Assessing Participation in Daily Living and the Effectiveness of Rehabiliation in Age Related Macular Degeneration Patients Using the Impact of Vision Impairment Scale

2008 ◽  
Vol 15 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Ecosse L. Lamoureux ◽  
Julie F. Pallant ◽  
Konrad Pesudovs ◽  
Alan Tennant ◽  
Gwyn Rees ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Daily Living ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
The Impact

scholarly journals Simulating Macular Degeneration to Investigate Activities of Daily Living: A Systematic Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Anne Macnamara ◽  
Celia Chen ◽  
Victor R. Schinazi ◽  
Dimitrios Saredakis ◽  
Tobias Loetscher
Keyword(s):  
Activities Of Daily Living ◽  
Macular Degeneration ◽  
Daily Living ◽  
Vision Loss ◽  
Contact Lenses ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Simulation Methods ◽  
Advantages And Disadvantages ◽  
Age Related

Purpose: Investigating difficulties during activities of daily living is a fundamental first step for the development of vision-related intervention and rehabilitation strategies. One way to do this is through visual impairment simulations. The aim of this review is to synthesize and assess the types of simulation methods that have been used to simulate age-related macular degeneration (AMD) in normally sighted participants, during activities of daily living (e.g., reading, cleaning, and cooking).Methods: We conducted a systematic literature search in five databases and a critical analysis of the advantages and disadvantages of various AMD simulation methods (following PRISMA guidelines). The review focuses on the suitability of each method for investigating activities of daily living, an assessment of clinical validation procedures, and an evaluation of the adaptation periods for participants.Results: Nineteen studies met the criteria for inclusion. Contact lenses, computer manipulations, gaze contingent displays, and simulation glasses were the main forms of AMD simulation identified. The use of validation and adaptation procedures were reported in approximately two-thirds and half of studies, respectively.Conclusions: Synthesis of the methodology demonstrated that the choice of simulation has been, and should continue to be, guided by the nature of the study. While simulations may never completely replicate vision loss experienced during AMD, consistency in simulation methodology is critical for generating realistic behavioral responses under vision impairment simulation and limiting the influence of confounding factors. Researchers could also come to a consensus regarding the length and form of adaptation by exploring what is an adequate amount of time and type of training required to acclimatize participants to vision impairment simulations.

scholarly journals Simulating Macular Degeneration to Investigate Activities of Daily Living: Systematic Review

2021 ◽  
Author(s):  
Anne Macnamara ◽  
Celia Chen ◽  
Victor Roger Schinazi ◽  
Dimitrios Saredakis ◽  
Tobias Loetscher
Keyword(s):  
Activities Of Daily Living ◽  
Macular Degeneration ◽  
Daily Living ◽  
Simulation Method ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Simulation Methods ◽  
Advantages And Disadvantages ◽  
Age Related ◽  
Time Required

Purpose: The aim of this review is to synthesise the types of simulation methods that have been used to simulate age-related macular degeneration (AMD) during activities of daily living. Since investigating activities of daily living is a fundamental first step in developing intervention and rehabilitation strategies, it is imperative that simulation methods are as realistic as possible.Methods: A systematic search was conducted in five databases. A critical analysis of the advantages and disadvantages of each AMD simulation method followed. Of particular interest was the suitability of each method for the investigated activity, an assessment of clinical validation procedures, and evaluating adaptation periods for participants.Results: Eighteen studies met the criteria for inclusion. Synthesis of the methodology demonstrated that the choice of AMD simulation has been, and should continue to be, guided by the nature of the study. The review also revealed a clear gap in the literature regarding the lack of standardised time periods for adaptation.Conclusions: When used appropriately, simulation studies can effectively examine how AMD impacts activities of daily living. Consistency in simulation methodology is crucial to generating realistic behavioural responses under vision impairment simulation and limiting the influence of confounding stressors. Researchers should address the gap in knowledge regarding adaptation by exploring what is an adequate time required to acclimate to vision impairment simulations.

scholarly journals The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 64
Author(s):  
Annamaria Tisi ◽  
Marco Feligioni ◽  
Maurizio Passacantando ◽  
Marco Ciancaglini ◽  
Rita Maccarone
Keyword(s):  
Oxidative Stress ◽  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Blood Retinal Barrier ◽  
Functional Changes ◽  
Beneficial Effects ◽  
Age Related ◽  
The Impact

The blood retinal barrier (BRB) is a fundamental eye component, whose function is to select the flow of molecules from the blood to the retina and vice-versa, and its integrity allows the maintenance of a finely regulated microenvironment. The outer BRB, composed by the choriocapillaris, the Bruch’s membrane, and the retinal pigment epithelium, undergoes structural and functional changes in age-related macular degeneration (AMD), the leading cause of blindness worldwide. BRB alterations lead to retinal dysfunction and neurodegeneration. Several risk factors have been associated with AMD onset in the past decades and oxidative stress is widely recognized as a key factor, even if the exact AMD pathophysiology has not been exactly elucidated yet. The present review describes the BRB physiology, the BRB changes occurring in AMD, the role of oxidative stress in AMD with a focus on the outer BRB structures. Moreover, we propose the use of cerium oxide nanoparticles as a new powerful anti-oxidant agent to combat AMD, based on the relevant existing data which demonstrated their beneficial effects in protecting the outer BRB in animal models of AMD.

scholarly journals Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels

2021 ◽  
Vol 22 (3) ◽  
pp. 1296
Author(s):  
Yue Ruan ◽  
Subao Jiang ◽  
Adrian Gericke
Keyword(s):  
Oxidative Stress ◽  
Macular Degeneration ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Therapeutic Strategies ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Oxygen Species ◽  
Age Related

Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.

