References for growth and pubertal development from birth to 21 years in Flanders, Belgium

Puberty is a crucial developmental stage in the life span, necessary to achieve reproductive and somatic maturity. Timing of puberty is modulated by and responds to central neurotransmitters, hormones, and environmental factors leading to hypothalamic-pituitary-gonadal axis maturation. The connection between hormones and nutrition during critical periods of growth, like fetal life or infancy, is fundamental for metabolic adaptation response and pubertal development control and prediction. Since birth weight is an important indicator of growth estimation during fetal life, restricted prenatal growth, such as intrauterine growth restriction (IUGR) and small for gestational age (SGA), may impact endocrine system, affecting pubertal development. Successively, lactation along with early life optimal nutrition during infancy and childhood may be important in order to set up timing of sexual maturation and provide successful reproduction at a later time. Sexual maturation and healthy growth are also influenced by nutrition requirements and diet composition. Early nutritional surveillance and monitoring of pubertal development is recommended in all children, particularly in those at risk, such as the ones born SGA and/or IUGR, as well as in the case of sudden weight gain during infancy. Adequate macro and micronutrient intake is essential for healthy growth and sexual maturity.

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Urinary gonadotropin measurements by enhanced luminometric assays (LIA) for the evaluation of pubertal development

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0598 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

And Demir ◽

Adem Aydın ◽

Atilla Büyükgebiz ◽

Ulf-Håkan Stenman ◽

Matti Hero

Keyword(s):

Healthy Subjects ◽

Reliable Method ◽

Pubertal Development ◽

High Sensitivity ◽

Tanner Stage ◽

Time Resolved ◽

Stage 1 ◽

Sensitive Detection Technique ◽

Serum And Urine

Abstract Objectives Determination of LH in urine has proved to be a reliable method for evaluation of pubertal development. The human LH assay based on time-resolved immunofluorometric (IFMA) technology (AutoDELFIA, PerkinElmer, Wallac) has been found to be suitable for this purpose thanks to its high sensitivity but other assays have not been evaluated. We have analyzed our data obtained by another potentially sensitive detection technique, enhanced luminometric assay (LIA) with the objective of finding a viable alternative to IFMA since these may not be available in the future. Methods LIA was used to measure LH and FSH in serum and urine samples from 100 healthy subjects of each Tanner stage and both genders, whose pubertal development has been determined. Results Urinary gonodotropin concentrations measured by LIA correlated well with Tanner stage [(r=0.93 for girls, r=0.81 for boys; p<0.01 for LH) and (r=0.81 for girls, r=0.73 for boys; p<0.01 for FSH)]. LIA determinations revealed the increase in U-LH concentrations during the transition from Tanner stage 1–2 in both girls and boys (p<0.001), whereas U-FSH and S-LH were able to detect the increase from Tanner stage 1–2 only in boys or girls, respectively (both p<0.001). Conclusions Measurement of urinary gonadotropin concentrations by LIA may be useful for the evaluation of overall pubertal development and also in the detection of transition from prepuberty to puberty.

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Body phenotypes and sexual maturation in Brazilian and US adolescents: evidence for a change in body mass index Category

Public Health Nutrition ◽

10.1017/s1368980020004589 ◽

2020 ◽

pp. 1-26

Author(s):

Jéssica Cumpian Silva ◽

Ana Elisa Madalena Rinaldi ◽

Francisco de Assis Guedes Vasconcelos ◽

Maria Alice Altenburg Assis ◽

Camila Medeiros Mazzeti ◽

...

