scholarly journals Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop

2022 ◽  
pp. 1-42
Author(s):  
Susan P. Felter ◽  
Virunya S. Bhat ◽  
Philip A. Botham ◽  
David A. Bussard ◽  
Warren Casey ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Hazard Identification ◽  
Chemical Carcinogenicity ◽  
State Of The Science

scholarly journals Generalized Read-Across prediction using genra-py

2021 ◽  
Author(s):  
Imran Shah ◽  
Tia Tate ◽  
Grace Patlewicz
Keyword(s):  
Risk Assessment ◽  
Human Health Risk ◽  
Chemical Properties ◽  
Predictive Performance ◽  
Hazard Identification ◽  
Data Driven ◽  
Chemical Safety ◽  
Physico Chemical ◽  
Data Driven Approach ◽  
Assessment Problems

Abstract Motivation Generalized Read-Across (GenRA) is a data-driven approach to estimate physico-chemical, biological or eco-toxicological properties of chemicals by inference from analogues. GenRA attempts to mimic a human expert’s manual read-across reasoning for filling data gaps about new chemicals from known chemicals with an interpretable and automated approach based on nearest-neighbors. A key objective of GenRA is to systematically explore different choices of input data selection and neighborhood definition to objectively evaluate predictive performance of automated read-across estimates of chemical properties. Results We have implemented genra-py as a python package that can be freely used for chemical safety analysis and risk assessment applications. Automated read-across prediction in genra-py conforms to the scikit-learn machine learning library's estimator design pattern, making it easy to use and integrate in computational pipelines. We demonstrate the data-driven application of genra-py to address two key human health risk assessment problems namely: hazard identification and point of departure estimation. Availability and implementation The package is available from github.com/i-shah/genra-py.

Applying the Quantitative Risk Assessment (QRA) to Improve Safety Management of Oil and Gas Pipeline Stations in China

2012 ◽  
Author(s):  
Wenxing Feng ◽  
Xiaoqiang Xiang ◽  
Guangming Jia ◽  
Lianshuang Dai ◽  
Yulei Gu ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Environmental Protection ◽  
Oil And Gas ◽  
Hazard Identification ◽  
Gas Pipeline ◽  
Industrial Safety ◽  
Quantitative Risk Assessment ◽  
Chinese Government ◽  
Land Resource ◽  
Oil Pipeline

The oil and gas pipeline companies in China are facing unprecedented opportunities and challenges because of China’s increasing demand for oil and gas energy that is attributed to rapid economic and social development. Limitation of land resource and the fast urbanization lead to a determinate result that many pipelines have to go through or be adjacent to highly populated areas such as cities or towns. The increasing Chinese government regulation, and public concerns about industrial safety and environmental protection push the pipeline companies to enhance the safety, health and environmental protection management. In recent years, PetroChina Pipeline Company (PPC) pays a lot of attention and effort to improve employees and public safety around the pipeline facilities. A comprehensive, integrated HSE management system is continuously improved and effectively implemented in PPC. PPC conducts hazard identification, risk assessment, risk control and mitigation, risk monitoring. For the oil and gas stations in highly populated area or with numerous employees, PPC carries out quantitative risk assessment (QRA) to evaluate and manage the population risk. To make the assessment, “Guidelines for quantitative risk assessments” (purple book) published by Committee for the Prevention of Disasters of Netherlands is used along with a software package. The basic principles, process, and methods of QRA technology are introduced in this article. The process is to identify the station hazards, determinate the failure scenarios of the facilities, estimate the possibilities of leakage failures, calculate the consequences of failures and damages to population, demonstrate the individual risk and social risk, and evaluate whether the risk is acceptable. The process may involve the mathematical modeling of fluid and gas spill, dispersion, fire and explosion. One QRA case in an oil pipeline station is described in this article to illustrate the application process and discuss several key issues in the assessment. Using QRA technique, about 20 stations have been evaluated in PPC. On the basis of the results, managers have taken prevention and mitigation plans to control the risk. QRAs in the pipeline station can provide a quantitative basis and valuable reference for the company’s decision-making and land use planning. Also, QRA can play a role to make a better relationship between the pipeline companies and the local regulator and public. Finally, this article delivers limitations of QRA in Chinese pipeline stations and discusses issues of the solutions.