The Impact of Disease Activity on 5 year Outcomes in patients undergoing treatment for Neovascular Age Related Macular Degeneration

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kelvin Yi Chong Teo ◽  
Vuong Nguyen ◽  
Chui Ming Gemmy Cheung ◽  
Jennifer J Arnold ◽  
Fred K. Chen ◽  
...  
Keyword(s):  
Disease Activity ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
The Impact

scholarly journals Prevalence and causes of vision loss in East Asia in 2015: magnitude, temporal trends and projections

2019 ◽  
Vol 104 (5) ◽  
pp. 616-622 ◽  
Author(s):  
Ching-Yu Cheng ◽  
Ningli Wang ◽  
Tien Y Wong ◽  
Nathan Congdon ◽  
Mingguang He ◽  
...  
Keyword(s):  
Visual Acuity ◽  
East Asia ◽  
Macular Degeneration ◽  
Refractive Error ◽  
Temporal Trends ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Public Healthcare ◽  
Age Related ◽  
Uncorrected Refractive Error

BackgroundTo determine the prevalence and causes of blindness and vision impairment (VI) in East Asia in 2015 and to forecast the trend to 2020.MethodsThrough a systematic literature review and meta-analysis, we estimated prevalence of blindness (presenting visual acuity <3/60 in the better eye), moderate-to-severe vision impairment (MSVI; 3/60≤presenting visual acuity <6/18), mild vision impairment (mild VI: 6/18≤presenting visual acuity <6/12) and uncorrected presbyopia for 1990, 2010, 2015 and 2020. A total of 44 population-based studies were included.ResultsIn 2015, age-standardised prevalence of blindness, MSVI, mild VI and uncorrected presbyopia was 0.37% (80% uncertainty interval (UI) 0.12%–0.68%), 3.06% (80% UI 1.35%–5.16%) and 2.65% (80% UI 0.92%–4.91%), 32.91% (80% UI 18.72%–48.47%), respectively, in East Asia. Cataract was the leading cause of blindness (43.6%), followed by uncorrected refractive error (12.9%), glaucoma, age-related macular degeneration, corneal diseases, trachoma and diabetic retinopathy (DR). The leading cause for MSVI was uncorrected refractive error, followed by cataract, age-related macular degeneration, glaucoma, corneal disease, trachoma and DR. The burden of VI due to uncorrected refractive error, cataracts, glaucoma and DR has continued to rise over the decades reported.ConclusionsAddressing the public healthcare barriers for cataract and uncorrected refractive error can help eliminate almost 57% of all blindness cases in this region. Therefore, public healthcare efforts should be focused on effective screening and effective patient education, with access to high-quality healthcare.

scholarly journals ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

2020 ◽  
pp. bjophthalmol-2019-315717 ◽  
Author(s):  
Sandra Liakopoulos ◽  
Georg Spital ◽  
Christian K Brinkmann ◽  
Tina Schick ◽  
Focke Ziemssen ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Image Interpretation ◽  
Subretinal Fluid ◽  
Treatment Decisions ◽  
Age Related Macular Degeneration ◽  
Correct Identification ◽  
Age Related ◽  
Ocean Study ◽  
The Impact ◽  
Sd Oct

Background/aimsThe prospective, non-interventional ORCA module of the OCEAN study (Observation of Treatment Patterns with Lucentis in Approved Indications) evaluated the qualiy of spectral domain-optical coherence tomography (SD-OCT) image interpretation and treatment decisions by clinicians in Germany and the impact on visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD).Methods2286 SD-OCT scans of 205 eyes were independently evaluated by clinicians and reading centres (RCs) regarding signs of choroidal neovascularisation (CNV) activity, including presence of intraretinal fluid, subretinal fluid, and/or increase in pigment epithelial detachments. Agreement between clinicians and RCs was calculated. Treatment decisions by clinicians and the impact on treatment outcomes were evaluated.ResultsCNV activity was detected by RCs on 1578 scans (69.0%) and by clinicians on 1392 scans (60.9%), with agreement in 74.9% of cases. Of the 1578 scans with RC detected CNV activity, anti-vascular endothelial growth factor injections were performed by clinicians in only 35.5% (560/1578). In 19.7% of cases (311/1578), lack of treatment was justified by patients request, termination criteria or chronic cystoid spaces without other signs for CNV activity. In 44.8% of cases (707/1578) with RC detected CNV activity, clinicians claimed no treatment was necessary despite having correctly detected CNV activity in about 2/3 of these cases. In 34% of cases with presumed undertreatment, visual acuity declined in the following visit.ConclusionAlthough broad agreement on CNV activity parameters was observed between clinicians and RCs, correct identification of CNV activity did not always lead to the initiation of (re-)treatment. To preserve vision over time, correct interpretation of SD-OCT scans and careful retreatment decisions are required.Trial registration numberNCT02194803.

Sign in / Sign up

Export Citation Format

Share Document