Influence of Ionic Surfactants on the Properties of Nanoemulsions Emulsified by Nonionic Surfactants Span 80/Tween 80

2015 ◽  
Vol 37 (10) ◽  
pp. 1511-1517 ◽  
Author(s):  
Yonghong Tian ◽  
Lianghong Chen ◽  
Wanping Zhang
Keyword(s):  
Nonionic Surfactants ◽  
Tween 80 ◽  
Ionic Surfactants ◽  
Span 80

scholarly journals EFFECT OF HYDROPHILICITY SURFACTANTS TOWARD CHARACTERIZATION AND IN VITRO TRANSFERSOMES PENETRATION IN GELS USING FRANZ DIFFUSION TEST

2017 ◽  
Vol 9 ◽  
pp. 112 ◽  
Author(s):  
Wiranti Anggraini ◽  
Erny Sagita ◽  
Iskandarsyah Iskandarsyah
Keyword(s):  
Tween 80 ◽  
Bioactive Compound ◽  
The Other ◽  
Ionic Surfactants ◽  
Diffusion Test ◽  
Solubility In Water ◽  
Characterization Result ◽  
Cumulative Amount ◽  
Span 80

Objective: Capsaicin is a bioactive compound with poor solubility in water. Transfersomes can increase the solubility and thus the penetration ofcapsaicin into the epidermis. Transfersomes also offer the advantage of being ultradeformable vesicles that are made using the thin layer hydrationmethod. The aim of this study is to determine the effect of the hydrophilicity of surfactants on the characterization and in vitro penetrative ability ofcapsaicin transfersomes in gels using non-ionic surfactants with different hydrophile-lipophile balances, namely, Span 80, Tween 80, and a mixtureof Span 80, and Tween 80.Methods: The best characterization result for transfersomes is the formula using Tween 80. The total cumulative amount of capsaicin penetratedfrom the transfersome gel using Tween 80 is 1663.89±1.58 mg/cm2, the percentage is 57.96±0.05%, and the flux is 166.38±0.15 μg/cm2.hr−1.Results: In terms of the transfersome gel using a mixture of Span 80 and Tween 80, the cumulative amount of capsaicin penetrated is1539.8±21.23 μg/cm2, the percentage is 54.47±0.75%, and the flux is 153.98±2.12 μg/cm2.hr−1. Finally, from the transfersome gel using Span 80, thecumulative amount of capsaicin penetrated is 1395.10±7.23 mg/cm2, the percentage is 50.80±0.26%, and the flux is 139.51±0.72 mg/cm2.hr−1.Conclusions: The best characteristics resulted from the transfersome formulation using Tween 80, which demonstrated the highest entrapmentefficiency calculation result, the smallest particle size, the best deformability index, and the highest penetration when compared to the other twoformulations.

scholarly journals PENGARUH PEMBERIAN SEDIAAN MIKROEMULSI EKSTRAK DAUN KENIKIR (Cosmos caudatus) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS YANG DI INDUKSI HATI AYAM

2020 ◽  
Vol 4 (1) ◽  
pp. 67-77
Author(s):  
Muhammad Yusuf ◽  
Poppy Dwi Citra Jaluri ◽  
Yogie Irawan
Keyword(s):  
Coconut Oil ◽  
Tween 80 ◽  
Virgin Coconut Oil ◽  
Cosmos Caudatus ◽  
Span 80

Hiperurisemia adalah keadaan dimana terjadi peningkatan kadar asam urat dalam darah diatas normal. Tanaman kenikir (Cosmos caudatus) merupakan tanaman yang banyak dijumpai di lingkungan sekitar, serta tanaman yang sudah tidak asing lagi dan telah banyak dikonsumsi sebagai sayuran. Salah satu kandungan dalam kenikir adalah senyawa golongan flavonoid. Pada penelitian ini mikroemulsi ekstrak kenikir digunakan untuk menurunkan kadar asam urat pada tikus yang diinduksi hati ayam. Mikroemulsi dibuat dengan menggunakan virgin coconut oil (VCO) sebagai fase minyak, Tween 80 dan Span 80 sebagai surfaktan dan gliserin sebagai kosurfaktan. Penelitian menggunakan 15 ekor tikus putih jantan galur wistar yang diinduksi jus hati ayam. Tikus dibagi menjadi 3 kelompok, yaitu kelompok kontrol negatif mikroemulsi placebo, kontrol positif mikroemulsi Allopurinol 3,6 mg/200 g BB tikus, serta kelompok perlakuan mikroemulsi daun kenikir  10 mg/200 g BB tikus yang diberikan secara peroral. Pengukuran kadar asam urat dilakukan pada hari ke-0 (kadar awal), hari ke-7 (kadar setelah induksi) dan hari ke-13(kadar setelah perlakuan). Persen penurunan kadar asam urat dalam darah dianalisis secara statistika dengan taraf kepercayaan 95%. Hasil uji statistika menyatakan ada perbedaan antara kelompok kontrol negatif dan positif dengan kelompok perlakuan mikroemulsi daun kenikir memiliki nilai signifikansi 0,000. Sehingga mikroemulsi daun kenikir dapat menurunkan kadar urisemia tikus yang diinduksi ekstrak hati ayam namun memiliki kemampuan yang tidak sebaik mikroemulsi allopurinol. Kata Kunci : Mikroemulsi, Kenikir (Cosmos Caudatus), Hiperurisemia, Ekstrak Hati Ayam, Allopurinol.

