Reduction of the chronic stress response by inhalation of hiba (Thujopsis dolabrata) essential oil in rats

The infantile, childhood, and adolescent periods of growth and development represent times of increased vulnerability to stressors. The rate of growth in each period depends on the interplay of genetic, environmental, dietary, socioeconomic, developmental, behavioral, nutritional, metabolic, biochemical, and hormonal factors. A stressor may have an impact on growth directly through modulation of the growth hormone axis or indirectly through modulation of other factors. The adaptive response to stressors culminates in behavioral, physiological, and biochemical responses, which together support survival and conservation of energy. The process begins within seconds and involves activation of sympathetic nervous system and Hypothalamic-Pituitary-Adrenal axis. The time-limited stress response is at once anti-growth, anti-reproductive and catabolic with no lasting adverse consequences. However, chronic activation of the stress system and hypercortisolism have consequential negative impacts on growth, thyroid function, reproduction-puberty, and metabolism. They suppress Growth Hormone-Insulin like growth factor 1, Hypothalamic-Pituitary-Gonadal and Thyroid axes and can be responsible for an increase in visceral adiposity, a decrease in lean mass, suppression of osteoblastic activity with risk of osteoporosis, and induction of insulin resistance. Early life adversities, emotional or physical, have been associated with long-term negative physical and mental health outcomes. There are many models of chronic stress that corroborate that early life adversities affect optimal growth and have consequences throughout the lifespan. Targeted interventions to reduce stress during infancy, childhood and adolescence can have far reaching benefits to long-term health as well as attaining adequate growth. In this review we describe the neuroendocrinology of the stress response, the factors influencing growth, and the impact of chronic stress on growth during critical periods of infancy, childhood, and puberty with reference to each of growth, thyroid, and gonadal axis.

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Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety

10.21203/rs.3.rs-823079/v1 ◽

2021 ◽

Author(s):

Malalaniaina Rakotobe ◽

Niels Fjerdingstad ◽

Nuria Ruiz-Reig ◽

Thomas Lamonerie ◽

Fabien D'Autréaux

Keyword(s):

Stress Response ◽

Brain Development ◽

Chronic Stress ◽

Environmental Stressors ◽

Critical Node ◽

Sensitive Periods ◽

Early Stress ◽

Effects Of Stress

Abstract Experiencing stress during sensitive periods of brain development has a major impact on how individuals cope with later stress. Although many become more prone to develop anxiety or depression, some appear resilient. The mechanisms underlying these differences are unknown. Key answers may lie in how genetic and environmental stressors interact to shape the circuits controlling emotions. Here we studied the role of the habenulo-interpeducuncular system (HIPS), a critical node of reward circuits, in early stress-induced anxiety. We found that a subcircuit of this system, characterized by Otx2 expression, is particularly responsive to chronic stress during puberty, which induces HIPS hypersensitivity to later stress and susceptibility to develop anxiety. We further show that Otx2 deletion restricted to the HIPS counteracts these effects of stress. Together, these results demonstrate that Otx2 and stress interact, around puberty, to shape the HIPS stress-response, revealed here as a key modulator of susceptibility/resilience to develop anxiety.

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Untargetted Metabolomic Exploration of the Mycobacterium tuberculosis Stress Response to Cinnamon Essential Oil

Biomolecules ◽

10.3390/biom10030357 ◽

2020 ◽

Vol 10 (3) ◽

pp. 357 ◽

Cited By ~ 2

Author(s):

Elwira Sieniawska ◽

Rafał Sawicki ◽

Joanna Golus ◽

Milen I. Georgiev

Keyword(s):

Stress Response ◽

Essential Oil ◽

Redox Homeostasis ◽

Membrane Integrity ◽

Antimycobacterial Activity ◽

Stress Factors ◽

Stress Response System ◽

Reactive Compound ◽

Cinnamon Essential Oil ◽

Cell Wall Permeability

The antimycobacterial activity of cinnamaldehyde has already been proven for laboratory strains and for clinical isolates. What is more, cinnamaldehyde was shown to threaten the mycobacterial plasma membrane integrity and to activate the stress response system. Following promising applications of metabolomics in drug discovery and development we aimed to explore the mycobacteria response to cinnamaldehyde within cinnamon essential oil treatment by untargeted liquid chromatography–mass spectrometry. The use of predictive metabolite pathway analysis and description of produced lipids enabled the evaluation of the stress symptoms shown by bacteria. This study suggests that bacteria exposed to cinnamaldehyde could reorganize their outer membrane as a physical barrier against stress factors. They probably lowered cell wall permeability and inner membrane fluidity, and possibly redirected carbon flow to store energy in triacylglycerols. Being a reactive compound, cinnamaldehyde may also contribute to disturbances in bacteria redox homeostasis and detoxification mechanisms.

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Alleviation of the acute stress response following mild orange essential oil administration

IEEJ Transactions on Electrical and Electronic Engineering ◽

10.1002/tee.22428 ◽

2017 ◽

Vol 12 ◽

pp. S158-S163 ◽

Cited By ~ 3

Author(s):

Sugeeswari Lekamge ◽

Masaki Nakachi ◽

Shu Sato ◽

Kanetoshi Ito ◽

Shusaku Nomura

Keyword(s):

Stress Response ◽

Essential Oil ◽

Acute Stress ◽

Acute Stress Response ◽

Orange Essential Oil

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Fumigant Activity of thePsidium guajavaVar. Pomifera (Myrtaceae) Essential Oil inDrosophila melanogasterby Means of Oxidative Stress

Oxidative Medicine and Cellular Longevity ◽

10.1155/2014/696785 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 10

Author(s):

Antonio Ivanildo Pinho ◽

Gabriel Luz Wallau ◽

Mauro Eugenio Medina Nunes ◽

Nadghia Figueiredo Leite ◽

Saulo Relison Tintino ◽

...

