scholarly journals Inflammatory Markers in Cystic Fibrosis Patients with LungPseudomonas AeruginosaInfection

1999 ◽  
Vol 8 (3) ◽  
pp. 159-167 ◽  
Author(s):  
A. L. Pukhalsky ◽  
N. I. Kapranov ◽  
E. A. Kalashnikova ◽  
G. V. Shmarina ◽  
L. A. Shabalova ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Antibiotic Treatment ◽  
Inflammatory Markers ◽  
Chloride Channels ◽  
Genetic Disorder ◽  
Peripheral Blood Lymphocytes ◽  
Tnf Α ◽  
Elevated Activity ◽  
The Relationship ◽  
Immunomodulating Drugs

Chronic endobronchial inflammation and bacterial infection are the main causes of morbidity and mortality in cystic fibrosis (CF), an autosomal recessive genetic disorder associated with improper function of chloride channels. Inflammation in CF lung is greatly amplified afterPseudomonas aeruginosainfection. In this study the relationship betweenP. aeruginosastatus and inflammatory markers has been investigated. Seventeen CF children in acute lung exacerbation were examined. CF patients withoutP. aeruginosainfection were characterized by elevated activity of sputum elastase, reduced response of peripheral blood lymphocytes to PHA and significant resistance to the antiproliferative action of glucocorticoids. These parameters were normalized after antibiotic treatment. The patients with prolongedP. aeruginosainfection demonstrated extremely high levels of elastase activity and elevated amounts of sputum IL-8 and TNF-α. Although antibiotic treatment resulted in clinical improvement, it failed to suppress excessive immune response in the lung. The data indicate that CF patients with prolongedP. aeruginosaneed the modified treatment, which should include immunomodulating drugs and protease inhibitors as well as antibacterial therapy.

The association between a metabolically healthy overweight/obesity phenotype and markers of inflammation among Chinese children and adolescents aged 10–18 years

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jinyu Zhou ◽  
Ling Bai ◽  
Yangyang Dong ◽  
Rongrong Cai ◽  
Wenqing Ding
Keyword(s):  
Children And Adolescents ◽  
Inflammatory Markers ◽  
Normal Weight ◽  
Chinese Children ◽  
Metabolic Phenotypes ◽  
Tnf Α ◽  
Metabolically Healthy ◽  
Hs Crp ◽  
The Relationship ◽  
Chinese Children And Adolescents

Abstract Objectives The association between metabolically healthy overweight/obesity (MHO) and inflammatory markers remains controversial. The aim of the present study was to describe the prevalence of different metabolic phenotypes and to examine the relationship of different metabolic phenotypes with inflammatory markers among Chinese children and adolescents. Methods The study included 1,125 children and adolescents aged 10–18 years using a cross-sectional survey, and all subjects were classified into four groups based on a combination of BMI and metabolic status. In addition, the inflammatory markers we measured were high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6). Results The prevalence of metabolically healthy with normal-weight (MHNW), MHO, metabolically unhealthy with normal-weight (MUNW), and metabolically unhealthy overweight/obesity (MUO) phenotypes was 38.76, 7.11, 38.67 and 15.47%, respectively. The results of logistic regression analysis showed that the MHO was associated with the z scores of hs-CRP in Chinese children and adolescents (OR=0.57, 95% CI: 0.39–0.83). Meanwhile, multivariate adjusted regression analysis showed that the relationship between hs-CRP and MHO among the overweight/obese was consistent with the results above, but among the normal-weight, only the highest quartile of TNF-α could increase the risk of MUNW (OR=1.65, 95% CI: 1.09–2.52). Conclusions MHO phenotypes were not common in Chinese children and adolescents. Individuals with MHO had a more beneficial hs-CRP profile than those with MUO.