scholarly journals Effect of nonionic surfactants on the release of paracetamol from suppositories

2015 ◽  
Vol 26 (1) ◽  
pp. 40-44
Keyword(s):  
Drug Release ◽  
Physical Properties ◽  
Phosphate Buffer ◽  
Nonionic Surfactants ◽  
Tween 80 ◽  
Content Uniformity ◽  
Fusion Method ◽  
Disintegration Time ◽  
Span 60

The preparation suppositories contain 250 mg of paracetamol on different bases using Novata BD, Novata BCF and composition of Novata BCF/BD (1:1). Suppositories were prepared by the fusion method. The prepared formulations with or without surfactants (Tween 80, Span 60) at concentrations of 2% and 4% (w/w) were tested for hardness, to tal time of de for ma tion, disintegration time, content uniformity and release of the drug. The release of the drug was carried in the apparatus with the stirrer shade in phosphate buffer (pH 7.2) at 100 rpm. The physical properties of the prepared suppositories were according with the requirement of Polish Pharmacopoeia 9th edition. Addition of 4 % Tween 80 to suppository bases significantly increased the drug release from all the investigated formulations. However, incorporation of Span 60 did not result in improvement of the drug release significantly.

Glyphosate Toxicity to Common Milkweed and Hemp Dogbane as Influenced by Surfactants

Weed Science ◽  
1977 ◽  
Vol 25 (3) ◽  
pp. 275-287 ◽  
Author(s):  
J.B. Wyrill ◽  
O.C. Burnside
Keyword(s):  
Contact Angle ◽  
Ethylene Oxide ◽  
Quaternary Ammonium ◽  
Nonionic Surfactants ◽  
Ionic Surfactants ◽  
Oxide Content ◽  
Asclepias Syriaca ◽  
Molar Basis ◽  
Dimethyl Amine ◽  
Percentage Basis

Surfactants were evaluated in the greenhouse for their ability to enhance glyphosate [N-(phosphonomethyl) glycine] toxicity to common milkweed (Asclepias syriacaL.) and hemp dogbane (Apocynum cannabinumL.). Ethoxylated amines were among the most effective groups of surfactants. Nonionic ether and ester ethoxylates combined with a dimethyl amine or a quaternary ammonium salt were more effective than any of these surfactants alone. Effectiveness of ethoxylated amine surfactants was altered by pH changes. Cat-ionic surfactants tended to be more effective than nonionic surfactants. With exceptions, surfactants were more effective with increased ethoxylation. Amine surfactant effectiveness increased with increasing concentrations up to 0.3% (w/v). Surfactant effectiveness on a molar basis was more closely related to the ethylene oxide content of the surfactant than was effectiveness on a percentage basis. Contact angle was not related to surfactant effectiveness at high or low surfactant concentrations. Ethoxylated stearyl ether and amine surfactants gave optimum effectiveness at hydrophile-lipophile balance (HLB) values of 15 to 16 and 19 to 20, respectively. Surfactants with a low HLB were usually less effective. Effectiveness of surfactant combinations was quite variable and difficult to predict. Therefore, the indiscriminate addition of surfactants to glyphosate spray mixtures which already contain a surfactant should be avoided.

scholarly journals Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories

2014 ◽  
Vol 27 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Regina Kasperek ◽  
Krzysztof Galczynski ◽  
Magdalena Nalesniak ◽  
Karol Iwaniak ◽  
Ewa Poleszak
Keyword(s):  
Cocoa Butter ◽  
Acidic Medium ◽  
Tween 80 ◽  
Rectal Administration ◽  
Dissolution Medium ◽  
Release Process ◽  
Vaginal Administration ◽  
Release Study ◽  
Span 80 ◽  
Pharmacopoeial Requirements