ANALISIS KESELAMATAN KESEHATAN KERJA (K3) TERHADAP RISIKO BAHAYA LINGKUNGAN FISIK DENGAN METODE “HIRARC” DI RUMAH POTONG HEWAN KOTA PEKANBARU TAHUN 2020

2021 ◽  
Vol 1 (2) ◽  
pp. 215-224
Author(s):  
Diana Putri ◽  
Asril Asril ◽  
Beny Yulianto
Keyword(s):  
Risk Assessment ◽  
Risk Control ◽  
Health And Safety ◽  
Hazard Identification ◽  
Work Activities ◽  
Administrative Control ◽  
Engineering Control ◽  
Safety And Health ◽  
Key Informant ◽  
Work Shifts

ABSTRAK Rumah Potong Hewan merupakan suatu bangunan yang memiliki desain dan konstruksi khusus digunakan sebagai tempat pemotongan hewan. Aktivitas kerja di RPH memiliki potensi bahaya yang dapat mengancam keselamatan dan kesehatan kerja. Berdasarkan observasi awal, RPH Kota Pekanbaru ini tidak memiliki laporan bulanan maupun tahunan mengenai data kecelakaan, dan juga belum pernah melakukan identifikasi, dan penilaian terhadap bahaya yang ada. Adapun tujuan penelitian ini yaitu untuk menganalisis keselamatan kesehatan kerja (K3) terhadap risiko bahaya lingkungan fisik di tempat kerja dengan metode “HIRARC” (Hazard Identification, Risk Assessment, and Risk Control). Jenis penelitian ini adalah kualitatif analitik. Lokasi penenlitian dilakukan di rumah potong hewan Kota Pekanbaru, penelitian dilakukan pada bulan Juli-Agustus 2020. Informan dalam penelitian ini sebanyak 6 orang, sebagai informan utama yaitu Kepala UPTD, 2 orang informan pendukung yaitu koordinator lapangan dan dokter hewan, dan informan kunci yaitu pekerja, metode yang digunakan peneliti yaitu wawancara mendalam dan observasi langsung. Berdasarkan hasil penelitian yang dilakukan potensi bahaya tingkatan risiko “Ekstrim” seperti diseruduk sapi pada proses penggiringan sapi menuju killing box, tertimpa katrol dan sapi pada proses penggantungan dan pemindahan sapi menggunakan katrol. Rumah Potong Hewan belum pernah melakukan identifikasi bahaya, penilaian risiko akan tetapi untuk pengendalian risiko sudah dilakukan beberapa upaya di rumah potong hewan, seperti SOP, Shift kerja, dan juga APD. Rekomendasi yang diberikan yaitu diharapkan sebaiknya RPH memiliki fasilitas yang berhubungan dengan kesehatan pekerja. Perlu adanya upaya pengendalian risiko secara engineering control, contohnya, membuat kerangkeng sapi. administrative control, seperti, memberikan sosialisasi, maintenance, housekeeping dan inspeksi, terhadap alat, mesin dan pekerja. ABSTRACTSlaughterhouse is a building having the design and construction specifically used as animal slaughterhouse. Slaughterhouse’s work activities have potential of hazards which can cause harm to workers’ safety and health. Based on pre observation, the slaughterhouse in Pekanbaru does not have any monthly and annual report about the data of accident. This livestock production also has no doing identification and assessment of hazard. The purposes of this study are to analyze occupational health and safety toward risk of danger physical environment at work, this study uses Hazard Identification, Risk Assessment, and Risk Control “HIRARC” method which using likelihood and severity level of each hazard as references to define a risk value. There are 6 informants the maininfromants is a UPTD head, 2 supporting informants are the field coordinator and venetarian, and the key informant is a worker, The methode that use in this study is interview And observation. The study shows that the most extreme are getting hit by a cow in cattle herding to killing box, falling of a cow hoist material from conveyor railing in shackling and hoisting process. Slaughterhouse has never done hazard identification and risk assessment. However, for risk control have done several attempts in slaughterhouse, such as Standard Operating Procedures, work shifts, and Personal Protective Equipment. Recommendation is given that the slaughterhouse should has facilities related to health of workers. It needs an effort to risk control through engineering control such as making cow cages, administrative control, such as giving socialization, maintenance, housekeeping and inspection of tools, machines and workersKeywords : Slaughterhouse, Hazard, Risk, Physical Environtmen, HIRARC.

