-sectional study consisting of 2,350 people aged ≥ 70 years. Trained nurses interviewed participants at home between 2008 and 2010. Information was collected concerning socio-demographic and health characteristics, including medication use. The study population consisted of the 318 AD users from the SIPAF study (13.5%). PIP of ADs was defined according to national and international criteria. Factors associated with PIP of ADs were assessed using a multivariate logistic regression model. The influence of PIP of ADs on mortality was assessed using a Cox model (median follow-up 2.8 years).Results:Among the SIPAF study, 71% of AD users were female and the mean age was 84 ± 7 years. Selective serotonin reuptake inhibitors (SSRIs) were the most prescribed ADs (19.8%). We found PIP of ADs in 36.8% of the study population, mainly the co-prescription of diuretics with SSRIs (17.6%) and the prescription of tricyclics (12.9%). PIP of ADs was associated with polypharmacy (aOR5-9 drugs 2. 61, 95% CI 1.11–6.16 and aOR≥10 drugs 2.69, 95% CI 1.06–6.87) and comorbidity (aOR3-4 chronic diseases 2.59, 95%CI 1.04–6.44 and aOR≥5 chronic diseases 2.33, 95%CI 0.94–5.79), and increased the risk of mortality during follow-up (aHR 2.30, 95%CI 1.28–4.12).Conclusions:This study shows that more than one third of AD prescriptions may be inappropriate in old people. PIP of ADs was related to polypharmacy and comorbidity and increased mortality among AD users.


Sangyo Igaku ◽  
1967 ◽  
Vol 9 (3) ◽  
pp. 299-300
Author(s):  
K. Sato ◽  
M. Ichinose ◽  
K. Shonaka

2019 ◽  
Vol 28 ◽  
Author(s):  
Leiliane Teixeira Bento Fernandes ◽  
Vanessa Medeiros da Nóbrega ◽  
Malueska Luacche Xavier Ferreira Sales ◽  
Altamira Pereira da Silva Reichert ◽  
Flávia Moura de Moura ◽  
...  

ABSTRACT Objective: to analyze actions of Primary Health Care teams from the perspective of supported self-care for children and adolescents with chronic diseases. Method: a qualitative study, conducted between April and August 2016, with 11 primary care professionals from a municipality of Paraíba, Brazil. A semi-structured interview supported data collection; and a thematic analysis backed interpretation, which categorized the actions according to the 5 A ́s methodology (Evaluation, Guidance, Agreement, Assistance, Follow-up). Results: there were insufficient actions in the specific care plans. Isolated interventions are performed including: assessment of barriers to self-care and emotional state of the individual; provision of information on signs, symptoms of disease and treatment; stimulating the search for community resources; actions inherent to professional training; and follow-up by active search and home visits. Conclusions: actions in Primary Health Care do not yet value the active and co-responsible role of the individual in the control of their disease, with gaps to be overcome in the five pillars of supported self-care. Intervention studies are recommended that train professionals regarding supported self-care of these individuals.


Sign in / Sign up

Export Citation Format

Share Document