The influence of low-impact dance intervention on bone metabolism, cognition, and function fitness of old women

2021 ◽  
pp. 1-11
Author(s):  
Chung Bing Yang ◽  
Chin Hsing Hsu ◽  
Chih Neng Huang ◽  
Te Hung Tsao
Keyword(s):  
Bone Metabolism ◽  
Dance Intervention ◽  
And Function

scholarly journals Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review

2020 ◽  
Vol 4 (8) ◽  
pp. 336-342
Author(s):  
Abdelhafid Nani ◽  
Meriem Belarbi ◽  
Naim Akhtar Khan ◽  
Aziz Hichami
Keyword(s):  
Bone Metabolism ◽  
Pearl Millet ◽  
Bone Health ◽  
Bone Cells ◽  
Pennisetum Glaucum ◽  
Whole Grains ◽  
Tnf Α ◽  
Sahel Region ◽  
And Function ◽  
Bone Tissue Formation

Bone is a hard connective tissue that undergoes a systematic renewal. This highly dynamic organ is made up of four different types of cells, however, bone formation is commonly attributed to osteoblasts and bone resorption to osteoclasts. Bone tissue formation occurs during embryonic development and in certain post-birth pathological conditions. The immune system could influence the functions of bone cells, and the crosstalk between hematopoietic, immune, and bone cells is known as osteoimmunology. Indeed, cytokines produced by immune cells, including TNF-α and IL-6, are critically implicated in bone pathogenesis. It is well established that diet plays an important role in bone health and function. Indeed, antioxidant nutraceuticals-rich diet, of which pearl millet is one, can be effective in treating osteoporosis. Pearl millet (PM) is an African native cereal that constitutes the staple food for African Sahel region inhabitants as well as for many peoples in rural regions in India. Pearl millet grains content in amino acids, minerals, and phytochemicals may contribute to promoting bone health and metabolism. Accordingly, in the current review, we discuss the putative effects of PM nutrients, with a focus on polyphenols, on bone metabolism and osteoimmunology. In the light of our previous studies and others from literature, we speculate that PM whole grains may be effective in the prevention and management of bone pathogenesis. ​Keywords: PM whole grains, polyphenols, osteoblasts, osteoclasts, osteoimmunology, TNF-α.

scholarly journals Role of Biomolecules in Osteoclasts and Their Therapeutic Potential for Osteoporosis

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 747
Author(s):  
Xin Zhao ◽  
Suryaji Patil ◽  
Fang Xu ◽  
Xiao Lin ◽  
Airong Qian
Keyword(s):  
Transcription Factors ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Therapeutic Potential ◽  
Bone Microarchitecture ◽  
Treatment Of Osteoporosis ◽  
Non Coding Rnas ◽  
And Function

Osteoclasts (OCs) are important cells that are involved in the regulation of bone metabolism and are mainly responsible for coordinating bone resorption with bone formation to regulate bone remodeling. The imbalance between bone resorption and formation significantly affects bone metabolism. When the activity of osteoclasts exceeds the osteoblasts, it results in a condition called osteoporosis, which is characterized by reduced bone microarchitecture, decreased bone mass, and increased occurrences of fracture. Molecules, including transcription factors, proteins, hormones, nucleic acids, such as non-coding RNAs, play an important role in osteoclast proliferation, differentiation, and function. In this review, we have highlighted the role of these molecules in osteoclasts regulation and osteoporosis. The developed therapeutics targeting these molecules for the treatment of osteoporosis in recent years have also been discussed with challenges faced in clinical application.

scholarly journals Osteoprotegerin, a Crucial Regulator of Bone Metabolism, Also Regulates B Cell Development and Function

2001 ◽  
Vol 166 (3) ◽  
pp. 1482-1491 ◽  
Author(s):  
Theodore J. Yun ◽  
Michelle D. Tallquist ◽  
Alexandra Aicher ◽  
Katherine L. Rafferty ◽  
Aaron J. Marshall ◽  
...  
Keyword(s):  
B Cell ◽  
Bone Metabolism ◽  
Cell Development ◽  
B Cell Development ◽  
And Function

scholarly journals Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review

2020 ◽  
Vol 4 (08) ◽  
pp. 336-342
Author(s):  
Abdelhafid Nani ◽  
Meriem Belarbi ◽  
Naim Akhtar Khan ◽  
Aziz Hichami
Keyword(s):  
Bone Metabolism ◽  
Pearl Millet ◽  
Bone Health ◽  
Bone Cells ◽  
Pennisetum Glaucum ◽  
Whole Grains ◽  
Tnf Α ◽  
Sahel Region ◽  
And Function ◽  
Bone Tissue Formation

