Mechanism of Hydroxyl Radical Scavenging by Rebamipide: Identification of Mono-hydroxylated Rebamipide as a Major Reaction Product

2004 ◽  
Vol 38 (5) ◽  
pp. 487-494 ◽  
Author(s):  
Kazushi Sakurai ◽  
Hiroyuki Sasabe ◽  
Toshihisa koga ◽  
Tetsuya Konishi
Keyword(s):  
Hydroxyl Radical ◽  
Radical Scavenging ◽  
Major Reaction Product ◽  
Major Reaction

METHYL 3-NITRO- AND 3-AMINO-3-DEOXY-β-D-GALACTOPYRANOSIDE AND -MANNOPYRANOSIDE

1963 ◽  
Vol 41 (6) ◽  
pp. 1606-1611 ◽  
Author(s):  
Hans Helmut Baer ◽  
Frank Kienzle
Keyword(s):  
Crystalline State ◽  
Major Reaction Product ◽  
Major Reaction ◽  
Amino Derivatives ◽  
Facile Preparation ◽  
Hydrolysis Of

The steric course of the nitromethane cyclization of L′-methoxy-D-hydroxymethyldiglycolic aldehyde was investigated. Methyl 3-nitro-3-deoxy-β-D-galactopyranoside was shown to arise as a second major reaction product in addition to the previously isolated principal stereoisomer, the gluco derivative. The corresponding manno stereoisomer is formed to a smaller extent. The configurations of the new methyl nitrodeoxyglycosides were established by conversion into the corresponding amino derivatives and hydrolysis of these latter to the known 3-amino-3-deoxy-D-galactose and -D-mannose hydrochlorides. All the products were obtained in a crystalline state. The reaction lends itself to a facile preparation of the nitrogenous galactose derivatives.

scholarly journals IN VITRO - ANTIOXIDANT AND PRELIMINARY PHYTOCHEMICAL ANALYSIS OF AEGLE MARMELOS (L.) CORREA. LEAF EXTRACT

2017 ◽  
Vol 10 (6) ◽  
pp. 367
Author(s):  
Samidha M Pawaskar ◽  
Sasangan Kc
Keyword(s):  
Hydroxyl Radical ◽  
Leaf Extract ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Aegle Marmelos ◽  
Leaf Powder ◽  
Phenolic And Flavonoid

Objective: In this study, the leaf powder of Aegle marmelos (L.) Correa. was subjected to preliminary phytochemical and in vitro antioxidant analysis. Methods: The freshly prepared plant leaf extract was subjected to preliminary phytochemical screening, which revealed the presence of alkaloids, tannins, saponins, flavonoids, glycosides, phenolic compounds, terpenoids, and steroids. Reducing power, superoxide (SO) anion radical, nitric oxide (NO) radical, and hydroxyl radical scavenging assays were carried out to evaluate the antioxidant potential of the methanolic leaf extract of this plant. The amounts of total phenolic and flavonoid compounds were also determined. Results: This study has revealed that the A. marmelos (L.) Correa. leaf extract showed considerably high amounts of most of the phytochemicals, total antioxidant capacity, total phenolic, and flavonoid content. The study also indicated that the A. marmelos (L.) Correa. showed comparatively good scavenging activity, i.e., inhibition of hydroxyl radical, NO and SO anion scavenging and reducing power activities when compared with the respective standards. Conclusion: The leaf powder of A. marmelos (L.) Correa. can be used as easily accessible source of natural antioxidant and as a possible food supplement or in pharmaceutical industry.

scholarly journals Pharmacological studies of Mangifera indica leaf extract

2021 ◽  
Vol 7 (3) ◽  
pp. 073-079
Author(s):  
Agrawal RC
Keyword(s):  
Hydroxyl Radical ◽  
Radical Scavenging Activity ◽  
Mangifera Indica ◽  
Radical Scavenging ◽  
Antibacterial Activities ◽  
Positive Control ◽  
Screening Methods ◽  
Phytochemical Screening ◽  
Test Organisms ◽  
Almost All

The present study was undertaken to explore the phytochemical screening, anti-bacterial and anti-oxidant activities of the hydro-methanolic leaves extract of Mangifera indica using standard screening methods such as disc diffusion and DPPH methods. In phytochemical screening, Mangifera indicaextract showed presence of secondary metabolites such as carbohydrate, phenols, tanins and proteins whereas Saponins were absent. It also showed antibacterial activities against almost all the test organisms. The extracts possessed potent hydroxyl radical scavenging activity against the positive control standard Ascorbic acid. Results denote the presence of hydroxyl radical scavenging principles in the extracts.

scholarly journals Biological Properties of Silver Nanoparticles from β (1-3) Glucan Isolated from the Edible Mushroom Pleurotus florida

2020 ◽  
Vol 10 (2) ◽  
pp. 2096-2106
Keyword(s):  
Silver Nanoparticles ◽  
Drug Development ◽  
Hydroxyl Radical ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Edible Mushroom ◽  
Hot Water ◽  
Dependent Manner ◽  
Pleurotus Florida ◽  
Radical Scavenging Assay

Pleurotus florida of the genus Pleurotus is a delicious edible mushroom with high therapeutic potential. Silver nanoparticles (AgNPs) are gaining a lot of importance nowadays because of their wide industrial and biomedical applications. Capping of AgNPs with polysaccharides, the most potent mushroom derived metabolites, is promising towards natural drug development for free radical-induced ailments. In the present investigation, silver nanoparticles were synthesized using β-glucan isolated from P. florida, and their antioxidant properties were studied. Polysaccharide (PS) isolation was carried out by hot water extraction, alcohol precipitation, deproteinization, and dialysis. Preliminary characterization of PS by Anthrone, Lowry’s method, Paper Chromatography, and FT-IR showed that PS is protein-bound β-(1-3) - Glucan. Synthesis of Silver nanoparticle from PS (PS-AgNPs) was confirmed by UV spectroscopy. Antioxidant properties of PS and PS-AgNPs were evaluated by Total antioxidant capacity assay, DPPH assay, Total reducing power, and Hydroxyl radical scavenging assay. Both PS and PS-AgNPs showed profound antioxidant activity in a dose-dependent manner, and PS-AgNPs was more active than PS. The highest activity was shown in Hydroxyl radical scavenging assay in which PS and PS-AgNPs showed 81.8% and 89.4% activity, respectively, at the highest tested dose. The present study revealed the possible use of P. florida in antioxidant drug development.

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