Role of lung iron in determining the bacterial and host struggle in cystic fibrosis

2009 ◽  
Vol 297 (5) ◽  
pp. L795-L802 ◽  
Author(s):  
D. W. Reid ◽  
G. J. Anderson ◽  
I. L. Lamont
Keyword(s):  
Cystic Fibrosis ◽  
Iron Homeostasis ◽  
Iron Acquisition ◽  
Genetic Disorder ◽  
Bacterial Species ◽  
System Disease ◽  
Liver And Pancreas ◽  
Pseudomonas Aeruginosa Infection ◽  
The Relationship

Cystic fibrosis (CF) is the most common lethal genetic disorder in Caucasian populations. It is a multiorgan system disease that affects the lungs, gastrointestinal tract, liver, and pancreas. The majority of morbidity and mortality in CF relates to chronic airway infection with a variety of bacterial species, commencing in very early infancy, which results in lung destruction and ultimately organ failure ( 41 , 43 ). This review focuses on iron homeostasis in the CF lung and its role in determining the success and chronicity of Pseudomonas aeruginosa infection. There have been previous excellent reviews regarding iron metabolism in the lower respiratory tract and mechanisms of P. aeruginosa iron acquisition, and we direct readers to these articles for further background reading ( 31 , 53 , 58 , 77 , 96 ). In this review, we have brought the “two sides of the coin” together to provide a holistic overview of the relationship between host and bacterial iron homeostasis and put this information into the context of current understanding on infection in the CF lung.

scholarly journals Inflammatory markers and suicidal attempts in depressed patients: A review

2016 ◽  
Vol 29 (4) ◽  
pp. 583-594 ◽  
Author(s):  
Stefano Marini ◽  
Federica Vellante ◽  
Ilaria Matarazzo ◽  
Domenico De Berardis ◽  
Nicola Serroni ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Psychiatric Illness ◽  
Suicidal Behaviors ◽  
Major Depressive ◽  
Depressed Patients ◽  
Tnf Α ◽  
Suicidal Attempts ◽  
The Relationship ◽  
Depressive States ◽  
Pro Inflammatory Cytokines

Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.

The relationship of clinical and inflammatory markers to outcome in stable patients with cystic fibrosis

2007 ◽  
Vol 42 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Damian G. Downey ◽  
S. Lorraine Martin ◽  
Martin Dempster ◽  
John E. Moore ◽  
Mary T. Keogan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Inflammatory Markers ◽  
Relationship Of ◽  
The Relationship

scholarly journals Effect of antibiotic treatment on inflammatory markers and lung function in cystic fibrosis patients with Pseudomonas cepacia.

Thorax ◽  
1994 ◽  
Vol 49 (8) ◽  
pp. 803-807 ◽  
Author(s):  
D Peckham ◽  
S Crouch ◽  
H Humphreys ◽  
B Lobo ◽  
A Tse ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Antibiotic Treatment ◽  
Inflammatory Markers ◽  
Pseudomonas Cepacia

scholarly journals Cystic fibrosis: current treatment and future direction

2021 ◽  
Vol 10 (4) ◽  
pp. 444
Author(s):  
Shreya Gupta ◽  
Niti Mittal ◽  
Mahesh C. Gupta
Keyword(s):  
Cystic Fibrosis ◽  
Chloride Channels ◽  
Genetic Disorder ◽  
Pancreatic Insufficiency ◽  
Genetic Defect ◽  
Disease Process ◽  
Holistic Approach ◽  
Current Treatment ◽  
Cftr Gene ◽  
Long Term Effects

Cystic fibrosis is an autosomal recessive genetic disorder, characterized by mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leading to abnormality in the chloride channels of the mucus and sweat producing glands. Multiple organs systems are affected in this disorder, like respiratory system and gastrointestinal tract, severely impacting the patient’s quality of life, eventually leading on to several complications and death. Since the uncovering of the underlying genetic defect in cystic fibrosis (CF), our knowledge of the disease process has increased substantially, but we still lack a holistic approach to its management, which comprises of multiple facades, requiring both pharmacological and non-pharmacological or rehabilitatory approaches. So far, the therapeutic options were limited to targeting the consequences and complications of the disease, such as respiratory infection, mucus retention, pancreatic insufficiency, etc., but now several promising therapies may be able to address the underlying pathology rather than its long-term effects. This review summarizes the current and upcoming pharmacological options for CF, such as those targeting the CFTR gene defect directly, including gene editing, CFTR correctors and potentiators; drugs targeting the epithelial sodium channels (ENaC inhibitors); repositioning of some existing drugs and evaluating their role in CF; and understanding the disease better by transcriptomic approaches and the role of gut microbiota in the disease process and severity.