Bone is a hard connective tissue that undergoes a systematic renewal. This highly dynamic organ is made up of four different types of cells, however, bone formation is commonly attributed to osteoblasts and bone resorption to osteoclasts. Bone tissue formation occurs during embryonic development and in certain post-birth pathological conditions. The immune system could influence the functions of bone cells, and the crosstalk between hematopoietic, immune, and bone cells is known as osteoimmunology. Indeed, cytokines produced by immune cells, including TNF-α and IL-6, are critically implicated in bone pathogenesis. It is well established that diet plays an important role in bone health and function. Indeed, an antioxidant nutraceuticals-rich diet, of which pearl millet is one, can be effective in treating osteoporosis. Pearl millet (PM) is an African native cereal that constitutes the staple food for African Sahel region inhabitants as well as for many peoples in rural regions in India. Pearl millet grains’ content in amino acids, minerals, and phytochemicals may contribute to promoting bone health and metabolism. Accordingly, in the current review, we discuss the putative effects of PM nutrients, with a focus on polyphenols, bone metabolism and osteoimmunology. In the light of our previous studies and others from the literature, we suggest that PM whole grains can be effective in the prevention and management of bone pathogenesis. Keywords: PM whole grains, nutrients, polyphenols, osteoblasts, osteoclasts, osteoimmunology, TNF-α.

scholarly journals H2S Donor and Bone Metabolism

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanming Hao ◽  
Hongzhen Wang ◽  
Lingna Fang ◽  
Jinsong Bian ◽  
Yan Gao ◽  
...  
Keyword(s):  
Side Effects ◽  
Bone Metabolism ◽  
Metabolic Diseases ◽  
Biological Effects ◽  
Bone Diseases ◽  
The Body ◽  
Metabolic Bone Diseases ◽  
Physiological Processes ◽  
Metabolic Bone ◽  
And Function

Hydrogen sulfide (H2S) has been recognized as the third gasotransmitter, following nitric oxide and carbon monoxide, and it exerts important biological effects in the body. Growing evidence has shown that H2S is involved in many physiological processes in the body. In recent years, much research has been carried out on the role of H2S in bone metabolism. Bone metabolic diseases have been linked to abnormal endogenous H2S functions and metabolism. It has been found that H2S plays an important role in the regulation of bone diseases such as osteoporosis and osteoarthritis. Regulation of H2S on bone metabolism has many interacting signaling pathways at the molecular level, which play an important role in bone formation and absorption. H2S releasing agents (donors) have achieved significant effects in the treatment of metabolic bone diseases such as osteoporosis and osteoarthritis. In addition, H2S donors and related drugs have been widely used as research tools in basic biomedical research and may be explored as potential therapeutic agents in the future. Donors are used to study the mechanism and function of H2S as they release H2S through different mechanisms. Although H2S releasers have biological activity, their function can be inconsistent. Additionally, donors have different H2S release capabilities, which could lead to different effects. Side effects may form with the formation of H2S; however, it is unclear whether these side effects affect the biological effects of H2S. Therefore, it is necessary to study H2S donors in detail. In this review, we summarize the current information about H2S donors related to bone metabolism diseases and discuss some mechanisms and biological applications.

Conformation of Ribosomes from Escherichia Coli

1974 ◽  
Vol 32 ◽  
pp. 210-211
Author(s):  
M. Boublik ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Binding Sites ◽  
Ribosomal Proteins ◽  
Fluorescent Dyes ◽  
Protein Biosynthesis ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Dimensional Structure ◽  
Complete Understanding ◽  
And Function

The present knowledge of the three-dimensional structure of ribosomes is far too limited to enable a complete understanding of the various roles which ribosomes play in protein biosynthesis. The spatial arrangement of proteins and ribonuclec acids in ribosomes can be analysed in many ways. Determination of binding sites for individual proteins on ribonuclec acid and locations of the mutual positions of proteins on the ribosome using labeling with fluorescent dyes, cross-linking reagents, neutron-diffraction or antibodies against ribosomal proteins seem to be most successful approaches. Structure and function of ribosomes can be correlated be depleting the complete ribosomes of some proteins to the functionally inactive core and by subsequent partial reconstitution in order to regain active ribosomal particles.

The Effect of Oxidized Cholesterol on the Aorta of Rabbits- Scanning Electron Microscopic Observations

1982 ◽  
Vol 40 ◽  
pp. 340-341
Author(s):  
S. K. Pena ◽  
C. B. Taylor ◽  
J. Hill ◽  
J. Safarik
Keyword(s):  
Cholesterol Biosynthesis ◽  
Cholesterol Content ◽  
Arterial Injury ◽  
Electron Microscopic ◽  
Aortic Smooth Muscle ◽  
Oxidized Cholesterol ◽  
Initial Event ◽  
Membrane Structure And Function ◽  
Scanning Electron Microscopic ◽  
And Function

Introduction: Oxidized cholesterol derivatives have been demonstrated in various cell cultures to be very potent inhibitors of 3-hvdroxy-3- methylglutaryl Coenzyme A reductase which is a principle regulator of cholesterol biosynthesis in the cell. The cholesterol content in the cells exposed to oxidized cholesterol was found to be markedly decreased. In aortic smooth muscle cells, the potency of this effect was closely related to the cytotoxicity of each derivative. Furthermore, due to the similarity of their molecular structure to that of cholesterol, these oxidized cholesterol derivatives might insert themselves into the cell membrane, alter membrane structure and function and eventually cause cell death. Arterial injury has been shown to be the initial event of atherosclerosis.

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