Evaluation of serum alanine aminotransferase and aspartate aminotransferase enzyme levels in women patients with chronic periodontitis

2021 ◽  
pp. 1-9
Author(s):  
Amir Reza Ahmadinia ◽  
Mina Pakkhesal ◽  
Mohammad Ali Vakili
Keyword(s):  
Chronic Periodontitis ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Women Patients ◽  
Serum Alanine Aminotransferase

The Effects of Four Types of Restraint on Serum Alanine Aminotransferase and Aspartate Aminotransferase in the Macaca fascicularis

1990 ◽  
Vol 9 (5) ◽  
pp. 517-523 ◽  
Author(s):  
M.S. Landi ◽  
J.T. Kissinger ◽  
S.A. Campbell ◽  
C.A. Kenney ◽  
E.L. Jenkins
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Macaca Fascicularis ◽  
Clinical Laboratory ◽  
Clinical Chemistry ◽  
Blood Samples ◽  
Cynomolgus Monkeys ◽  
Serum Alanine Aminotransferase ◽  
Time Points ◽  
Over Time

To determine the effect of restraint on selected clinical laboratory parameters, cynomolgus monkeys were continuously restrained for 60 and 120 minutes in a restraining box, a restraint chair, and on a restraining board. Animals were also hand caught for manual restraint. Blood samples were collected at 11 time points over 168 hours and evaluated with a standard clinical chemistry profile. Only aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were statistically evaluated; no overt changes were noted in any other parameter. Significant differences between the enzyme levels of different restraint methods were not seen during the 60-min restraint studies, but were present during the 120-min restraint duration. For AST, chair and board restraint resulted in lower and higher enzyme levels, respectively, than the other methods. Levels of ALT for board restraint were significantly higher when compared with other methods. For both the 60-and 120-min restraint periods, AST values that were significantly elevated when compared with baseline were common at 4, 6, and 24 h. Significant ALT increases, when compared with baseline, occurred primarily at 6, 24, and 48 h. The results indicate that over time, restraint methods alone can affect AST and ALT levels in cynomolgus monkeys.

Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase

Pharmacology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Shiqi Wang ◽  
Yasong Ding ◽  
Ruoyao Dong ◽  
Hongyun Wang ◽  
Lingdi Yin ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Liver Injury ◽  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Nuclear Translocation ◽  
Asparagine Synthetase ◽  
Related Factor ◽  
Impaired Liver Function ◽  
Serum Alanine Aminotransferase

<b><i>Introduction:</i></b> Canagliflozin (CANA) is a sodium-glucose cotransporter 2 inhibitor that was recently approved for treating diabetes. However, its effects on liver function are not well understood. The function of asparagine synthetase (ASNS) has been studied in several cancers but not in liver injury. Therefore, we investigated the connection between CANA and ASNS in alleviating damage (i.e., their hepatoprotective effect) in a rat liver injury model. <b><i>Methods:</i></b> The rat model of liver injury was established using carbon tetrachloride treatment. Rats with liver injury were administered CANA orally for 8 weeks daily. After week 8, peripheral blood was collected to measure serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase levels. Liver histopathology was examined using hematoxylin and eosin staining to determine the degree of liver injury. Protein expression in the rat livers was examined using Western blotting. <b><i>Results:</i></b> CANA treatment decreased serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase levels compared with those of the untreated group, demonstrating diminished liver injury. Mechanistically, CANA treatment activated AMP-activated protein kinase (AMPK), leading to increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and activating transcription factor 4 (ATF4), which upregulated ASNS expression in liver-injured rats. <b><i>Conclusion:</i></b> CANA significantly alleviated liver injury by activating the AMPK/Nrf2/ATF4 axis and upregulating ASNS expression, indicating its potential for treating patients with type 2 diabetes mellitus with impaired liver function.

scholarly journals Influence of Eclipta alba on serum alanine aminotransferase and aspartate aminotransferase activity in rabbits