Abstract Suppositories with cocoa butter containing dehydroepiandrosterone (DHEA) without and with the addition of Span 80 and Tween 80 as surfactants with low and high HLB values were prepared. The physical properties and the drug content of all prepared suppositories were in accordance with the pharmacopoeial requirements. The release study tests in three dissolution media such as water, lactic acid solution at pH 4.2 and phosphate buffer at pH 7.4 were carried out. In acidic and alkalic media only about 10% and 27% of DHEA were released, respectively. The addition of Span 80 to the suppository mass did not improve the release process, but the addition of Tween 80 caused the increase in the amount of DHEA released in the acidic medium to about 35%. The data showed that rectal administration of suppositories with DHEA based on cocoa butter caused about 30% availability and after vaginal administration, only topical activity can be expected. By the addition of Tween 80 to the suppository mass availability of DHEA of about 35% from vaginal suppositories can be achieved.

Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides

2015 ◽  
Vol 39 (2) ◽  
pp. 677-682 ◽  
Author(s):  
Diqiu Li ◽  
Xiwei Wu ◽  
Xiaoqin Yu ◽  
Qingchun Huang ◽  
Liming Tao
Keyword(s):  
Synergistic Effect ◽  
Tween 80 ◽  
Ionic Surfactants

Structure behaviors of hemoglobin in PEG 6000/Tween 80/Span 80/H2O niosome system

2007 ◽  
Vol 293 (1-3) ◽  
pp. 255-261 ◽  
Author(s):  
Tianqing Liu ◽  
Rong Guo ◽  
Wei Hua ◽  
Jing Qiu
Keyword(s):  
Tween 80 ◽  
Peg 6000 ◽  
Span 80

Novel solid–solid phase change materials with biodegradable trihydroxy surfactants for thermal energy storage

RSC Advances ◽  
2015 ◽  
Vol 5 (84) ◽  
pp. 68881-68889 ◽  
Author(s):  
Xiaowei Fu ◽  
Weibo Kong ◽  
Yanyan Zhang ◽  
Liang Jiang ◽  
Jiliang Wang ◽  
...  
Keyword(s):  
Energy Storage ◽  
Phase Change ◽  
Thermal Energy ◽  
Thermal Energy Storage ◽  
Phase Change Materials ◽  
Solid Phase ◽  
Tween 80 ◽  
Span 80 ◽  
First Time ◽  
Crosslinking Agents

Polyurethane polymers were synthesized as novel solid–solid phase change materials (SSPCMs) by bulk polyaddition in the absence of organic solvents using Span 80 and Tween 80 as crosslinking agents for the first time.

scholarly journals Formulasi dan Evaluasi Sediaan Anti Aging dari Ekstrak Tumbuhan

2019 ◽  
Vol 4 (4) ◽  
Author(s):  
Nadia Fauziah Rahmadiani ◽  
Aliya Nur Hasanah
Keyword(s):  
Tween 80 ◽  
Span 80

Tumbuh-tumbuhan yang berasal dari Indonesia memiliki banyak potensi sebagai bahan dasar produk kosmetika seperti produk antiaging. Sediaan antiaging adalah produk yang bermanfaat untuk menghambat proses kerusakan akibat bertambahnya usia pada kulit. Pengembangan dari formula berbagai sediaan anti aging yang berasal dari ekstrak tumbuhan telah banyak dilakukan, setiap formula pada jenis sediaan yang berbeda dievaluasi untuk mendapat formula terbaik yang memiliki karakteristik yang paling stabil dalam waktu penyimpanan tertentu. Oleh karena itu, pada review artikel ini, berbagai formulasi dan evaluasi pada sediaan krim, gel dan masker peel off antiaging dari ekstrak tumbuhan dikaji lebih lanjut untuk mendapatkan formula paling stabil dengan menggunakan  9 jurnal untuk membandingkan hasil formulasi dan evaluasi  dan 27 pustaka sebagai kajian teori. Hasil review menunjukan formula terbaik adalah formula krim yang menggunakan tween 80 dan span 80 dengan konsentrasi 5,11gr dan 0,25gr, formula masker peel off yang mengandung PVA 12% dan HPMC 2% dan formula gel yang menggunakan Na CMC 2% . Kata Kunci : Antiaging, Masker peel-off, krim, gel

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