scholarly journals Serum inflammatory profiles in cystic fibrosis mice with and without Bordetella pseudohinzii infection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Paul M. Litman ◽  
Alexander Day ◽  
Thomas J. Kelley ◽  
Rebecca J. Darrah
Keyword(s):  
Cystic Fibrosis ◽  
Inflammatory Cytokines ◽  
Chronic Infection ◽  
Inflammatory Markers ◽  
Acute Infection ◽  
Humoral Response ◽  
Lavage Fluid ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Inflammatory Profile

AbstractCystic fibrosis (CF) is an autosomal recessive disease caused by dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) protein, and is marked by an accumulation of mucus in affected airways resulting in persistent infection and chronic inflammation. Quantitative differences in inflammatory markers have been observed in CF patient serum, tracheal cells, and bronchoalveolar lavage fluid, in the absence of detectable infection, implying that absent CFTR function alone may result in dysregulated immune responses. To examine the relationship between absent CFTR and systemic inflammation, 22 analytes were measured in CF mice (F508del/F508del) sera using the MSD multiplex platform. Pro-inflammatory cytokines IL-2, TNF-α, IL-17α, IFN-γ, IL-1β, and MIP-3α are significantly elevated in infection-naïve CF mice (p < 0.050). Anti-inflammatory cytokines IL-10 and IL-4 are also significantly increased (p = 0.00003, p = 0.004). Additionally, six general markers of inflammation are significantly different from non-CF controls (p < 0.050). To elucidate the effects of chronic infection on the CF inflammatory profile, we examined CF mice exposed to spontaneous Bordetella pseudohinzii infections. There are no statistical differences in nearly all inflammatory markers when compared to their infection-naïve CF counterparts, except in the Th2-derived IL-4 and IL-5 which demonstrate significant decreases following exposure (p = 0.046, p = 0.045). Lastly, following acute infection, CF mice demonstrate elevations in nearly all inflammatory markers, but exhibit a shortened return to uninfected levels over time, and suppression of Th1-derived IL-2 and IL-5 (p = 0.043, p = 0.011). These results imply that CF mice have a persistent inflammatory profile often indistinguishable from chronic infection, and a dysregulated humoral response during and following active infection.

Endothelial Dysfunction and Inflammatory Markers of Vascular Disease

2020 ◽  
Vol 19 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Sevket Balta
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Disease ◽  
Inflammatory Markers ◽  
Vascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Non Invasive ◽  
Von Willebrand ◽  
The Relationship ◽  
Willebrand Factor

: Vascular diseases are the main reason for morbidity and mortality worldwide. As we know, the earlier phase of vascular diseases is endothelial dysfunction in humans, the endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via organizing ligand-receptor associations and the various mediators’ secretion. We can use many inflammatory non-invasive tests (flowmediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and anklebrachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modified albumin, pentraxin-3, E-selectin, angiopoietin, endothelial cell specific molecule 1, asymmetrical dimethylarginine, von Willebrand factor, endothelial microparticles and endothelial progenitor cells) can be used to evaluate endothelial dysfunction. We have focused on the relationship between endothelial dysfunction and inflammatory markers of vascular disease in this review.

Rhinosinusitis in the Pediatric Patient with Cystic Fibrosis

2014 ◽  
Vol 10 (3) ◽  
pp. 198-201 ◽  
Author(s):  
Christopher Fundakowski ◽  
Rosemary Ojo ◽  
Ramzi Younis
Keyword(s):  
Cystic Fibrosis ◽  
Autosomal Recessive ◽  
Pediatric Patients ◽  
Surgical Intervention ◽  
Chronic Sinusitis ◽  
Genetic Disorder ◽  
Symptomatic Relief ◽  
Recurrence Rates ◽  
Polyp Recurrence ◽  
Sinonasal Polyposis

Cystic fibrosis (CF) is a common autosomal recessive genetic disorder where a deletion mutation and subsequent downstream alteration in transmembrane regulator proteins results in increased mucus viscosity. CF manifests clinically with chronic multisystem inflammation and recurrent infections. Nearly all children with CF have chronic sinusitis, and a large majority will have concurrent sinonasal polyposis. Chronic sinusitis and sinonasal polyposis in pediatric patients with CF can be managed conservatively initially, though most will fail medical management and require surgical intervention. Unfortunately, symptom resolution is marginal and polyp recurrence rates are high. Currently, no cure exists for CF and the mainstay of treatment is to provide symptomatic relief, and minimize disease morbidity.

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