2018 ◽  
Vol 7 (7) ◽  
pp. 1243
Author(s):  
B. P. Kale ◽  
Mujawar Jahir Rauf
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Treated Group ◽  
Biologically Active ◽  
Control Group ◽  
Serum Alanine Aminotransferase ◽  
Eclipta Alba ◽  
Group A ◽  
High Doses ◽  
Group B

Background: Paracetamol is a recognized antipyretic, analgesic drug which produces hepatic necrosis in high doses. Eclipta alba elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex.Methods: Randomized open controlled experimental study Estimated levels of Serum aspartate aminotransferase (AST), Serum alanine aminotransferase (ALT) and Hepatoprotective action of in High doses of Paracetamol on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity.Results: ALT in all the groups including Control group (A) was (51.8±4.56IU/L). Paracetamol treated group (B) the ALT level increased at 48 hours and continued to be high up to 60 days (136.4±20.73IU/L) then decreased to (113.7±11.35IU/L) at 90 days. AST in all the groups including Control group (A) was (22.5±1.23IU/L). Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed. In Paracetamol treated group (B) the AST level increased at 48 hours and continued to be high up to 60 days (99.4±9.73IU/L) then decreased to (85.4±7.39IU/L) at 90 days.Conclusions: Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed.

scholarly journals Study of Liver and Kidney functions in non-pregnant, pregnant and preeclamptic women

2012 ◽  
Vol 9 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Pregnant Women ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Spectrophotometric Analysis ◽  
Serum Alanine Aminotransferase ◽  
Liver And Kidney ◽  
Group A ◽  
Group B ◽  
Kidney Functions

Three groups of subjects have been divided (25/group): healthy normotensive non-pregnant women (Group A), normal normotensive pregnant women (Group B), and women with preeclampsia (Group C).The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin , creatinine , blood urea nitrogen, triglyceride , total cholesterol and glucose have been estimated in all subjects. All measured parameters were determined by spectrophotometric analysis. The results showed a significant(P

scholarly journals Observational Study of Serum Alanine Aminotransferase (ALT), Serum Aspartate Aminotransferase (AST) and Serum Alkaline Phosphatase (ALP) Levels in Type 2 Diabetic Patients

2020 ◽  
Vol 7 (48) ◽  
pp. 2852-2855
Author(s):  
Himanshu Jindal ◽  
Abhilasha Singh ◽  
Rajan Goyal ◽  
Abhishek Kamendu
Keyword(s):  
Alkaline Phosphatase ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Serum Alkaline Phosphatase ◽  
Diabetic Patients ◽  
Weak Correlation ◽  
Serum Alanine Aminotransferase ◽  
Serum Aspartate Aminotransferase

BACKGROUND The relationship between liver enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and diabetes has been studied, but the results of these are inconsistent. Several prospective studies have reported that ALT was associated with incident diabetes. We wanted to study the levels of serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST) and serum alkaline phosphatase (ALP) in patients of Type 2 DM. METHODS This is a hospital based observational study which was conducted in Narayan Medical College and Hospital, Jamuhar, Sasaram, Rohtas, Bihar. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), glycosylated haemoglobin (HbA1c), FBS, PPBS, total bilirubin, and hepatitis B surface antigen (HBsAg) were determined in all study participants. RESULTS The mean value was 96.35, 67.37, 152.78 and 1.098 for AST, ALT, ALP and total bilirubin. On multivariate analysis for effect of FBS, PPBS, HbA1c on the value of AST weak correlation was found with R square of 0.11. On the effect of FBS, PPBS, HbA1c on the value of ALT we found weak correlation with an R square of 0.079. CONCLUSIONS There is a weak correlation between deranged liver enzyme (AST, ALT and ALP) with HbA1c, FBS and PPBS. But still, liver functions should be monitored in diabetic patients. KEYWORDS ALT, AST, Diabetes, HbA1c, FBS, PPBS

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