Keyword(s):

Body Mass Index ◽

Body Composition ◽

Body Mass ◽

Phase Angle ◽

Sexual Maturation ◽

Biochemical Parameters ◽

Pubertal Development ◽

The United States ◽

Pubic Hair ◽

Cholesterol Ratio

ABSTRACT Objective: Our study aimed to describe body phenotypes (BP) estimated by multivariate analysis and their association with body mass. Design: Body phenotypes were defined based on demographic variables, anthropometric data (body mass, height, skinfolds and circumferences), body composition (phase angle measured by bioelectrical impedance analysis), biochemical parameters (triglycerides, glucose, total cholesterol ratio/Low Density Lipoproteins (LDL), haemoglobin and sexual maturation (pubic hair and breasts or gonads). Analysis of variance (ANOVA) was performed to verify the differences between skin colour and the stages of pubertal development, body phenotypes, body composition, anthropometric, and biochemical variables. Setting: Cities of São Paulo-SP, Piracicaba-SP and Florianópolis-SC from Brazil and the United States. Participants: 9269 adolescents aged between 10 to 15 years old. Results: The composition of BP was similar in all surveys, which are: BP1 was composed by skinfolds, body mass and circumferences variables; BP2 by pubic hair, breast in girls or gonad in boys, height and age; BP3 by cholesterol, triglycerides and glucose; and BP4 by phase angle, haemoglobin and glucose (negative loading). There was a strong correlation (r = 0.9, p <0.001) between BP1 and body mass index. Conclusion: We highlighted independence observed between biochemical parameters, anthropometry, body composition and sexual maturation. BP may support the calculation of scores for diagnosis of obesity based on anthropometric variables and overcome ambiguity in the isolated use of body mass index.

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Juvenile granulosa cell tumor

10.1055/s-0039-1685332 ◽

2016 ◽

Author(s):

Geetanjali Tuteja ◽

S. Unmesh ◽

S. Shree ◽

S. Rudra ◽

Keyword(s):

Granulosa Cell ◽

Precocious Puberty ◽

Early Stage ◽

Pubertal Development ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Cell Tumour ◽

Tumour Resection ◽

Granulosa Cell Tumour ◽

Juvenile Granulosa Cell Tumor

The differential diagnosis for precocious puberty in a young female includes peripheral causes. This case report documents a rare cause of isosexual precocious puberty, a juvenile granulosa cell tumour of the ovary–and a brief literature review. A one year-old baby girl presented with mass abdomen, vaginal discharge and rapid onset of pubertal development. She underwent an exploratory laparotomy for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

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Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0285 ◽

2020 ◽

Vol 33 (11) ◽

pp. 1449-1455

Author(s):

Suzana Nesi-França ◽

Rodrigo B. Silveira ◽

Juliana Cristina R. Rojas Ramos ◽

Adriane A. Cardoso-Demartini ◽

Monica N. Lima Cat ◽

...

Keyword(s):

Congenital Hypothyroidism ◽

Neonatal Screening ◽

Adult Height ◽

Screening Program ◽

Pubertal Development ◽

Z Score ◽

Normal Range ◽

Adequate Treatment ◽

Increased Risk ◽

Puberty Onset

AbstractObjectivesAdequate treatment of congenital hypothyroidism (CH) is required for normal growth and sexual development. To evaluate pubertal development in patients with permanent CH detected by a statewide Neonatal Screening Program of Paraná and, secondly, to evaluate adult height (AH) in a subgroup of patients.MethodsClinical, laboratory, and auxological data obtained from medical records of 174 patients (123 girls).ResultsMedian chronological age (CA) at treatment initiation was 24 days, and mean initial levothyroxine dose was 11.7 ± 1.9 μg/kg/day; mean CA at puberty onset was 11.5 ± 1.3 years (boys) and 9.7 ± 1.2 years (girls); mean CA in girls who underwent menarche (n=81) was 12.1 ± 1.1 years. Thyroid-stimulating hormone (TSH) values above the normal range were observed in 36.4% of the boys and 32.7% of the girls on puberty onset, and in 44.6% around menarche. Among 15 boys and 66 girls who had reached the AH, the median height z-score value was significantly greater than the target height (TH) z-score value in boys (p=0.01) and in girls (p<0.001). Boys with normal TSH values at puberty onset had greater mean AH z-score compared with boys with TSH values above the normal range (p=0.04).ConclusionsIn this group, pubertal development in girls with CH was not different from that reported in healthy girls in the general Brazilian population. Boys with higher TSH at puberty onset may have an increased risk of not reaching their potential height compared with those with normal TSH during this period. In a subgroup who attained AH, the median AH z-score was greater than the median TH z-score.

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