Keyword(s):

Oxidative Stress ◽

Stress Response ◽

Essential Oil ◽

Psidium Guajava ◽

Oxidative Stress Response ◽

Model Organisms ◽

Native Plant ◽

Mechanisms Of Toxicity ◽

Popular Medicine ◽

Guava Fruit

The guava fruit,Psidium guajavavar. pomifera (Myrtaceae family), is a native plant from South America. Its leaves and fruits are widely used in popular medicine in tropical and subtropical countries.Drosophila melanogasterhas been used as one of the main model organisms in genetic studies since the 1900s. The extensive knowledge about this species makes it one of the most suitable organisms to study many aspects of toxic compound effects. Due to the lack of studies on the effects of the bioactive compounds present in theP. guajavavar. pomifera essential oil, we performed a phytochemical characterization by CG-MS and evaluated the toxicity induced by the essential oil in theD. melanogasterinsect model. In order to understand the biochemical mechanisms of toxicity, changes on the Nrf2 signaling as well as hallmarks of oxidative stress response were followed in the exposed flies. Our results showed that exposure of insects to theP. guajavaoil increased mortality and locomotor deficits in parallel with an oxidative stress response signaling. Therefore, it suggested a bioinsecticidal activity forP. guajavavolatile compounds by means of oxidative stress. Further studies are ongoing to identify which oil compounds are responsible for such effect.

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Sedative effect of 2-phenoxyethanol and essential oil of Lippia alba on stress response in gilthead sea bream (Sparus aurata)

Research in Veterinary Science ◽

10.1016/j.rvsc.2015.09.006 ◽

2015 ◽

Vol 103 ◽

pp. 20-27 ◽

Cited By ~ 34

Author(s):

Cândida Toni ◽

Juan Antonio Martos-Sitcha ◽

Bernardo Baldisserotto ◽

Berta Maria Heinzmann ◽

Lenise de Lima Silva ◽

...

Keyword(s):

Stress Response ◽

Essential Oil ◽

Sparus Aurata ◽

Sedative Effect ◽

Gilthead Sea Bream ◽

Sea Bream ◽

Lippia Alba

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Maternal stress in pregnancy and breastfeeding

10.1093/med/9780198722700.003.0033 ◽

2015 ◽

Author(s):

Sir Peter Gluckman ◽

Mark Hanson ◽

Chong Yap Seng ◽

Anne Bardsley

Keyword(s):

Immune System ◽

Stress Response ◽

Energy Metabolism ◽

Chronic Stress ◽

Severe Stress ◽

Daily Stress ◽

Placental Function ◽

Under Nutrition ◽

Infant Behaviour ◽

In Pregnancy

Acute and/or chronic stress in pregnancy is potentially detrimental to the health of both the mother and the developing fetus. The stress response triggers the release of glucocorticoids, mainly cortisol, into the maternal bloodstream, with subsequent effects on energy metabolism, growth processes, and in the functioning of the immune system and brain. The placenta provides a barrier to natural glucocorticoids, buffering the fetus from minor changes in maternal cortisol levels but can be saturated by high maternal levels of cortisol and under conditions of maternal under-nutrition or compromised placental function. Various outcomes can be affected, including birthweight and infant behaviour. Severe stress is not always easily avoided, but daily stress, and specifically that associated with pregnancy itself, should be minimized as much as possible.

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Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil inCampylobacter jejuni

BioMed Research International ◽

10.1155/2019/2971741 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

J. K. Kovács ◽

P. Felső ◽

Gy. Horváth ◽

J. Schmidt ◽

Á. Dorn ◽

...

Keyword(s):

Stress Response ◽

Essential Oil ◽

Stress Responses ◽

Gastrointestinal Symptoms ◽

Gastrointestinal Diseases ◽

Sublethal Concentration ◽

Scanning Electron Micrographs ◽

Stress Genes ◽

General Stress ◽

Virulence Potential

Campylobacter jejuniis one of the most common food-borne bacteria that causes gastrointestinal symptoms. In the present study we have investigated the molecular basis of the anti-Campylobactereffect of peppermint essential oil (PEO), one of the oldest EO used to treat gastrointestinal diseases. Transcriptomic, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and proteomic, two-dimensional polyacryl amid gel electrophoresis (2D-PAGE) methods have revealed that, in the presence of a sublethal concentration of PEO, the expression of several virulence-associated genes was decreased (cheY0.84x;flhB0.79x;flgE0.205x;cadF0.08x;wlaB0.89x;porA0.25x;cbf24.3x) while impaired motility was revealed with a functional analysis. Scanning electron micrographs of the exposed cells showed that, unlike in the presence of other stresses, the originally curvedC. jejunicells straightened upon PEO exposure. Gaining insight into the molecular background of this stress response, we have revealed that in the presence of PEOC. jejunidominantly exerts a general stress response that elevates the expression of general stress genes likednaK,groEL,groES(10.41x, 3.63x, and 4.77x). The most important genesdps,sodB, andkatAinvolved in oxidative stress responses showed however moderate transcriptional elevations (1,58x, 1,55x, and 1,85x).

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