Hazard identification and risk assessment in firework industry

2021 ◽  
Author(s):  
S. Ajith ◽  
V. Arumugaprabu ◽  
V. Ajith ◽  
K. Naresh ◽  
P.S. Rama Sreekanth
Keyword(s):  
Risk Assessment ◽  
Hazard Identification

scholarly journals RISK ASSESSMENT PERUSAHAAN EXPORT SEPATU PADA BAGIAN LINE UPPER PT. X

2015 ◽  
Vol 4 (1) ◽  
pp. 22
Author(s):  
Novita Dewi Vebriyana Dankis ◽  
Mulyono Mulyono
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Risk Control ◽  
Consumer Products ◽  
Hazard Identification ◽  
Low Risk ◽  
Residual Risk ◽  
Control Measures ◽  
On Line ◽  
Punch Hole

ABSTRACTRevolution in the industry sector has been rapidly grown to fill up all the needs of the consumer products. One involves  supporting advanced machinery such as “Cutting, Skiving, Stitching, Emboss Logo, Roving, Punch Hole, Juki, BrushingEdge, Hammer Over Lapping and Two Molding”. In the factory production process, there are various types of high-risk activities, especially on line upper. The main of this research is to study the risk assessment on export companies line the upper part of the shoes export company using Job Safety Analysis. This research was conducted observational crosssectional design. Observations made to the hazards and control measures. Interviews were conducted to 12 employees. Variables in this research is production activity, hazard identification, risk assessment, risk control and residual risk. The results of hazard identification has been done, there are 91 known potential hazards, for risk assessment found 7 high risk and low risk 5. Machine classified as high risk on the risk assessment is roving machine, whereas low-risk is two molding machine. Control efforts on the upper line in accordance with the hierarchy of controlling a number of 91 controls, whereas for the residual risk still remains as much as 30 residual risk. Control has been applied quite well by pressing the consequences of hazards and risk management.Keywords: risk assessment, controlling, residual risk

scholarly journals Implementasi Metode Hazard Identification Risk Assessment And Risk Control Guna Peningkatan Keselamatan dan Kesehatan Karyawan di PT ABC

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Alfina Fitri Damayanti ◽  
Nina Aini Mahbubah
Keyword(s):  
Risk Assessment ◽  
Service Providers ◽  
Low Voltage ◽  
Risk Control ◽  
Health And Safety ◽  
Primary Source ◽  
Hazard Identification ◽  
Research Approach ◽  
Risk Levels ◽  
Extreme Risk

Zero accident was considered as the primary occupational health and safety value in manufacturing and service enterprises.  PT. ABC provided  electrical and instrument services, including a low-voltage installation, high-voltage installation and an instrument installation. This company is known to excellent electricity and instrument service providers across the country . Moreover, men’s power is used as a primary source to maintain  these kind  of services. Installation projects depend not only on the high working speed, but also on  high working  accuracy within  certain timeframes . As a result, work  accidents  have occurred with a classification varying from minor to fatal accidents.  The purpose of this research is to identify potential hazards to assess risk levels and  obtain recommendations for  preventing accident. The HIRARC method is employed as a research approach. This research is initiated through Hazard Identification, Risk Assessment and Risk Control.  This research identified that two hazards were classified as  extreme risk, three hazards as high- risk, eight hazards as moderate risk , and two hazards have been identified as low risk . Furthermore, a number of action lists have been suggested in order to minimize accident rates and finally the working conditions are designed to maintain zero accidents.

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